Journal of Movement Disorders

Jeong-Wook Park

2 Articles

Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease: Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee; J Mov Disord. 2016;9(2):97-103. Published online March 28, 2016; DOI: https://doi.org/10.14802/jmd.16001

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Objective
The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson’s disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups.
Methods
This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naïve or dopaminergic drug treatment).
Results
Orthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.
Conclusions
Cardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.

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The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease: Hye-Young Sung, Jeong-Wook Park, Joong-Seok Kim; J Mov Disord. 2014;7(1):7-12. Published online April 30, 2014; DOI: https://doi.org/10.14802/jmd.14002

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Abstract PDF

Objective: Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires.
Methods: Early PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2.
Results: Of the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/ vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero.
Conclusions: Our findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency.

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Simone Engelender, Ole Isacson
Trends in Neurosciences.2017; 40(1): 4. CrossRef
Constipation in parkinson's disease: Subjective symptoms, objective markers, and new perspectives
Karoline Knudsen, Klaus Krogh, Karen Østergaard, Per Borghammer
Movement Disorders.2017; 32(1): 94. CrossRef
Is Levodopa Pharmacokinetics in Patients with Parkinson’s Disease Depending on Gastric Emptying?
Maria Nord, Anita Kullman, Ulf Hannestad, Nil Dizdar
Advances in Parkinson's Disease.2017; 06(01): 1. CrossRef
Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic
Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
Journal of Movement Disorders.2017; 10(1): 29. CrossRef
Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis
C.-H. Chen, C.-L. Lin, C.-H. Kao
Osteoporosis International.2016; 27(6): 2117. CrossRef
Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies
Syed Ali, Ning Yin, Arkam Rehman, Verline Justilien
Medical Sciences.2016; 4(1): 1. CrossRef
Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models
C. Pellegrini, R. Colucci, L. Antonioli, E. Barocelli, V. Ballabeni, N. Bernardini, C. Blandizzi, W. J. de Jonge, M. Fornai
Neurogastroenterology & Motility.2016; 28(12): 1781. CrossRef
Gut dysfunction in Parkinson's disease
Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
World Journal of Gastroenterology.2016; 22(25): 5742. CrossRef
Inflammation is genetically implicated in Parkinson’s disease
N. Dzamko, C.L Geczy, G.M Halliday
Neuroscience.2015; 302: 89. CrossRef
Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-OHDA-induced Parkinson’s disease rats
Xiaoli Zhang, Yun Li, Chenzhe Liu, Ruifang Fan, Ping Wang, Lifei Zheng, Feng Hong, Xiaoyan Feng, Yue Zhang, Lisheng Li, Jinxia Zhu
Translational Research.2015;[Epub] CrossRef
The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease
Jose L Barboza, Michael S Okun, Baharak Moshiree
Expert Opinion on Pharmacotherapy.2015; 16(16): 2449. CrossRef
Gastrointestinal Dysfunctions in Parkinson’s Disease
Joong-Seok Kim, Hey Young Sung
Journal of the Korean Neurological Association.2015; 33(4): 247. CrossRef

Author index