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Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD).
We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.
The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.
This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.
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A decreased cardiac 123I-metaiodobenzylguanidine (123I-MIBG) uptake has been used as a powerful tool to identify Lewy body disease, such as idiopathic parkinson’s disease (IPD). We performed cardiac 123I-MIBG scintigraphy in patient with autosomal recessive juvenile parkinsonism (ARJP) with
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Abnormal muscle tone, such as spasm s, rigidity, and stiffness, following acute transverse myelitis (ATM) was such a rare manifestation that hardly reported until now. We experienced a 50-year-old patient with ATM associated with Sjögren’s syndrome. Furthermore, the patients complained painful spasms and rigidity of left lower limb which begun after episode of ATM.
We report a 70-year-old man who manifested with hemidystonia associated with focal status epilepticus. The subsequent clinical symptoms and signs including rapid progressive dementia, and generalized myoclonus and the presence of 14-3-3 protein in cerebrospinal fluid, typical magnetic resonance imaging and eletroencephalography findings provide the evidences for diagnosis of probable Creutzfeldt-Jakob disease (CJD). Movement disorders or epilepsy rarely occur in the early stage of CJD. Furthermore, co-occurrence of both disorders in the early stage has been hardly reported. To the best of the authors’ knowledge, this is the first report in Korea of CJD presenting as dystonia. Our case suggests that CJD can present with a variety of movement disorders.