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Ma. Lourdes P. Corrales 1 Article
The Occurrence of Fatigue in Independent and Clinically Stable Filipino Patients with Idiopathic Parkinson’s Disease
Carter S. Rabo, Raymond L. Rosales, Ma. Lourdes P. Corrales
J Mov Disord. 2009;2(1):18-21.
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AbstractAbstract PDF

Fatigue is a multidimensional problem affecting patients suffering from Parkinson’s disease (PD). It is ranked as one of the most bothersome symptom of patients with Parkinson’s disease. The study primarily aims to determine the presence of fatigue among clinically stable and independent Filipino patients suffering from idiopathic PD.


This study is a prospective cross-sectional study. Recruited patients and control group were all Filipinos. Only independent patients with idiopathic, stable and non-fluctuating PD were included in the study. Those eligible underwent a multitude of screening tests to rule out presence of dementia (Mini Mental Status Examination, MMSE), depression (Montgomery-Åsberg Depression Rating Scale, MADRS), anxiety (Hamilton Anxiety Scale, HAM-A) and sleep disturbance. Disease severity was assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS) and fatigue severity using both the Multicomponent Fatigue Index (MFI) and Fatigue Severity Inventory (FSI).


Twenty-eight patients underwent the study. The mean Hoehn and Yahr staging was 1.79. Patients with PD scored higher on both FSI and MFI (individual dimension scores and total score) as compared to the normal controls.


The outcome of the study confirmed the presence of fatigue (general, physical, mental), even in clinically stable and independent patients suffering from idiopathic PD, when compared with age-matched healthy controls.


Citations to this article as recorded by  
  • The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease
    Stefania Diaconu, Vlad Monescu, Rafaela Filip, Laura Marian, Cristian Kakucs, Iulia Murasan, K. Ray Chaudhuri, Dragos Catalin Jianu, Cristian Falup-Pecurariu, Bianca Opritoiu
    Brain Sciences.2024; 14(4): 397.     CrossRef
  • Mental Fatigue in Parkinson’s Disease: Systematic Review and Evaluation of Self‐Reported Fatigue Scales
    Junle Chen, Yanjun Zhou, Hengyi Rao, Jianghong Liu, Karsten Witt
    Parkinson's Disease.2024;[Epub]     CrossRef
  • A Community-based study on the prevalence and predisposing factors of Parkinson’s disease in Barangay Mangilag Sur, Quezon Province, Philippines
    Raymond L. Rosales, Mary Camille E. Rosales, Danica Jane S.J. Robles, Ron Christian Neil T. Rodriguez, Nadia Beatrice S. Romana, Joseph Mariuz B. Rosales, Gerardo B. Salazar, Richelle Ann S. Santiano
    Clinical Parkinsonism & Related Disorders.2022; 7: 100169.     CrossRef
  • The effect of Non-Motor symptoms on Health-Related quality of life in patients with young onset Parkinson’s Disease: A single center Vietnamese Cross-Sectional study
    Tai Ngoc Tran, Uyen Ngoc Le Ha, Tuan Manh Nguyen, Thuan Duc Nguyen, Khang Ngoc Chung Vo, Thuong Huyen Dang, Paula Mai Phuong Trinh, Daniel Truong
    Clinical Parkinsonism & Related Disorders.2021; 5: 100118.     CrossRef
  • Neural and dopaminergic correlates of fatigue in Parkinson’s disease
    Suk Yun Kang, Mirim Bang, Jing Yong Hong, Jungsu Oh, Jae Seung Kim, You Mie Han, Suk Ki Chang, Seun Ah Lee, Uicheul Yoon, Na-Young Shin
    Journal of Neural Transmission.2020; 127(3): 301.     CrossRef
  • Prevalence and Predisposing Factors of Parkinson Disease: A Community-Based Study In Barangay Mangilag Sur, Candelaria, Quezon: A Research Protocol
    Danica Jane S.J Robles, Ron Christian Neil T Rodriguez, Nadia Beatrice S Romana, Joseph Mariuz B Rosales, Mary Camille E Rosales, Gerardo B Salazar, Raymond L Rosales
    Journal of Medicine, University of Santo Tomas.2017; 1(1): 109.     CrossRef

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