- Orthostatic Hypotension and Cognitive Impairment in De Novo Patients with Parkinson’s Disease
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Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
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J Mov Disord. 2014;7(2):102-104. Published online October 30, 2014
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DOI: https://doi.org/10.14802/jmd.14016
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Citations
Citations to this article as recorded by  - A systematic review and meta-analysis on the association between orthostatic hypotension and mild cognitive impairment and dementia in Parkinson’s disease
Débora Loureiro, Rodrigo Bilbao, Sofía Bordet, Lina Grasso, Matilde Otero-Losada, Francisco Capani, Osvaldo J. Ponzo, Santiago Perez-Lloret
Neurological Sciences.2023; 44(4): 1211. CrossRef - The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study
Xiaofan Xue, Anqi Huang, Jingrong Zeng, Haixia Song, Yingqi Xing, Piu Chan, Erhe Xu, Lichun Zhou
Frontiers in Neurology.2023;[Epub] CrossRef - Cognitive and Autonomic Dysfunction in Multiple System Atrophy Type P and C: A Comparative Study
Giulia Lazzeri, Giulia Franco, Teresa Difonzo, Angelica Carandina, Chiara Gramegna, Maurizio Vergari, Federica Arienti, Anisa Naci, Costanza Scatà, Edoardo Monfrini, Gabriel Dias Rodrigues, Nicola Montano, Giacomo P. Comi, Maria Cristina Saetti, Eleonora
Frontiers in Neurology.2022;[Epub] CrossRef - Impaired dynamic cerebral autoregulation: A potential mechanism of orthostatic hypotension and dementia in Parkinson’s disease
Hongxiu Chen, Erhe Xu, Fubo Zhou, Qiuping Li, Jingrong Zeng, Shanshan Mei, Yingqi Xing
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Relationship Between Orthostatic Hypotension and Cognitive Functions in Multiple System Atrophy: A Longitudinal Study
Sofia Cuoco, Immacolata Carotenuto, Arianna Cappiello, Sara Scannapieco, Maria Claudia Russillo, Valentina Andreozzi, Lorenzo Forino, Marianna Amboni, Marina Picillo, Roberto Erro, Paolo Barone, Maria Teresa Pellecchia
Frontiers in Neurology.2021;[Epub] CrossRef - Cognition in multiple system atrophy: a single‐center cohort study
Sabine Eschlböck, Margarete Delazer, Florian Krismer, Thomas Bodner, Alessandra Fanciulli, Beatrice Heim, Antonio Heras Garvin, Christine Kaindlstorfer, Elfriede Karner, Katherina Mair, Christoph Rabensteiner, Cecilia Raccagni, Klaus Seppi, Werner Poewe,
Annals of Clinical and Translational Neurology.2020; 7(2): 219. CrossRef - Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
Geriatrics & Gerontology International.2020; 20(5): 443. CrossRef - Orthostatic Intolerance in Older Persons: Etiology and Countermeasures
Nandu Goswami, Andrew P. Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Frontiers in Physiology.2017;[Epub] CrossRef - Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef - Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
Journal of Movement Disorders.2016; 9(2): 97. CrossRef - The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review
Panagiotis Zis, Roberto Erro, Courtney C Walton, Anna Sauerbier, Kallol Ray Chaudhuri
npj Parkinson's Disease.2015;[Epub] CrossRef - Diagnosing and treating neurogenic orthostatic hypotension in primary care
Louis Kuritzky, Alberto J. Espay, Jeffrey Gelblum, Richard Payne, Eric Dietrich
Postgraduate Medicine.2015; 127(7): 702. CrossRef
- Orthostatic Hypotension in Drug-Naïve Patients with Parkinson’s Disease
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Hyo-Jin Bae, Sang-Myung Cheon, Jae Woo Kim
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J Mov Disord. 2011;4(1):33-37.
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DOI: https://doi.org/10.14802/jmd.11005
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10,621
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Background and Purpose
Orthostatic hypotension (OH) is known to be present even in patients with early Parkinson’s disease (PD). To affirm the presence of OH and find correlation between OH and other dysautonomic symptoms in PD, this study has done in newly-diagnosed PD patients.
Methods
Forty-five non-demented patients with no prior history of treatment for PD were recruited (17 men, 63.8 ± 10.1 years of age). All the patients were evaluated for OH before starting medications. Autonomic symptoms were evaluated with structured questionnaires. Clinical characteristics of PD were evaluated (median Hoehn and Yahr stage 2.0 (1–3), 1.3 ± 1.1 years of disease duration), and comorbid medical conditions that could affect blood pressure were also recorded.
Results
OH was prevalent, and eighteen patients (40%) showed orthostatic hypotension, and twenty-seven (60%) did not (normotensive group). There was no significant difference in demographic and clinical characteristics between groups. The presence or severity of symptoms of autonomic dysfunction in the OH group also not differed from those of the normotensive group.
Conclusions
OH was prevalent even in the early stage of PD, and was not related to presence or severity of any other symptoms of autonomic dysfunction. Our findings suggest that clinicians should pay attention to OH from the early stage of disease.
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Citations
Citations to this article as recorded by - Reported Symptoms in Prodromal and Early Motor Parkinson's Disease: A Scoping Review on the Patient Perspective
Joseph Saade, Alice van Wyk, Glenn T. Stebbins, Tiago A. Mestre
Movement Disorders Clinical Practice.2025;[Epub] CrossRef - Pathophysiology of non-motor signs in Parkinson’s disease: some recent updating with brief presentation
Khaled Radad, Rudolf Moldzio, Christopher Krewenka, Barbara Kranner, Wolf-Dieter Rausch
Exploration of Neuroprotective Therapy.2023; : 24. CrossRef - Central retinal microvasculature damage is associated with orthostatic hypotension in Parkinson’s disease
Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
npj Parkinson's Disease.2023;[Epub] CrossRef - Pronounced Orthostatic Hypotension in GBA-Related Parkinson’s Disease
Tatiana Usnich, Henrike Hanssen, Katja Lohmann, Christina Lohse, Christine Klein, Meike Kasten, Norbert Brüggemann
Journal of Parkinson's Disease.2022; 12(5): 1539. CrossRef - Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?
Javier Navarro-Zaragoza, Lorena Cuenca-Bermejo, Pilar Almela, María-Luisa Laorden, María-Trinidad Herrero
International Journal of Molecular Sciences.2021; 22(6): 3038. CrossRef - Delayed orthostatic hypotension in Parkinson’s disease
Sang-Won Yoo, Joong-Seok Kim, Ji-Yeon Yoo, Eunkyeong Yun, Uicheul Yoon, Na-Young Shin, Kwang-Soo Lee
npj Parkinson's Disease.2021;[Epub] CrossRef - Neurogenic orthostatic hypotension in early stage Parkinson's disease: New insights from the first 105 patients of the BoProPark study
Francesca Baschieri, Luisa Sambati, Pietro Guaraldi, Giorgio Barletta, Pietro Cortelli, Giovanna Calandra-Buonaura
Parkinsonism & Related Disorders.2021; 93: 12. CrossRef - Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort
Kui Chen, Kangshuai Du, Yichen Zhao, Yongzhe Gu, Yanxin Zhao
Frontiers in Aging Neuroscience.2021;[Epub] CrossRef - Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
Zhichun Chen, Guanglu Li, Jun Liu
Neurobiology of Disease.2020; 134: 104700. CrossRef - Prevalence and factors related to orthostatic syndromes in recently diagnosed, drug-naïve patients with Parkinson disease
Cecilia Quarracino, Matilde Otero-Losada, Francisco Capani, Santiago Pérez-Lloret
Clinical Autonomic Research.2020; 30(3): 265. CrossRef - Orthostatic hypotension in Parkinson disease
Ylva Hivand Hiorth, Kenn Freddy Pedersen, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves
Neurology.2019;[Epub] CrossRef - The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review
Panagiotis Zis, Roberto Erro, Courtney C Walton, Anna Sauerbier, Kallol Ray Chaudhuri
npj Parkinson's Disease.2015;[Epub] CrossRef - Orthostatic Hypotension and Cognitive Impairment in <i>De Novo</i> Patients with Parkinson’s Disease
Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
Journal of Movement Disorders.2014; 7(2): 102. CrossRef
- Autonomic Dysfunctions in Parkinsonian Disorders
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Hyo-Jin Bae, Sang-Myung Cheon, Jae Woo Kim
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J Mov Disord. 2009;2(2):72-77.
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DOI: https://doi.org/10.14802/jmd.09019
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34,416
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101
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8
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Abstract
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Background and Purpose:
Symptoms of autonomic dysfunctions are common in the patients with parkinsonian disorders. Because clinical features of autonomic dysfunctions are diverse, the comprehensive evaluation is essential for the appropriate management. For the appreciation of autonomic dysfunctions and the identification of differences, patients with degenerative parkinsonisms are evaluated using structured questionnaire for autonomic dysfunction (ADQ).
Methods:
Total 259 patients, including 192 patients with [idiopathic Parkinson’s disease (IPD, age 64.6 ± 9.6 years)], 37 with [multiple system atrophy (MSA, 62.8 ± 9.1)], 9 with [dementia with Lewy body (DLB, 73.9 ± 4.3)], and 21 with [progressive supranuclear palsy (PSP, 69.4 ± 9.6)]. The ADQ was structured for evaluation of the presence of symptoms and its severity due to autonomic dysfunction, covering gastrointestinal, urinary, sexual, cardiovascular and thermoregulatory domains. Patients were also evaluated for the orthostatic hypotension.
Results:
Although dementia with Lewy body (DLB) patients were oldest and duration of disease was longest in IPD, total ADQ scores of MSA and PSP (23.9 ± 12.6 and 21.1 ± 7.8) were significantly increased than that of IPD (15.1 ± 10.6). Urinary and cardiovascular symptom scores of MSA and gastrointestinal symptom score of PSP were significantly worse than those of IPD. The ratio of patient with orthostatic hypotension in IPD was 31.2% and not differed between groups (35.1% in MSA, 33.3% in DLB and 33.3% in PSP). But the systolic blood pressure dropped drastically after standing in patients with MSA and DLB than in patients with IPD and PSP.
Conclusions:
Patients with degenerative parkinsonism showed widespread symptoms of autonomic dysfunctions. The severity of those symptoms in patients with PSP were comparing to that of MSA patients and worse than that of IPD.
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Citations
Citations to this article as recorded by - The association of vagal atrophy with parameters of autonomic function in multiple system atrophy and progressive supranuclear palsy
Teresa Kleinz, Leonard Scholz, Sophie Huckemann, Rachel Rohmann, Eva Kühn, Paulina Averdunk, Saskia Kools, Lovis Hilker, Antonia Bieber, Katharina Müller, Jeremias Motte, Anna-Lena Fisse, Christiane Schneider-Gold, Ralf Gold, Eun Hae Kwon, Lars Tönges, Ka
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Lauren Talman, Delaram Safarpour
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Seyed-Mohammad Fereshtehnejad, Ronald B. Postuma
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Ruwei Ou, Wei Song, Qianqian Wei, Ke Chen, Bei Cao, Yanbing Hou, Bi Zhao, Huifang Shang
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