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Min Jeong Park 1 Article
Mild Cognitive Impairment in Parkinson’s Disease
Jae Woo Kim, Hee Young Jo, Min Jeong Park, Sang-Myung Cheon
J Mov Disord. 2008;1(1):19-25.
DOI: https://doi.org/10.14802/jmd.08004
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  • 6 Citations
AbstractAbstract PDF
Background

To determine the frequency of mild cognitive impairment (MCI) of Parkinson’s disease (PD, PDMCI) and its subtypes among non-demented PD patients, and to identify the influence of the age and presenting symptom on the development of PDMCI.

Methods:

A total 141 non-demented PD patients underwent a comprehensive neuropsychological assessment including attention, language, visuospatial, memory and frontal functions. PDMCI was defined by neuropsychological testing and was classified into five subtypes. Patients were divided into two groups (tremor vs. akinetic-rigid type) for presenting symptom and three groups according to the age. Neuropsychological performance of patients was compared with normative data.

Results:

Almost half (49.6%) of non-demented PD patients had impairment in at least one domain and can be considered as having PDMCI. Executive type of PDMCI was the most frequent and amnestic, visuospatial, linguistic and attention types followed in the order of frequency. The population of PDMCI was increasing as the age of disease onset was higher. Whereas the frequency of executive and amnestic types of PDMCI was comparable in younger group, executive type was the most frequent in older group. The patients with tremor dominant type performed worse on tests, particularly on attention test.

Conclusions:

MCI was common even in the early stage of PD and the subtype was diverse. Unlike MCI developing Alzheimer’s disease later, executive type of PDMCI was the most common. Age was an important risk factor for development of MCI in PD. The concept of MCI should be introduced in PD.

Citations

Citations to this article as recorded by  
  • Orthostatic Hypotension and Cognitive Impairment in <i>De Novo</i> Patients with Parkinson’s Disease
    Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
    Journal of Movement Disorders.2014; 7(2): 102.     CrossRef
  • Correlated regions of cerebral blood flow with clinical parameters in Parkinson’s disease; comparison using ‘Anatomy’ and ‘Talairach Daemon’ software
    Hyun Jin Yoon, Sang Myung Cheon, Young Jin Jeong, Do-Young Kang
    Annals of Nuclear Medicine.2012; 26(2): 164.     CrossRef
  • Correlation between neuropsychological tests and hypoperfusion in MCI patients: anatomical labeling using xjView and Talairach Daemon Software
    Hyun Jin Yoon, Kyung Won Park, Young Jin Jeong, Do-Young Kang
    Annals of Nuclear Medicine.2012; 26(8): 656.     CrossRef
  • Significant correlation between cerebral hypoperfusion and neuropsychological assessment scores of patients with mild cognitive impairment
    Hyun Jin Yoon, Kyung Won Park, Young Jin Jeong, Do-Young Kang
    Nuclear Medicine Communications.2012; 33(8): 848.     CrossRef
  • Utility and Limitations of Addenbrooke’s Cognitive Examination-Revised for Detecting Mild Cognitive Impairment in Parkinson’s Disease
    Natalie C. Komadina, Zoe Terpening, Yue Huang, Glenda M. Halliday, Sharon L. Naismith, Simon J.G. Lewis
    Dementia and Geriatric Cognitive Disorders.2011; 31(5): 349.     CrossRef
  • Characterizing mild cognitive impairment in Parkinson's disease
    John C. Dalrymple‐Alford, Leslie Livingston, Michael R. MacAskill, Charlotte Graham, Tracy R. Melzer, Richard J. Porter, Richard Watts, Tim J. Anderson
    Movement Disorders.2011; 26(4): 629.     CrossRef

JMD : Journal of Movement Disorders