Focal hand dystonia (FHD) is characterized by excessive and unwanted muscle activation in both the hand and arm resulting in impaired performance in particular tasks. Understanding the pathophysiology of FHD has progressed significantly for several decades and this has led to consideration of other potential therapies such as non-invasive brain stimulation (NIBS). A number of studies have been conducted to develop new therapy for FHD using transcranial magnetic stimulation and transcranial direct current stimulation. In this paper, we review previous studies and describe the potential therapeutic use of NIBS for FHD. We also discuss the future direction of NIBS to treat FHD.
Citations
Citations to this article as recorded by
Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia Hyun Joo Cho, Hae-Won Shin, Pattamon Panyakaew, Panagiotis Kassavetis, Traian Popa, Tianxia Wu, Giorgio Leodori, Terance Camacho, Shivangi Singh, Sabine Meunier, Mark Hallett Neurobiology of Disease.2024; 202: 106724. CrossRef
Transcranial magnetic stimulation: the road to clinical therapy for dystonia Patrick J. Mulcahey, Angel V. Peterchev, Nicole Calakos, Noreen Bukhari-Parlakturk Dystonia.2023;[Epub] CrossRef
Treatment of writer’s cramp based on current pathophysiological concepts Kirsten E. Zeuner, Alexander Baumann, Karsten Witt Dystonia.2023;[Epub] CrossRef
The Technical Ability and Performing Scale (TAPS): A newly developed patient-reported functional rating scale for Musician's focal dystonia Marina Ramella, Rosa Maria Converti, Giulia Giacobbi, Anna Castagna, Enrico Saibene, Francesca Borgnis, Francesca Baglio Parkinsonism & Related Disorders.2022; 99: 79. CrossRef
Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis Jordan Morrison-Ham, Gillian M. Clark, Elizabeth G. Ellis, Andris Cerins, Juho Joutsa, Peter G. Enticott, Daniel T. Corp Therapeutic Advances in Neurological Disorders.2022;[Epub] CrossRef
Botulinum neurotoxin for writer’s cramp Divyani Garg, Suvorit S. Bhowmick, Jacky Ganguly, Shivam O. Mittal, Rupam Borgohain, Prashanth L. Kukkle Annals of Movement Disorders.2022; 5(3): 159. CrossRef
New modalities and directions for dystonia care Genko Oyama, Nobutaka Hattori Journal of Neural Transmission.2021; 128(4): 559. CrossRef
Taakspecifieke focale dystonie bij musici T. DOOMS Tijdschrift voor Geneeskunde.2021;[Epub] CrossRef
Laryngeal Dystonia Kristina Simonyan, Julie Barkmeier-Kraemer, Andrew Blitzer, Mark Hallett, John F. Houde, Teresa Jacobson Kimberley, Laurie J. Ozelius, Michael J. Pitman, Robert Mark Richardson, Nutan Sharma, Kristine Tanner, Gerald Berke, Tanya Eadie, Jeremy Greenlee, Mi Neurology.2021; 96(21): 989. CrossRef
Treatment of focal hand dystonia: current status Navnika Gupta, Sanjay Pandey Neurological Sciences.2021; 42(9): 3561. CrossRef
Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study Wenyan Jiang, Yiwu Lei, Jing Wei, Lu Yang, Shubao Wei, Qiong Yin, Shuguang Luo, Wenbin Guo Neural Plasticity.2019; 2019: 1. CrossRef
Update On Current and Emerging Therapies for Dystonia Karlo J Lizarraga, Duha Al-Shorafat, Susan Fox Neurodegenerative Disease Management.2019; 9(3): 135. CrossRef
Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation in Writer’s Cramp: A Case Report Antonino Naro, Luana Billeri, Simona Portaro, Placido Bramanti, Rocco Salvatore Calabrò Frontiers in Human Neuroscience.2019;[Epub] CrossRef
A unifying motor control framework for task-specific dystonia Anna Sadnicka, Katja Kornysheva, John C. Rothwell, Mark J. Edwards Nature Reviews Neurology.2018; 14(2): 116. CrossRef
Pain in focal dystonias – A focused review to address an important component of the disease Micol Avenali, R. De Icco, M. Tinazzi, G. Defazio, L. Tronconi, G. Sandrini, C. Tassorelli Parkinsonism & Related Disorders.2018; 54: 17. CrossRef
Transcranial Direct Current Stimulation Combined with Action Observation and Electromyographic Biofeedback Training in a Patient with Writer’s Cramp Yohei Okada, Chiharu Shibamoto, Yukari Osumi, Chihiro Asano, Riho Takeuchi, Sachio Nabeshima, Shu Morioka, Koji Shomoto Journal of Movement Disorders.2018; 11(2): 82. CrossRef
Dystonia Bettina Balint, Niccolò E. Mencacci, Enza Maria Valente, Antonio Pisani, John Rothwell, Joseph Jankovic, Marie Vidailhet, Kailash P. Bhatia Nature Reviews Disease Primers.2018;[Epub] CrossRef
Stereotactic Lesioning of the Thalamic Vo Nucleus for the Treatment of Writer's Cramp (Focal Hand Dystonia) Takeshi Shimizu, Tomoyuki Maruo, Shimpei Miura, Haruhiko Kishima, Yukitaka Ushio, Satoshi Goto Frontiers in Neurology.2018;[Epub] CrossRef
Biased Visuospatial Attention in Cervical Dystonia Gaetana Chillemi, Caterina Formica, Adriana Salatino, Alessandro Calamuneri, Paolo Girlanda, Francesca Morgante, Demetrio Milardi, Carmen Terranova, Alberto Cacciola, Angelo Quartarone, Raffaella Ricci Journal of the International Neuropsychological Society.2018; 24(1): 22. CrossRef
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) Jean-Pascal Lefaucheur, Andrea Antal, Samar S. Ayache, David H. Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, Dirk De Ridder, Roberta Ferrucci, Berthold Langguth, Paola Marangolo, Veit Mylius, Michael A. Nitsche, Frank Padberg, Ulrich Pa Clinical Neurophysiology.2017; 128(1): 56. CrossRef
Research Priorities in Limb and Task-Specific Dystonias Sarah Pirio Richardson, Eckart Altenmüller, Katharine Alter, Ron L. Alterman, Robert Chen, Steven Frucht, Shinichi Furuya, Joseph Jankovic, H. A. Jinnah, Teresa J. Kimberley, Codrin Lungu, Joel S. Perlmutter, Cecília N. Prudente, Mark Hallett Frontiers in Neurology.2017;[Epub] CrossRef
Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease Yeo Jin Kim Brain & Neurorehabilitation.2017;[Epub] CrossRef
Non‐invasive brain stimulation for dystonia: therapeutic implications R. Erro, M. Tinazzi, F. Morgante, K. P. Bhatia European Journal of Neurology.2017; 24(10): 1228. CrossRef
Cathodal Transcranial Direct Current Stimulation Improves Focal Hand Dystonia in Musicians: A Two-Case Study Sara Marceglia, Simona Mrakic-Sposta, Manuela Fumagalli, Roberta Ferrucci, Francesca Mameli, Maurizio Vergari, Sergio Barbieri, Alberto Priori Frontiers in Neuroscience.2017;[Epub] CrossRef
Post-stroke movement disorders are uncommon, but comprise an important part of secondary movement disorders. These exert variable and heterogeneous clinical courses according to the stroke lesion and its temporal relationships. Moreover, the predominant stroke symptoms hinder a proper diagnosis in clinical practice. This article describes the etiology, treatment options and prognosis of post-stroke movement disorders.
Citations
Citations to this article as recorded by
Post-stroke movement disorders disappearance: a report of disappearance of tardive dyskinesia after stroke and a literature review Min Seung Kim, InJa Shin, Don Gueu Park, Jung han Yoon Acta Neurologica Belgica.2023; 123(5): 2005. CrossRef
Monochorea after acute contralateral pontine infarction: A case report Yun Su Hwang, Byoung-Soo Shin, Han Uk Ryu, Hyun Goo Kang Medicine.2023; 102(3): e32660. CrossRef
Adult-onset sporadic chorea: real-world data from a single-centre retrospective study Roberta Bovenzi, Matteo Conti, Rocco Cerroni, Mariangela Pierantozzi, Alessandro Stefani, Antonio Pisani, Nicola Biagio Mercuri, Tommaso Schirinzi Neurological Sciences.2022; 43(1): 387. CrossRef
Parkinsonism and ataxia Giulia Franco, Giulia Lazzeri, Alessio Di Fonzo Journal of the Neurological Sciences.2022; 433: 120020. CrossRef
Movement Disorders Associated With Cerebral Artery Stenosis: A Nationwide Study Kye Won Park, Nari Choi, Eungseok Oh, Chul Hyoung Lyoo, Min Seok Baek, Han-Joon Kim, Dalla Yoo, Jee-Young Lee, Ji-Hyun Choi, Jae Hyeok Lee, Seong-Beom Koh, Young Hee Sung, Jin Whan Cho, Hui-Jun Yang, Jinse Park, Hae-Won Shin, Tae-Beom Ahn, Ho-Sung Ryu, So Frontiers in Neurology.2022;[Epub] CrossRef
Hemibalismo y hemicorea secundarios a un ataque cerebrovascular isquémico insular, una presentación inusual: reporte de caso Carlos Martínez-Rubio, Hellen Kreinter-Rosenbaum, Habib Moutran-Barroso Neurología Argentina.2020; 12(3): 207. CrossRef
Hemiballismus in subcortical lacunar infarcts ChinyeluUchenna Ufoaroh, OvercomerNnaemeka Agah, Nnamdi Morah, ErnestNdukaife Anyabolu Nigerian Journal of Medicine.2020; 29(3): 527. CrossRef
COVID-19 and stroke: Red flags for secondary movement disorders? Daniella Balduino Victorino, Marcia Guimarães-Marques, Mariana Nejm, Fulvio Alexandre Scorza, Carla Alessandra Scorza eNeurologicalSci.2020; 21: 100289. CrossRef
Post-stroke restless arm syndrome mimicking hemichorea–hemiballism Ha-yom Kim, Moon-Ho Park, Do-Young Kwon Acta Neurologica Belgica.2017; 117(3): 791. CrossRef
Vascular Pathology Causing Late Onset Generalized Chorea: A Clinico‐Pathological Case Report Paula Salgado, Ricardo Taipa, Joana Domingos, Daniel Dias, Manuel Melo Pires, Marina Magalhães Movement Disorders Clinical Practice.2017; 4(6): 819. CrossRef
Movement disorders are primarily associated with the basal ganglia and the thalamus; therefore, movement disorders are more frequently manifest after stroke compared with neurological injuries associated with other structures of the brain. Overall clinical features, such as types of movement disorder, the time of onset and prognosis, are similar with movement disorders after stroke in other structures. Dystonia and chorea are commonly occurring post-stroke movement disorders in basal ganglia circuit, and these disorders rarely present with tremor. Rarer movement disorders, including tic, restless leg syndrome, and blepharospasm, can also develop following a stroke. Although the precise mechanisms underlying the pathogenesis of these conditions have not been fully characterized, disruptions in the crosstalk between the inhibitory and excitatory circuits resulting from vascular insult are proposed to be the underlying cause. The GABA (gamma-aminobutyric acid)ergic and dopaminergic systems play key roles in post-stroke movement disorders. This review summarizes movement disorders induced by basal ganglia and thalamic stroke according to the anatomical regions in which they manifest.
Citations
Citations to this article as recorded by
Pairwise hemorrhage-brain region interaction-driven hemorrhagic stroke assessment in CT Wei Liang, Haixiong Wu, Hongbin Guo, Zhanyao Huang, Shibin Liang, Jinhuang Zhang, Huiling Zhang, Xiangyuan Ma, Zibi Xu Physics in Medicine & Biology.2025; 70(1): 015006. CrossRef
Secondary parkinsonism associated with focal brain lesions Rok Berlot, Anđela Pavlović, Maja Kojović Frontiers in Neurology.2024;[Epub] CrossRef
Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice Max Gentenaar, Fleur L. Meulmeester, Ximaine R. van der Burg, Anna T. Hoekstra, Hazel Hunt, Jan Kroon, Willeke M.C. van Roon-Mom, Onno C. Meijer Experimental Neurology.2024; 374: 114675. CrossRef
Hemichorea in patients with temporal lobe infarcts: Two case reports Xu-Dong Wang, Xing Li, Chun-Lian Pan World Journal of Clinical Cases.2024; 12(4): 806. CrossRef
Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity Leonardo Rigon, Danilo Genovese, Carla Piano, Valerio Brunetti, Valeria Guglielmi, Angelo Tiziano Cimmino, Irene Scala, Salvatore Citro, Anna Rita Bentivoglio, Eleonora Rollo, Riccardo Di Iorio, Aldobrando Broccolini, Roberta Morosetti, Mauro Monforte, Gi European Journal of Neurology.2024;[Epub] CrossRef
Movement disorders in pediatric stroke survivors: A case series Rafaello Ibrado, Annie M. Abraham, Jared Stowers, Melissa Fleming PM&R.2024;[Epub] CrossRef
Human–Robot Cooperation Control Strategy Design Based on Trajectory Deformation Algorithm and Dynamic Movement Primitives for Lower Limb Rehabilitation Robots Jie Zhou, Yao Sun, Laibin Luo, Wenxin Zhang, Zhe Wei Processes.2024; 12(5): 924. CrossRef
Refined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke Matej Skrobot, Rafael De Sa, Josefine Walter, Arend Vogt, Raik Paulat, Janet Lips, Larissa Mosch, Susanne Mueller, Sina Dominiak, Robert Sachdev, Philipp Boehm-Sturm, Ulrich Dirnagl, Matthias Endres, Christoph Harms, Nikolaus Wenger Journal of Cerebral Blood Flow & Metabolism.2024; 44(9): 1551. CrossRef
Elucidation of the clinical traits of diabetic chorea through a questionnaire survey of people with diabetic chorea from 59 Japanese hospitals Naoko Arakawa, Tomohisa Aoyama, Hirotsugu Suwanai, Gotaro Toda, Iseki Takamoto, Yukiko Okazaki, Takashi Kadowaki, Toshimasa Yamauchi Journal of Diabetes Investigation.2024;[Epub] CrossRef
Dystonic posturing with athetoid movements in stroke without thalamic lesion Axel Ferreira, Vanessa Carvalho, Paulo Simões Coelho BMJ Case Reports.2023; 16(1): e248977. CrossRef
Monochorea after acute contralateral pontine infarction: A case report Yun Su Hwang, Byoung-Soo Shin, Han Uk Ryu, Hyun Goo Kang Medicine.2023; 102(3): e32660. CrossRef
Post-stroke Chorea in the Neurology Department of Ignace Deen Hospital of Conakry, Guinea Idrissa Doumbouya, Souleymane Djigue Barry, Mohamed Lamine Toure, Djénabou Négué Barry, Karinka Diawara , Mohamed Traoré, Mamadou Hady Diallo, Fodé Abass Cissé, Amara Cissé Cureus.2023;[Epub] CrossRef
Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease Hanna E. Berk-Rauch, Arnab Choudhury, Allison T. Richards, Pradeep K. Singh, Zu-Lin Chen, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn Frontiers in Aging Neuroscience.2023;[Epub] CrossRef
Constraint-induced movement therapy alleviates motor impairment by inhibiting the accumulation of neutrophil extracellular traps in ischemic cortex Congqin Li, Jian Hu, Ying Xing, Jing Han, Anjing Zhang, Yuqian Zhang, Yan Hua, Zhanzhuang Tian, Yulong Bai Neurobiology of Disease.2023; 179: 106064. CrossRef
Deep brain stimulation in posterior subthalamic area for Holmes tremor: Case reports with review of the literature Hikaru Kamo, Genko Oyama, Masanobu Ito, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori Frontiers in Neurology.2023;[Epub] CrossRef
Síndrome fronto-subcortical: cuando la red falla, a propósito de un caso María Noemí García-Calderón Díaz, María Isabel Ramos García Revista Española de Geriatría y Gerontología.2023; 58(5): 101379. CrossRef
Functional and structural brain reorganization in patients with ischemic stroke: a multimodality MRI fusion study Fangyuan Cui, Lei Zhao, Mengxin Lu, Ruoyi Liu, Qiuyi Lv, Dan Lin, Kuangshi Li, Yong Zhang, Yahui Wang, Yue Wang, Liping Wang, Zhongjian Tan, Yiheng Tu, Yihuai Zou Cerebral Cortex.2023; 33(19): 10453. CrossRef
Hypoglycemic Encephalopathy Manifesting with Cortical Hemichorea-Hemiballismus Syndrome: A Case Report Francesco Pasini, Aristotelis Karantzoulis, Gaia Fanella, Francesco Brovelli, Davide Iacobucci, Vittoria Aprea, Benedetta Storti, Francesco Santangelo, Francesco Canonico, Paolo Remida, Carlo Ferrarese, Laura Brighina Case Reports in Neurology.2023; 15(1): 24. CrossRef
Lesion network mapping of eye-opening apraxia Pardis Zarifkar, Nicholas A Shaff, Vardan Nersesjan, Andrew R Mayer, Sephira Ryman, Daniel Kondziella Brain Communications.2023;[Epub] CrossRef
Late-onset, first-ever involuntary movement after successful surgical revascularization for pediatric moyamoya disease – Report of two cases Shunsuke Hasegawa, Tomomi Tanaka, Shusuke Yamamoto, Daina Kashiwazaki, Kyo Noguchi, Satoshi Kuroda Surgical Neurology International.2023; 14: 430. CrossRef
A Rare Pathologic Collecting and Hoarding Behavior Following Left Middle Cerebral Artery Territory Infarction Minwoo Lee, Yeo J Kim, Yerim Kim Neurology India.2022; 70(3): 1263. CrossRef
Hyperkinetic Choreiform Movements Secondary to Basal Ganglia Calcification and Underlying Developmental Venous Anomaly Jay Patel, Muhammad Khalil, Sidra Zafar Cureus.2022;[Epub] CrossRef
Case Report: Dystonic Storm Following Japanese Encephalitis Virus Infection Ritwik Ghosh, Souvik Dubey, Shambaditya Das, Julián Benito-León The American Journal of Tropical Medicine and Hygiene.2022; 107(3): 557. CrossRef
Adult-Onset Idiopathic Cervical Dystonia Shameer Rafee, Mahmood Al-Hinai, Michael Hutchinson European Medical Journal.2022; : 69. CrossRef
Hemichorea after successful treatment with mechanical thrombectomy in a patient with acute ischemic stroke Satoshi Kimura, Jun Tsugawa, Takafumi Mitsutake, Yuji Tateishi, Hayatsura Hanada, Yusuke Morinaga, Ritsuro Inoue, Yoko Hirata, Yusuke Takemura, Kouhei Nii, Yoshio Tsuboi, Toshio Higashi Interdisciplinary Neurosurgery.2021; 25: 101156. CrossRef
Diagnostic Challenges in Outpatient Stroke: Stroke Chameleons and Atypical Stroke Syndromes Emma JC Wallace, Ava L Liberman Neuropsychiatric Disease and Treatment.2021; Volume 17: 1469. CrossRef
Ischemic stroke-induced polyaxonal innervation at the neuromuscular junction is attenuated by robot-assisted mechanical therapy Maria H.H. Balch, Hallie Harris, Deepti Chugh, Surya Gnyawali, Cameron Rink, Shahid M. Nimjee, W. David Arnold Experimental Neurology.2021; 343: 113767. CrossRef
Rare coexistence of multiple manifestations secondary to thalamic hemorrhage: A case report Qi-Wei Yu, Tian-Fen Ye, Wen-Jun Qian World Journal of Clinical Cases.2021; 9(18): 4817. CrossRef
Human–Robot Cooperation Control Based on Trajectory Deformation Algorithm for a Lower Limb Rehabilitation Robot Jie Zhou, Zhijun Li, Xianming Li, Xiaoyun Wang, Rong Song IEEE/ASME Transactions on Mechatronics.2021; 26(6): 3128. CrossRef
Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application Aleksandra Steliga, Przemysław Kowiański, Ewelina Czuba, Monika Waśkow, Janusz Moryś, Grażyna Lietzau Translational Stroke Research.2020; 11(4): 553. CrossRef
Activity‐dependent cleavage of dyskinesia‐related proline‐rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons Daisuke Hatta, Keiro Shirotani, Yuma Hori, Naohiro Kurotaki, Nobuhisa Iwata The FASEB Journal.2020; 34(1): 180. CrossRef
Vascularization of the Subthalamic Nucleus: Highlighting the Significance of the Premamillary Artery Serhat Baydin, Oguz Baran, Abuzer Gungor, Enis Kuruoglu, Necmettin Tanriover World Neurosurgery.2020; 135: e562. CrossRef
Hemichorea as Presentation of Acute Cortical Ischemic Stroke. Case Series and Review of the Literature Álvaro Carbayo, Jordi Sarto, Daniel Santana, Yaroslau Compta, Xabier Urra Journal of Stroke and Cerebrovascular Diseases.2020; 29(10): 105150. CrossRef
Differentiating the Brain’s involvement in Executed and Imagined Stepping using fMRI Adrienne Kline, Daniel Pittman, Janet Ronsky, Bradley Goodyear Behavioural Brain Research.2020; 394: 112829. CrossRef
Hemichorea-hemiballismus as the initial manifestation of symptomatic middle cerebral artery dissection Hanfeng Chen, Ziqi Xu Medicine.2020; 99(36): e22116. CrossRef
Deficits in motor and cognitive functions in an adult mouse model of hypoxia-ischemia induced stroke Li Feng, Chun-Xia Han, Shu-Yu Cao, He-Ming Zhang, Gang-Yi Wu Scientific Reports.2020;[Epub] CrossRef
Effectiveness of rehabilitation of patients with cerebrovascular insufficiency using the biofeedback method A. V. Rylskiy, A. N. Oranskaya, K. G. Gurevich Fizioterapevt (Physiotherapist).2020; (5): 8. CrossRef
A phase IIb, randomised, double-blind, placebo-controlled, dose-ranging investigation of the safety and efficacy of NTCELL® [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease Barry Snow, Eoin Mulroy, Arnold Bok, Mark Simpson, Andrew Smith, Kenneth Taylor, Michelle Lockhart, BB Janice Lam, Christopher Frampton, Patrick Schweder, Benson Chen, Gregory Finucane, Adele McMahon, Lorraine Macdonald Parkinsonism & Related Disorders.2019; 61: 88. CrossRef
'Stroke chameleons' D. A. Demin, V. V. Belopasov, E. V. Asfandiiarova, E. N. Zhuravleva, I. S. Mintulaev, E. V. Nikolaeva Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2019; 119(4): 72. CrossRef
Double Hit Theory for the Development of Vascular Parkinsonism Herbert Alejandro Manosalva Neurophysiology and Rehabilitation.2019; : 42. CrossRef
Deep Brain Stimulation for Intractable Involuntary Movement Yoshinori Higuchi, Kyoko Aoyagi, Masaki Izumi, Maidinamu Yakufujiang, Yoji Okahara, Osamu Nagano, Yasuo Iwadate Japanese Journal of Neurosurgery.2019; 28(6): 342. CrossRef
Interaction between ventricular expansion and structural changes in the corpus callosum and putamen in males with FMR1 normal and premutation alleles Jun Yi Wang, David Hessl, Flora Tassone, Kyoungmi Kim, Randi J. Hagerman, Susan M. Rivera Neurobiology of Aging.2019;[Epub] CrossRef
Progressive chorea and dystonia associated with a large arteriovenous malformation Jeffrey S Raskin, Mered Parnes, Sandi Lam Journal of the International Child Neurology Association.2019;[Epub] CrossRef
Acute-onset Restless legs syndrome in acute neurological conditions-a prospective study on patients with the Guillain-Barre syndrome and acute stroke S. Chandan, G. Shukla, A. Gupta, A. Srivastava, D. Vibha, K. Prasad Acta Neurologica Scandinavica.2018; 137(5): 488. CrossRef
Levofloxacin-induced hemichorea-hemiballism in a patient with previous thalamic infarction Ruggero Bacchin, Francesco Macchione, Davide Cardellini, Riccardo Orlandi, Alberto Gajofatto, Gianluigi Zanusso, Gaetano Vattemi Neurological Sciences.2018; 39(8): 1483. CrossRef
Post-Thalamic Stroke Movement Disorders: A Systematic Review Navnika Gupta, Sanjay Pandey European Neurology.2018; 79(5-6): 303. CrossRef
Individualized Immunological Data for Precise Classification of OCD Patients Hugues Lamothe, Jean-Marc Baleyte, Pauline Smith, Antoine Pelissolo, Luc Mallet Brain Sciences.2018; 8(8): 149. CrossRef
Dystonia: A Leading Neurological Movement Disorder Md. Tanvir Kabir, Hasina Yasmin, Umme Salma Khanam, Mohd. Raeed Jamiruddin, Md. Sahab Uddin, Mohamed M. Abdel-Daim Journal of Intellectual Disability - Diagnosis and Treatment.2018; 6(3): 63. CrossRef
Poststroke Choreodystonia Responsive to Zopiclone: Further Evidence of a Role for the “Z‐Drugs” in Hyperkinetic Movement Disorders Petya Bogdanova‐Mihaylova, Richard A. Walsh Movement Disorders Clinical Practice.2017; 4(4): 616. CrossRef
Vascular Pathology Causing Late Onset Generalized Chorea: A Clinico‐Pathological Case Report Paula Salgado, Ricardo Taipa, Joana Domingos, Daniel Dias, Manuel Melo Pires, Marina Magalhães Movement Disorders Clinical Practice.2017; 4(6): 819. CrossRef
Cerebellar circuitry is important to controlling and modifying motor activity. It conducts the coordination and correction of errors in muscle contractions during active movements. Therefore, cerebrovascular lesions of the cerebellum or its pathways can cause diverse movement disorders, such as action tremor, Holmes’ tremor, palatal tremor, asterixis, and dystonia. The pathophysiology of abnormal movements after stroke remains poorly understood. However, due to the current advances in functional neuroimaging, it has recently been described as changes in functional brain networks. This review describes the clinical features and pathophysiological mechanisms in different types of movement disorders following cerebrovascular lesions in the cerebellar circuits.
Citations
Citations to this article as recorded by
Clinical study of six patients with pure dysarthria and dysarthria—(Central) facial nerve palsy/isolated central facial nerve palsy caused by extracerebellar infarction Katsuhiko Ogawa, Takayoshi Akimoto, Makoto Hara, Midori Fujishiro, Hideto Nakajima Neurology and Clinical Neuroscience.2024; 12(2): 100. CrossRef
Flapping Tremor: Unraveling Asterixis—A Narrative Review Jamir Pitton Rissardo, Sara Muhammad, Venkatesh Yatakarla, Nilofar Murtaza Vora, Paras Paras, Ana Letícia Fornari Caprara Medicina.2024; 60(3): 362. CrossRef
Influencing factors of corticomuscular coherence in stroke patients Zhixian Gao, Shiyang Lv, Xiangying Ran, Yuxi Wang, Mengsheng Xia, Junming Wang, Mengyue Qiu, Yinping Wei, Zhenpeng Shao, Zongya Zhao, Yehong Zhang, Xuezhi Zhou, Yi Yu Frontiers in Human Neuroscience.2024;[Epub] CrossRef
Hypertrophic olivary degeneration following head injury: a case report Neha Singh, Kishan Kumar Thakur, Deepak Kumar Singh, James Marak Egyptian Journal of Radiology and Nuclear Medicine.2024;[Epub] CrossRef
Meningioma‑associated parkinsonism related to basal ganglia and cerebellar motor circuits: A case report and literature review Shintaro Takeda, Shohei Nagasaka, Kohei Suzuki, Koichiro Futatsuya, Junkoh Yamamoto Experimental and Therapeutic Medicine.2024;[Epub] CrossRef
Unveiling Benedikt’s syndrome: A rare midbrain stroke presenting with oculomotor nerve palsy Arumugam Balraj, Sunil Kumar Indian Journal of Ophthalmology - Case Reports.2024; 4(4): 908. CrossRef
Genome-wide association study of cerebellar white matter microstructure and genetic overlap with common brain disorders Bang-Sheng Wu, Yi-Jun Ge, Wei Zhang, Shi-Dong Chen, Shi-Tong Xiang, Ya-Ru Zhang, Ya-Nan Ou, Yu-Chao Jiang, Lan Tan, Wei Cheng, John Suckling, Jian-Feng Feng, Jin-Tai Yu, Ying Mao NeuroImage.2023; 269: 119928. CrossRef
Deep Brain Stimulation for Holmes Tremors and Literature Review Kunkala Lavanya, P. Vijaya Shankar, K. Visvanathan, S. Sundar, P. Philohazeena Annals of Indian Academy of Neurology.2023; 26(3): 296. CrossRef
The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders Eren Ogut, Kutay Armagan, Doruktan Tufekci Neurosurgical Review.2023;[Epub] CrossRef
Morphological and Functional Principles Governing the Plasticity Reserve in the Cerebellum: The Cortico-Deep Cerebellar Nuclei Loop Model Hiroshi Mitoma, Shinji Kakei, Hirokazu Tanaka, Mario Manto Biology.2023; 12(11): 1435. CrossRef
Delayed cervicobrachial segmental dystonia secondary to ipsilateral cerebellar infarction Vikram V. Holla, Sudhakar Pushpa Chaithra, Shweta Prasad, Pramod Kumar Pal Annals of Movement Disorders.2021; 4(2): 89. CrossRef
Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor Shinji Kakei, Mario Manto, Hirokazu Tanaka, Hiroshi Mitoma Frontiers in Neurology.2021;[Epub] CrossRef
Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder Ron Gadot, Ben Shofty, Ricardo A. Najera, Adrish Anand, Garrett Banks, Abdul Basit Khan, Melissa A. LoPresti, Nora Vanegas Arroyave, Sameer A. Sheth Frontiers in Neuroscience.2021;[Epub] CrossRef
Gadolinium-based contrast agents – what is the evidence for ‘gadolinium deposition disease’ and the use of chelation therapy? Kerry A. Layne, David M. Wood, Paul I. Dargan Clinical Toxicology.2020; 58(3): 151. CrossRef
POLR3A variants with striatal involvement and extrapyramidal movement disorder Inga Harting, Murtadha Al-Saady, Ingeborg Krägeloh-Mann, Annette Bley, Maja Hempel, Tatjana Bierhals, Stephanie Karch, Ute Moog, Geneviève Bernard, Richard Huntsman, Rosalina M. L. van Spaendonk, Maaike Vreeburg, Agustí Rodríguez-Palmero, Aurora Pujol, Ma neurogenetics.2020; 21(2): 121. CrossRef
Ataxic hemiparesis after corona radiata infarct: Diffusion tensor imaging correlation of corticoponto-cerebellar tract injury Jun Young Kim, Jeong Pyo Seo, Min Cheol Chang Translational Neuroscience.2020; 11(1): 1. CrossRef
The Rehapiano—Detecting, Measuring, and Analyzing Action Tremor Using Strain Gauges Norbert Ferenčík, Miroslav Jaščur, Marek Bundzel, Filippo Cavallo Sensors.2020; 20(3): 663. CrossRef
Oxygen Cost During Walking in Individuals With Stroke: Hemiparesis Versus Cerebellar Ataxia Maxence Compagnat, Jean-Christophe Daviet, Charles Batcho, Nicolas Vuillerme, Jean-Yves Salle, Romain David, Stephane Mandigout Neurorehabilitation and Neural Repair.2020; 34(4): 289. CrossRef
An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes Katherine Ellis, Chris Oliver, Chrysi Stefanidou, Ian Apperly, Jo Moss Journal of Autism and Developmental Disorders.2020; 50(11): 4001. CrossRef
Injury of the dentato-rubro-thalamic tract in a patient with intentional tremor after mild traumatic brain injury: a case report Min Cheol Chang, Jeong Pyo Seo Brain Injury.2020; 34(9): 1283. CrossRef
KCND3-Related Neurological Disorders: From Old to Emerging Clinical Phenotypes Luca Pollini, Serena Galosi, Manuela Tolve, Caterina Caputi, Carla Carducci, Antonio Angeloni, Vincenzo Leuzzi International Journal of Molecular Sciences.2020; 21(16): 5802. CrossRef
Posterior Subthalamic Area Deep Brain Stimulation for Treatment of Refractory Holmes Tremor Malgorzata Dec-Ćwiek, Marcin Tutaj, Wojciech Pietraszko, Witold Libionka, Mariusz Krupa, Marek Moskała, Monika Rudzińska-Bar, Agnieszka Słowik, Joanna Pera Stereotactic and Functional Neurosurgery.2019; 97(3): 183. CrossRef
Teaching Video NeuroImages: A patient with Holmes tremor due to demyelinating lesion of the inferior cerebellar peduncle Daniel G. Di Luca, Andres De Leon-Benedetti, Stacey Williamson, Le Treice Irving, Jason Margolesky Neurology.2019;[Epub] CrossRef
Acute hemorrhagic cerebellar infarction presenting with isolated head titubation Tatsuya Ueno, Haruo Nishijima, Akira Arai, Masahiko Tomiyama Journal of the Neurological Sciences.2017; 372: 456. CrossRef
Rubral Tremor Associated with Klinefelter Syndrome; a Case Report and Literature Review Reihaneh Dehghani, Elmira Agah, Zeinab Falsafi, Abbas Tafakhori Archives of Neuroscience.2017;[Epub] CrossRef
Parkinson’s disease (PD) is a neurodegenerative disease with heterogeneous pathological and clinical features. Cognitive dysfunction, a frequent non-motor complication, is a risk factor for poor prognosis and shows inter-individual variation in its progression. Of the clinical studies performed to identify biomarkers of PD progression, the Parkinson’s Progression Markers Initiative (PPMI) study is the largest study that enrolled drug-naïve and very early stage PD patients. The baseline characteristics of the PPMI cohort were recently published. The diagnostic utility of cerebrospinal fluid (CSF) biomarkers, including alpha-synuclein (α-syn), total tau, phosphorylated tau at Thr181, and amyloid β1-42, was not satisfactory. However, the baseline data on CSF biomarkers in the PPMI study suggested that the measurement of the CSF biomarkers enables the prediction of future cognitive decline in PD patients, which was consistent with previous studies. To prove the hypothesis that the interaction between Alzheimer’s pathology and α-syn pathology is important to the progression of cognitive dysfunction in PD, longitudinal observational studies must be followed. In this review, the neuropathological nature of heterogeneous cognitive decline in PD is briefly discussed, followed by a summarized interpretation of baseline CSF biomarkers derived from the data in the PPMI study. The combination of clinical, biochemical, genetic and imaging biomarkers of PD constitutes a feasible strategy to predict the heterogeneous progression of PD.
Citations
Citations to this article as recorded by
Highly sensitive biosensor based on IGZO thin-film transistors for detection of Parkinson's disease Tongzheng Li, Tongying Xu, Zhengyang Yao, Yanan Ding, Guoxia Liu, Fukai Shan Applied Physics Letters.2023;[Epub] CrossRef
Extracellular vesicle biomarkers for cognitive impairment in Parkinson’s disease Joseph Blommer, Toni Pitcher, Maja Mustapic, Erden Eren, Pamela J Yao, Michael P Vreones, Krishna A Pucha, John Dalrymple-Alford, Reza Shoorangiz, Wassilios G Meissner, Tim Anderson, Dimitrios Kapogiannis Brain.2023; 146(1): 195. CrossRef
Imaging Biomarkers for Central Nervous System Drug Development and Future Clinical Utility: Lessons from Neurodegenerative Disorders John P. Seibyl Journal of Nuclear Medicine.2023; 64(1): 12. CrossRef
REM sleep behavior disorder and cerebrospinal fluid alpha-synuclein, amyloid beta, total tau and phosphorylated tau in Parkinson’s disease: a cross-sectional and longitudinal study Fardin Nabizadeh, Kasra Pirahesh, Parya Valizadeh Journal of Neurology.2022; 269(9): 4836. CrossRef
Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease Thomas Kremer, Kirsten I. Taylor, Juliane Siebourg‐Polster, Thomas Gerken, Andreas Staempfli, Christian Czech, Juergen Dukart, Douglas Galasko, Tatiana Foroud, Lana M. Chahine, Christopher S. Coffey, Tanya Simuni, Daniel Weintraub, John Seibyl, Kathleen L Movement Disorders.2021; 36(8): 1972. CrossRef
Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis J. M. Hatcher-Martin, J. L. McKay, A. F. Pybus, B. Sommerfeld, J. C. Howell, F. C. Goldstein, L. Wood, W. T. Hu, S. A. Factor npj Parkinson's Disease.2021;[Epub] CrossRef
Melatonin affects the release of exosomes and tau-content in in vitro amyloid-beta toxicity model Mehmet Ozansoy, Muzaffer Beyza Ozansoy, Burak Yulug, Seyda Cankaya, Ertugrul Kilic, Sule Goktekin, Ulkan Kilic Journal of Clinical Neuroscience.2020; 73: 237. CrossRef
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology Maja Malmberg, Tarja Malm, Oskar Gustafsson, Andrea Sturchio, Caroline Graff, Alberto J. Espay, Anthony P. Wright, Samir El Andaloussi, Anders Lindén, Kariem Ezzat Frontiers in Neuroscience.2020;[Epub] CrossRef
Why would Parkinson’s disease lead to sudden changes in creativity, motivation, or style with visual art?: A review of case evidence and new neurobiological, contextual, and genetic hypotheses Jon O. Lauring, Tomohiro Ishizu, Hana H. Kutlikova, Felix Dörflinger, Steven Haugbøl, Helmut Leder, Ron Kupers, Matthew Pelowski Neuroscience & Biobehavioral Reviews.2019; 100: 129. CrossRef
Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Tracy R. Melzer, Megan R. Stark, Ross J. Keenan, Daniel J. Myall, Michael R. MacAskill, Toni L. Pitcher, Leslie Livingston, Sophie Grenfell, Kyla-Louise Horne, Bob N. Young, Maddie J. Pascoe, Mustafa M. Almuqbel, Jian Wang, Steven H. Marsh, David H. Mille Frontiers in Neurology.2019;[Epub] CrossRef
Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies Kurt A. Jellinger Journal of Neural Transmission.2018; 125(4): 615. CrossRef
Identification of a prospective early motor progression cluster of Parkinson's disease: Data from the PPMI study George D. Vavougios, Triantafyllos Doskas, Constantinos Kormas, Karen A. Krogfelt, Sotirios G. Zarogiannis, Leonidas Stefanis Journal of the Neurological Sciences.2018; 387: 103. CrossRef
Relationship between cerebrospinal fluid biomarkers and structural brain network properties in Parkinson's disease Nooshin Abbasi, Bahram Mohajer, Sima Abbasi, Payam Hasanabadi, Amirhussein Abdolalizadeh, Reza Rajimehr Movement Disorders.2018; 33(3): 431. CrossRef
Longitudinal Alterations of Alpha-Synuclein, Amyloid Beta, Total, and Phosphorylated Tau in Cerebrospinal Fluid and Correlations Between Their Changes in Parkinson's Disease Mahsa Dolatshahi, Shayan Pourmirbabaei, Aida Kamalian, Amir Ashraf-Ganjouei, Mehdi Yaseri, Mohammad H. Aarabi Frontiers in Neurology.2018;[Epub] CrossRef
Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study Manuel Delgado‐Alvarado, Rosalía Dacosta‐Aguayo, Irene Navalpotro‐Gómez, Belén Gago, Ana Gorostidi, Haritz Jiménez‐Urbieta, Ana Quiroga‐Varela, Javier Ruiz‐Martínez, Alberto Bergareche, María C. Rodríguez‐Oroz Movement Disorders.2018; 33(11): 1809. CrossRef
Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases Ji-Young Choi, Sujin Kim, Hyo-Bum Kwak, Dong-Ho Park, Jae-Hyoung Park, Jeong-Seon Ryu, Chang-Shin Park, Ju-Hee Kang International Neurourology Journal.2017; 21(2): 83. CrossRef
Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, Jianjun Chang, Jaegwon Chung, Chelsea Caspell-Garcia, Peggy Taylor, Brit Mollenhauer, Michael G. Schlossmacher, Larry Ereshefsky, Mark Yen, Catherine Kopil, Mark Frasier, Kenneth Marek, Vicki S. Journal of Neuroinflammation.2017;[Epub] CrossRef
Cognitive and Neuropsychiatric Features in Parkinson's and Lewy Body Dementias Julie A Fields Archives of Clinical Neuropsychology.2017; 32(7): 786. CrossRef
Objective
The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson’s disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naïve and dopaminergic drug-treated groups.
Methods
This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naïve or dopaminergic drug treatment).
Results
Orthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.
Conclusions
Cardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.
Citations
Citations to this article as recorded by
Parkinson's disease patients with absence of normal dipping status were more vulnerable to cognitive impairment from the early stages Lanlan Chen, Li Jiang, Chenxin Wang, Tingting Qiao, Cancan Ma, Yingzhu Chen, Chunfeng Liu, Xin Wang, Yao Xu Parkinsonism & Related Disorders.2024; 121: 106013. CrossRef
Associations of sleep-related variables with reverse dipping patterns of blood pressure in α-synucleinopathies Yunchuang Sun, Luhua Wei, Fan Li, Chen Ling, Fei Zhai, Yunfeng Lv, Hong Zhou, Cheng Zhang, Jing Ma, Jing Chen, Wei Sun, Zhaoxia Wang Parkinsonism & Related Disorders.2024; 121: 106046. CrossRef
Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation Carlos Rafael Sierra-Fernández, Luis Rodrigo Garnica-Geronimo, Alejandra Huipe-Dimas, Jorge A. Ortega-Hernandez, María Alejandra Ruiz-Mafud, Amin Cervantes-Arriaga, Ana Jimena Hernández-Medrano, Mayela Rodríguez-Violante Frontiers in Cardiovascular Medicine.2024;[Epub] CrossRef
The correlation of orthostatic hypotension in Parkinson disease with the disease course and severity and its impact on quality of life Yuanyuan Meng, Tianping Tang, Juanjuan Wang, Kun Yu Medicine.2024; 103(19): e38169. CrossRef
Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study Shubhra Acharya, Andrew I. Lumley, Yvan Devaux, Muhammad Ali, Nancy E. Ramia, Giuseppe Arena, Rudi Balling, Michele Bassis, Regina Becker, Ibrahim Boussaad, Piotr Gawron, Soumyabrata Ghosh, Enrico Glaab, Elisa Gómez De Lope, Valentin Groues, Anne Grünewal BMC Neuroscience.2024;[Epub] CrossRef
Reverse nocturnal blood pressure dipping in Parkinson's disease is affected by physical activity but not sleep disturbances Kazushi Deguchi, Kazuyo Ikeda, Tetsuo Touge, Asahiro Morishita, Hideki Kobara, Tsutomu Masaki Neurology and Clinical Neuroscience.2024;[Epub] CrossRef
Autonomic control of heart and vessels in patients with very early stage of Parkinson disease J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca Physiological Measurement.2023; 44(5): 054002. CrossRef
Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating feasibility, safety, and preliminary efficacy Daniel H. Lench, Travis H. Turner, Colin McLeod, Heather A. Boger, Lilia Lovera, Lisa Heidelberg, Jordan Elm, Anh Phan, Bashar W. Badran, Vanessa K. Hinson Frontiers in Neurology.2023;[Epub] CrossRef
Neurogenic Supine Hypertension and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease Sunil Kapoor, Alvee Saluja, Shubha Laxmi Margekar, Mayank Agarwal, Sunita Mondal, Rajinder K. Dhamija Annals of Indian Academy of Neurology.2023; 26(1): 33. CrossRef
Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad Parkinson's Disease.2022; 2022: 1. CrossRef
Cardiovascular Autonomic Dysfunction in Idiopathic Parkinson's Disease Sahil Mehta Annals of Indian Academy of Neurology.2022; 25(5): 803. CrossRef
Spectrum of Cardiovascular Autonomic Dysfunction and 24-hour Blood Pressure Variability in Idiopathic Parkinson's Disease Ivy Sebastian, Mahesh P. Kate, Himani Khatter, Bharat Singh, Jeyaraj D. Pandian Annals of Indian Academy of Neurology.2022; 25(5): 902. CrossRef
Blood Pressure Patterns in Patients with Parkinson’s Disease: A Systematic Review Delia Tulbă, Liviu Cozma, Paul Bălănescu, Adrian Buzea, Cristian Băicuș, Bogdan Ovidiu Popescu Journal of Personalized Medicine.2021; 11(2): 129. CrossRef
Inverted circadian variation of arterial pressure in a geriatric patient: an indicator of autonomic dysfunction Siddhartha Lieten, Aziz Debain, Bert Bravenboer, Tony Mets BMC Geriatrics.2021;[Epub] CrossRef
Autonomic dysfunction and heart rate variability with Holter monitoring: a diagnostic look at autonomic regulation Beatrice De Maria, Laura Adelaide Dalla Vecchia, Alberto Porta, Maria Teresa La Rovere Herzschrittmachertherapie + Elektrophysiologie.2021; 32(3): 315. CrossRef
Heart Rate Variability Analyses in Parkinson’s Disease: A Systematic Review and Meta-Analysis Konstantin G. Heimrich, Thomas Lehmann, Peter Schlattmann, Tino Prell Brain Sciences.2021; 11(8): 959. CrossRef
Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis Feifei Mu, Qian Jiao, Xixun Du, Hong Jiang Neurological Sciences.2020; 41(6): 1419. CrossRef
Dizziness in patients with early stages of Parkinson's disease: Prevalence, clinical characteristics and implications Kyum‐Yil Kwon, Suyeon Park, Mina Lee, Hyunjin Ju, Kayeong Im, Byung‐Euk Joo, Kyung Bok Lee, Hakjae Roh, Moo‐Young Ahn Geriatrics & Gerontology International.2020; 20(5): 443. CrossRef
The Dysfunctional Autonomic Function and “Dysfunctional” Fatigue in Drug Naïve Parkinson’s Disease Jong Hyeon Ahn, Minkyeong Kim, Jun Kyu Mun, Yoonsu Cho, Ji Sun Kim, Jinyoung Youn, Joong-Seok Kim, Jin Whan Cho Journal of Parkinson's Disease.2020; 10(2): 605. CrossRef
Clinical Perspectives of Parkinson's Disease for Ophthalmologists, Otorhinolaryngologists, Cardiologists, Dentists, Gastroenterologists, Urologists, Physiatrists, and Psychiatrists Ji-Hyun Choi, Jong-Min Kim, Hee Kyung Yang, Hyo-Jung Lee, Cheol Min Shin, Seong Jin Jeong, Won-Seok Kim, Ji Won Han, In-Young Yoon, Yoo Sung Song, Yun Jung Bae Journal of Korean Medical Science.2020;[Epub] CrossRef
Autonomic Dysfunction in Parkinson's Disease Ronald F. Pfeiffer Neurotherapeutics.2020; 17(4): 1464. CrossRef
Dysautonomia Is Linked to Striatal Dopamine Deficits and Regional Cerebral Perfusion in Early Parkinson Disease Hae-Won Shin, Seok Jong Chung, Sangwon Lee, Jungho Cha, Young H. Sohn, Mijin Yun, Phil Hyu Lee Clinical Nuclear Medicine.2020; 45(8): e342. CrossRef
Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease – the SFC BP multicentre study in China Shi-Wu Chen, Yu-Kai Wang, Rong-Hua Dou, Xin-Yi Xie, Yong-Bo Hu, Nan Ding, Guo-Hua Zhang, Hai-Fang Jing, Wei-Dong Zhao, Yan Xue, Yan Li, Gang Wang Journal of Hypertension.2020; 38(11): 2270. CrossRef
Parkinson’s disease with orthostatic hypotension: analyses of clinical characteristics and influencing factors Lixia Li, Peng Guo, Duyu Ding, Tenghong Lian, Lijun Zuo, Fenghe Du, Wei Zhang Neurological Research.2019; 41(8): 734. CrossRef
Neurogenic Orthostatic Hypotension in
Parkinson Disease: A Primer Jeremy K. Cutsforth-Gregory, Phillip A. Low Neurology and Therapy.2019; 8(2): 307. CrossRef
Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson’s disease Claudia Carricarte Naranjo, Connie Marras, Naomi P. Visanji, David J. Cornforth, Lazaro Sanchez-Rodriguez, Birgitt Schüle, Samuel M. Goldman, Mario Estévez, Phyllis K. Stein, Anthony E. Lang, Herbert F. Jelinek, Andrés Machado Clinical Autonomic Research.2019; 29(6): 603. CrossRef
Considerations before initiating therapy in Parkinsonism: basing on the quality of life Shu-Jin He, Zhen-Yang Liu, Yu-Jie Yang, Cong Shen, Yu-Jie Du, Xin-Yue Zhou, Jue Zhao, Yi-Min Sun, Ke Yang, Jian-Jun Wu, Feng-Tao Liu, Jian Wang Journal of Neurology.2019; 266(12): 3119. CrossRef
Increased risk of all‐cause mortality associated with domperidone use in Parkinson's patients: a population‐based cohort study in the UK Marina Simeonova, Frank de Vries, Sander Pouwels, Johanna H. M. Driessen, Hubert G.M. Leufkens, Suzanne M. Cadarette, Andrea M. Burden British Journal of Clinical Pharmacology.2018; 84(11): 2551. CrossRef
Validation of the Korean Version of the Scale for Outcomes in Parkinson’s Disease-Autonomic Ji-Young Kim, In-Uk Song, Seong-Beom Koh, Tae-Beom Ahn, Sang Jin Kim, Sang-Myung Cheon, Jin Whan Cho, Yun Joong Kim, Hyeo-Il Ma, Mee-Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong-Min Kim, Han-Joon Kim, Young-Hee Sung, Do Young Kwon, Jae-Hyeo Journal of Movement Disorders.2017; 10(1): 29. CrossRef
Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee Journal of Clinical Neurology.2017; 13(1): 15. CrossRef
Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype? J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee European Journal of Neurology.2017; 24(2): 349. CrossRef
The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism Younsoo Kim, Jin Myoung Seok, Jongkyu Park, Kun-Hyun Kim, Ju-Hong Min, Jin Whan Cho, Suyeon Park, Hyun-jin Kim, Byoung Joon Kim, Jinyoung Youn, Pedro Gonzalez-Alegre PLOS ONE.2017; 12(7): e0180744. CrossRef
Cardiac sympathetic denervation predicts PD in at-risk individuals David S. Goldstein, Courtney Holmes, Grisel J. Lopez, Tianxia Wu, Yehonatan Sharabi Parkinsonism & Related Disorders.2017;[Epub] CrossRef
Loss of cutaneous large and small fibers in naive and
l
-dopa–treated PD patients
Maria Nolano, Vincenzo Provitera, Fiore Manganelli, Rosa Iodice, Annamaria Stancanelli, Giuseppe Caporaso, Annamaria Saltalamacchia, Francesca Califano, Bernardo Lanzillo, Marina Picillo, Paolo Barone, Lucio Santoro Neurology.2017; 89(8): 776. CrossRef
Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee Neurodegenerative Diseases.2017; 17(2-3): 89. CrossRef
Prevalence and Prescribed Treatments of Orthostatic Hypotension in Institutionalized Patients with Parkinson’s Disease ALAJ Hommel, MJ Faber, NJ Weerkamp, JG van Dijk, BR Bloem, RT Koopmans Journal of Parkinson's Disease.2016; 6(4): 805. CrossRef
Objective
The aim of this subgroup analysis was to identify the risk factors associated with the development of various movement disorder phenotypes.
Methods
Eighty-three non-Wilsonian cirrhotic patients with abnormal movements were allocated into the following groups: intention tremor, bradykinesia, Parkinsonism, and abnormal ocular movements. These movement types were considered the primary outcomes as there was a sufficient sample size. Researchers took into consideration the gender, etiologies of cirrhosis, cirrhosis-related complications, hepatic encephalopathy, medical illness, and some neurological deficits as potential factors associated with these movement disorders.
Results
The male gender (p = 0.002) and alcoholic cirrhosis (p = 0.005) were significant factors for the prevalence of intention tremors. In bradykinesia, hepatic encephalopathy was highly statistically significant (p < 0.001), and females more commonly developed bradykinesia (p = 0.04). The Parkinsonism features in this study were confounded by hyperlipidemia (p = 0.04) and motor or sensory deficits (p = 0.02). Jerky pursuits and a horizontal nystagmus were detected. Jerky pursuits were significantly related to hepatic encephalopathy (p = 0.003) and bradykinesia, but there were no factors associated with the prevalence of nystagmus other than an intention tremor.
Conclusions
The association of alcoholic cirrhosis with the development of intention tremor indicates that the persistent cerebellar malfunction in cirrhotic patients is due to alcohol toxicity. The slowness of finger tapping and jerky pursuit eye movements are significantly associated with hepatic encephalopathy. Thus, further studies are needed to evaluate the diagnostic value of these two signs for an early detection of mild hepatic encephalopathy.
Citations
Citations to this article as recorded by
Unveiling the link: hepatitis C virus and Parkinson’s disease Rasha Eletreby, Eman Elhady, Shaimaa Shaheen, Iman Hamza, Ahmed Hashem The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2024;[Epub] CrossRef
Objective
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson’s disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
Methods
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson’s Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients’ demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
Results
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
Conclusions
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.
Citations
Citations to this article as recorded by
Cerebellar Microstructural Abnormalities in Parkinson’s Disease: a Systematic Review of Diffusion Tensor Imaging Studies Maryam Haghshomar, Parnian Shobeiri, Seyed Arsalan Seyedi, Fatemeh Abbasi-Feijani, Amirhossein Poopak, Houman Sotoudeh, Arash Kamali, Mohammad Hadi Aarabi The Cerebellum.2022; 21(4): 545. CrossRef
A data-driven system to identify REM sleep behavior disorder and to predict its progression from the prodromal stage in Parkinson's disease Matteo Cesari, Julie A.E. Christensen, Maria-Lucia Muntean, Brit Mollenhauer, Friederike Sixel-Döring, Helge B.D. Sorensen, Claudia Trenkwalder, Poul Jennum Sleep Medicine.2021; 77: 238. CrossRef
Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson's Disease Mohamed Elfil, Eshak I. Bahbah, Mahmoud M. Attia, Mohamed Eldokmak, Brian B. Koo Movement Disorders.2021; 36(3): 570. CrossRef
Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo Neuropsychology Review.2021; 31(4): 643. CrossRef
Risk stratification for REM sleep behavior disorder in patients with Parkinson’s disease: A PRISMA-compliant meta-analysis and systematic review Chengjuan Xie, Mingyu Zhu, Ying Hu Clinical Neurology and Neurosurgery.2021; 202: 106484. CrossRef
REM sleep behavior disorder portends poor prognosis in Parkinson’s disease: A systematic review Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon Journal of Clinical Neuroscience.2018; 47: 6. CrossRef
Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie Neurological Sciences.2017; 38(1): 163. CrossRef
Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis Ruo-lin Zhu, Cheng-juan Xie, Pan-pan Hu, Kai Wang Scientific Reports.2017;[Epub] CrossRef
Woodhouse-Sakati syndrome (WSS) is an infrequent autosomal recessive condition characterized by progressive extrapyramidal signs, mental retardation, hypogonadism, alopecia, and diabetes mellitus. This syndrome belongs to a heterogeneous group of inherited neurodegenerative disorders characterized iron accumulation in the brain, and it is caused by mutations of the C2orf37 gene. We report the first Tunisian family with two affected sisters presenting with a phenotype suggestive of WSS. We examined the index patient presenting with movement disorders and mental retardation and then searched for similar cases in her family, which identified a sister with similar signs. We performed a genetic study that confirmed the diagnosis and revealed a c.436delC mutation of the C2orf37 gene. Therefore, WSS is an important consideration in patients presenting with movement disorders and intellectual disability. A high consanguinity contributes to the clustering of such rare autosomal recessive syndromes.
Citations
Citations to this article as recorded by
Genetic epidemiology of Woodhouse-Sakati Syndrome in the Greater Middle East region and beyond: a systematic review Amira Kohil, Atiyeh M. Abdallah, Khalid Hussain, Mashael Al-Shafai Orphanet Journal of Rare Diseases.2023;[Epub] CrossRef
The Successful Management of Primary Amenorrhea in Woodhouse–Sakati Syndrome: A Case Report and a Literature Review Hanadi Bakhsh, Norah Alqntash, Ebtesam Almajed Life.2023; 13(10): 2022. CrossRef
Expanding on the phenotypic spectrum ofWoodhouse‐Sakatisyndrome due to founder pathogenic variant inDCAF17: Report of 58 additional patients from Qatar and literature review Rehab Ali, Nader Al‐Dewik, Shayma Mohammed, Mahmud Elfituri, Sahar Agouba, Sara Musa, Laila Mahmoud, Mariam Almulla, Karen El‐Akouri, Howaida Mohd, Reem Bux, Hajer Almulla, Amna Othman, Fatma Al‐Mesaifri, Noora Shahbeck, Mariam Al‐Muriekhi, Amal Khalifa, American Journal of Medical Genetics Part A.2022; 188(1): 116. CrossRef
Woodhouse-Sakati Syndrome Presenting With Psychotic Features After Starting Trihexyphenidyl: A Case Report Mohammed A Aljaffer, Ahmad H Almadani, Mohammad AlMutlaq, Abdulaziz Alhammad , Ahmed S Alyahya Cureus.2022;[Epub] CrossRef
Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family Guangmin Chen, Ling Zhou, Qimou Chen, Juan Wang, Peng Jiang, Rufei Shen, Min Long, Houdi Zhou Frontiers in Genetics.2021;[Epub] CrossRef
Woodhouse–Sakati syndrome in a family is associated with a homozygous start loss mutation in the
DCAF
17
gene
K. Shah, A. Jan, F. Ahmad, S. Basit, K. Ramzan, W. Ahmad Clinical and Experimental Dermatology.2020; 45(2): 159. CrossRef
A novel DCAF17 homozygous mutation in a girl with Woodhouse-Sakati syndrome and review of the current literature Erdal Kurnaz, Ayberk Türkyılmaz, Oğuzhan Yaralı, Berrin Demir, Atilla Çayır Journal of Pediatric Endocrinology and Metabolism.2019; 32(11): 1287. CrossRef
Brain MR Imaging Findings in Woodhouse-Sakati Syndrome A.H. Abusrair, S. Bohlega, A. Al-Semari, F.S. Al-Ajlan, K. Al-Ahmadi, B. Mohamed, A. AlDakheel American Journal of Neuroradiology.2018; 39(12): 2256. CrossRef