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Rupali Roy 1 Article
Parkinson’s Disease and the COVID-19 Pandemic: A Review Article on the Association between SARS-CoV-2 and α-Synucleinopathy
Smriti Sinha, Swati Mittal, Rupali Roy
J Mov Disord. 2021;14(3):184-192.   Published online July 29, 2021
DOI: https://doi.org/10.14802/jmd.21046
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  • 10 Citations
AbstractAbstract PDF
There is an extensive debate on the neurological consequences of 2019 novel coronavirus disease (COVID-19) and its impact on Parkinson’s disease (PD) patients, which seems to puzzle neurologists. Links between viral infections and PD have long been suspected and studied, but the exact relationship remains elusive. Since severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) enters the brain through multiple routes and has a direct impact on the brain, cumulative damage occurs due to the activation of proinflammatory cytokines and chemokines. SARS-CoV-2 seems to aggravate PD due to its effects on α-synuclein, mitochondrial dysfunction, and dopamine depletion. A few studies have even highlighted the higher vulnerability of PD patients to COVID-19. The sudden dramatic change in lifestyle caused by the pandemic and the widespread lockdowns that were implemented have added to the hidden sorrows of PD patients, as they already have a compromised mechanism for coping with stress. This review summarizes insights from basic science and the clinical effect of SARS-CoV-2 infection on the human brain, with a specific focus on PD.

Citations

Citations to this article as recorded by  
  • Axial Improvement after Casirivimab/Imdevimab Treatment for COVID-19 in Parkinson’s Disease
    Valentina Fioravanti, Francesco Cavallieri, Alessio Di Fonzo, Giulia Toschi, Sara Grisanti, Gaetano Salomone, Mario Zappia, Franco Valzania
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2023; 50(5): 777.     CrossRef
  • Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms
    Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan, Sheng-Di Chen
    Translational Neurodegeneration.2023;[Epub]     CrossRef
  • Does the SARS-CoV-2 Spike Receptor-Binding Domain Hamper the Amyloid Transformation of Alpha-Synuclein after All?
    Yulia Stroylova, Anastasiia Konstantinova, Victor Stroylov, Ivan Katrukha, Fedor Rozov, Vladimir Muronetz
    Biomedicines.2023; 11(2): 498.     CrossRef
  • Sex and age affect acute and persisting COVID-19 illness
    Anna Vasilevskaya, Asma Mushtaque, Michelle Y. Tsang, Batoul Alwazan, Margaret Herridge, Angela M. Cheung, Maria Carmela Tartaglia
    Scientific Reports.2023;[Epub]     CrossRef
  • Vulnerability of Parkinson’s Patients to COVID-19 and Its Consequences and Effects on Them: A Systematic Review
    Sorayya Rezayi, Meysam Rahmani Katigari, Leila Shahmoradi, Mehrbakhsh Nilashi, Hélio Teive
    Parkinson's Disease.2023; 2023: 1.     CrossRef
  • COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
    Sebastián García Menéndez, Virna Margarita Martín Giménez, Michael F. Holick, Francisco J. Barrantes, Walter Manucha
    Life Sciences.2022; 297: 120464.     CrossRef
  • SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro
    Zhengcun Wu, Xiuao Zhang, Zhangqiong Huang, Kaili Ma
    International Journal of Molecular Sciences.2022; 23(6): 3394.     CrossRef
  • COVID-19 and Parkinsonism: A Critical Appraisal
    Francesco Cavallieri, Valentina Fioravanti, Francesco Bove, Eleonora Del Prete, Sara Meoni, Sara Grisanti, Marialuisa Zedde, Rosario Pascarella, Elena Moro, Franco Valzania
    Biomolecules.2022; 12(7): 970.     CrossRef
  • SARS-CoV-2 mediated neurological disorders in COVID-19: Measuring the pathophysiology and immune response
    Pi-Ching Hsu, Md. Shahed-Al-Mahmud
    Life Sciences.2022; 308: 120981.     CrossRef
  • COVID-19 і хвороба Паркінсона
    I.M. Karaban, T.V. Hasiuk, N.V. Karasevych
    INTERNATIONAL NEUROLOGICAL JOURNAL.2022; 18(3): 46.     CrossRef

JMD : Journal of Movement Disorders