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JMD : Journal of Movement Disorders

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2 "Ji Eun Lee"
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Original Article
Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease
Hee Jin Kim, Ji Eun Lee, Soo Jeong Shin, Young Ho Sohn, Phil Hyu Lee
J Mov Disord. 2011;4(2):68-72.
DOI: https://doi.org/10.14802/jmd.11014
  • 11,680 View
  • 76 Download
  • 10 Citations
AbstractAbstract PDF
Background and Purpose

The substantia innominata (SI) contains the nucleus basalis of Meynert, which is the major source of cholinergic input to the cerebral cortex. We hypothesized that degeneration of the SI and its relationship to general cognitive performance differs in amyloidopathy and synucleinopathy.

Methods

We used magnetic resonance imaging (MRI)-based volumetric analysis to evaluate the SI volume in patients with amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD), Parkinson’s disease-mild cognitive impairment (PD-MCI), PD with dementia (PDD), dementia with Lewy bodies (DLB), and healthy elderly controls. The correlation between SI volume and general cognitive performance, measured using the Korean version of the Mini-Mental State Examination (K-MMSE), was examined.

Results

Compared to control subjects, the mean normalized SI volume was significantly decreased in all of the other groups. The normalized SI volume did not differ between the subjects with PDD and DLB, whereas it was significantly smaller in subjects with PDD (p = 0.029) and DLB (p = 0.011) compared with AD. In subjects with PD-related cognitive impairment (PD-MCI, PDD, or DLB), there was a significant positive correlation between the SI volume and K-MMSE score (r = 0.366, p < 0.001), whereas no correlation was seen in subjects with AD-related cognitive impairment (aMCI or AD).

Conclusions

Our data suggest that the SI loss is greater in synucleinopathy-related dementia (PDD or DLB) than in AD and that the contribution of the SI to cognitive performance is greater in synucleinopathy than in amyloidopathy.

Citations

Citations to this article as recorded by  
  • Manual and automated analysis of atrophy patterns in dementia with Lewy bodies on MRI
    Eya Khadhraoui, Sebastian Johannes Müller, Niels Hansen, Christian Heiner Riedel, Philip Langer, Charles Timäeus, Jens Wiltfang, Caroline Bouter, Claudia Lange, Marielle Ernst
    BMC Neurology.2022;[Epub]     CrossRef
  • Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer’s disease
    Julia Schumacher, Nicola J Ray, Calum A Hamilton, Paul C Donaghy, Michael Firbank, Gemma Roberts, Louise Allan, Rory Durcan, Nicola Barnett, John T O’Brien, John-Paul Taylor, Alan J Thomas
    Brain.2022; 145(5): 1773.     CrossRef
  • Metric magnetic resonance imaging analysis reveals pronounced substantia-innominata atrophy in dementia with Lewy bodies with a psychiatric onset
    Niels Hansen, Sebastian Johannes Müller, Eya Khadhraoui, Christian Heiner Riedel, Philip Langer, Jens Wiltfang, Charles-Arnold Timäus, Caroline Bouter, Marielle Ernst, Claudia Lange
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies
    Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
    NeuroImage: Clinical.2021; 30: 102604.     CrossRef
  • EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease
    Julia Schumacher, Alan J. Thomas, Luis R. Peraza, Michael Firbank, Ruth Cromarty, Calum A. Hamilton, Paul C. Donaghy, John T. O’Brien, John-Paul Taylor
    Alzheimer's Research & Therapy.2020;[Epub]     CrossRef
  • Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies
    Gabriel Santpere, Paula Garcia-Esparcia, Pol Andres-Benito, Belen Lorente-Galdos, Arcadi Navarro, Isidro Ferrer
    Brain Pathology.2018; 28(3): 315.     CrossRef
  • Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations
    Deepak Kumbhare, Viktoras Palys, Jamie Toms, Chathurika S. Wickramasinghe, Kasun Amarasinghe, Milos Manic, Evan Hughes, Kathryn L. Holloway
    Frontiers in Neuroscience.2018;[Epub]     CrossRef
  • Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms
    Paula Garcia-Esparcia, Irene López-González, Oriol Grau-Rivera, María Francisca García-Garrido, Anusha Konetti, Franc Llorens, Saima Zafar, Margarita Carmona, José Antonio del Rio, Inga Zerr, Ellen Gelpi, Isidro Ferrer
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Biomarkers for dementia and mild cognitive impairment in Parkinson's disease
    Manuel Delgado-Alvarado, Belén Gago, Irene Navalpotro-Gomez, Haritz Jiménez-Urbieta, María C. Rodriguez-Oroz
    Movement Disorders.2016; 31(6): 861.     CrossRef
  • Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease
    Alan King Lun Liu, Raymond Chuen-Chung Chang, Ronald K. B. Pearce, Steve M. Gentleman
    Acta Neuropathologica.2015; 129(4): 527.     CrossRef
Case Report
Chorea as an Initial Manifestation of Polycythemia Vera
Ji Eun Lee, Hae-Won Shin, Young H. Sohn
J Mov Disord. 2008;1(2):82-85.
DOI: https://doi.org/10.14802/jmd.08015
  • 9,942 View
  • 122 Download
AbstractAbstract PDF

Chorea is a rare complication of polycythemia vera (PV). We report a 58-year-old woman with acute onset chorea without structural lesion in the basal ganglia. The physical and laboratory findings were compatible with the diagnosis of PV. After repeated phlebotomies her chorea was improved. PV should be considered as one of the possible etiologies of chorea, as early diagnosis is important to lead to the effective treatment and prevention of complications.


JMD : Journal of Movement Disorders