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Kalpana Prasad 1 Article
Progressive Encephalomyelitis with Rigidity and Myoclonus in an Intellectually Disabled Patient Mimicking Neuroleptic Malignant Syndrome
Zheyu Xu, Kalpana Prasad, Tianrong Yeo
J Mov Disord. 2017;10(2):99-101.   Published online March 24, 2017
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AbstractAbstract PDF
We present a case of 32-year-old male with profound mental retardation and autism spectrum disorder who had presented with seizures, rigidity and elevated creatine kinase and was initially diagnosed as neuroleptic malignant syndrome (NMS). The patient subsequently had a complicated clinical course, developing refractory status epilepticus, which lead to the eventual diagnosis of progressive encephalomyelitis with rigidity and myoclonus (PERM). We discuss the clinical similarities and differences between NMS and PERM, and highlight the need to consider alternative diagnoses when the clinical picture of NMS is atypical, particularly in this patient group where the history and clinical examination may be challenging.


Citations to this article as recorded by  
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  • Neuroleptic Malignant Syndrome in Children with Autism Spectrum Disorder (ASD): A Case Report and Brief Review of Recent Literature
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    Children.2021; 8(12): 1201.     CrossRef
  • A case report of rigidity and recurrent lower limb myoclonus: progressive encephalomyelitis rigidity and myoclonus syndrome, a chameleon
    Aurélie Degeneffe, Marie Dagonnier, Alain D’hondt, Jose Antonio Elosegi
    BMC Neurology.2018;[Epub]     CrossRef

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