Journal of Movement Disorders

Volume 7(2); October 2014

Review Articles

Electrophysiological Evaluation of Oropharyngeal Dysphagia in Parkinson’s Disease: Cumhur Ertekin; J Mov Disord. 2014;7(2):31-56. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14008

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Parkinson’s disease (PD) is a chronic, neurodegenerative movement disorder that typically affects elderly patients. Swallowing disorders are highly prevalent in PD and can have grave consequences, including pneumonia, malnutrition, dehydration and mortality. Neurogenic dysphagia in PD can manifest with both overt clinical symptoms or silent dysphagia. Regardless, early diagnosis and objective follow- up of dysphagia in PD is crucial for timely and appropriate care for these patients. In this review, we provide a comprehensive summary of the electrophysiological methods that can be used to objectively evaluate dysphagia in PD. We discuss the electrophysiological abnormalities that can be observed in PD, their clinical correlates and the pathophysiology underlying these findings.

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Impact of autonomic symptoms on the clinical course of Parkinson’s disease
Hiroaki Fujita, Keitaro Ogaki, Tomohiko Shiina, Hirotaka Sakuramoto, Narihiro Nozawa, Keisuke Suzuki
Neurological Sciences.2024; 45(8): 3799. CrossRef
Appropriate volumes of water for non-invasive swallowing assessments of nursing home residents: A descriptive correlational study
Meng Rung Tsai, Wann Yun Shieh, Hsiu Hsin Tsai, Yea Ing Lotus Shyu, Kuo Hsuan Chang, Fur Hsing Wen, Chia Yih Liu
Heliyon.2024; 10(17): e37340. CrossRef
Electrokinesiographic Study of Oropharyngeal Swallowing in Neurogenic Dysphagia
Enrico Alfonsi, Massimiliano Todisco, Mauro Fresia, Cristina Tassorelli, Giuseppe Cosentino
Dysphagia.2023; 38(2): 543. CrossRef
Respiratory-Swallow Coordination in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis
Rabab Rangwala, Raneh Saadi, Jungwha Julia Lee, Erin L. Reedy, Cagla Kantarcigil, Megan Roberts, Bonnie Martin-Harris
Journal of Parkinson's Disease.2023; 13(5): 681. CrossRef
History of Oropharyngeal Organs and Swallowing
Cumhur Ertekin, İbrahim Aydoğdu
Turkish Journal Of Neurology.2023; 29(3): 165. CrossRef
Wearable, epidermal devices for assessment of swallowing function
Tarek Rafeedi, Abdulhameed Abdal, Beril Polat, Katherine A. Hutcheson, Eileen H. Shinn, Darren J. Lipomi
npj Flexible Electronics.2023;[Epub] CrossRef
Endoscopic Characteristics of Dysphagia in Multiple System Atrophy Compared to Parkinson's Disease
Annemarie Vogel, Inga Claus, Sigrid Ahring, Doreen Gruber, Aiden Haghikia, Ulrike Frank, Rainer Dziewas, Georg Ebersbach, Florin Gandor, Tobias Warnecke
Movement Disorders.2022; 37(3): 535. CrossRef
Deep Learning Analysis to Automatically Detect the Presence of Penetration or Aspiration in Videofluoroscopic Swallowing Study
Jeoung Kun Kim, Yoo Jin Choo, Gyu Sang Choi, Hyunkwang Shin, Min Cheol Chang, Donghwi Park
Journal of Korean Medical Science.2022;[Epub] CrossRef
Pilot study of a novel transmembranous electromyography device for assessment of oral cavity and oropharyngeal muscles
Deepak Menon, Perry Mansfield, Derrick Cordice, Chris Studer, Michael O'Leary, Geoffrey Sheean, Vera Bril
Muscle & Nerve.2022; 65(3): 303. CrossRef
Role of Catechol-O-methyltransferase Val158Met Polymorphism on Transcranial Direct Current Stimulation in Swallowing
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Journal of Personalized Medicine.2022; 12(3): 488. CrossRef
Parkinson Hastalığında Yutma Bozukluklarına Yaklaşım
Merve SAPMAZ ATALAR, Gençer GENÇ
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A new swallowing supplement for dysphagia in patients with Parkinson’s disease
Eungseok Oh, Sungju Jee, Beom Keun Kim, Jung Seon Lee, Kanghee Cho, Soyoung Ahn
Neurological Sciences.2021; 42(5): 1949. CrossRef
The Potential of Electromyography Signals as Markers to Detect and Monitor Parkinson’s Disease
Elta Diah Pasmanasari, Jeanne Adiwinata Pawitan
Biomedical and Pharmacology Journal.2021; 14(1): 373. CrossRef
Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
Zhichun Chen, Guanglu Li, Jun Liu
Neurobiology of Disease.2020; 134: 104700. CrossRef
Prevalence and characterisation of vocal fold motion impairment (VFMI) in patients with Multiple system atrophy compared with Parkinson's disease
S. Grimaldi, M. Renaud, D. Robert, A. Lagier, H. Somma, S. Soulayrol, D. Korchia, F. Fluchère, O. Lagha-Boukbiza, M. Schaeffer, T. Witjas, J.-P. Azulay, A. Eusebio
Revue Neurologique.2020; 176(7-8): 608. CrossRef
A comprehensive review of the diagnosis and treatment of Parkinson’s disease dysphagia and aspiration
Bhavana Patel, Joseph Legacy, Karen W. Hegland, Michael S. Okun, Nicole E. Herndon
Expert Review of Gastroenterology & Hepatology.2020; 14(6): 411. CrossRef
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Ediz NECATİ, Numan DEMIR, Selen SEREL ARSLAN, Amber EKER, Bahar KAYMAKAMZADE, Aynur Ayşe KARADUMAN
Türk Fizyoterapi ve Rehabilitasyon Dergisi.2020; 31(2): 202. CrossRef
Effects of age and gender on swallowing activity assessed by electromyography and laryngeal elevation
Hiroshi Endo, Nobuyuki Ohmori, Manabu Chikai, Hiroyasu Miwa, Shuichi Ino
Journal of Oral Rehabilitation.2020; 47(11): 1358. CrossRef
Swallow-breathing coordination during incremental ascent to altitude
Alyssa Huff, Trevor A. Day, Mason English, Mitchell D. Reed, Shaelynn Zouboules, Gurkarn Saran, Jack K. Leacy, Carli Mann, Joel D.B. Peltonen, Ken D. O’Halloran, Mingma T. Sherpa, Teresa Pitts
Respiratory Physiology & Neurobiology.2019; 265: 121. CrossRef
Swallowing in Parkinson’s disease: How is it affected?
Ebru Umay, Erhan Ozturk, Eda Gurcay, Oguz Delibas, Feyza Celikel
Clinical Neurology and Neurosurgery.2019; 177: 37. CrossRef
Synergistically enhanced piezoelectric output in highly aligned 1D polymer nanofibers integrated all-fiber nanogenerator for wearable nano-tactile sensor
Sujoy Kumar Ghosh, Dipankar Mandal
Nano Energy.2018; 53: 245. CrossRef
NEURAL CONTROL OF SWALLOWING
Milton Melciades Barbosa COSTA
Arquivos de Gastroenterologia.2018; 55(suppl 1): 61. CrossRef
Soft Electronics Enabled Ergonomic Human-Computer Interaction for Swallowing Training
Yongkuk Lee, Benjamin Nicholls, Dong Sup Lee, Yanfei Chen, Youngjae Chun, Chee Siang Ang, Woon-Hong Yeo
Scientific Reports.2017;[Epub] CrossRef
Improving surface EMG burst detection in infrahyoid muscles during swallowing using digital filters and discrete wavelet analysis
Sebastian Restrepo-Agudelo, Sebastian Roldan-Vasco, Lina Ramirez-Arbelaez, Santiago Cadavid-Arboleda, Estefania Perez-Giraldo, Andres Orozco-Duque
Journal of Electromyography and Kinesiology.2017; 35: 1. CrossRef
Spontaneous yawning in patients with multiple sclerosis: A polygraphic study
Hülya Uluğut Erkoyun, Yeşim Beckmann, Nazlı Gamze Bülbül, Tülay Kurt İncesu, Nevin Gürgör Kanat, Cumhur Ertekin
Multiple Sclerosis and Related Disorders.2017; 17: 179. CrossRef
Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies
Syed Ali, Ning Yin, Arkam Rehman, Verline Justilien
Medical Sciences.2016; 4(1): 1. CrossRef
Clinical Characteristics and Lesions Responsible for Swallowing Hesitation After Acute Cerebral Infarction
Tsukasa Saito, Keisuke Hayashi, Hajime Nakazawa, Tetsuo Ota
Dysphagia.2016; 31(4): 567. CrossRef
Spontaneous Swallowing during All-Night Sleep in Patients with Parkinson Disease in Comparison with Healthy Control Subjects
Irem Fatma Uludag, Bedile Irem Tiftikcioglu, Cumhur Ertekin
Sleep.2016; 39(4): 847. CrossRef
Combination Technique with Ultrasonography and Electromyography for Botulinum Injection in the Cricopharyngeal Muscle: A Case Report
이상억, 심희정, 김효정, 손석일, 김민솔, 황성혜, 김병희, 허진희
Journal of the Korean Dysphagia Society.2016; 6(1): 42. CrossRef
Electrophysiological association of spontaneous yawning and swallowing
Cumhur Ertekin, Nazlı Gamze Bulbul, Irem Fatma Uludag, Bedile Irem Tiftikcioglu, Sehnaz Arici, Nevin Gurgor
Experimental Brain Research.2015; 233(7): 2073. CrossRef
Central cholinergic dysfunction could be associated with oropharyngeal dysphagia in early Parkinson’s disease
Kyung Duck Lee, Jung Hoi Koo, Sun Hong Song, Kwang Deog Jo, Moon Kyu Lee, Wooyoung Jang
Journal of Neural Transmission.2015; 122(11): 1553. CrossRef
Electrophysiological Techniques to Evaluate Swallowing in Central and Peripheral Nervous System Disorders
Cumhur Ertekin
Journal of Clinical Neurophysiology.2015; 32(4): 314. CrossRef
Management of oropharyngeal neurogenic dysphagia in adults
Anna Miles, Jacqui E. Allen
Current Opinion in Otolaryngology & Head and Neck Surgery.2015; 23(6): 433. CrossRef

Complementary & Alternative Management of Parkinson’s Disease: An Evidence-Based Review of Eastern Influenced Practices: Danny Bega, Cindy Zadikoff; J Mov Disord. 2014;7(2):57-66. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14009

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Abstract PDF

The prevalence of Parkinson’s disease (PD) appears to be lower in Asia compared to the Western world. It is unclear if this is related to the ubiquitous use of traditional medicine in Eastern healthcare, but the use of complementary and alternative medicine (CAM) modalities in countries like Korea may be as high as 76%. Among patients with PD, herbal medicines, health supplement foods, and acupuncture are interventions which are increasingly used throughout the world. Countries like Korea, China, India, and Japan have long embraced and incorporated traditional medicine into modern management of conditions such as PD, but research into various CAM modalities remains in its infancy limiting evidence-based recommendations for many treatments. We reviewed the literature on CAM treatments for PD, focusing on mind-body interventions and natural products. Based on evidence limited to randomized-controlled trials we found that mind-body interventions are generally effective forms of physical activity that are likely to foster good adherence and may reduce disability associated with PD. Based on the current data, modalities like Tai Chi and dance are safe and beneficial in PD, but better studies are needed to assess the effects of other frequently used modalities such as yoga and acupuncture. Furthermore, despite centuries of experience using medicinal herbs and plants in Eastern countries, and despite substantial preclinical data on the beneficial effects of nutritional antioxidants as neuroprotective agents in PD, there is insufficient clinical evidence that any vitamin, food additive, or supplement, can improve motor function or delay disease progression in PD.

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Wellness in Parkinson’s Disease: A Framework for Management Using a Holistic Culturally Sensitive Approach
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Muhammad Naeem, Aziz Khan, Shahzaib Ashraf, Saleem Abdullah, Muhammad Ayaz, Nejib Ghanmi
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Effectiveness and safety of herbal medicine Ukgansan for clinical symptoms in Parkinson's disease: A pilot, randomized, assessor-blinded clinical trial
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Parkinsonism & Related Disorders.2021; 93: 97. CrossRef
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Dong Hyuk Lee
The Journal of Internal Korean Medicine.2020; 41(1): 59. CrossRef
Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study
Seung Hyun Lee, Sang-Soo Park, Jung-hee Jang, Sang Hyeon Jin, Young-Soo Baik, Ho-Ryong Yoo
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Yeonju Woo, Min Kyung Hyun
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Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies
Ines Banjari, Tihana Marček, Svetlana Tomić, Viduranga Y. Waisundara
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Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson’s disease model
Sang Min Kim, Yong Joo Park, Myoung-Sook Shin, Ha-Ryong Kim, Min Jae Kim, Sang Hun Lee, Seung Pil Yun, Seung-Hwan Kwon
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The Effects of Whole Body Periodic Acceleration on Non-Motor Symptoms in Persons with Parkinson’s disease: A Pilot Study
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Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update: Jee-Young Lee, Beom Seok Jeon; J Mov Disord. 2014;7(2):67-76. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14010

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Abstract PDF

Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.

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Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
Dana Bell, Vaughn J. Waldron, P. Leon Brown
Frontiers in Behavioral Neuroscience.2023;[Epub] CrossRef
No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
Journal of Parkinson's Disease.2022; 12(3): 1045. CrossRef
Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
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Original Articles

Dopamine Does Not Appear to Affect Mental Rotation in Parkinson’s Disease: Gregory P. Crucian, Sheyan Armaghani, Avan Armaghani, Paul S. Foster, David W. Burks, Barry Skoblar, Valeria Drago, Kenneth M. Heilman; J Mov Disord. 2014;7(2):77-83. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14011

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Abstract PDF

Objective Patients with Parkinson’s disease (PD) often have deficits with mental rotation (MR). The neuropathological factors underlying these deficits, however, remain to be elucidated. One hypothesis suggests that dopamine depletion in nigro-striatal systems adversely influences MR. Another hypothesis suggests that deterioration of cortical (fronto-temporo-parietal basal ganglia) networks that mediate this function are responsible for this deficit. The goal of this study was to test the dopamine hypothesis by determining if dopamine abstinence negatively influences MR performance.
Methods Thirty three non-demented right-handed individuals with PD were assess for their ability to perform a pencil and paper MR test while “on” and “off” dopaminergic medications. Dopamine abstinence followed the typical overnight withdrawal procedures.
Results No differences in mental rotation abilities were found between “on” and “off” dopaminergic medications.
Conclusions These results suggest that other neuropathological factors, such as cortical-basal ganglia neurodegeneration, or dysfunction of other neurotransmitters systems, might account for these cognitive deficits and future research will have to test these alternative hypotheses.

Citations

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Functional neurological disorder: Extending the diagnosis to other disorders, and proposing an alternate disease term—Attentionally-modifiable disorder
Victor W. Mark, Victor W. Mark
NeuroRehabilitation.2022; 50(2): 179. CrossRef
Pharmacological Dopamine Manipulation Does Not Alter Reward-Based Improvements in Memory Retention during a Visuomotor Adaptation Task
Graziella Quattrocchi, Jessica Monaco, Andy Ho, Friederike Irmen, Wolfgang Strube, Diane Ruge, Sven Bestmann, Joseph M. Galea
eneuro.2018; 5(3): ENEURO.0453-17.2018. CrossRef

Nationwide Survey of Patient Knowledge and Attitudes towards Human Experimentation Using Stem Cells or Bee Venom Acupuncture for Parkinson’s Disease: Sun Ju Chung, Seong Beom Koh, Young-Su Ju, Jae Woo Kim; J Mov Disord. 2014;7(2):84-91. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14012

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Abstract PDF Supplementary Material

Objective Stem cell treatment is a well-recognized experimental treatment among patients with Parkinson’s disease (PD), for which there are high expectations of a positive impact. Acupuncture with bee venom is one of the most popular complementary and alternative treatments for PD. Patient knowledge and attitudes towards these experimental treatments are unknown.
Methods Using a 12-item questionnaire, a nationwide survey was conducted of 963 PD patients and 267 caregivers in 44 Korean Movement Disorders Society member hospitals from April 2013 to June 2013. The survey was performed by trained interviewers using conventional methods.
Results Regarding questions on experimental treatments using stem cells or bee venom acupuncture, 5.1–17.7% of PD patients answered questions on safety, efficacy, and evidence-based practice incorrectly; however, more than half responded that they did not know the correct answer. Although safety and efficacy have not been established, 55.5% of PD patients responded that they were willing to receive stem cell treatment. With regard to participating in experimental treatments, there was a strong correlation between stem cell treatment and bee venom acupuncture (p < 0.0001, odds ratio = 5.226, 95% confidence interval 3.919–6.969). Younger age, higher education, and a longer duration of PD were all associated with a correct understanding of experimental treatments.
Conclusions Our data suggest that relatively few PD patients correctly understand the safety and efficacy of experimental treatments and that PD patients are greatly interested in new treatments. We hope that our data will be used to educate or to plan educational programs for PD patients and caregivers.

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Knowledge, Attitude, and Practice of Bee Venom Acupuncture Therapy on Rheumatoid Arthritis Among Patients in Saudi Arabia
Shahd E Sharaf, Safaa Alsanosi, Abdullah R Alzahrani, Saeed S Al-Ghamdi, Sharaf E Sharaf, Nahla Ayoub
International Journal of General Medicine.2022; Volume 15: 1171. CrossRef
Comparison of Patient and Expert Perceptions of the Attainment of Research Milestones in Parkinson's Disease
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Olalekan Lee Aiyegbusi, Karen Macpherson, Lauren Elston, Susan Myles, Jennifer Washington, Nisha Sungum, Mark Briggs, Philip N. Newsome, Melanie J. Calvert
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Knowledge, attitudes and perceptions of Parkinson's disease: A cross-sectional survey of Asian patients
Onanong Jitkritsadakul, Nonglak Boonrod, Roongroj Bhidayasiri
Journal of the Neurological Sciences.2017; 374: 69. CrossRef
Attitudes to Stem Cell Therapy Among Ischemic Stroke Survivors in the Lund Stroke Recovery Study
Joseph Aked, Hossein Delavaran, Olle Lindvall, Bo Norrving, Zaal Kokaia, Arne Lindgren
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Professional ethics in complementary and alternative medicines in management of Parkinson’s disease
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Case Reports

Globus Pallidus Interna Deep Brain Stimulation in a Patient with Medically Intractable Meige Syndrome: Dae-Woong Bae, Byung-chul Son, Joong-Seok Kim; J Mov Disord. 2014;7(2):92-94. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14013

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Abstract PDF

Medical therapies in patients with Meige syndrome, including botulinum toxin injection, have been limited because of incomplete response or adverse side effects. We evaluated a patient with Meige syndrome who was successfully treated with deep brain stimulation (DBS) in the globus pallidus interna (GPi). This case report and other previous reports suggest that bilateral GPi DBS may be an effective treatment for medically refractory Meige syndrome, without significant adverse effects.

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Pallidal versus subthalamic deep brain stimulation for Meige syndrome: A systematic review and meta-analysis
Xin Wu, Tao Xue, Shiqing Pan, Weikang Xing, Chuanjun Huang, Jianguo Zhang, Guozheng Zhao
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Bilateral pallidal DBS for blepharospasm: A case report and review of the literature
Joshua Lucas, Dorian Kusyk, Donald Whiting
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Blepharospasm, Oromandibular Dystonia, and Meige Syndrome: Clinical and Genetic Update
Hongying Ma, Jian Qu, Liangjun Ye, Yi Shu, Qiang Qu
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Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
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Treatment of Gait Ignition Failure with Ropinirole: Alexis N. Cohen-Oram, Jonathan T. Stewart, Kim Bero, Michael W. Hoffmann; J Mov Disord. 2014;7(2):95-98. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14014

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Gait ignition failure (GIF) is a syndrome characterized by hesitation or inability to initiate gait from a static position. It may occur in a variety of conditions, including normal pressure hydrocephalus, subcortical vascular disease, parkinsonian syndromes and a variety of focal lesions. Previous information on the treatment of GIF has been primarily anecdotal, but there have been a few reports of response to dopamine agonists. We report a 63-year-old man with anoxic encephalopathy who developed GIF nine years after the initial anoxic insult. The patient’s GIF responded robustly, albeit transiently, to ropinirole. MRI was unrevealing, but a positron emission tomography scan showed hypometabolism in the deep frontal ACA/MCA watershed area; this may have disconnected the basal ganglia from the motor cortex and/or interrupted dopaminergic mesocortical transmission. Our understanding of the pathophysiology and the treatment of GIF remains limited, but there may be at least a limited therapeutic role for dopamine agonists.

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Letters to the editor

Normal Cerebellar Metabolism in a Patient with Superficial Siderosis: Dae-Woong Bae, Seung-Hee Na, In-Seok Park, Joong-Seok Kim; J Mov Disord. 2014;7(2):99-101. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14015

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Idiopathic superficial siderosis of the central nervous system
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Journal of the Neurological Sciences.2016; 362: 59. CrossRef
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
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