Journal of Movement Disorders

Case Report

Treatment of Gait Ignition Failure with Ropinirole: Alexis N. Cohen-Oram, Jonathan T. Stewart, Kim Bero, Michael W. Hoffmann; J Mov Disord. 2014;7(2):95-98. Published online October 30, 2014; DOI: https://doi.org/10.14802/jmd.14014

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Gait ignition failure (GIF) is a syndrome characterized by hesitation or inability to initiate gait from a static position. It may occur in a variety of conditions, including normal pressure hydrocephalus, subcortical vascular disease, parkinsonian syndromes and a variety of focal lesions. Previous information on the treatment of GIF has been primarily anecdotal, but there have been a few reports of response to dopamine agonists. We report a 63-year-old man with anoxic encephalopathy who developed GIF nine years after the initial anoxic insult. The patient’s GIF responded robustly, albeit transiently, to ropinirole. MRI was unrevealing, but a positron emission tomography scan showed hypometabolism in the deep frontal ACA/MCA watershed area; this may have disconnected the basal ganglia from the motor cortex and/or interrupted dopaminergic mesocortical transmission. Our understanding of the pathophysiology and the treatment of GIF remains limited, but there may be at least a limited therapeutic role for dopamine agonists.

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Gait Ignition Failure in JNPL3 Human Tau-mutant Mice
HoChung Jang, Jung Hwa Ryu, Kyung Min Shin, Na-young Seo, Gyu Hyun Kim, Yang Hoon Huh, Ae Nim Pae, Kea Joo Lee
Experimental Neurobiology.2019; 28(3): 404. CrossRef

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