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Review Article
Tau Positron Emission Tomography Imaging in Degenerative Parkinsonisms
Chul Hyoung Lyoo, Hanna Cho, Jae Yong Choi, Young Hoon Ryu, Myung Sik Lee
J Mov Disord. 2018;11(1):1-12.   Published online January 23, 2018
DOI: https://doi.org/10.14802/jmd.17071
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AbstractAbstract PDF
In recent years, several radiotracers that selectively bind to pathological tau proteins have been developed. Evidence is emerging that binding patterns of in vivo tau positron emission tomography (PET) studies in Alzheimer’s disease (AD) patients closely resemble the distribution patterns of known neurofibrillary tangle pathology, with the extent of tracer binding reflecting the clinical and pathological progression of AD. In Lewy body diseases (LBD), tau PET imaging has clearly revealed cortical tau burden with a distribution pattern distinct from AD and increased cortical binding within the LBD spectrum. In progressive supranuclear palsy, the globus pallidus and midbrain have shown increased binding most prominently. Tau PET patterns in patients with corticobasal syndrome are characterized by asymmetrical uptake in the motor cortex and underlying white matter, as well as in the basal ganglia. Even in the patients with multiple system atrophy, which is basically a synucleinopathy, 18F-flortaucipir, a widely used tau PET tracer, also binds to the atrophic posterior putamen, possibly due to off-target binding. These distinct patterns of tau-selective radiotracer binding in the various degenerative parkinsonisms suggest its utility as a potential imaging biomarker for the differential diagnosis of parkinsonisms.

Citations

Citations to this article as recorded by  
  • Current directions in tau research: Highlights from Tau 2020
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    Alzheimer's & Dementia.2022; 18(5): 988.     CrossRef
  • 18F‐Florzolotau Tau Positron Emission Tomography Imaging in Patients with Multiple System Atrophy–Parkinsonian Subtype
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    Movement Disorders.2022; 37(9): 1915.     CrossRef
  • Imaging pathological tau in atypical parkinsonisms: A review
    Anastassia M. Mena, Antonio P. Strafella
    Clinical Parkinsonism & Related Disorders.2022; 7: 100155.     CrossRef
  • Integrated 18F-T807 Tau PET, Structural MRI, and Plasma Tau in Tauopathy Neurodegenerative Disorders
    Cheng-Hsuan Li, Ta-Fu Chen, Ming-Jang Chiu, Ruoh-Fang Yen, Ming-Chieh Shih, Chin-Hsien Lin
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Dual-Phase 18F-FP-CIT PET in Corticobasal Syndrome
    Je Hong Min, Dong Gyu Park, Jung Han Yoon, Young Sil An
    Clinical Nuclear Medicine.2019; 44(1): e49.     CrossRef
  • Tau Positron-Emission Tomography in Former National Football League Players
    Robert A. Stern, Charles H. Adler, Kewei Chen, Michael Navitsky, Ji Luo, David W. Dodick, Michael L. Alosco, Yorghos Tripodis, Dhruman D. Goradia, Brett Martin, Diego Mastroeni, Nathan G. Fritts, Johnny Jarnagin, Michael D. Devous, Mark A. Mintun, Michael
    New England Journal of Medicine.2019; 380(18): 1716.     CrossRef

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