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- Investigation of Nocturnal Hypokinesia and Health-Related Quality of Life in Parkinsonian Patients with the Korean Version of the Nocturnal Hypokinesia Questionnaire
- Ji-Hyun Choi, Jee-Young Lee, Chaewon Shin, Dallah Yoo, Jin Hee Im, Kyung Ah Woo, Han-Joon Kim, Tae-Beom Ahn, Jong-Min Kim, Beomseok Jeon
- J Mov Disord. 2021;14(3):221-225. Published online May 26, 2021
- DOI: https://doi.org/10.14802/jmd.20172
- 8,154 View
- 86 Download
- 6 Web of Science
- 6 Crossref
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Abstract
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Supplementary Material - Objective
To assess nocturnal hypokinesia using the Korean version of the Nocturnal Hypokinesia Questionnaire (NHQ-K) in Parkinson’s disease (PD) patients across disease stages.
Methods
We developed the NHQ-K and performed questionnaire-based interviews with 108 PD patients from three referral hospitals. Clinical associations of nocturnal hypokinesia and its impact on health-related quality of life (HRQoL) were also analyzed.
Results
The NHQ-K showed acceptable internal consistency (0.83) and interrater reliability (0.95). Nocturnal hypokinesia significantly affected HRQoL in PD patients at both the early and advanced stages (adjusted p < 0.001). Increased severity of nocturnal hypokinesia was associated with dyskinesias, off-period disability, apathy, and anxious mood in PD patients (adjusted p < 0.01) after controlling for disease severity and medication dose.
Conclusion
The NHQ-K is useful for screening nocturnal hypokinesia in PD patients. Given the high impact of nocturnal hypokinesia on HRQoL, comprehensive management of nocturnal disability is needed for PD patients. -
Citations
Citations to this article as recorded by
- Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs
Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R. Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A. Mestre, Alvaro Sanchez Ferro, Alberto J. Espay, Michelle H.S. Tosin, Matej
Movement Disorders Clinical Practice.2026; 13(5): 1124. CrossRef - Telerehabilitation for the treatment of nocturnal hypokinesia in people with Parkinson’s disease: a pilot study
Edoardo Bianchini, Francesco Bianchini, Pietro Lombardo, Silvia Galli, Flavia D’Audino, Marika Alborghetti, Domiziana Rinaldi
Neurological Sciences.2026;[Epub] CrossRef - Opicapone for the Treatment of Nocturnal Hypokinesia in Patients With Parkinson’s Disease: An Open-Label Pilot Clinical Trial
Chaewon Shin, Jong-Min Kim
Journal of Movement Disorders.2026; 19(1): 81. CrossRef - Digital Technology for Sleep Symptoms in Parkinson’s Disease: A Scoping Review
Kye Won Park, Ki-Young Jung, Han-Joon Kim, Jung Hwan Shin
Journal of Movement Disorders.2026; 19(2): 119. CrossRef - Deep profiling of nocturnal hypokinesia in multiple system atrophy and its clinical implications
Jongmok Ha, Suin Lee, Yoonha Hwang, Jinyoung Youn, Jin Whan Cho, Eun Yeon Joo
Sleep Medicine.2025; 131: 106516. CrossRef - Technological evaluation of strategies to get out of bed by people with Parkinson's disease: Insights from multisite wearable sensors
Jirada Sringean, Chusak Thanawattano, Roongroj Bhidayasiri
Frontiers in Medical Technology.2022;[Epub] CrossRef
- Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs
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