Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders

OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > Browse Articles > Previous issues
9 Previous issues
Filter
Filter
Article category
Keywords
Authors
Volume 7(2); October 2014
Prev issue Next issue
Review Articles
Electrophysiological Evaluation of Oropharyngeal Dysphagia in Parkinson’s Disease
Cumhur Ertekin
J Mov Disord. 2014;7(2):31-56.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14008
  • 26,902 View
  • 240 Download
  • 28 Citations
AbstractAbstract PDF
Parkinson’s disease (PD) is a chronic, neurodegenerative movement disorder that typically affects elderly patients. Swallowing disorders are highly prevalent in PD and can have grave consequences, including pneumonia, malnutrition, dehydration and mortality. Neurogenic dysphagia in PD can manifest with both overt clinical symptoms or silent dysphagia. Regardless, early diagnosis and objective follow- up of dysphagia in PD is crucial for timely and appropriate care for these patients. In this review, we provide a comprehensive summary of the electrophysiological methods that can be used to objectively evaluate dysphagia in PD. We discuss the electrophysiological abnormalities that can be observed in PD, their clinical correlates and the pathophysiology underlying these findings.

Citations

Citations to this article as recorded by  
  • Endoscopic Characteristics of Dysphagia in Multiple System Atrophy Compared to Parkinson's Disease
    Annemarie Vogel, Inga Claus, Sigrid Ahring, Doreen Gruber, Aiden Haghikia, Ulrike Frank, Rainer Dziewas, Georg Ebersbach, Florin Gandor, Tobias Warnecke
    Movement Disorders.2022; 37(3): 535.     CrossRef
  • Deep Learning Analysis to Automatically Detect the Presence of Penetration or Aspiration in Videofluoroscopic Swallowing Study
    Jeoung Kun Kim, Yoo Jin Choo, Gyu Sang Choi, Hyunkwang Shin, Min Cheol Chang, Donghwi Park
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Pilot study of a novel transmembranous electromyography device for assessment of oral cavity and oropharyngeal muscles
    Deepak Menon, Perry Mansfield, Derrick Cordice, Chris Studer, Michael O'Leary, Geoffrey Sheean, Vera Bril
    Muscle & Nerve.2022; 65(3): 303.     CrossRef
  • Role of Catechol-O-methyltransferase Val158Met Polymorphism on Transcranial Direct Current Stimulation in Swallowing
    Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
    Journal of Personalized Medicine.2022; 12(3): 488.     CrossRef
  • A new swallowing supplement for dysphagia in patients with Parkinson’s disease
    Eungseok Oh, Sungju Jee, Beom Keun Kim, Jung Seon Lee, Kanghee Cho, Soyoung Ahn
    Neurological Sciences.2021; 42(5): 1949.     CrossRef
  • The Potential of Electromyography Signals as Markers to Detect and Monitor Parkinson’s Disease
    Elta Diah Pasmanasari, Jeanne Adiwinata Pawitan
    Biomedical and Pharmacology Journal.2021; 14(1): 373.     CrossRef
  • Electrokinesiographic Study of Oropharyngeal Swallowing in Neurogenic Dysphagia
    Enrico Alfonsi, Massimiliano Todisco, Mauro Fresia, Cristina Tassorelli, Giuseppe Cosentino
    Dysphagia.2021;[Epub]     CrossRef
  • Parkinson Hastalığında Yutma Bozuklukları
    Merve SAPMAZ ATALAR, Gençer GENÇ
    Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi.2021;[Epub]     CrossRef
  • Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment
    Zhichun Chen, Guanglu Li, Jun Liu
    Neurobiology of Disease.2020; 134: 104700.     CrossRef
  • Prevalence and characterisation of vocal fold motion impairment (VFMI) in patients with Multiple system atrophy compared with Parkinson's disease
    S. Grimaldi, M. Renaud, D. Robert, A. Lagier, H. Somma, S. Soulayrol, D. Korchia, F. Fluchère, O. Lagha-Boukbiza, M. Schaeffer, T. Witjas, J.-P. Azulay, A. Eusebio
    Revue Neurologique.2020; 176(7-8): 608.     CrossRef
  • A comprehensive review of the diagnosis and treatment of Parkinson’s disease dysphagia and aspiration
    Bhavana Patel, Joseph Legacy, Karen W. Hegland, Michael S. Okun, Nicole E. Herndon
    Expert Review of Gastroenterology & Hepatology.2020; 14(6): 411.     CrossRef
  • PARKİNSON HASTALARINDA KİNEZYO BANTLAMANIN YUTMA FONKSİYONUNA ETKİSİ: BİR YÜZEYEL ELEKTROMİYOGRAFİK YUTMA ÇALIŞMASI
    Ediz NECATİ, Numan DEMİR, Selen SEREL ARSLAN, Amber EKER, Bahar KAYMAKAMZADE, A. Ayşe KARADUMAN
    Türk Fizyoterapi ve Rehabilitasyon Dergisi.2020;[Epub]     CrossRef
  • Effects of age and gender on swallowing activity assessed by electromyography and laryngeal elevation
    Hiroshi Endo, Nobuyuki Ohmori, Manabu Chikai, Hiroyasu Miwa, Shuichi Ino
    Journal of Oral Rehabilitation.2020; 47(11): 1358.     CrossRef
  • Swallow-breathing coordination during incremental ascent to altitude
    Alyssa Huff, Trevor A. Day, Mason English, Mitchell D. Reed, Shaelynn Zouboules, Gurkarn Saran, Jack K. Leacy, Carli Mann, Joel D.B. Peltonen, Ken D. O’Halloran, Mingma T. Sherpa, Teresa Pitts
    Respiratory Physiology & Neurobiology.2019; 265: 121.     CrossRef
  • Swallowing in Parkinson’s disease: How is it affected?
    Ebru Umay, Erhan Ozturk, Eda Gurcay, Oguz Delibas, Feyza Celikel
    Clinical Neurology and Neurosurgery.2019; 177: 37.     CrossRef
  • Synergistically enhanced piezoelectric output in highly aligned 1D polymer nanofibers integrated all-fiber nanogenerator for wearable nano-tactile sensor
    Sujoy Kumar Ghosh, Dipankar Mandal
    Nano Energy.2018; 53: 245.     CrossRef
  • NEURAL CONTROL OF SWALLOWING
    Milton Melciades Barbosa COSTA
    Arquivos de Gastroenterologia.2018; 55(suppl 1): 61.     CrossRef
  • Soft Electronics Enabled Ergonomic Human-Computer Interaction for Swallowing Training
    Yongkuk Lee, Benjamin Nicholls, Dong Sup Lee, Yanfei Chen, Youngjae Chun, Chee Siang Ang, Woon-Hong Yeo
    Scientific Reports.2017;[Epub]     CrossRef
  • Improving surface EMG burst detection in infrahyoid muscles during swallowing using digital filters and discrete wavelet analysis
    Sebastian Restrepo-Agudelo, Sebastian Roldan-Vasco, Lina Ramirez-Arbelaez, Santiago Cadavid-Arboleda, Estefania Perez-Giraldo, Andres Orozco-Duque
    Journal of Electromyography and Kinesiology.2017; 35: 1.     CrossRef
  • Spontaneous yawning in patients with multiple sclerosis: A polygraphic study
    Hülya Uluğut Erkoyun, Yeşim Beckmann, Nazlı Gamze Bülbül, Tülay Kurt İncesu, Nevin Gürgör Kanat, Cumhur Ertekin
    Multiple Sclerosis and Related Disorders.2017; 17: 179.     CrossRef
  • Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies
    Syed Ali, Ning Yin, Arkam Rehman, Verline Justilien
    Medical Sciences.2016; 4(1): 1.     CrossRef
  • Clinical Characteristics and Lesions Responsible for Swallowing Hesitation After Acute Cerebral Infarction
    Tsukasa Saito, Keisuke Hayashi, Hajime Nakazawa, Tetsuo Ota
    Dysphagia.2016; 31(4): 567.     CrossRef
  • Spontaneous Swallowing during All-Night Sleep in Patients with Parkinson Disease in Comparison with Healthy Control Subjects
    Irem Fatma Uludag, Bedile Irem Tiftikcioglu, Cumhur Ertekin
    Sleep.2016; 39(4): 847.     CrossRef
  • Combination Technique with Ultrasonography and Electromyography for Botulinum Injection in the Cricopharyngeal Muscle: A Case Report
    이상억, 심희정, 김효정, 손석일, 김민솔, 황성혜, 김병희, 허진희
    Journal of the Korean Dysphagia Society.2016; 6(1): 42.     CrossRef
  • Electrophysiological association of spontaneous yawning and swallowing
    Cumhur Ertekin, Nazlı Gamze Bulbul, Irem Fatma Uludag, Bedile Irem Tiftikcioglu, Sehnaz Arici, Nevin Gurgor
    Experimental Brain Research.2015; 233(7): 2073.     CrossRef
  • Central cholinergic dysfunction could be associated with oropharyngeal dysphagia in early Parkinson’s disease
    Kyung Duck Lee, Jung Hoi Koo, Sun Hong Song, Kwang Deog Jo, Moon Kyu Lee, Wooyoung Jang
    Journal of Neural Transmission.2015; 122(11): 1553.     CrossRef
  • Electrophysiological Techniques to Evaluate Swallowing in Central and Peripheral Nervous System Disorders
    Cumhur Ertekin
    Journal of Clinical Neurophysiology.2015; 32(4): 314.     CrossRef
  • Management of oropharyngeal neurogenic dysphagia in adults
    Anna Miles, Jacqui E. Allen
    Current Opinion in Otolaryngology & Head and Neck Surgery.2015; 23(6): 433.     CrossRef
Complementary & Alternative Management of Parkinson’s Disease: An Evidence-Based Review of Eastern Influenced Practices
Danny Bega, Cindy Zadikoff
J Mov Disord. 2014;7(2):57-66.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14009
  • 31,768 View
  • 176 Download
  • 18 Citations
AbstractAbstract PDF
The prevalence of Parkinson’s disease (PD) appears to be lower in Asia compared to the Western world. It is unclear if this is related to the ubiquitous use of traditional medicine in Eastern healthcare, but the use of complementary and alternative medicine (CAM) modalities in countries like Korea may be as high as 76%. Among patients with PD, herbal medicines, health supplement foods, and acupuncture are interventions which are increasingly used throughout the world. Countries like Korea, China, India, and Japan have long embraced and incorporated traditional medicine into modern management of conditions such as PD, but research into various CAM modalities remains in its infancy limiting evidence-based recommendations for many treatments. We reviewed the literature on CAM treatments for PD, focusing on mind-body interventions and natural products. Based on evidence limited to randomized-controlled trials we found that mind-body interventions are generally effective forms of physical activity that are likely to foster good adherence and may reduce disability associated with PD. Based on the current data, modalities like Tai Chi and dance are safe and beneficial in PD, but better studies are needed to assess the effects of other frequently used modalities such as yoga and acupuncture. Furthermore, despite centuries of experience using medicinal herbs and plants in Eastern countries, and despite substantial preclinical data on the beneficial effects of nutritional antioxidants as neuroprotective agents in PD, there is insufficient clinical evidence that any vitamin, food additive, or supplement, can improve motor function or delay disease progression in PD.

Citations

Citations to this article as recorded by  
  • A novel decision making technique based on spherical hesitant fuzzy Yager aggregation information: application to treat Parkinson's disease
    Muhammad Naeem, Aziz Khan, Shahzaib Ashraf, Saleem Abdullah, Muhammad Ayaz, Nejib Ghanmi
    AIMS Mathematics.2022; 7(2): 1678.     CrossRef
  • A Case Report of Acupuncture Treatment in a Patient with Parkinson's Disease Tremor
    Hagdong Kim, Daewon Shin
    Journal of Korean Medical Society of Soft Tissue.2022; 6(1): 81.     CrossRef
  • Effectiveness and safety of herbal medicine Ukgansan for clinical symptoms in Parkinson's disease: A pilot, randomized, assessor-blinded clinical trial
    Chul Jin, Ki-Ho Cho, Seungwon Kwon, Han-Gyul Lee, Tae-Hun Kim, Woo-Sang Jung, Sang-Kwan Moon, Seung-Yeon Cho, Byoung-Kab Kang, Jung-Mi Park, Hi-Joon Park, Chang-Nam Ko
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Quantitative analysis of cerebrovascular characteristics of Parkinson’s disease treated with acupuncture based on magnetic resonance angiography
    Yuan Yang, Le He, Suhua Miao, Rongsong Zhou, Yuqi Zhang, Yu Ma
    Brain Science Advances.2021; 7(2): 141.     CrossRef
  • Mind the gap: Inequalities in mental health care and lack of social support in Parkinson disease
    Indu Subramanian, Jared T. Hinkle, K. Ray Chaudhuri, Zoltan Mari, Hubert H. Fernandez, Gregory M. Pontone
    Parkinsonism & Related Disorders.2021; 93: 97.     CrossRef
  • Review of Studies on Clinical Trials of Acupuncture Treatment for Parkinson’s Disease Using Neuroimaging Methods
    Dong Hyuk Lee
    The Journal of Internal Korean Medicine.2020; 41(1): 59.     CrossRef
  • Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study
    Seung Hyun Lee, Sang-Soo Park, Jung-hee Jang, Sang Hyeon Jin, Young-Soo Baik, Ho-Ryong Yoo
    Applied Sciences.2020; 10(24): 8954.     CrossRef
  • Effectiveness of Integrative Therapy for Parkinson’s Disease Management
    Yeonju Woo, Min Kyung Hyun
    Frontiers in Aging Neuroscience.2019;[Epub]     CrossRef
  • Treatment of psychiatric disturbances in hypokinetic movement disorders
    Isabella Berardelli, Daniele Belvisi, Massimo Pasquini, Andrea Fabbrini, Federica Petrini, Giovanni Fabbrini
    Expert Review of Neurotherapeutics.2019; 19(10): 965.     CrossRef
  • The effect of Tai Chi and Qigong on health-related quality of life in Parkinson’s disease: a systematic review and meta-analysis of systematic reviews
    Oznur Fidan, Gulce Kallem Seyyar, Bahar Aras, Ertugrul Colak, Ozgen Aras
    International Journal of Rehabilitation Research.2019; 42(3): 196.     CrossRef
  • Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies
    Ines Banjari, Tihana Marček, Svetlana Tomić, Viduranga Y. Waisundara
    Frontiers in Nutrition.2018;[Epub]     CrossRef
  • Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson’s Disease
    Ji-Yeun Park, Seung-Nam Kim, Junsang Yoo, Jaehwan Jang, Ahreum Lee, Ju-Young Oh, Hongwon Kim, Seung Tack Oh, Seong-Uk Park, Jongpil Kim, Hi-Joon Park, Songhee Jeon
    Molecular Neurobiology.2017; 54(10): 7706.     CrossRef
  • Ethnobiological treatments of neurological conditions in the Chota Nagpur Plateau, India
    Abhijit Dey, Partha Gorai, Anuradha Mukherjee, Raghunath Dhan, Biplob Kumar Modak
    Journal of Ethnopharmacology.2017; 198: 33.     CrossRef
  • Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson’s disease model
    Sang Min Kim, Yong Joo Park, Myoung-Sook Shin, Ha-Ryong Kim, Min Jae Kim, Sang Hun Lee, Seung Pil Yun, Seung-Hwan Kwon
    Bioorganic & Medicinal Chemistry Letters.2017; 27(23): 5207.     CrossRef
  • The Effects of Whole Body Periodic Acceleration on Non-Motor Symptoms in Persons with Parkinson’s disease: A Pilot Study
    Southard Veronica
    Journal of Novel Physiotherapy and Physical Rehabilitation.2017; : 077.     CrossRef
  • The effects of a mindfulness-based lifestyle program for adults with Parkinson’s disease: a mixed methods, wait list controlled randomised control study
    Jenny Advocat, Joanne Enticott, Brooke Vandenberg, Craig Hassed, Jennifer Hester, Grant Russell
    BMC Neurology.2016;[Epub]     CrossRef
  • A Clinical Study of Integrating Acupuncture and Western Medicine in Treating Patients with Parkinson's Disease
    Fang-Pey Chen, Ching-Mao Chang, Jing-Huei Shiu, Jen-Hwey Chiu, Ta-Peng Wu, Jen-Lin Yang, Yen-Ying Kung, Fun-Jou Chen, Chang-Ming Chern, Shinn-Jang Hwang
    The American Journal of Chinese Medicine.2015; 43(03): 407.     CrossRef
  • Levodopa in Mucuna pruriens and its degradation
    Haridas Pulikkalpura, Rajani Kurup, Paravanparampil Jacob Mathew, Sabulal Baby
    Scientific Reports.2015;[Epub]     CrossRef
Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update
Jee-Young Lee, Beom Seok Jeon
J Mov Disord. 2014;7(2):67-76.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14010
  • 36,795 View
  • 120 Download
  • 8 Citations
AbstractAbstract PDF
Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.

Citations

Citations to this article as recorded by  
  • No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
    Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
    Journal of Parkinson's Disease.2022; 12(3): 1045.     CrossRef
  • Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
    Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
    Movement Disorders Clinical Practice.2021; 8(3): 469.     CrossRef
  • Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial
    Jee-Young Lee, Beomseok Jeon, Seong-Beom Koh, Won Tae Yoon, Ho-Won Lee, Oh Dae Kwon, Jae Woo Kim, Jong-Min Kim, Hyeo-Il Ma, Hee-Tae Kim, Jong Sam Baik, Jinwhan Cho
    Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(1): 30.     CrossRef
  • Impulse control disorders in Parkinson disease: A cross-sectional study in Morocco
    H. El Otmani, F.Z. Mouni, Z. Abdulhakeem, Z. Attar, L. Rashad, I. Saali, B. El Moutawakil, M.A. Rafai, I. Slassi, S. Nadifi
    Revue Neurologique.2019; 175(4): 233.     CrossRef
  • Dopamine Agonists and Impulse Control Disorders: A Complex Association
    Marie Grall-Bronnec, Caroline Victorri-Vigneau, Yann Donnio, Juliette Leboucher, Morgane Rousselet, Elsa Thiabaud, Nicolas Zreika, Pascal Derkinderen, Gaëlle Challet-Bouju
    Drug Safety.2018; 41(1): 19.     CrossRef
  • Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors
    Daniel O. Claassen, Adam J. Stark, Charis A. Spears, Kalen J. Petersen, Nelleke C. van Wouwe, Robert M. Kessler, David H. Zald, Manus J. Donahue
    Movement Disorders.2017; 32(11): 1574.     CrossRef
  • Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
    Mona Buhusi, Kaitlin Olsen, Benjamin Z. Yang, Catalin V. Buhusi
    Frontiers in Behavioral Neuroscience.2016;[Epub]     CrossRef
  • Patients’ Reluctance to undergo Deep Brain Stimulation for Parkinson’s Disease
    Mi-Ryoung Kim, Ji Young Yun, Beomseok Jeon, Yong Hoon Lim, Kyung Ran Kim, Hui-Jun Yang, Sun Ha Paek
    Parkinsonism & Related Disorders.2015;[Epub]     CrossRef
Original Articles
Dopamine Does Not Appear to Affect Mental Rotation in Parkinson’s Disease
Gregory P. Crucian, Sheyan Armaghani, Avan Armaghani, Paul S. Foster, David W. Burks, Barry Skoblar, Valeria Drago, Kenneth M. Heilman
J Mov Disord. 2014;7(2):77-83.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14011
  • 13,279 View
  • 43 Download
  • 1 Citations
AbstractAbstract PDF
Objective Patients with Parkinson’s disease (PD) often have deficits with mental rotation (MR). The neuropathological factors underlying these deficits, however, remain to be elucidated. One hypothesis suggests that dopamine depletion in nigro-striatal systems adversely influences MR. Another hypothesis suggests that deterioration of cortical (fronto-temporo-parietal basal ganglia) networks that mediate this function are responsible for this deficit. The goal of this study was to test the dopamine hypothesis by determining if dopamine abstinence negatively influences MR performance.
Methods Thirty three non-demented right-handed individuals with PD were assess for their ability to perform a pencil and paper MR test while “on” and “off” dopaminergic medications. Dopamine abstinence followed the typical overnight withdrawal procedures.
Results No differences in mental rotation abilities were found between “on” and “off” dopaminergic medications.
Conclusions These results suggest that other neuropathological factors, such as cortical-basal ganglia neurodegeneration, or dysfunction of other neurotransmitters systems, might account for these cognitive deficits and future research will have to test these alternative hypotheses.

Citations

Citations to this article as recorded by  
  • Functional neurological disorder: Extending the diagnosis to other disorders, and proposing an alternate disease term—Attentionally-modifiable disorder
    Victor W. Mark, Victor W. Mark
    NeuroRehabilitation.2022; 50(2): 179.     CrossRef
Nationwide Survey of Patient Knowledge and Attitudes towards Human Experimentation Using Stem Cells or Bee Venom Acupuncture for Parkinson’s Disease
Sun Ju Chung, Seong Beom Koh, Young-Su Ju, Jae Woo Kim
J Mov Disord. 2014;7(2):84-91.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14012
  • 15,699 View
  • 79 Download
  • 8 Citations
AbstractAbstract PDFSupplementary Material
Objective Stem cell treatment is a well-recognized experimental treatment among patients with Parkinson’s disease (PD), for which there are high expectations of a positive impact. Acupuncture with bee venom is one of the most popular complementary and alternative treatments for PD. Patient knowledge and attitudes towards these experimental treatments are unknown.
Methods Using a 12-item questionnaire, a nationwide survey was conducted of 963 PD patients and 267 caregivers in 44 Korean Movement Disorders Society member hospitals from April 2013 to June 2013. The survey was performed by trained interviewers using conventional methods.
Results Regarding questions on experimental treatments using stem cells or bee venom acupuncture, 5.1–17.7% of PD patients answered questions on safety, efficacy, and evidence-based practice incorrectly; however, more than half responded that they did not know the correct answer. Although safety and efficacy have not been established, 55.5% of PD patients responded that they were willing to receive stem cell treatment. With regard to participating in experimental treatments, there was a strong correlation between stem cell treatment and bee venom acupuncture (p < 0.0001, odds ratio = 5.226, 95% confidence interval 3.919–6.969). Younger age, higher education, and a longer duration of PD were all associated with a correct understanding of experimental treatments.
Conclusions Our data suggest that relatively few PD patients correctly understand the safety and efficacy of experimental treatments and that PD patients are greatly interested in new treatments. We hope that our data will be used to educate or to plan educational programs for PD patients and caregivers.

Citations

Citations to this article as recorded by  
  • Knowledge, Attitude, and Practice of Bee Venom Acupuncture Therapy on Rheumatoid Arthritis Among Patients in Saudi Arabia
    Shahd E Sharaf, Safaa Alsanosi, Abdullah R Alzahrani, Saeed S Al-Ghamdi, Sharaf E Sharaf, Nahla Ayoub
    International Journal of General Medicine.2022; Volume 15: 1171.     CrossRef
  • Comparison of Patient and Expert Perceptions of the Attainment of Research Milestones in Parkinson's Disease
    Patrick Bodilly Kane, Daniel M. Benjamin, Roger A. Barker, Anthony E. Lang, Todd Sherer, Jonathan Kimmelman
    Movement Disorders.2021; 36(1): 171.     CrossRef
  • A scoping review of patient and public perspectives on cell and gene therapies
    Karen Macpherson, Olalekan Lee Aiyegbusi, Lauren Elston, Susan Myles, Jennifer Washington, Nisha Sungum, Mark Briggs, Philip Newsome, Melanie Calvert
    Regenerative Medicine.2021; 16(11): 1005.     CrossRef
  • Clinical Applications of Bee Venom Acupoint Injection
    Ting-Yen Lin, Ching-Liang Hsieh
    Toxins.2020; 12(10): 618.     CrossRef
  • Patient and public perspectives on cell and gene therapies: a systematic review
    Olalekan Lee Aiyegbusi, Karen Macpherson, Lauren Elston, Susan Myles, Jennifer Washington, Nisha Sungum, Mark Briggs, Philip N. Newsome, Melanie J. Calvert
    Nature Communications.2020;[Epub]     CrossRef
  • Knowledge, attitudes and perceptions of Parkinson's disease: A cross-sectional survey of Asian patients
    Onanong Jitkritsadakul, Nonglak Boonrod, Roongroj Bhidayasiri
    Journal of the Neurological Sciences.2017; 374: 69.     CrossRef
  • Attitudes to Stem Cell Therapy Among Ischemic Stroke Survivors in the Lund Stroke Recovery Study
    Joseph Aked, Hossein Delavaran, Olle Lindvall, Bo Norrving, Zaal Kokaia, Arne Lindgren
    Stem Cells and Development.2017; 26(8): 566.     CrossRef
  • Professional ethics in complementary and alternative medicines in management of Parkinson’s disease
    Hee Jin Kim, Beomseok Jeon, Sun Ju Chung
    Journal of Parkinson's Disease.2016; 6(4): 675.     CrossRef
Case Reports
Globus Pallidus Interna Deep Brain Stimulation in a Patient with Medically Intractable Meige Syndrome
Dae-Woong Bae, Byung-chul Son, Joong-Seok Kim
J Mov Disord. 2014;7(2):92-94.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14013
  • 12,136 View
  • 95 Download
  • 6 Citations
AbstractAbstract PDF
Medical therapies in patients with Meige syndrome, including botulinum toxin injection, have been limited because of incomplete response or adverse side effects. We evaluated a patient with Meige syndrome who was successfully treated with deep brain stimulation (DBS) in the globus pallidus interna (GPi). This case report and other previous reports suggest that bilateral GPi DBS may be an effective treatment for medically refractory Meige syndrome, without significant adverse effects.

Citations

Citations to this article as recorded by  
  • Bilateral pallidal DBS for blepharospasm: A case report and review of the literature
    Joshua Lucas, Dorian Kusyk, Donald Whiting
    Surgical Neurology International.2022; 13: 200.     CrossRef
  • Blepharospasm, Oromandibular Dystonia, and Meige Syndrome: Clinical and Genetic Update
    Hongying Ma, Jian Qu, Liangjun Ye, Yi Shu, Qiang Qu
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
    Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
    Scientific Reports.2021;[Epub]     CrossRef
  • Predictive factors for long-term clinical outcomes of deep brain stimulation in the treatment of primary Meige syndrome
    Xin Wang, Zhiqi Mao, Zhiqiang Cui, Xin Xu, Longsheng Pan, Shuli Liang, Zhipei Ling, Xinguang Yu
    Journal of Neurosurgery.2020; 132(5): 1367.     CrossRef
  • Long-Term Efficacy of Deep Brain Stimulation of Bilateral Globus Pallidus Internus in Primary Meige Syndrome
    Hong Tian, Yanbing Yu, Xueke Zhen, Li Zhang, Yue Yuan, Bo Zhang, Liang Wang
    Stereotactic and Functional Neurosurgery.2019; 97(5-6): 356.     CrossRef
  • Meige's syndrome: History, epidemiology, clinical features, pathogenesis and treatment
    Sanjay Pandey, Soumya Sharma
    Journal of the Neurological Sciences.2017; 372: 162.     CrossRef
Treatment of Gait Ignition Failure with Ropinirole
Alexis N. Cohen-Oram, Jonathan T. Stewart, Kim Bero, Michael W. Hoffmann
J Mov Disord. 2014;7(2):95-98.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14014
  • 11,669 View
  • 36 Download
  • 1 Citations
AbstractAbstract PDF
Gait ignition failure (GIF) is a syndrome characterized by hesitation or inability to initiate gait from a static position. It may occur in a variety of conditions, including normal pressure hydrocephalus, subcortical vascular disease, parkinsonian syndromes and a variety of focal lesions. Previous information on the treatment of GIF has been primarily anecdotal, but there have been a few reports of response to dopamine agonists. We report a 63-year-old man with anoxic encephalopathy who developed GIF nine years after the initial anoxic insult. The patient’s GIF responded robustly, albeit transiently, to ropinirole. MRI was unrevealing, but a positron emission tomography scan showed hypometabolism in the deep frontal ACA/MCA watershed area; this may have disconnected the basal ganglia from the motor cortex and/or interrupted dopaminergic mesocortical transmission. Our understanding of the pathophysiology and the treatment of GIF remains limited, but there may be at least a limited therapeutic role for dopamine agonists.

Citations

Citations to this article as recorded by  
  • Gait Ignition Failure in JNPL3 Human Tau-mutant Mice
    HoChung Jang, Jung Hwa Ryu, Kyung Min Shin, Na-young Seo, Gyu Hyun Kim, Yang Hoon Huh, Ae Nim Pae, Kea Joo Lee
    Experimental Neurobiology.2019; 28(3): 404.     CrossRef
Letters to the editor
Normal Cerebellar Metabolism in a Patient with Superficial Siderosis
Dae-Woong Bae, Seung-Hee Na, In-Seok Park, Joong-Seok Kim
J Mov Disord. 2014;7(2):99-101.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14015
  • 11,566 View
  • 50 Download
  • 2 Citations
PDF

Citations

Citations to this article as recorded by  
  • Idiopathic superficial siderosis of the central nervous system
    Shakila Meshkat, Parnia Ebrahimi, Abbas Tafakhori, Aidin Taghiloo, Sajad Shafiee, Amir Salimi, Vajiheh Aghamollaii
    Cerebellum & Ataxias.2021;[Epub]     CrossRef
  • Superficial siderosis of central nervous system with unknown cause: report of 2 cases and review of the literature
    Hao Chen, Hafiz Khuram Raza, Jia Jing, Xinchun Ye, Zuohui Zhang, Fang Hua, Guiyun Cui
    British Journal of Neurosurgery.2019; 33(3): 305.     CrossRef
Orthostatic Hypotension and Cognitive Impairment in De Novo Patients with Parkinson’s Disease
Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
J Mov Disord. 2014;7(2):102-104.   Published online October 30, 2014
DOI: https://doi.org/10.14802/jmd.14016
  • 13,729 View
  • 60 Download
  • 9 Citations
PDF

Citations

Citations to this article as recorded by  
  • Cognitive and Autonomic Dysfunction in Multiple System Atrophy Type P and C: A Comparative Study
    Giulia Lazzeri, Giulia Franco, Teresa Difonzo, Angelica Carandina, Chiara Gramegna, Maurizio Vergari, Federica Arienti, Anisa Naci, Costanza Scatà, Edoardo Monfrini, Gabriel Dias Rodrigues, Nicola Montano, Giacomo P. Comi, Maria Cristina Saetti, Eleonora
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Relationship Between Orthostatic Hypotension and Cognitive Functions in Multiple System Atrophy: A Longitudinal Study
    Sofia Cuoco, Immacolata Carotenuto, Arianna Cappiello, Sara Scannapieco, Maria Claudia Russillo, Valentina Andreozzi, Lorenzo Forino, Marianna Amboni, Marina Picillo, Roberto Erro, Paolo Barone, Maria Teresa Pellecchia
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Cognition in multiple system atrophy: a single‐center cohort study
    Sabine Eschlböck, Margarete Delazer, Florian Krismer, Thomas Bodner, Alessandra Fanciulli, Beatrice Heim, Antonio Heras Garvin, Christine Kaindlstorfer, Elfriede Karner, Katherina Mair, Christoph Rabensteiner, Cecilia Raccagni, Klaus Seppi, Werner Poewe,
    Annals of Clinical and Translational Neurology.2020; 7(2): 219.     CrossRef
  • Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications
    Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn
    Geriatrics & Gerontology International.2020; 20(5): 443.     CrossRef
  • Orthostatic Intolerance in Older Persons: Etiology and Countermeasures
    Nandu Goswami, Andrew P. Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
    Journal of the Neurological Sciences.2016; 362: 59.     CrossRef
  • Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
    Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
    Journal of Movement Disorders.2016; 9(2): 97.     CrossRef
  • The range and nature of non-motor symptoms in drug-naive Parkinson’s disease patients: a state-of-the-art systematic review
    Panagiotis Zis, Roberto Erro, Courtney C Walton, Anna Sauerbier, Kallol Ray Chaudhuri
    npj Parkinson's Disease.2015;[Epub]     CrossRef
  • Diagnosing and treating neurogenic orthostatic hypotension in primary care
    Louis Kuritzky, Alberto J. Espay, Jeffrey Gelblum, Richard Payne, Eric Dietrich
    Postgraduate Medicine.2015; 127(7): 702.     CrossRef

JMD : Journal of Movement Disorders