Journal of Movement Disorders

Volume 5(1); April 2012

Original Articles

Preliminary Study of Intravenous Amantadine Treatment for Ataxia Management in Patients with Probable Multiple System Atrophy with Predominant Cerebellar Ataxia: Jinyoung Youn, Hyeeun Shin, Ji Sun Kim, Jin Whan Cho; J Mov Disord. 2012;5(1):1-4.; DOI: https://doi.org/10.14802/jmd.12001

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Background and Purpose:

Multiple system atrophy with predominant cerebellar ataxia is a disabling neurologic disease. However, effective management has not yet been established. We conducted a short-term, open-label preliminary study to assess the benefits of intravenous amantadine treatment in patients with probable multiple system atrophy with predominant cerebellar ataxia.

Methods:

Twenty patients (10 male, 10 female) with probable multiple system atrophy with predominant cerebellar ataxia received 400 mg of amantadine by intravenous per day for 5 days. Ataxia severity was evaluated by the International Cooperative Ataxia Rating Scale before and after intravenous amantadine therapy and all subjects reported subjective improvement after intravenous amantadine treatment using a patient global impression scale. We analyzed the total and subscale scores by the ataxia scale and patient global impression scale.

Results:

The mean age was 57.4 years (range: 47–72) and the mean disease duration was 30.8 months (range: 11–79). The ataxia severity significantly decreased after intravenous amantadine therapy from 42.5 to 37.3 (p < 0.001). The mean patient global impression scale for improvement was 2.9 and there were no side effects of intravenous amantadine treatment observed. When we assessed responders, the duration of intravenous amantadine effect was more than 1 month in 4 subjects of 7 responders.

Conclusions:

Our findings suggest that intravenous amantadine treatment can be a safe management option in cerebellar ataxia, although the mechanism is unclear. Thus, further double-blind, long-term studies with a larger sample size are needed.

Citations

Citations to this article as recorded by

Low Dose Amantadine and Escitalopram in Progressive Supranuclear Palsy and Multiple System Atrophy
Porimita Chutia, Shailendra Mohan Tripathi
Annals of Neurosciences.2024;[Epub] CrossRef
Amantadine withdrawal in a patient with spinocerebellar ataxia
Andrew Pak, Emiley Chang
BMJ Case Reports.2023; 16(11): e256840. CrossRef
M1 and Cerebellar tDCS for MSA-C: a Double-Blind, Randomized, Sham-Controlled, Crossover Study
Jong Hyeon Ahn, Dongyeong Lee, Minkyeong Kim, Jin Whan Cho, Won Hyuk Chang, Jinyoung Youn
The Cerebellum.2022; 22(3): 386. CrossRef
Effects of preoperative intravenous amantadine sulfate infusion on wake up test duration and postoperative opioid consumption in adolescents undergoing spine corrective surgery
Ghada M. Aboelfadl, Saeid Elsawy, Belal O. Elnady, Rasha Hamed
Perioperative Care and Operating Room Management.2021; 24: 100166. CrossRef
Amantadine in the treatment of Parkinson’s disease. New opportunities in the context of COVID-19
E.A. Katunina
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2021; 121(4): 101. CrossRef
Efficacy of Parenteral Amantadine Therapy in the Treatment of Multiple System Atrophy With Predominant Parkinsonism
Adit Friedberg, Ilana Erikh, Maria Nassar, Elliot Sprecher, Ilana Schlesinger
Clinical Neuropharmacology.2018; 41(5): 160. CrossRef

Reorganization of the Human Somatosensory Cortex in Hand Dystonia: Maria Jose Catalan, Kenji Ishii, William Bara-Jimenez, Mark Hallett; J Mov Disord. 2012;5(1):5-8.; DOI: https://doi.org/10.14802/jmd.12002

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Abstract PDF

Background and Purpose:

Abnormalities of finger representations in the somatosensory cortex have been identified in patients with focal hand dystonia. Measuring blood flow with positron emission tomography (PET) can be use to demonstrate functional localization of receptive fields.

Methods:

A vibratory stimulus was applied to the right thumb and little finger of six healthy volunteers and six patients with focal hand dystonia to map their receptive fields using H₂¹⁵O PET.

Results:

The cortical finger representations in the primary somatosensory cortex were closer to each other in patients than in normal subjects. No abnormalities were found in secondary somatosensory cortex, but the somatotopy there is less well distinguished.

Conclusions:

These data confirm prior electrophysiological and functional neuroimaging observations showing abnormalities of finger representations in somatosensory cortex of patients with focal hand dystonia.

Citations

Citations to this article as recorded by

Laminar VASO fMRI in focal hand dystonia patients
Laurentius Huber, Panagiotis Kassavetis, Omer Faruk Gulban, Mark Hallett, Silvina G. Horovitz
Dystonia.2023;[Epub] CrossRef
Sensory Alterations in Patients with Isolated Idiopathic Dystonia: An Exploratory Quantitative Sensory Testing Analysis
Lejla Paracka, Florian Wegner, Christian Blahak, Mahmoud Abdallat, Assel Saryyeva, Dirk Dressler, Matthias Karst, Joachim K. Krauss
Frontiers in Neurology.2017;[Epub] CrossRef

Botulinum Toxin Clinic-Based Epidemiologic Survey of Adults with Primary Dystonia in East China: Li Wang, Xingyue Hu, Chunfeng Liu, Yiwen Wu, Changqing Wang, Zhiqiang Wang, Jun Chen; J Mov Disord. 2012;5(1):9-13.; DOI: https://doi.org/10.14802/jmd.12003

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Abstract PDF

Background and Purpose:

Primary focal or segmental dystonia is a rare clinical condition. The clinical features of dystonia have not been evaluated in China. We performed a study to investigate the epidemiology of primary dystonia and its clinical variants in an adult population.

Methods:

A Botulinum Toxin Clinic-based study was conducted in the period 18 May through 8 October 2010 in East China. We identified 523 dystonia patients from the Movement disorders and Botulinum Toxin clinic Cases.

Results:

The most common focal dystonia were blepharospasm (59%), cervical dystonia (35%), limb dystonia (3%), oromandibular dystonia (2%) and laryngeal dystonia (1%). Males with primary dystonia were noted to have earlier age of onset. A female predominance was noted for most of the primary dystonias with a male to female ratio (M : F) ranging from 1 : 1.48 to 1 : 3.

Conclusions:

The epidemiological features of dystonia in East China we collected were similar to the report in Japan which contrasts partly with that reported in Europe.

Citations

Citations to this article as recorded by

Dystonia: A Leading Neurological Movement Disorder
Md. Tanvir Kabir, Hasina Yasmin, Umme Salma Khanam, Mohd. Raeed Jamiruddin, Md. Sahab Uddin, Mohamed M. Abdel-Daim
Journal of Intellectual Disability - Diagnosis and Treatment.2018; 6(3): 63. CrossRef
Late-onset primary dystonia in Zhejiang province of China: a service-based epidemiological study
Li Wang, Yin Chen, Beibei Hu, Xingyue Hu
Neurological Sciences.2016; 37(1): 111. CrossRef
Tätigkeitsbezogene primäre fokale Dystonien außerhalb der Musikermedizin und ihre Bedeutung für die Arbeitswelt
F. Sladeczek
Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie.2015; 65(1): 31. CrossRef

Case Reports

Hypomania Induced by Subthalamic Nucleus Stimulation in a Parkinson’s Disease Patient: Does It Suggest a Dysfunction of the Limbic Circuit?: Ji Seon Kim, Hee Jin Kim, Ji-Young Lee, Jong Min Kim, Ji Young Yun, Beom S. Jeon; J Mov Disord. 2012;5(1):14-17.; DOI: https://doi.org/10.14802/jmd.12004

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Abstract PDF

The aim of this report was to describe a case of hypomania after deep brain stimulation of the subthalamic nucleus (STN DBS) in a Parkinson’s disease (PD) patient. 59-year-old man with a 15-year history of PD underwent bilateral implantation of electrodes to the STN. Immediately after surgery, his motor function was markedly improved and his mood was elevated to hypomania. Fusion images of the preoperative MRI and postoperative CT scan showed that the electrodes were located in the medial portion of the STN. In this case, behavioral mood change was related to the deep brain stimulation. Moreover, the anatomical location and the functional alteration of the STN after the DBS surgery might be related to the regulatory system of the associative and limbic cortico-subcortical circuits.

Citations

Citations to this article as recorded by

Architecture of the subthalamic nucleus
Asheeta A. Prasad, Åsa Wallén-Mackenzie
Communications Biology.2024;[Epub] CrossRef
Treating addiction with deep brain stimulation: Ethical and legal considerations
Clara Lo, Mansee Mane, Jee Hyun Kim, Michael Berk, Richard R. Sharp, Kendall H. Lee, Jason Yuen
International Journal of Drug Policy.2023; 113: 103964. CrossRef
The anatomo-functional organization of the hyperdirect cortical pathway to the subthalamic area using in vivo structural connectivity imaging in humans
Gizem Temiz, Sophie B. Sébille, Chantal Francois, Eric Bardinet, Carine Karachi
Brain Structure and Function.2020; 225(2): 551. CrossRef
Hypomania and saccadic changes in Parkinson’s disease: influence of D2 and D3 dopaminergic signalling
Esther A. Pelzer, Barbara Dillenburger, Sophie Grundmann, Vladimir Iliaev, Sophie Aschenberg, Corina Melzer, Martin Hess, Gereon R. Fink, Carsten Eggers, Marc Tittgemeyer, Lars Timmermann
npj Parkinson's Disease.2020;[Epub] CrossRef
Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson’s disease
Frank Schwartz, Masoud Tahmasian, Franziska Maier, Luisa Rochhausen, Kim L. Schnorrenberg, Fateme Samea, Joseph Seemiller, Mojtaba Zarei, Christian Sorg, Alexander Drzezga, Lars Timmermann, Thomas D. Meyer, Thilo van Eimeren, Carsten Eggers
Brain Imaging and Behavior.2019; 13(1): 241. CrossRef
Affective modulation of the associative-limbic subthalamic nucleus: deep brain stimulation in obsessive–compulsive disorder
Mircea Polosan, Fabien Droux, Astrid Kibleur, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Valerie Voon
Translational Psychiatry.2019;[Epub] CrossRef
Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation
Lisa-Maria Schönfeld, Lars Wojtecki
Frontiers in Neuroscience.2019;[Epub] CrossRef

Apparently Ipsilateral Parkinsonism in a Patient with Chronic Subdural Hematoma: Tae Hwan Roh, Dokyung Lee, Il Ki Hong, Deog Yoon Kim, Tae-Beom Ahn; J Mov Disord. 2012;5(1):18-20.; DOI: https://doi.org/10.14802/jmd.12005

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Abstract PDF

Symptomatic parkinsonism secondary to ipsilateral lesion is rarely reported. Although the contribution of the contralateral lesions was assumed in some cases, the pathomechanism remains undetermined. Herein we report a patient with a subdural hematoma, who developed parkinsonism in the ipsilateral hemibody. Structural and functional imaging suggests the contralateral dopaminergic dysfunction as the major culprit of apparently ipsilateral parkinsonism.

Citations

Citations to this article as recorded by

Secondary parkinsonism caused by chronic subdural hematomas owing to compressed cortex and a disturbed cortico–basal ganglia–thalamocortical circuit: illustrative case
Masao Fukumura, Sho Murase, Yuzo Kuroda, Kazutomo Nakazawa, Yasufumi Gon
Journal of Neurosurgery: Case Lessons.2021;[Epub] CrossRef

An Elderly Case of Acute Cerebellitis after Alleged Vaccination: Kang Min Park, Si Eun Kim, Sung Eun Kim; J Mov Disord. 2012;5(1):21-23.; DOI: https://doi.org/10.14802/jmd.12006

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Abstract PDF

Acute cerebellitis (AC) is a benign and self-limiting inflammatory disease. It typically occurs as a primary infectious or postinfectious disorder. Although AC mostly presents in early childhood, it can appear in adult. A 66-year-old man admitted to our hospital because of limb and gait ataxia. Three weeks ago, he took an influenza vaccination. There was no abnormality on brain MRI with contrast enhancement, but Technetium-99m hexamethyl propylene amine oxime-single photon emission computed tomography (HMPAO-SPECT) showed markedly cerebellar asymmetry, suggesting hypoperfusion in the right cerebellum. Influenza vaccination can cause AC in the elderly and brain HMPAO-SPECT imaging is more useful than MRI in identifying patients with AC.

Citations

Citations to this article as recorded by

Acute cerebellitis following COVID‐19 vaccination: A case report
Seyedehnarges Tabatabaee, Fahimeh H. Akhoundi, Afsaneh Khobeydeh, Seyed Mohammad Tabatabaei, Bahram Haghi Ashtiani
Clinical Case Reports.2023;[Epub] CrossRef
Advanced neuroimaging findings of pseudotumoral hemicerebellitis in an elderly male requiring surgical decompression
Rajesh Gupta, Pejman J. Maralani, Sanjeev Chawla, Pallavi P. Gopal, Suyash Mohan
Journal of Neurosurgery.2014; 120(2): 522. CrossRef

Psychogenic Balance Disorders: Is It a New Entity of Psychogenic Movement Disorders?: Jong Sam Baik, Myung Sik Lee; J Mov Disord. 2012;5(1):24-27.; DOI: https://doi.org/10.14802/jmd.12007

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Abstract PDF

The various reported psychogenic dyskinesias include tremor, dystonia, myoclonus, gait disorder, Parkinsonism, tics, and chorea. It is not easy to diagnose psychogenic movement disorders, especially in patients with underlying organic disease. We describe three patients with balance and/or posture abnormalities that occur when they stand up, start to move, or halt from walking, although their gaits are normal. One had an underlying unilateral frontal lobe lesion. All patients improved dramatically after receiving a placebo-injection or medication. These abnormal features differ from the previously reported features of astasia without abasia and of psychogenic gait disorders, including recumbent gait. We describe and discuss the patients’ unique clinical characteristics.

Citations

Citations to this article as recorded by

Somatization in Parkinson's Disease: A systematic review
Danilo Carrozzino, Per Bech, Chiara Patierno, Marco Onofrj, Bo Mohr Morberg, Astrid Thomas, Laura Bonanni, Mario Fulcheri
Progress in Neuro-Psychopharmacology and Biological Psychiatry.2017; 78: 18. CrossRef
Functional movement disorders
Anita Barbey, Selma Aybek
Current Opinion in Neurology.2017; 30(4): 427. CrossRef

Levodopa-Induced Facial Dystonia in a Case of Progressive Supranuclear Palsy: Eun Joo Chung, Sang Jin Kim; J Mov Disord. 2012;5(1):28-32.; DOI: https://doi.org/10.14802/jmd.12008

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Abstract PDF

Progressive supranuclear palsy (PSP) is frequently misdiagnosed as other Parkinsonism because of clinical heterogeneity of PSP. We present here a case of a 67-year-old male patient with frontotemporal dementia-like cognitive impairment including language difficulties and abnormal behaviors. He showed severe facial dystonia after the levodopa treatment. Herein, we describe an unusual case of a patient presenting with PSP which, we believe could contribute to our knowledge about atypical leveodopa-induced facial dystonia in PSP.

Citations

Citations to this article as recorded by

Use of botulinum toxin in the management of dystonia in Parkinson’s disease
Charenya Anandan, Joseph Jankovic
Frontiers in Neuroscience.2024;[Epub] CrossRef
Lower Cranial Dystonia with Inflated Cheeks: A Case of Dystonic Respiratory Failure
Takashi Suzuki, Takao Makifuchi, Nobuyoshi Fukuhara
Internal Medicine.2023; 62(11): 1671. CrossRef
Dystonia in atypical parkinsonian disorders
Luca Marsili, Matteo Bologna, Maja Kojovic, Alfredo Berardelli, Alberto J. Espay, Carlo Colosimo
Parkinsonism & Related Disorders.2019; 66: 25. CrossRef
A Review of Treatment Options for Progressive Supranuclear Palsy
Maria Stamelou, Günter Höglinger
CNS Drugs.2016; 30(7): 629. CrossRef

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