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Letter to the editor
- A Rare Case of Uner Tan Syndrome With Incidentally Detected Choroid Plexus Papilloma
- Uddalak Chakraborty, Adreesh Mukherjee, Amlan Kusum Datta, Atanu Biswas, Goutam Gangopadhyay
- J Mov Disord. 2024;17(2):223-225. Published online December 21, 2023
- DOI: https://doi.org/10.14802/jmd.23192
- 6,205 View
- 79 Download
Original Article
- Analysis of Semiology, Lesion Topography and Treatment Outcomes: A Prospective Study on Post Thalamic Stroke Holmes Tremor
- Amlan Kusum Datta, Adreesh Mukherjee, Sudeshna Malakar, Atanu Biswas
- J Mov Disord. 2024;17(1):71-81. Published online October 20, 2023
- DOI: https://doi.org/10.14802/jmd.23095
- 7,450 View
- 523 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
Supplementary Material - Objective
Holmes tremor (HT) comprises rest, postural and intention tremor subtypes, usually involving both proximal and distal musculature. Perturbations of nigro-striatal pathways might be fundamental in the pathogenesis of HT along with cerebello-thalamic connections.
Methods
Nine patients with an HT phenotype secondary to thalamic stroke were included. Epidemiological and clinical records were obtained. Structural and functional brain imaging were performed with magnetic resonance imaging (MRI) or computed tomography (CT) and positron emission tomography (PET), respectively. Levodopa was administered in sequentially increasing dosage, with various other drugs in case of inadequate response. Longitudinal follow-up was performed for at least three months. The essential tremor rating assessment scale (TETRAS) was used for assessment.
Results
The mean latency from stroke to tremor onset was 50.4 ± 30.60 days (range 21–90 days). Dystonia was the most frequently associated hyperkinetic movement (88.8%). Tremor was bilateral in 22.2% of participants. Clinical response was judged based on a reduction in the TETRAS score by a prefixed value (≥ 30%), pertaining to which 55.5% (n = 5) of subjects were classified as responders and the rest as non-responders. The responders showed improvement with significantly lower doses of levodopa than the remaining nonresponders (240 ± 54.7 mg vs. 400 ± 40.8 mg; p = 0.012).
Conclusion
Although levodopa is useful in HT, augmenting the dosage of levodopa beyond a certain point might not benefit patients clinically. Topography of vascular lesions within the thalamus might additionally influence the phenomenology of HT. -
Citations
Citations to this article as recorded by
- Holmes Tremor with Dystonia after Parietal and Premotor Ischemic Stroke in an Essential Tremor Patient: A Case Report
Luca Angelini, Rick C.G. Helmich
Movement Disorders Clinical Practice.2026;[Epub] CrossRef - Holmes Tremor Following Thalamic Tuberculoma—A Case Report and Literature Review
Abera Kuma, Amanuel Anegagregn, Misganaw Yiglete Damte, Adugna Getahun Deboch, Yishak Endalew, Melat Demisse, Yegzeru Belete
Clinical Case Reports.2026;[Epub] CrossRef - Tremor pathophysiology
Rodger J. Elble
Clinical Parkinsonism & Related Disorders.2026; 14: 100455. CrossRef - PET tracers targeting pathophysiological mechanisms of ischemic stroke: A comprehensive review
Chuanzhi Huang, Jingfei Yang, Xiaohua Zhu
Journal of Nuclear Medicine and Molecular Imaging.2025; 1(2): 38. CrossRef
- Holmes Tremor with Dystonia after Parietal and Premotor Ischemic Stroke in an Essential Tremor Patient: A Case Report
Letter to the editor
- Ataxia and Myoclonus with a Cherry-Red Spot Unfurling an Unusual Phenotypic Presentation of Sialidosis Type 1
- Debaleena Mukherjee, Sougata Bhattacharya, Srimant Pattnaik, Subhadeep Gupta, Biman Kanti Ray, Atanu Biswas
- J Mov Disord. 2021;14(3):256-258. Published online April 26, 2021
- DOI: https://doi.org/10.14802/jmd.20119
- 7,115 View
- 70 Download
- 4 Web of Science
- 4 Crossref
-
PDFSupplementary Material
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Citations
Citations to this article as recorded by- Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature
Janina Gburek‐Augustat, I‐Chun Lee, Marica Rubino, Vehap Topçu, Melissa Chavez‐Castillo, Shao Ching Tu, Marwan Shinawi, Isabel Alfradique‐Dunham, Manouela Valtcheva, Astrid Adarmes‐Gómez, Daniel Macias‐Garcia, Laura Laura Muñoz‐Delgado, Silvia Jesús, Pabl
Epilepsia Open.2026; 11(2): 577. CrossRef - Sialidosis type 1 in a Turkish family: a case report and review of literatures
Mustafa Kılıç, Suzan İcil, Abdullah Sezer, Öznur Kaya-Güneş, Selim S. Comoğlu
Journal of Pediatric Endocrinology and Metabolism.2025; 38(2): 176. CrossRef - Long-standing macular cherry red spot – A case series and review of literature
Disha Agarwal, Shreyas Temkar, Aahan Shah, Amit Kumar Deb, Hemanth Ramachandar, A Arun Sahi
Oman Journal of Ophthalmology.2025; 18(3): 359. CrossRef - Novel Pathogenic Variant in the NEU1 Gene in a Patient With Sialidosis With Progressive Myoclonus Ataxia With Cherry-Red Spot
Lulup K. Sahoo, Vidyasagar Kota, Pradeep K. Panigrahi, Srimant Pattnaik, Ajit P. Mishra, Srikanta K. Sahoo
Neurology.2023; 101(19): 861. CrossRef
- Sialidosis type I: How to alleviate disabling myoclonic seizures?—A multicenter analysis of eight cases and review of the literature
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