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Won Ryang Wee 1 Article
Amantadine Induced Corneal Edema in a Patient with Primary Progressive Freezing of Gait
Young Eun Kim, Ji Young Yun, Hui-Jun Yang, Han-Joon Kim, Mee Kum Kim, Won Ryang Wee, Beom S. Jeon
J Mov Disord. 2013;6(2):34-36.   Published online October 30, 2013
DOI: https://doi.org/10.14802/jmd.13008
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  • 7 Citations
AbstractAbstract PDF

Amantadine is commonly used for Parkinsonism. However amantadine can induce adverse corneal reaction. Here we report a patient with primary progressive freezing of gait who had severe corneal edema associated with amantadine, which was reversible after discontinuation of the amantadine. This report alerts neurologists for this reversible but potentially critical corneal edema in patients with Parkinsonism who are receiving amantadine.

Citations

Citations to this article as recorded by  
  • Amantadine-induced corneal edema: A case and literature review
    Antony Raharja, Wessam Mina, Zahra Ashena
    American Journal of Ophthalmology Case Reports.2023; 32: 101881.     CrossRef
  • Experience of diagnosis and managements for patients with primary progressive freezing of gait
    Li-Li Zhang, Ya-Jie Zhao, Liang Zhang, Xiao-Ping Wang
    Journal of Neurorestoratology.2022; : 100039.     CrossRef
  • Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells
    Po-Yen Lee, Yu-Hung Lai, Po-Len Liu, Ching-Chih Liu, Chia-Cheng Su, Fang-Yen Chiu, Wei-Chung Cheng, Shiuh-Liang Hsu, Kai-Chun Cheng, Li-Yi Chiu, Tzu-En Kao, Chia-Ching Lin, Yo-Chen Chang, Shu-Chi Wang, Chia-Yang Li
    Scientific Reports.2021;[Epub]     CrossRef
  • Efficacy and safety of amantadine for the treatment of l-DOPA-induced dyskinesia
    Santiago Perez-Lloret, Olivier Rascol
    Journal of Neural Transmission.2018; 125(8): 1237.     CrossRef
  • Ocular and visual disorders in Parkinson's disease: Common but frequently overlooked
    Merel S. Ekker, Sabine Janssen, Klaus Seppi, Werner Poewe, Nienke M. de Vries, Thomas Theelen, Jorik Nonnekes, Bastiaan R. Bloem
    Parkinsonism & Related Disorders.2017; 40: 1.     CrossRef
  • Parkinson’s disease between internal medicine and neurology
    Ilona Csoti, Wolfgang H. Jost, Heinz Reichmann
    Journal of Neural Transmission.2016; 123(1): 3.     CrossRef
  • Amantadine Use as a Risk Factor for Corneal Edema: A Nationwide Cohort Study in Taiwan
    Po Yen Lee, Hung Pin Tu, Chang Ping Lin, Cheng Hsien Chang, Kai Chun Cheng, Chia Ching Lin, Shiuh Liang Hsu
    American Journal of Ophthalmology.2016; 171: 122.     CrossRef

JMD : Journal of Movement Disorders