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Yoon-Sang Oh 8 Articles
Fasting Plasma Glucose Levels and Longitudinal Motor and Cognitive Outcomes in Parkinson’s Disease Patients
Ko-Eun Choi, Dong-Woo Ryu, Yoon-Sang Oh, Joong-Seok Kim
J Mov Disord. 2024;17(2):198-207.   Published online March 6, 2024
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  • 46 Download
AbstractAbstract PDFSupplementary Material
Hyperglycemia and diabetes mellitus have been identified as poor prognostic factors for motor and nonmotor outcomes in patients with Parkinson’s disease (PD), although there is some controversy with this finding. In the present study, we investigated the effects of fasting plasma glucose (FPG) levels on longitudinal motor and cognitive outcomes in PD patients.
We included a total of 201 patients who were diagnosed with PD between January 2015 and January 2020. The patients were categorized based on FPG level into euglycemia (70 mg/dL < FPG < 100 mg/dL), intermediate glycemia (100 mg/dL ≤ FPG < 126 mg/dL), and hyperglycemia (FPG ≥ 126 mg/dL), and longitudinal FPG trajectories were analyzed using group-based trajectory modeling. Survival analysis was conducted to determine the time until motor outcome (Hoehn and Yahr stage ≥ 2) and the conversion from normal cognition to mild cognitive impairment.
Among the patient cohort, 82 had euglycemia, 93 had intermediate glycemia, and 26 had hyperglycemia. Intermediate glycemia (hazard ratio 1.747, 95% confidence interval [CI] 1.083–2.816, p = 0.0221) and hyperglycemia (hazard ratio 3.864, 95% CI 1.996–7.481, p < 0.0001) were found to be significant predictors of worsening motor symptoms. However, neither intermediate glycemia (hazard ratio 1.183, 95% CI 0.697–2.009, p = 0.5339) nor hyperglycemia (hazard ratio 1.297, 95% CI 0.601–2.800, p = 0.5078) demonstrated associations with the longitudinal progression of cognitive impairment. Diabetes mellitus, defined by self-reported medical history, was not related to poor motor or cognitive impairment outcomes.
Our results suggest that both impaired glucose tolerance and hyperglycemia could be associated with motor progression in PD patients.
Validity and Reliability of the Korean-Translated Version of the International Cooperative Ataxia Rating Scale in Cerebellar Ataxia
Jinse Park, Jin Whan Cho, Jinyoung Youn, Engseok Oh, Wooyoung Jang, Joong-Seok Kim, Yoon-Sang Oh, Hyungyoung Hwang, Chang-Hwan Ryu, Jin-Young Ahn, Jee-Young Lee, Seong-Beom Koh, Jae H. Park, Hee-Tae Kim
J Mov Disord. 2023;16(1):86-90.   Published online December 20, 2022
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  • 99 Download
AbstractAbstract PDFSupplementary Material
The International Cooperative Ataxia Rating Scale (ICARS) is a semiquantitative clinical scale for ataxia that is widely used in numerous countries. The purpose of this study was to investigate the validity and reliability of the Korean-translated version of the ICARS.
Eighty-eight patients who presented with cerebellar ataxia were enrolled. We investigated the construct validity using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). We also investigated the internal consistency using Cronbach’s α and intrarater and interrater reliability using intraclass correlation coefficients.
The Korean-translated ICARS showed satisfactory construct validity using EFA and CFA. It also revealed good interrater and intrarater reliability and showed acceptable internal consistency. However, subscale 4 for assessing oculomotor disorder showed moderate internal consistency.
This is the first report to investigate the validity and reliability of the Korean-translated ICARS. Our results showed excellent construct and convergent validity. The reliability is also acceptable.
The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
J Mov Disord. 2021;14(2):176-176.   Published online May 26, 2021
Corrects: J Mov Disord 2019;12(3):172
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The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
J Mov Disord. 2019;12(3):172-176.   Published online August 9, 2019
Correction in: J Mov Disord 2021;14(2):176
  • 5,515 View
  • 108 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.


Citations to this article as recorded by  
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    Alexandros Kapsomenakis, Dimitrios Kasselimis, Emily Vaniotis, Anastasia Bougea, Christos Koros, Athina Maria Simitsi, Leonidas Stefanis, Constantin Potagas
    Medicina.2023; 59(11): 1942.     CrossRef
  • Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy
    Rong Ye, Frank H. Hezemans, Claire O'Callaghan, Kamen A. Tsvetanov, Catarina Rua, P. Simon Jones, Negin Holland, Maura Malpetti, Alexander G. Murley, Roger A. Barker, Caroline H. Williams-Gray, Trevor W. Robbins, Luca Passamonti, James B. Rowe
    The Journal of Neuroscience.2023; 43(42): 7028.     CrossRef
  • Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation
    Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
    Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald
    Clinical Parkinsonism & Related Disorders.2021; 5: 100113.     CrossRef
  • A Review of the Concept of Impulsivity
    Mohammed Munther Al-Hammouri, Jehad A. Rababah, Celeste Shawler
    Advances in Nursing Science.2021; 44(4): 357.     CrossRef
  • Assessment of therapeutic strategies for management of impulse control disorder in Parkinson’s disease
    Mayela Rodríguez-Violante, Yazmín Ríos-Solís, Oscar Esquivel-Zapata, Fanny Herrera, Susana López-Alamillo, Cynthia Sarabia-Tapia, Amin Cervantes-Arriaga
    Arquivos de Neuro-Psiquiatria.2021; 79(11): 989.     CrossRef
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
J Mov Disord. 2016;9(2):97-103.   Published online March 28, 2016
  • 19,694 View
  • 214 Download
  • 39 Web of Science
  • 33 Crossref
AbstractAbstract PDF
The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson’s disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups.
This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naïve or dopaminergic drug treatment).
Orthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.
Cardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.


Citations to this article as recorded by  
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    Parkinsonism & Related Disorders.2024; 121: 106013.     CrossRef
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  • The correlation of orthostatic hypotension in Parkinson disease with the disease course and severity and its impact on quality of life
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    Medicine.2024; 103(19): e38169.     CrossRef
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    BMC Neuroscience.2024;[Epub]     CrossRef
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    Neurology and Clinical Neuroscience.2024;[Epub]     CrossRef
  • Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
    J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca
    Physiological Measurement.2023; 44(5): 054002.     CrossRef
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    Daniel H. Lench, Travis H. Turner, Colin McLeod, Heather A. Boger, Lilia Lovera, Lisa Heidelberg, Jordan Elm, Anh Phan, Bashar W. Badran, Vanessa K. Hinson
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study
    Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad
    Parkinson's Disease.2022; 2022: 1.     CrossRef
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    Journal of Personalized Medicine.2021; 11(2): 129.     CrossRef
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    Siddhartha Lieten, Aziz Debain, Bert Bravenboer, Tony Mets
    BMC Geriatrics.2021;[Epub]     CrossRef
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    Beatrice De Maria, Laura Adelaide Dalla Vecchia, Alberto Porta, Maria Teresa La Rovere
    Herzschrittmachertherapie + Elektrophysiologie.2021; 32(3): 315.     CrossRef
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    Konstantin G. Heimrich, Thomas Lehmann, Peter Schlattmann, Tino Prell
    Brain Sciences.2021; 11(8): 959.     CrossRef
  • Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis
    Feifei Mu, Qian Jiao, Xixun Du, Hong Jiang
    Neurological Sciences.2020; 41(6): 1419.     CrossRef
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    Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
    Geriatrics & Gerontology International.2020; 20(5): 443.     CrossRef
  • The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease
    Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho
    Journal of Parkinson's Disease.2020; 10(2): 605.     CrossRef
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    Ji-Hyun Choi, Jong-Min Kim, Hee Kyung Yang, Hyo-Jung Lee, Cheol Min Shin, Seong Jin Jeong, Won-Seok Kim, Ji Won Han, In-Young Yoon, Yoo Sung Song, Yun Jung Bae
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • Autonomic Dysfunction in Parkinson's Disease
    Ronald F. Pfeiffer
    Neurotherapeutics.2020; 17(4): 1464.     CrossRef
  • Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease
    Hae-Won Shin, Seok Jong Chung, Sangwon Lee, Jungho Cha, Young H. Sohn, Mijin Yun, Phil Hyu Lee
    Clinical Nuclear Medicine.2020; 45(8): e342.     CrossRef
  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease – the SFC BP multicentre study in China
    Shi-Wu Chen, Yu-Kai Wang, Rong-Hua Dou, Xin-Yi Xie, Yong-Bo Hu, Nan Ding, Guo-Hua Zhang, Hai-Fang Jing, Wei-Dong Zhao, Yan Xue, Yan Li, Gang Wang
    Journal of Hypertension.2020; 38(11): 2270.     CrossRef
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    Lixia Li, Peng Guo, Duyu Ding, Tenghong Lian, Lijun Zuo, Fenghe Du, Wei Zhang
    Neurological Research.2019; 41(8): 734.     CrossRef
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    Clinical Autonomic Research.2019; 29(6): 603.     CrossRef
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    Journal of Neurology.2019; 266(12): 3119.     CrossRef
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    Marina Simeonova, Frank de Vries, Sander Pouwels, Johanna H. M. Driessen, Hubert G.M. Leufkens, Suzanne M. Cadarette, Andrea M. Burden
    British Journal of Clinical Pharmacology.2018; 84(11): 2551.     CrossRef
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    Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo
    Journal of Movement Disorders.2017; 10(1): 29.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism
    Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee
    Journal of Clinical Neurology.2017; 13(1): 15.     CrossRef
  • Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
    J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee
    European Journal of Neurology.2017; 24(2): 349.     CrossRef
  • The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism
    Younsoo Kim, Jin Myoung Seok, Jongkyu Park, Kun-Hyun Kim, Ju-Hong Min, Jin Whan Cho, Suyeon Park, Hyun-jin Kim, Byoung Joon Kim, Jinyoung Youn, Pedro Gonzalez-Alegre
    PLOS ONE.2017; 12(7): e0180744.     CrossRef
  • Cardiac sympathetic denervation predicts PD in at-risk individuals
    David S. Goldstein, Courtney Holmes, Grisel J. Lopez, Tianxia Wu, Yehonatan Sharabi
    Parkinsonism & Related Disorders.2017;[Epub]     CrossRef
  • Loss of cutaneous large and small fibers in naive and l -dopa–treated PD patients
    Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro
    Neurology.2017; 89(8): 776.     CrossRef
  • Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
    Neurodegenerative Diseases.2017; 17(2-3): 89.     CrossRef
  • Prevalence and Prescribed Treatments of Orthostatic Hypotension in Institutionalized Patients with Parkinson’s Disease
    ALAJ Hommel, MJ Faber, NJ Weerkamp, JG van Dijk, BR Bloem, RT Koopmans
    Journal of Parkinson's Disease.2016; 6(4): 805.     CrossRef
Effect of Rivastigmine on Behavioral and Psychiatric Symptoms of Parkinson’s Disease Dementia
Yoon-Sang Oh, Joong-Seok Kim, Phil Hyu Lee
J Mov Disord. 2015;8(2):98-102.   Published online May 31, 2015
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  • 257 Download
  • 28 Web of Science
  • 30 Crossref
AbstractAbstract PDF
Objective A recent study showed that rivastigmine and memantin improved behavioral and psychiatric symptoms of dementia (BPSD) in Alzheimer’s dementia. Furthermore, according to recent guidelines presented by the Movement Disorder Society, rivastigmine is efficacious for the treatment of dementia in Parkinson’s disease (PD). We investigated the efficacy of rivastigmine for BPSD in patients with Parkinson’s disease dementia (PDD).
Methods Twenty-three patients in whom cognitive impairment occurred at least one year after a diagnosis of PD participated in this open-label trial. Cognitive, psychiatric, and motor symptoms were assessed before and after 24 weeks of treatment with rivastigmine using unstructured clinical assessments and rating scales including the Unified Parkinson’s Disease Rating Scale, Mini-Mental State Examination (MMSE), and the Neuropsychiatric Inventory.
Results Age (± standard deviation) was 74.7 ± 5.9 years, average duration of PD was 3.5 ± 3.7 years, Hoehn and Yahr scores were 2.2 ± 0.8, and baseline MMSE scores were 19.1 ± 4.2. Improvements in global mental symptoms and neuropsychiatric symptoms were significant; among them, hallucination, depression and appetite changes improved. Caregiver distress significantly decreased, including distress resulting from hallucinations, depression, apathy, and appetite changes.
Conclusions Although controlled trials are required, the findings suggest that rivastigmine is useful for control of several neuropsychiatric symptoms and beneficial for caregiver distress in patients with PDD.


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  • Diagnosis and treatment of old-onset Parkinson's disease
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  • Neuropsychiatrische Störungen bei idiopathischem Parkinson-Syndrom
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    Medicina.2021; 57(10): 1107.     CrossRef
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  • Neuropsychiatric Disorders in Parkinson’s Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?
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  • Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson’s Disease, and Multiple Sclerosis: Diagnosis and Treatment
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    FOCUS.2020; 18(2): 150.     CrossRef
  • Identifying and responding to fatigue and apathy in Parkinson’s disease: a review of current practice
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    Expert Review of Neurotherapeutics.2020; 20(5): 477.     CrossRef
  • Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review
    Bria Mele, Shinia Van, Jayna Holroyd-Leduc, Zahinoor Ismail, Tamara Pringsheim, Zahra Goodarzi
    BMJ Open.2020; 10(9): e037632.     CrossRef
  • Pharmacological treatment of apathy in Lewy body disorders: A systematic review
    Jennifer Liu, Christine A. Cooper, Daniel Weintraub, Nabila Dahodwala
    Parkinsonism & Related Disorders.2019; 60: 14.     CrossRef
  • Current treatment of behavioral and cognitive symptoms of Parkinson's disease
    Irena Rektorova
    Parkinsonism & Related Disorders.2019; 59: 65.     CrossRef
  • Approach to the management of psychosis in Parkinson’s disease
    Abhishek Lenka, Vasanthi Gomathinayagam, Laxman Bahroo
    Annals of Movement Disorders.2019; 2(3): 83.     CrossRef
  • Risk factors for non-motor symptoms in Parkinson's disease
    Johan Marinus, Kangdi Zhu, Connie Marras, Dag Aarsland, Jacobus J van Hilten
    The Lancet Neurology.2018; 17(6): 559.     CrossRef
  • The efficacy of pharmacological approaches to therapy of the apathy syndrome in dementia disorders (the review)
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    Stephane Thobois, Stephane Prange, Véronique Sgambato-Faure, Léon Tremblay, Emmanuel Broussolle
    Current Neurology and Neuroscience Reports.2017;[Epub]     CrossRef
  • Parkinson’s Disease Psychosis: Presentation, Diagnosis and Management
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    Neurodegenerative Disease Management.2017; 7(6): 365.     CrossRef
  • Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson’s Disease
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  • Neuropsychiatric Issues in Parkinson’s Disease
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    Neurodegenerative Disease Management.2016; 6(4): 319.     CrossRef
  • Pimavanserin for the treatment of Parkinson’s disease psychosis
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  • Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments
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  • Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration
    Santiago Perez-Lloret, María Cecilia Peralta, Francisco J. Barrantes
    Expert Opinion on Pharmacotherapy.2016; 17(18): 2405.     CrossRef
Neuropsychiatric Symptoms in Parkinson’s Disease Dementia Are Associated with Increased Caregiver Burden
Yoon-Sang Oh, Ji E. Lee, Phil Hyu Lee, Joong-Seok Kim
J Mov Disord. 2015;8(1):26-32.   Published online January 31, 2015
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AbstractAbstract PDF
Objective Neuropsychiatric symptoms are common in Parkinson’s disease dementia (PDD). Frequent and severe neuropsychiatric symptoms create high levels of distress for patients and caregivers, decreasing their quality of life. The aim of this study was to investigate neuropsychiatric symptoms that may contribute to increased caregiver burden in PDD patients.
Methods Forty-eight PDD patients were assessed using the 12-item Neuropsychiatric Inventory (NPI) to determine the frequency and severity of mental and behavioral problems. The Burden Interview and Caregiver Burden Inventory were used to evaluate caregiver burden.
Results All but one patient showed one or more neuropsychiatric symptoms. The three most frequent neuropsychiatric symptoms were apathy (70.8%) and anxiety (70.8%), followed by depression (68.7%). More severe neuropsychiatric symptoms were significantly correlated with increased caregiver burden. The domains of delusion, hallucination, agitation and aggression, anxiety, irritability and lability, and aberrant motor behavior were associated with caregiver stress. After controlling for age and other potential confounding variables, total NPI score was significantly associated with caregiver burden.
Conclusions The results of this study confirm that neuropsychiatric symptoms are frequent and severe in patients with PDD and are associated with increased caregiver distress. A detailed evaluation and management of neuropsychiatric symptoms in PDD patients appears necessary to improve patient quality of life and reduce caregiver burden.


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  • Risk factors and intervention of caregiver burden in Parkinson’s disease: a systematic review and meta-analysis
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    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Unawareness of Apathy in Parkinson’s Disease: The Role of Executive Dysfunction on Symptom Recognition
    Gianpaolo Maggi, Carmine Vitale, Alessia Delle Curti, Marianna Amboni, Gabriella Santangelo
    Brain Sciences.2023; 13(6): 964.     CrossRef
  • Caregiver Burden in Late-Stage Parkinsonism and Its Associations
    Stefania Kalampokini, Adrianus L. A. J. Hommel, Stefan Lorenzl, Joaquim J. Ferreira, Wassilios G. Meissner, Per Odin, Bastiaan R. Bloem, Richard Dodel, Anette-Eleonore Schrag
    Journal of Geriatric Psychiatry and Neurology.2022; 35(1): 110.     CrossRef
  • Psychometric Properties of Clinical Indicators for Identification and Management of Advanced Parkinson’s Disease: Real-World Evidence From G7 Countries
    Angelo Antonini, Rajesh Pahwa, Per Odin, Tove Henriksen, Michael J. Soileau, Ramon Rodriguez-Cruz, Stuart H. Isaacson, Aristide Merola, Susanna Lindvall, Josefa Domingos, Ali Alobaidi, Yash J. Jalundhwala, Prasanna L. Kandukuri, Juan Carlos Parra, Pavnit
    Neurology and Therapy.2022; 11(1): 303.     CrossRef
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    Neuropsychiatric Disease and Treatment.2022; Volume 18: 633.     CrossRef
  • Exploring the experiences of living with Lewy body dementia: An integrative review
    Allison Bentley, Tessa Morgan, Yakubu Salifu, Catherine Walshe
    Journal of Advanced Nursing.2021; 77(12): 4632.     CrossRef
  • Neuropsychiatric symptoms in Parkinson’s disease: association with caregiver distress and disease severity
    Wan-Chen Tsai, Hui-Chen Lin, Chiung-Chih Chang, Wen-Neng Chang, Chih-Cheng Huang, Kuei-Yueh Cheng, Hung-Chen Wang, Wei-Che Lin, Sheng-Yuan Hsiao, Yun-Ru Lai, Cheng-Hsien Lu, Nai-Wen Tsai
    International Psychogeriatrics.2020; 32(6): 733.     CrossRef
  • Caregiver Burden, Quality of Life and Related Factors in Family Caregivers of Dementia Patients in Turkey
    Zeliha Tulek, Dilek Baykal, Sumeyye Erturk, Basar Bilgic, Hasmet Hanagasi, I. Hakan Gurvit
    Issues in Mental Health Nursing.2020; 41(8): 741.     CrossRef
  • Identifying and responding to fatigue and apathy in Parkinson’s disease: a review of current practice
    Claudia Lazcano-Ocampo, Yi Min Wan, Daniel J van Wamelen, Lucia Batzu, Iro Boura, Nataliya Titova, Valentina Leta, Mubasher Qamar, Pablo Martinez-Martin, K Ray Chaudhuri
    Expert Review of Neurotherapeutics.2020; 20(5): 477.     CrossRef
  • A systematic review of the association between individual behavioural and psychological symptoms in dementia and carer burden
    Catriona George, Nuno Ferreira, Rosalind Evans, Victoria Honeyman
    Working with Older People.2020; 24(3): 181.     CrossRef
  • Impact of Supporting People with Advanced Parkinson’s Disease on Carer’s Quality of Life and Burden

    Nicola Modugno, Angelo Antonini, Alessandro Tessitore, Pietro Marano, Francesco Ernesto Pontieri, Nicola Tambasco, Margherita Canesi, Giovanni Fabbrini, Mariachiara Sensi, Rocco Quatrale, Paolo Solla, Giovanni Defazio, Gabriella Melzi, Giuliana Gualberti,
    Neuropsychiatric Disease and Treatment.2020; Volume 16: 2899.     CrossRef
  • A Comparative Study of the Behavioral Profile of the Behavioral Variant of Frontotemporal Dementia and Parkinson’s Disease Dementia
    Dinesh Saini, Adreesh Mukherjee, Arijit Roy, Atanu Biswas
    Dementia and Geriatric Cognitive Disorders Extra.2020; 10(3): 182.     CrossRef
  • The long‐term direct and indirect economic burden among Parkinson's disease caregivers in the United States
    Pablo Martinez‐Martin, Dendy Macaulay, Yash J. Jalundhwala, Fan Mu, Erika Ohashi, Thomas Marshall, Kavita Sail
    Movement Disorders.2019; 34(2): 236.     CrossRef
  • The association between specific neuropsychiatric disturbances in people with Alzheimer's disease and dementia with Lewy bodies and carer distress
    Toril Marie Terum, Ingelin Testad, Arvid Rongve, Dag Aarsland, Ellen Svendsboe, John Roger Andersen
    International Journal of Geriatric Psychiatry.2019; 34(10): 1421.     CrossRef
  • Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort
    Ashani Jeyadevan, Megan C. Bakeberg, Michelle Byrnes, Jade Kenna, Soumya Ghosh, Rick Stell, Sue Walters, Tess Evans, Sarah McGregor, Malcolm Horne, Frank L. Mastaglia, Ryan S. Anderton
    Parkinson's Disease.2019; 2019: 1.     CrossRef
  • Caregiver burden and its related factors in advanced Parkinson’s disease: data from the PREDICT study
    Alessandro Tessitore, Pietro Marano, Nicola Modugno, Francesco E. Pontieri, Nicola Tambasco, Margherita Canesi, Anna Latorre, Leonardo Lopiano, Mariachiara Sensi, Rocco Quatrale, Paolo Solla, Giovanni Defazio, Gabriella Melzi, Anna Maria Costanzo, Giulian
    Journal of Neurology.2018; 265(5): 1124.     CrossRef
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  • Cognitive impairment in Parkinson's disease: impact on quality of life of carers
    RA Lawson, AJ Yarnall, F Johnston, GW Duncan, TK Khoo, D Collerton, JP Taylor, DJ Burn
    International Journal of Geriatric Psychiatry.2017; 32(12): 1362.     CrossRef
  • Rivastigmine as a Symptomatic Treatment for Apathy in Parkinson’s Dementia Complex: New Aspects for This Riddle
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    International Journal of Geriatric Psychiatry.2017; 32(7): 703.     CrossRef
  • Neuropsychiatric symptoms in Alzheimer’s disease: associations with caregiver burden and treatment outcomes
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  • Hallucinations in Healthy Older Adults: An Overview of the Literature and Perspectives for Future Research
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  • Dementia Caregiver Burden: a Research Update and Critical Analysis
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  • Patients and Their Caregivers’ Burdens for Parkinson’s Disease in Korea
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  • Prevalence and treatment pattern ofParkinson's disease dementia inKorea
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Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease
Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee
J Mov Disord. 2013;6(2):23-27.   Published online October 30, 2013
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AbstractAbstract PDF
Background and Purpose:

Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD).


We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.


The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.


This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.


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  • Study protocol for the Heads-Up trial: a phase II randomized controlled trial investigating head-up tilt sleeping to alleviate orthostatic intolerance in Parkinson’s Disease and parkinsonism
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    BMC Neurology.2024;[Epub]     CrossRef
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    Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Interventions for orthostatic hypotension in Parkinson's disease: a systematic review and network meta-analysis
    Kunshan Li, Luyi Wu, Xuejun Cui, Wei Zhang, Jun Ji, Yiwen Wu, Zhaoqin Wang, Huirong Liu, Huangan Wu, Lu Zhu
    Cochrane Database of Systematic Reviews.2023;[Epub]     CrossRef
  • Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
    J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca
    Physiological Measurement.2023; 44(5): 054002.     CrossRef
  • The mechanism of impaired delayed recall verbal memory function in Parkinson's disease with orthostatic hypotension: a multiple imaging study
    Xiaofan Xue, Anqi Huang, Jingrong Zeng, Haixia Song, Yingqi Xing, Piu Chan, Erhe Xu, Lichun Zhou
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Cognitive Deficits in Parkinson's Disease Are Associated with Neuronal Dysfunction and Not White Matter Lesions
    Nils Schröter, Tobias Bormann, Michel Rijntjes, Ganna Blazhenets, Raissa Berti, Bastian E.A. Sajonz, Horst Urbach, Cornelius Weiller, Philipp T. Meyer, Alexander Rau, Lars Frings
    Movement Disorders Clinical Practice.2023; 10(7): 1066.     CrossRef
  • Orthostatic hypotension and its association with cerebral small vessel disease in a memory clinic population
    Julia H.I. Wiersinga, Hanneke F.M. Rhodius-Meester, Frank J. Wolters, Marijke C. Trappenburg, Afina W. Lemstra, Frederik Barkhof, Mike J.L. Peters, Wiesje M. van der Flier, Majon Muller
    Journal of Hypertension.2023; 41(11): 1738.     CrossRef
  • Mild cognitive impairment in patients with Parkinson´s disease and the analysis of associated factors
    Esma Kobak Tur, Buse Cagla Ari
    Neurological Research.2023; 45(12): 1161.     CrossRef
  • REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
    Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
    Aging Clinical and Experimental Research.2022; 34(1): 159.     CrossRef
  • Parkinsonism and cerebrovascular disease
    Manisha Narasimhan, Raymond Schwartz, Glenda Halliday
    Journal of the Neurological Sciences.2022; 433: 120011.     CrossRef
  • Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease
    Anna Pierzchlińska, Magdalena Kwaśniak-Butowska, Jarosław Sławek, Marek Droździk, Monika Białecka
    Molecules.2021; 26(6): 1523.     CrossRef
  • Adverse effects of hypertension, supine hypertension, and perivascular space on cognition and motor function in PD
    Na-Young Shin, Yae Won Park, Sang-Won Yoo, Ji-Yeon Yoo, Yangsean Choi, Jinhee Jang, Kook-Jin Ahn, Bum-soo Kim, Joong-Seok Kim
    npj Parkinson's Disease.2021;[Epub]     CrossRef
  • Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders
    Andrea Pilotto, Alberto Romagnolo, Andrea Scalvini, Mario Masellis, Yasushi Shimo, Laura Bonanni, Richard Camicioli, Lily L. Wang, Alok K. Dwivedi, Katherine Longardner, Federico Rodriguez-Porcel, Mark DiFrancesco, Joaquin A. Vizcarra, Elisa Montanaro, Si
    Neurology.2021;[Epub]     CrossRef
  • Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction
    Yoshiki Hase, Tuomo M. Polvikoski, Michael J. Firbank, Lucinda J. L. Craggs, Emily Hawthorne, Charlotte Platten, William Stevenson, Vincent Deramecourt, Clive Ballard, Rose Anne Kenny, Robert H. Perry, Paul Ince, Roxana O. Carare, Louise M. Allan, Karen H
    Brain Pathology.2020; 30(1): 191.     CrossRef
  • Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
    Alexander Levit, Vladimir Hachinski, Shawn N. Whitehead
    GeroScience.2020; 42(2): 445.     CrossRef
  • The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension
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    Parkinsonism & Related Disorders.2020; 75: 97.     CrossRef
  • White Matter Hyperintensities in the Synucleinopathies: Orthostatic Hypotension, Supine Hypertension, or Both?
    Horacio Kaufmann, Jose‐Alberto Palma
    Movement Disorders Clinical Practice.2020; 7(6): 595.     CrossRef
  • White Matter Hyperintensities Mediate Impact of Dysautonomia on Cognition in Parkinson's Disease
    Mahsa Dadar, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B. Postuma, D. Louis Collins
    Movement Disorders Clinical Practice.2020; 7(6): 639.     CrossRef
  • Blood pressure lability is associated with subcortical atrophy in early Parkinson's disease
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    Journal of Hypertension.2020; 38(10): 2043.     CrossRef
  • Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults
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    Movement Disorders.2019; 34(11): 1672.     CrossRef
  • Orthostatic hypotension in Parkinson disease
    Ylva Hivand Hiorth, Kenn Freddy Pedersen, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves
    Neurology.2019;[Epub]     CrossRef
  • Dysautonomia is associated with structural and functional alterations in Parkinson disease
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