Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders


Author index

Page Path
HOME > Browse Articles > Author index
Jee Hyun Ham 2 Articles
Gender Differences in Age-Related Striatal Dopamine Depletion in Parkinson’s Disease
Jae Jung Lee, Jee Hyun Ham, Phil Hyu Lee, Young H. Sohn
J Mov Disord. 2015;8(3):130-135.   Published online September 10, 2015
  • 22,991 View
  • 123 Download
  • 28 Web of Science
  • 28 Crossref
AbstractAbstract PDFSupplementary Material
Objective Gender differences are a well-known clinical characteristic of Parkinson’s disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibit more rapid aging-related striatal DAT reduction than do men, as the potential neuroprotective effect of estrogen wanes with age.
Methods This study included 307 de novo PD patients (152 men and 155 women) who underwent DAT scans for an initial diagnostic work-up. Gender differences in age-related DAT decline were assessed in striatal sub-regions using linear regression analysis.
Results Female patients exhibited greater DAT activity compared with male patients in all striatal sub-regions. The linear regression analysis revealed that age-related DAT decline was greater in the anterior and posterior caudate, and the anterior putamen in women compared with men; we did not observe this difference in other sub-regions.
Conclusions This study demonstrated the presence of gender differences in age-related DAT decline in striatal sub-regions, particularly in the antero-dorsal striatum, in patients with PD, presumably due to aging-related decrease in estrogen. Because this difference was not observed in the sensorimotor striatum, this finding also suggests that women may not have a greater capacity to tolerate PD pathogenesis than do men.


Citations to this article as recorded by  
  • Impact of frailty and sex-related differences on postural control and gait in older adults with Parkinson's Disease
    Mathieu Dallaire, Alexandra Houde-Thibeault, Jérôme Bouchard-Tremblay, Enafa Anais Wotto, Sharlène Côté, Claudia Santos Oliveira, Suzy Ngomo, Rubens A. da Silva
    Experimental Gerontology.2024; 186: 112360.     CrossRef
  • Dysphagia Pattern in Early to Moderate Parkinson’s Disease Caused by Abnormal Pharyngeal Kinematic Function
    Ping Wang, Xinhui Chen, Miao Chen, Leilei Gao, Bing Xiong, Changmeng Ji, Qian Shen, Yuanqing Shen, Sheng Wu, Yanhong Pan, Jinhui Li, Bo Wang, Wei Luo
    Dysphagia.2024;[Epub]     CrossRef
  • Cut-Off Value of Voluntary Peak Cough Flow in Patients with Parkinson’s Disease and Its Association with Severe Dysphagia: A Retrospective Pilot Study
    Kyeong-Woo Lee, Sang-Beom Kim, Jong-Hwa Lee, Seong-Woo Kim
    Medicina.2023; 59(5): 921.     CrossRef
  • The impact of COVID-19 on patients with Parkinson disease
    Esma KOBAK TUR, Buse Çağla ARI
    Journal of Health Sciences and Medicine.2023; 6(4): 815.     CrossRef
  • Worldwide trends in mortality related to Parkinson's disease in the period of 1994–2019: Analysis of vital registration data from the WHO Mortality Database
    Ioannis C. Lampropoulos, Foteini Malli, Olga Sinani, Konstantinos I. Gourgoulianis, Georgia Xiromerisiou
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Sex differences in Parkinson's Disease: An emerging health question
    Luiz Philipe de Souza Ferreira, Rafael André da Silva, Matheus Marques Mesquita da Costa, Vinicius Moraes de Paiva Roda, Santiago Vizcaino, Nilma R.L.L. Janisset, Renata Ramos Vieira, José Marcos Sanches, José Maria Soares Junior, Manuel de Jesus Simões
    Clinics.2022; 77: 100121.     CrossRef
  • Parkinson's disease in women: Mechanisms underlying sex differences
    Bhupesh Vaidya, Kritika Dhamija, Priyanka Guru, Shyam Sunder Sharma
    European Journal of Pharmacology.2021; 895: 173862.     CrossRef
  • Temporalis Muscle Thickness as an Indicator of Sarcopenia Is Associated With Long-term Motor Outcomes in Parkinson’s Disease
    Seok Jong Chung, Yun Joong Kim, Han Soo Yoo, Jin Ho Jung, KyoungWon Baik, Hye Sun Lee, Yang Hyun Lee, Ji-Man Hong, Young H Sohn, Phil Hyu Lee, Jay Magaziner
    The Journals of Gerontology: Series A.2021; 76(12): 2242.     CrossRef
  • Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review
    Giovanni Palermo, Sara Giannoni, Gabriele Bellini, Gabriele Siciliano, Roberto Ceravolo
    International Journal of Molecular Sciences.2021; 22(20): 11234.     CrossRef
  • Sex‐specific association of urate and levodopa‐induced dyskinesia in Parkinson’s disease
    J. H. Jung, S. J. Chung, H. S. Yoo, Y. H. Lee, K. Baik, B. S. Ye, Y. H. Sohn, P. H. Lee
    European Journal of Neurology.2020; 27(10): 1948.     CrossRef
  • Sex differences in primary delusional infestatation: An insight into etiology and potential novel therapy
    Stephanie Y. Chan, John Koo
    International Journal of Women's Dermatology.2020; 6(3): 226.     CrossRef
  • Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance
    Xiaojin Liu, Simon B. Eickhoff, Felix Hoffstaedter, Sarah Genon, Svenja Caspers, Kathrin Reetz, Imis Dogan, Claudia R. Eickhoff, Ji Chen, Julian Caspers, Niels Reuter, Christian Mathys, André Aleman, Renaud Jardri, Valentin Riedl, Iris E. Sommer, Kaustubh
    Neuroscience Bulletin.2020; 36(10): 1123.     CrossRef
  • Predictors of Pharyngeal Dysphagia in Patients with Parkinson’s Disease
    Inga Claus, Paul Muhle, Judith Suttrup, Bendix Labeit, Sonja Suntrup-Krueger, Rainer Dziewas, Tobias Warnecke
    Journal of Parkinson's Disease.2020; : 1.     CrossRef
  • Emerging Concepts of Motor Reserve in Parkinson’s Disease
    Seok Jong Chung, Jae Jung Lee, Phil Hyu Lee, Young H. Sohn
    Journal of Movement Disorders.2020; 13(3): 171.     CrossRef
  • Lack of consistent sex differences in d-amphetamine-induced dopamine release measured with [18F]fallypride PET
    Christopher T. Smith, Linh C. Dang, Leah L. Burgess, Scott F. Perkins, M. Danica San Juan, Darcy K. Smith, Ronald L. Cowan, Nam T. Le, Robert M. Kessler, Gregory R. Samanez-Larkin, David H. Zald
    Psychopharmacology.2019; 236(2): 581.     CrossRef
  • Predictive clinical factors for penetration and aspiration in Parkinson's disease
    Julie Cläre Nienstedt, Moritz Bihler, Almut Niessen, Rosemarie Plaetke, Monika Pötter‐Nerger, Christian Gerloff, Carsten Buhmann, Christina Pflug
    Neurogastroenterology & Motility.2019;[Epub]     CrossRef
  • Does the Side Onset of Parkinson’s Disease Influence the Time to Develop Levodopa-Induced Dyskinesia?
    Seok Jong Chung, Han Soo Yoo, Hye Sun Lee, Phil Hyu Lee, Young H. Sohn
    Journal of Parkinson's Disease.2019; 9(1): 241.     CrossRef
  • Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
    Yang Hyun Lee, Jungho Cha, Seok Jong Chung, Han Soo Yoo, Young H. Sohn, Byoung Seok Ye, Phil Hyu Lee
    Scientific Reports.2019;[Epub]     CrossRef
  • The sex-specific interaction of the microbiome in neurodegenerative diseases
    Laura M. Cox, Hadi Abou-El-Hassan, Amir Hadi Maghzi, Julia Vincentini, Howard L. Weiner
    Brain Research.2019; 1724: 146385.     CrossRef
  • Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D 2/3 receptors and sub-cortical volumes in the human basal ganglia: A PET study with 18 F-MNI-659 and 11 C-raclopride with correction for partial volume effect
    Patrik Fazio, Martin Schain, Ladislav Mrzljak, Nahid Amini, Sangram Nag, Nabil Al-Tawil, Cheryl J. Fitzer-Attas, Juliana Bronzova, Bernhard Landwehrmeyer, Cristina Sampaio, Christer Halldin, Andrea Varrone
    NeuroImage.2017; 152: 330.     CrossRef
  • Potential therapeutic effects of odorants through their ectopic receptors in pigmented cells
    Barbara Pavan, Antonio Capuzzo, Alessandro Dalpiaz
    Drug Discovery Today.2017; 22(7): 1123.     CrossRef
  • Gender differences in Parkinson's disease: A clinical perspective
    D. Georgiev, K. Hamberg, M. Hariz, L. Forsgren, G.-M. Hariz
    Acta Neurologica Scandinavica.2017; 136(6): 570.     CrossRef
  • The relationship between subcortical brain volume and striatal dopamine D2/3 receptor availability in healthy humans assessed with [11C]‐raclopride and [11C]‐(+)‐PHNO PET
    Fernando Caravaggio, Jun Ku Chung, Eric Plitman, Isabelle Boileau, Philip Gerretsen, Julia Kim, Yusuke Iwata, Raihaan Patel, M. Mallar Chakravarty, Gary Remington, Ariel Graff‐Guerrero
    Human Brain Mapping.2017; 38(11): 5519.     CrossRef
  • Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are associated with sporadic Parkinson’s disease in the North-eastern Han Chinese population
    Xiaoyuan Li, Li Xue, Jinfang Sun, Yanping Sun, Anmu Xie
    Neuroscience Letters.2017; 656: 72.     CrossRef
  • Trait impulsiveness is related to smaller post‐commissural putamen volumes in males but not females
    Fernando Caravaggio, Eric Plitman, Jun Ku Chung, Philip Gerretsen, Julia Kim, Yusuke Iwata, Mallar Chakravarty, Gary Remington, Ariel Graff‐Guerrero
    European Journal of Neuroscience.2017; 46(7): 2253.     CrossRef
  • Does smoking impact dopamine neuronal loss in de novo Parkinson disease?
    Yoonju Lee, Jungsu S. Oh, Seok Jong Chung, Su Jin Chung, Soo‐Jong Kim, Chung Mo Nam, Phil Hyu Lee, Jae Seung Kim, Young H. Sohn
    Annals of Neurology.2017; 82(5): 850.     CrossRef
  • The analysis of relationship between selected sociodemografic factors and disorders of speech organs in Parkinson`s patients
    Wioletta Pawlukowska, Karolina Skonieczna-Żydecka, Iwona Rotter, Krystyna Honczarenko, Przemysław Nowacki
    BMC Neurology.2017;[Epub]     CrossRef
  • Dose‐Response Analysis of the Effect of Carbidopa‐Levodopa Extended‐Release Capsules (IPX066) in Levodopa‐Naive Patients With Parkinson Disease
    Zhongping Lily Mao, Nishit B. Modi
    The Journal of Clinical Pharmacology.2016; 56(8): 974.     CrossRef
Apathy and Olfactory Dysfunction in Early Parkinson’s Disease
Jin Yong Hong, Mun Kyung Sunwoo, Jee Hyun Ham, Jae Jung Lee, Phil Hyu Lee, Young H. Sohn
J Mov Disord. 2015;8(1):21-25.   Published online January 31, 2015
  • 16,295 View
  • 112 Download
  • 22 Web of Science
  • 22 Crossref
AbstractAbstract PDF
Objective Olfactory and emotional dysfunctions are very common in patients with Parkinson’s disease (PD). Olfaction and emotions share common neuroanatomical substrates. Therefore, in this study, we evaluated the association between olfactory and emotional dysfunctions in patients with PD.
Methods Parkinson’s disease patients who had been assessed for their olfactory function and neuropsychiatric symptoms including emotional dysfunction were included. A logistic regression analysis was performed to evaluate the association between low olfaction and different neuropsychiatric symptoms.
Results The patients with low olfaction (cross cultural smell identification test score ≤ 6) showed a higher prevalence of apathy when compared with those with high olfaction, whereas the frequencies of other neuropsychiatric symptoms were comparable between the two groups. A multivariate logistic regression analysis revealed that the presence of apathy/indifference [odds ratio (OR) = 2.859, p = 0.007], age 70 years or more (OR = 2.281, p = 0.009), and the male gender (OR = 1.916, p = 0.030) were significantly associated with low olfaction.
Conclusions Our results demonstrate that apathy/indifference is a unique emotional dysfunction associated with olfactory dysfunction in PD. The findings also suggest that PD patients with low olfaction have a high prevalence of apathy.


Citations to this article as recorded by  
  • Clinical features and neurobiochemical mechanisms of olfactory dysfunction in patients with Parkinson disease
    Ruidan Wang, Tenghong Lian, Mingyue He, Peng Guo, Shuyang Yu, Lijun Zuo, Yang Hu, Wei Zhang
    Journal of Neurology.2024; 271(4): 1959.     CrossRef
  • Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment
    Irene Fatuzzo, Giovanni Francesco Niccolini, Federica Zoccali, Luca Cavalcanti, Mario Giuseppe Bellizzi, Gabriele Riccardi, Marco de Vincentiis, Marco Fiore, Carla Petrella, Antonio Minni, Christian Barbato
    International Journal of Molecular Sciences.2023; 24(3): 2117.     CrossRef
  • Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson’s disease
    Fardin Nabizadeh, Kasra Pirahesh, Elham Khalili
    Neurological Sciences.2022; 43(7): 4193.     CrossRef
  • The Power of Odor Persuasion: The Incorporation of Olfactory Cues in Virtual Environments for Personalized Relaxation
    Silvia Francesca Maria Pizzoli, Dario Monzani, Ketti Mazzocco, Emanuela Maggioni, Gabriella Pravettoni
    Perspectives on Psychological Science.2022; 17(3): 652.     CrossRef
  • Olfaction and apathy in early idiopathic Parkinson's disease
    Alfonso E. Martinez-Nunez, Kaitie Latack, Miguel Situ-Kcomt, Abhimanyu Mahajan
    Journal of the Neurological Sciences.2022; 439: 120314.     CrossRef
  • Apathy in Parkinson’s Disease: Defining the Park Apathy Subtype
    Ségolène De Waele, Patrick Cras, David Crosiers
    Brain Sciences.2022; 12(7): 923.     CrossRef
  • α‐Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC‐SNCA Mice
    Norihito Uemura, Jun Ueda, Toru Yoshihara, Masashi Ikuno, Maiko T. Uemura, Hodaka Yamakado, Masahide Asano, John Q. Trojanowski, Ryosuke Takahashi
    Movement Disorders.2021; 36(9): 2036.     CrossRef
  • Hyposmia may predict development of freezing of gait in Parkinson’s disease
    Jae Jung Lee, Jin Yong Hong, Jong Sam Baik
    Journal of Neural Transmission.2021; 128(6): 763.     CrossRef
  • Clinical and Dopamine Depletion Patterns in Hyposmia- and Dysautonomia-Dominant Parkinson’s Disease
    Han Soo Yoo, Sangwon Lee, Seong Ho Jeong, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Phil Hyu Lee
    Journal of Parkinson's Disease.2021; 11(4): 1703.     CrossRef
  • Is There a Shared Etiology of Olfactory Impairments in Normal Aging and Neurodegenerative Disease?
    Mahraz Parvand, Catharine H. Rankin, Lori Beason-Held
    Journal of Alzheimer's Disease.2020; 73(1): 1.     CrossRef
  • Open questions on the nature of Parkinson’s disease: from triggers to spreading pathology
    Lei Mou, Wei Ding, Pedro Fernandez-Funez
    Journal of Medical Genetics.2020; 57(2): 73.     CrossRef
  • Effect of Olfactory and Gustatory Dysfunction and Motor Symptoms on Body Weight in Patients with Parkinson’s Disease
    Carla Masala, Francesco Loy, Raffaella Piras, Anna Liscia, Laura Fadda, Alan Moat, Paolo Solla, Giovanni Defazio
    Brain Sciences.2020; 10(4): 218.     CrossRef
  • Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis
    Chama Belkhiria, Rodrigo C. Vergara, Simón San Martin, Alexis Leiva, Melissa Martinez, Bruno Marcenaro, Maricarmen Andrade, Paul H. Delano, Carolina Delgado
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
  • Contribution of Five Functional Loci of Dopamine Metabolism-Related Genes to Parkinson’s Disease and Multiple System Atrophy in a Chinese Population
    Yongping Chen, Ruwei Ou, Lingyu Zhang, Xiaojing Gu, Xiaoqin Yuan, Qian-qian Wei, Bei Cao, Bi Zhao, Ying Wu, Huifang Shang
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Olfactory Dysfunction Predicts Disease Progression in Parkinson’s Disease: A Longitudinal Study
    Runcheng He, Yuwen Zhao, Yan He, Yangjie Zhou, Jinxia Yang, Xiaoting Zhou, Liping Zhu, Xun Zhou, Zhenhua Liu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Beisha Tang, Jifeng Guo
    Frontiers in Neuroscience.2020;[Epub]     CrossRef
  • Characteristics of apathy in treatment-naïve patients with Parkinson’s disease
    Hiroo Terashi, Yuki Ueta, Haruhisa Kato, Hiroshi Mitoma, Hitoshi Aizawa
    International Journal of Neuroscience.2019; 129(1): 16.     CrossRef
  • Olfaction and taste in Parkinson’s disease: the association with mild cognitive impairment and the single cognitive domain dysfunction
    Maria Paola Cecchini, Angela Federico, Alice Zanini, Elisa Mantovani, Carla Masala, Michele Tinazzi, Stefano Tamburin
    Journal of Neural Transmission.2019; 126(5): 585.     CrossRef
  • The oral microbiome of early stage Parkinson’s disease and its relationship with functional measures of motor and non-motor function
    Dragos Mihaila, Jordan Donegan, Sarah Barns, Daria LaRocca, Qian Du, Danny Zheng, Michael Vidal, Christopher Neville, Richard Uhlig, Frank A. Middleton, Brenda A Wilson
    PLOS ONE.2019; 14(6): e0218252.     CrossRef
  • Hyposmia as a marker of (non-)motor disease severity in Parkinson’s disease
    Dareia S. Roos, Jos W. R. Twisk, Pieter G. H. M. Raijmakers, Richard L. Doty, Henk W. Berendse
    Journal of Neural Transmission.2019; 126(11): 1471.     CrossRef
  • Correlation among olfactory function, motors’ symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson’s disease
    Carla Masala, Paolo Solla, A. Liscia, G. Defazio, L. Saba, A. Cannas, A. Cavazzana, T. Hummel, A. Haehner
    Journal of Neurology.2018; 265(8): 1764.     CrossRef
  • Olfactory Dysfunction as an Early Biomarker in Parkinson’s Disease
    Michelle E. Fullard, James F. Morley, John E. Duda
    Neuroscience Bulletin.2017; 33(5): 515.     CrossRef
  • Human behavioral assessments in current research of Parkinson’s disease
    Tetsuya Asakawa, Huan Fang, Kenji Sugiyama, Takao Nozaki, Susumu Kobayashi, Zhen Hong, Katsuaki Suzuki, Norio Mori, Yilin Yang, Fei Hua, Guanghong Ding, Guoqiang Wen, Hiroki Namba, Ying Xia
    Neuroscience & Biobehavioral Reviews.2016; 68: 741.     CrossRef

JMD : Journal of Movement Disorders Twitter