Journal of Movement Disorders

Impact of Additional Occipital Involvement in Parkinson’s Disease With Posterior Cortical Hypoperfusion: Chan Wook Park, Su Hong Kim, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Yong Jeong, Seok Jong Chung; J Mov Disord. 2026;19(1):58-66. Published online November 7, 2025; DOI: https://doi.org/10.14802/jmd.25231

1,591 View
50 Download

Abstract PDF Supplementary Material: Objective
This study aims to investigate the clinical relevance of occipital hypoperfusion in patients with Parkinson’s disease (PD) with respect to clinical phenotype and the risk of dementia conversion.
Methods
We enrolled 349 patients with newly diagnosed PD and 48 healthy controls who underwent dual-phase ¹⁸F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (¹⁸F-FP-CIT) positron emission tomography (PET). Patients with PD were classified into three groups based on posterior cortical perfusion patterns on early-phase ¹⁸F-FP-CIT PET images: PD with preserved posterior cortical perfusion (n=186), PD with parieto-temporal hypoperfusion (n=84), and PD with parieto-temporo-occipital hypoperfusion (n=79). Baseline clinical features and dementia conversion risk were compared across PD groups.
Results
Patients with preserved posterior cortical perfusion were younger than those in the other PD groups. Compared with the other groups, the parieto-temporo-occipital hypoperfusion group tended to have lower Cross-Cultural Smell Identification Test scores, a higher prevalence of rapid eye movement sleep behavior disorder, higher Unified PD Rating Scale motor scores, and more severe reductions in striatal dopamine transporter availability. The risk of dementia conversion was lower in patients with preserved posterior cortical perfusion than in those with posterior cortical hypoperfusion. However, the risk of dementia conversion did not differ between the parieto-temporal and parieto-temporo-occipital hypoperfusion groups.
Conclusion
Additional occipital hypoperfusion was not associated with an imminent risk of dementia conversion in patients with PD with posterior cortical hypoperfusion. Nonetheless, occipital involvement may serve as an indicator of the diffuse malignant subtype of PD.

The First East Asian Patient With Parkinson’s Disease Caused by the A53E SNCA Mutation With Early Progression to Dementia: Yeo Jun Yoon, Chan Wook Park, Jin Ju Kim, Seok Jong Chung, Yun Joong Kim; J Mov Disord. 2024;17(3):364-367. Published online June 13, 2024; DOI: https://doi.org/10.14802/jmd.24118

3,053 View
41 Download

PDF Supplementary Material

A Case of Abnormal Postures in the Left Extremities after Pontine Hemorrhage: Dystonia or Pseudodystonia?: Chan Wook Park, Seok Jong Chung, Young H. Sohn, Phil Hyu Lee; J Mov Disord. 2020;13(1):62-65. Published online January 31, 2020; DOI: https://doi.org/10.14802/jmd.19074

8,611 View
138 Download
1 Web of Science
3 Crossref

Abstract PDF Supplementary Material

It is difficult to determine the pathoanatomical correlates of dystonia because of its complex pathophysiology, and most cases with secondary dystonia are associated with basal ganglia lesions. Moreover, it is a challenging issue that patients with abnormal postures accompanied by other neurological findings in the affected body part (e.g., sensory loss) can be diagnosed with true dystonia or pseudodystonia. Here, we report a case of abnormal postures with loss of proprioception in the left extremities after right dorsal pontine hemorrhage.

Citations

Citations to this article as recorded by

Pseudoathetotic Pseudodystonia as a Manifestation of Isolated Medullary Demyelination in Neuromyelitis Optica Spectrum Disorder
Prachi Mohapatra, Lekshmi Sambhu Hema, Aditya Mahadevan, Divyani Garg, Ayush Agarwal, Awadh Kishor Pandit, Ajay Garg, Achal Kumar Srivastava, Divya M. Radhakrishnan
Tremor and Other Hyperkinetic Movements.2026;[Epub] CrossRef
Rehabilitation of hemidystonia as a result of right pontine hemorrhagic stroke
Melanie Aing, Craig DiTommaso
The Journal of the International Society of Physical and Rehabilitation Medicine.2023; 6(4): 116. CrossRef
Hemidystonia after Pontine Hemorrhage Successfully Treated with Pharmacotherapy and Intensive Rehabilitation: a Case Report
Gyu Seong Kim, Yeon Gyu Jeong, Yoon Jeong Jeong, Seo Yeon Yoon
Brain & Neurorehabilitation.2021;[Epub] CrossRef

A Patient with Neuroferritinopathy Presenting with Juvenile-Onset Voice Tremor: Chan Wook Park, Nan Young Kim, Yun Joong Kim, Sook Keun Song, Chul Hyoung Lyoo; J Mov Disord. 2020;13(1):66-68. Published online August 9, 2019; DOI: https://doi.org/10.14802/jmd.19038

10,015 View
117 Download
3 Web of Science
3 Crossref

PDF

Citations

Citations to this article as recorded by

Cerebral Iron Deposition in Neurodegeneration
Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan O. Aaseth
Biomolecules.2022; 12(5): 714. CrossRef
Pathogenic mechanism and modeling of neuroferritinopathy
Anna Cozzi, Paolo Santambrogio, Maddalena Ripamonti, Ermanna Rovida, Sonia Levi
Cellular and Molecular Life Sciences.2021; 78(7): 3355. CrossRef
Brain MRI Pattern Recognition in Neurodegeneration With Brain Iron Accumulation
Jae-Hyeok Lee, Ji Young Yun, Allison Gregory, Penelope Hogarth, Susan J. Hayflick
Frontiers in Neurology.2020;[Epub] CrossRef

Search