- Increased Mortality in Young-Onset Parkinson’s Disease
-
Eldbjørg Hustad, Tor Åge Myklebust, Sasha Gulati, Jan O. Aasly
-
J Mov Disord. 2021;14(3):214-220. Published online July 29, 2021
-
DOI: https://doi.org/10.14802/jmd.21029
-
-
24,675
View
-
338
Download
-
10
Web of Science
-
11
Crossref
-
Abstract
PDF
- Objective
Few studies have followed Parkinson’s disease (PD) patients from the time of diagnosis to the date of death. This study compared mortality in the Trondheim PD cohort to the general population, investigated causes of death and analyzed the associations between mortality and age at disease onset (AAO) and cognitive decline defined as Montreal Cognitive Assessment (MoCA) score below 26.
Methods The cohort was followed longitudinally from 1997. By the end of January 2020, 587 patients had died. Comparisons to the Norwegian population were performed by calculating standardized mortality ratios (SMRs). Survival curves were estimated using the standard Kaplan-Meier estimator, and multivariable Cox proportional hazard models were estimated to investigate associations.
Results SMR was 2.28 [95% confidence interval (CI): 2.13–2.44] for the whole cohort. For participants with AAO 20–39 years, the SMR was 5.55 (95% CI: 3.38–8.61). Median survival was 15 years (95% CI: 14.2–15.5) for the whole cohort. Early-onset PD (EOPD) patients (AAO < 50 years) had the longest median survival time. For all groups, there was a significant shortening in median survival time and an almost 3-fold higher age- and sex-adjusted hazard ratio for death when the MoCA score decreased below 26.
Conclusion PD patients with an AAO before 40 years had a more than fivefold higher mortality rate compared to a similar general population. EOPD patients had the longest median survival; however, their life expectancy was reduced to a greater degree than that of late-onset PD patients. Cognitive impairment was strongly associated with mortality in PD.
-
Citations
Citations to this article as recorded by
- Case‐Fatality Rate in Parkinson's Disease: A Nationwide Registry Study
Jussi O.T. Sipilä, Valtteri Kaasinen, Päivi Rautava, Ville Kytö Movement Disorders Clinical Practice.2024; 11(2): 152. CrossRef - Genome-wide determinants of mortality and motor progression in Parkinson’s disease
Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherin npj Parkinson's Disease.2024;[Epub] CrossRef - Empowering the management of early-onset Parkinson’s disease: The role of technology
Roongroj Bhidayasiri, Ornanong Udomsirithamrong, Adrian de Leon, Walter Maetzler, Andrea Pilotto Parkinsonism & Related Disorders.2024; : 107052. CrossRef - Different neurotoxicity and seeding activity between α-synuclein oligomers formed in plasma of patients with Parkinson’s disease and multiple system atrophy
Hanjiang Luo, Xiaohan Yu, Pengjie Li, Junya Hu, Wei Li, Xin Li, Min Chen, Shun Yu Neuroscience.2024; 557: 1. CrossRef - Tinetti balance performance is associated with mortality in older adults with late-onset Parkinson’s disease: a longitudinal study
Louise Laurent, Pierre Koskas, Janina Estrada, Mélanie Sebbagh, Sophie Lacaille, Agathe Raynaud-Simon, Matthieu Lilamand BMC Geriatrics.2023;[Epub] CrossRef - Letter in response to Cole-Hunter et al., 2023: What does “Parkinson’s disease mortality” mean?
Isabell Katharina Rumrich, Valtteri Kaasinen, Otto Hänninen, Sirpa Hartikainen, Anna-Maija Tolppanen Environment International.2023; 173: 107852. CrossRef - Differences in Survival across Monogenic Forms of Parkinson's Disease
Aymeric Lanore, Fanny Casse, Christelle Tesson, Thomas Courtin, Poornima Jayadev Menon, Sara Sambin, Graziella Mangone, Louise‐Laure Mariani, Suzanne Lesage, Alexis Brice, Alexis Elbaz, Jean‐Christophe Corvol Annals of Neurology.2023; 94(1): 123. CrossRef - Real-World Prescription Patterns For Patients With Young-Onset Parkinson’s Disease in China: A Trend Analysis From 2014 to 2019
Xiao-qin Liu, Xiao-yu Wang, Hui-ming Shen, Wen-yuan Pang, Ming-kang Zhong, Chun-lai Ma Frontiers in Pharmacology.2022;[Epub] CrossRef - Montreal cognitive assessment (MoCA) is highly correlated with 1-year mortality in hip fracture patients
R. M. Y. Wong, R. W. K. Ng, W. W. Chau, W. H. Liu, S. K. H. Chow, C. Y. Tso, N. Tang, W.-H. Cheung Osteoporosis International.2022; 33(10): 2185. CrossRef - Obituary for Jan O. Aasly (1950–2022)
Matthew J. Farrer Movement Disorders.2022; 37(9): 1783. CrossRef - Age Cutoff for Early‐Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease
Raja Mehanna, Katarzyna Smilowska, Jori Fleisher, Bart Post, Taku Hatano, Maria Elisa Pimentel Piemonte, Kishore Raj Kumar, Victor McConvey, Baorong Zhang, Eng‐King Tan, Rodolfo Savica Movement Disorders Clinical Practice.2022; 9(7): 869. CrossRef
- Long-Term Outcomes of Genetic Parkinson’s Disease
-
Jan O. Aasly
-
J Mov Disord. 2020;13(2):81-96. Published online May 29, 2020
-
DOI: https://doi.org/10.14802/jmd.19080
-
-
14,712
View
-
433
Download
-
23
Web of Science
-
25
Crossref
-
Abstract
PDF
- Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects 1–2% of people by the age of 70 years. Age is the most important risk factor, and most cases are sporadic without any known environmental or genetic causes. Since the late 1990s, mutations in the genes SNCA, PRKN, LRRK2, PINK1, DJ-1, VPS35, and GBA have been shown to be important risk factors for PD. In addition, common variants with small effect sizes are now recognized to modulate the risk for PD. Most studies in genetic PD have focused on finding new genes, but few have studied the long-term outcome of patients with the specific genetic PD forms. Patients with known genetic PD have now been followed for more than 20 years, and we see that they may have distinct and different prognoses. New therapeutic possibilities are emerging based on the genetic cause underlying the disease. Future medication may be based on the pathophysiology individualized to the patient’s genetic background. The challenge is to find the biological consequences of different genetic variants. In this review, the clinical patterns and long-term prognoses of the most common genetic PD variants are presented.
-
Citations
Citations to this article as recorded by
- Navigating the Frontiers of Machine Learning in Neurodegenerative Disease Therapeutics
Yoonjeong Cha, Mohamedi N. Kagalwala, Jermaine Ross Pharmaceuticals.2024; 17(2): 158. CrossRef - The Molecular Impact of Glucosylceramidase Beta 1 (Gba1) in Parkinson’s Disease: a New Genetic State of the Art
Júlio César Claudino dos Santos, Gabriela Braga Cabrera Mano, André Rodrigues da Cunha Barreto-Vianna, Tulia Fernanda Meira Garcia, Aline Vieira de Vasconcelos, Caio Sérgio Gomes Sá, Sarah Lopes de Souza Santana, Ana Gabriela Ponte Farias, Beatriz Seimaru Molecular Neurobiology.2024; 61(9): 6754. CrossRef - Early Onset Parkinson’s Disease and It’s Genetic Consequences
Hatice ÖMERCİKOĞLU ÖZDEN, Dilek GÜNAL OSMANGAZİ JOURNAL OF MEDICINE.2024;[Epub] CrossRef - Genotype–phenotype correlation in PRKN-associated Parkinson’s disease
Poornima Jayadev Menon, Sara Sambin, Baptiste Criniere-Boizet, Thomas Courtin, Christelle Tesson, Fanny Casse, Melanie Ferrien, Louise-Laure Mariani, Stephanie Carvalho, Francois-Xavier Lejeune, Sana Rebbah, Gaspard Martet, Marion Houot, Aymeric Lanore, G npj Parkinson's Disease.2024;[Epub] CrossRef - Factors Influencing Patient Disclosure of Parkinson's Disease Genetic Testing Results to Relatives
Jeanine Schulze, Jasmine Kaur Dhaliwal, Mandy Miller, Emily Quinn, Leah Wetherill, Lola Cook Movement Disorders Clinical Practice.2024; 11(7): 786. CrossRef - Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review
Anthony E. Bishay, Natasha C. Hughes, Michael Zargari, Danika L. Paulo, Steven Bishay, Alexander T. Lyons, Mariam N. Morkos, Tyler J. Ball, Dario J. Englot, Sarah K. Bick Stereotactic and Functional Neurosurgery.2024; 102(3): 179. CrossRef - Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment
Eui-Hwan Choi, Mi-Hye Kim, Sun-Ji Park International Journal of Molecular Sciences.2024; 25(14): 7952. CrossRef - Suppression of Glioblastoma Stem Cell Potency and Tumor Growth via LRRK2 Inhibition
Saewhan Park, Kyung-Hee Kim, Yun-Hee Bae, Young Taek Oh, Hyemi Shin, Hyung Joon Kwon, Chan Il Kim, Sung Soo Kim, Hwan-Geun Choi, Jong Bae Park, Byoung Dae Lee International Journal of Stem Cells.2024; 17(3): 319. CrossRef - Genetic heterogeneity of early onset Parkinson disease: The dilemma of clinico-genetic correlation
Roopa Rajan, Vikram V. Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal Parkinsonism & Related Disorders.2024; : 107146. CrossRef - Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life
Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Iago García Díaz, Silvia Jesús, Maria Teresa Buongiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caball Journal of Parkinson's Disease.2023; 13(3): 379. CrossRef - To lump or to split? Deep brain stimulation may improve non-motor symptoms in certain Parkinson's disease subtypes
Neepa Patel Parkinsonism & Related Disorders.2023; 109: 105369. CrossRef - Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular Targets
Vincenza Rita Lo Vasco OBM Geriatrics.2023; 07(02): 1. CrossRef - Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features
Arash Yaghoobi, Homa Seyedmirzaei, Moein Ala, Cristine Alves da Costa Parkinson's Disease.2023; 2023: 1. CrossRef - Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson’s Disease: A Comprehensive Review
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara Brain Sciences.2023; 13(10): 1471. CrossRef - Applicability of clinical genetic testing for deep brain stimulation treatment in monogenic Parkinson’s disease and monogenic dystonia: a multidisciplinary team perspective
Valentino Rački, Mario Hero, Eliša Papić, Gloria Rožmarić, Nada Starčević Čizmarević, Darko Chudy, Borut Peterlin, Vladimira Vuletić Frontiers in Neuroscience.2023;[Epub] CrossRef - PTEN-Induced Putative Kinase 1 Dysfunction Accelerates Synucleinopathy
Tinh Thi Nguyen, Yun Joong Kim, Thuy Thi Lai, Phuong Thi Nguyen, Young Ho Koh, Linh Thi Nhat Nguyen, Hyeo-il Ma, Young Eun Kim Journal of Parkinson's Disease.2022; 12(4): 1201. CrossRef - Oncogenic Pathways in Neurodegenerative Diseases
Luis Varela, Maria E. R. Garcia-Rendueles International Journal of Molecular Sciences.2022; 23(6): 3223. CrossRef - Genetic Determinants of Survival in Parkinson's Disease in the Asian Population
Chunyu Li, Yanbing Hou, Ruwei Ou, Xiaojing Gu, Yongping Chen, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Bei Cao, Qianqian Wei, Xueping Chen, Wei Song, Bi Zhao, Ying Wu, Yiyuan Cui, Huifang Shang Movement Disorders.2022; 37(8): 1624. CrossRef - Obituary for Jan O. Aasly (1950–2022)
Matthew J. Farrer Movement Disorders.2022; 37(9): 1783. CrossRef - Genetics in parkinson’s disease: From better disease understanding to machine learning based precision medicine
Mohamed Aborageh, Peter Krawitz, Holger Fröhlich Frontiers in Molecular Medicine.2022;[Epub] CrossRef - Recent developments in nucleic acid-based therapies for Parkinson’s disease: Current status, clinical potential, and future strategies
Shivam Kumar Pandey, Rakesh Kumar Singh Frontiers in Pharmacology.2022;[Epub] CrossRef - Genetic stratification of motor and QoL outcomes in Parkinson's disease in the EARLYSTIM study
Daniel Weiss, Zied Landoulsi, Patrick May, Manu Sharma, Michael Schüpbach, Hana You, Jean Christophe Corvol, Steffen Paschen, Ann-Kristin Helmers, Michael Barbe, Gereon Fink, Andrea A. Kühn, Christine Brefel Courbon, Lars Wojtecki, Philippe Damier, Valeri Parkinsonism & Related Disorders.2022; 103: 169. CrossRef - Inflammatory Diseases Among Norwegian LRRK2 Mutation Carriers. A 15-Years Follow-Up of a Cohort
Jan O. Aasly Frontiers in Neuroscience.2021;[Epub] CrossRef - Increased Mortality in Young-Onset Parkinson’s Disease
Eldbjørg Hustad, Tor Åge Myklebust, Sasha Gulati, Jan O. Aasly Journal of Movement Disorders.2021; 14(3): 214. CrossRef - Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort
Sylvia Binck, Claire Pauly, Michel Vaillant, Geraldine Hipp, Manon Gantenbein, Rejko Krueger, Nico J Diederich Frontiers in Neurology.2020;[Epub] CrossRef
|