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Original Article
- Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy
- Jia Wei Hor, Shen-Yang Lim, Eng Soon Khor, Kah Kian Chong, Sze Looi Song, Norlinah Mohamed Ibrahim, Cindy Shuan Ju Teh, Chun Wie Chong, Ida Normiha Hilmi, Ai Huey Tan
- J Mov Disord. 2022;15(2):106-114. Published online December 24, 2021
- DOI: https://doi.org/10.14802/jmd.21085
- 8,407 View
- 367 Download
- 13 Web of Science
- 20 Crossref
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Abstract
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Supplementary Material - Objective
Converging evidence suggests that intestinal inflammation is involved in the pathogenesis of neurodegenerative diseases. Previous studies on fecal calprotectin in Parkinson’s disease (PD) were limited by small sample sizes, and literature regarding intestinal inflammation in multiple system atrophy (MSA) is very scarce. We investigated the levels of fecal calprotectin, a marker of intestinal inflammation, in PD and MSA.
Methods
We recruited 169 subjects (71 PD, 38 MSA, and 60 age-similar nonneurological controls). Clinico-demographic data were collected. PD and MSA were subtyped and the severity assessed using the MDS-UPDRS and UMSARS, respectively. Fecal calprotectin and blood immune markers were analyzed.
Results
Compared to controls (median: 35.7 [IQR: 114.2] μg/g), fecal calprotectin was significantly elevated in PD (median: 95.6 [IQR: 162.1] μg/g, p = 0.003) and even higher in MSA (median: 129.5 [IQR: 373.8] μg/g, p = 0.002). A significant interaction effect with age was observed; between-group differences were significant only in older subjects (i.e., ≥ 61 years) and became more apparent with increasing age. A total of 28.9% of MSA and 18.3% of PD patients had highly abnormal fecal calprotectin levels (≥ 250 μg/g); however, this difference was only significant for MSA compared to controls. Fecal calprotectin correlated moderately with selected blood immune markers in PD, but not with clinical features of PD or MSA.
Conclusions
Elevated fecal calprotectin suggests a role for intestinal inflammation in PD and MSA. A more complete understanding of gut immune alterations could open up new avenues of research and treatment for these debilitating diseases. -
Citations
Citations to this article as recorded by
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Nishant Sharma, Monika Sharma, Disha Thakkar, Hemant Kumar, Sona Smetanova, Lucie Buresova, Petr Andrla, Amit Khairnar
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Marta Leńska-Mieciek, Natalia Madetko-Alster, Piotr Alster, Leszek Królicki, Urszula Fiszer, Dariusz Koziorowski
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Amica C. Müller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorová, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya
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Laura Ghezzi, Claudia Cantoni, Emanuela Rotondo, Daniela Galimberti
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- Chronic DSS-Induced Colitis Exacerbates Parkinson’s Disease Phenotype and Its Pathological Features Following Intragastric Rotenone Exposure
Letter to the editor
- Chorea in Sporadic Creutzfeldt-Jakob Disease
- Ai Huey Tan, Tsun Haw Toh, Soon Chai Low, Si Lei Fong, Kah Kian Chong, Kee Wei Lee, Khean Jin Goh, Shen-Yang Lim
- J Mov Disord. 2018;11(3):149-151. Published online August 9, 2018
- DOI: https://doi.org/10.14802/jmd.18017
- 7,031 View
- 151 Download
- 3 Web of Science
- 4 Crossref
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PDFSupplementary Material
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Citations
Citations to this article as recorded by- Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature
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Clinical Case Reports.2024;[Epub] CrossRef - Atypical and early symptoms of sporadic Creutzfeldt – Jakob disease: case series and review of the literature
Grammatiki Katsikaki, Ioannis E. Dagklis, Petros Angelopoulos, Dimitrios Ntantos, Angeliki Prevezianou, Sevasti Bostantjopoulou
International Journal of Neuroscience.2021; 131(9): 927. CrossRef - Review of Hereditary and Acquired Rare Choreas
Daniel Martinez-Ramirez, Ruth H. Walker, Mayela Rodríguez-Violante, Emilia M. Gatto
Tremor and Other Hyperkinetic Movements.2020;[Epub] CrossRef - A Case of Creutzfeldt-Jakob Disease Presented as Rapid Progressive Parkinsonism
Yoonah Park, Chan-Nyeong Lee
Dementia and Neurocognitive Disorders.2019; 18(4): 152. CrossRef
- Parkinsonism as an initial presentation of Creutzfeldt‐Jakob disease: A case report and review of literature
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