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Original Article
- Comparing Montreal Cognitive Assessment Performance in Parkinson’s Disease Patients: Age- and Education-Adjusted Cutoffs vs. Machine Learning
- Kyeongmin Baek, Young Min Kim, Han Kyu Na, Junki Lee, Dong Ho Shin, Seok-Jae Heo, Seok Jong Chung, Kiyong Kim, Phil Hyu Lee, Young H. Sohn, Jeehee Yoon, Yun Joong Kim
- J Mov Disord. 2024;17(2):171-180. Published online February 13, 2024
- DOI: https://doi.org/10.14802/jmd.23271
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- 2 Web of Science
- 3 Crossref
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Abstract
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Supplementary Material - Objective
The Montreal Cognitive Assessment (MoCA) is recommended for general cognitive evaluation in Parkinson’s disease (PD) patients. However, age- and education-adjusted cutoffs specifically for PD have not been developed or systematically validated across PD cohorts with diverse education levels.
Methods
In this retrospective analysis, we utilized data from 1,293 Korean patients with PD whose cognitive diagnoses were determined through comprehensive neuropsychological assessments. Age- and education-adjusted cutoffs were formulated based on 1,202 patients with PD. To identify the optimal machine learning model, clinical parameters and MoCA domain scores from 416 patients with PD were used. Comparative analyses between machine learning methods and different cutoff criteria were conducted on an additional 91 consecutive patients with PD.
Results
The cutoffs for cognitive impairment decrease with increasing age within the same education level. Similarly, lower education levels within the same age group correspond to lower cutoffs. For individuals aged 60–80 years, cutoffs were set as follows: 25 or 24 years for those with more than 12 years of education, 23 or 22 years for 10–12 years, and 21 or 20 years for 7–9 years. Comparisons between age- and education-adjusted cutoffs and the machine learning method showed comparable accuracies. The cutoff method resulted in a higher sensitivity (0.8627), whereas machine learning yielded higher specificity (0.8250).
Conclusion
Both the age- and education-adjusted cutoff methods and machine learning methods demonstrated high effectiveness in detecting cognitive impairment in PD patients. This study highlights the necessity of tailored cutoffs and suggests the potential of machine learning to improve cognitive assessment in PD patients. -
Citations
Citations to this article as recorded by
- Does cognition affect supervised and unsupervised mobility differently in people with Parkinson’s disease? A cross-sectional study
Edoardo Bianchini, Francesco Garramone, Domiziana Rinaldi, Marika Alborghetti, Lanfranco De Carolis, Silvia Galli, Antonio Suppa, Marco Salvetti, Clint Hansen, Nicolas Vuillerme
Journal of NeuroEngineering and Rehabilitation.2026;[Epub] CrossRef - A spatio-temporal fusion-based approach for multi-dimensional classification of Parkinson’s disease progression using multi-modal dataset
Vinay Kukreja, Vandana Ahuja, Modafar Ati, Hariharan Shanmugasundaram, Murugaperumal Krishnamoorthy, Rishabh Sharma, Abhishek Bhattacherjee
Results in Engineering.2025; 26: 105317. CrossRef - Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis
Hong Jiang, Xinling Yang, Wenxing Wang, Lin Jiang, Xiao’e Jiang
Frontiers in Aging Neuroscience.2025;[Epub] CrossRef
- Does cognition affect supervised and unsupervised mobility differently in people with Parkinson’s disease? A cross-sectional study
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