Journal of Movement Disorders

Original Articles

Association Between Statin Use and Mortality in Adults With Parkinson’s Disease: A Nationwide Cohort Study: Mincheol Park, Hokyung Lee, Yeonju Jin, Sanghee Yoo, Sung-Woo Kim, Sojeong Park, Jiwon Hong, Jin Yong Hong, Ickpyo Hong, Min Seok Baek; J Mov Disord. 2026;19(2):157-166. Published online January 20, 2026; DOI: https://doi.org/10.14802/jmd.25240

922 View
58 Download
1 Crossref

Objective
The impact of statin use on the progression and survival of patients with Parkinson’s disease (PD) remains unclear. Moreover, evidence in Asian populations is limited. This study aimed to assess the associations between statin prescription, cumulative dosage, and all-cause mortality in PD patients.
Methods
This retrospective cohort study was conducted using sample data obtained from the Korean National Health Insurance Service (KNHIS) claims database. The study included 3,152 adults who were diagnosed with PD and whose history of statin use and cumulative dose information were obtained from claims records. Data were collected from the KNHIS database, and all eligible participants were followed longitudinally to determine all-cause mortality. The primary outcome was all-cause mortality, and the exposures were statin use (yes or no) and cumulative dose. The analysis was conducted using Cox proportional hazards regression adjusted for relevant covariates.
Results
Statin use was associated with a lower risk of all-cause mortality (hazard ratio [HR], 0.600; 95% confidence interval [CI], 0.521–0.691). Among statin users, a higher cumulative statin dose was linked to a further reduction in mortality (HR, 0.800; 95% CI, 0.761–0.842).
Conclusion
Statin use and increased cumulative exposure were associated with reduced all-cause mortality in patients with PD, and these findings suggest a potential survival benefit and warrant further investigation in diverse populations.

Citations

Citations to this article as recorded by

Lovastatin Potentiates the Function of α7-Nicotinic Acetylcholine Receptors
Dmytro Isaev, Keun-Hang Susan Yang, Murat Oz
Pharmaceuticals.2026; 19(6): 849. CrossRef

Gait Parameters in Healthy Older Adults in Korea: Han-Kyeol Kim, Sung-Woo Kim, Jin Yong Hong, Min Seok Baek; J Mov Disord. 2025;18(1):55-64. Published online November 25, 2024; DOI: https://doi.org/10.14802/jmd.24181

7,425 View
237 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material

Objective
Gaits constitute the most fundamental and common form of human locomotion and are essential in daily activities. We aimed to investigate gait parameters in medically and cognitively healthy older adults to determine the independent effects of age, physical attributes, and cognition on these parameters.
Methods
This retrospective study enrolled healthy older adult participants aged 50 years or older with normal cognition and no neurological symptoms or medical/surgical history that could affect gait. Quantitative gait analysis was conducted via the GAITRite Electronic Walkway, which categorizes gait parameters into spatiotemporal, spatial, temporal, phase, and variability. Gait parameters were compared between sexes across different age groups. The independent effects of age, Mini-Mental State Examination score, and physical characteristics were analyzed via a multiple regression model.
Results
This study included 184 participants with an average age of 72.2 years. After adjusting for age, height, and footwear, only the base width and its variability differed between the sexes. Gait parameters varied significantly among different age groups, revealing multiple interparameter associations. Age was independently correlated with decreased velocity, step and stride lengths, single support time percentage and increased double support time, double support time percentage, and variability parameters, excluding the coefficient of variance of base width. Height was positively correlated with velocity, step and stride lengths, and base width, whereas leg length was negatively associated with cadence and positively associated with temporal parameters of gait.
Conclusion
Gait parameters in healthy older adults were not only associated with age and physical characteristics but also had interparameter correlations.

Citations

Citations to this article as recorded by

Relationship between joint angles and gait parameters in healthy older adults aged 60 ~ 80 years
Zhisheng Zhang, Xinyi Deng, Huihui Wu, Yue Liu, Tieyi Yang
Frontiers in Public Health.2026;[Epub] CrossRef

Letters to the editor

Factors associated with anticholinergic-induced oral-buccal-lingual dyskinesia in Parkinson’s disease: Joonyoung Ha, Suk Yun Kang, Kyoungwon Baik, Young H. Sohn, Phil Hyu Lee, Min Seok Baek, Jin Yong Hong; J Mov Disord. 2024;17(1):109-111. Published online September 22, 2023; DOI: https://doi.org/10.14802/jmd.23069

3,287 View
98 Download

PDF Supplementary Material

Asymmetric Parkinsonism With Progressive Nigrosomal Change Secondary to Kernohan’s Notch Phenomenon: Han-Kyeol Kim, Min Seok Baek, Sung Jun Ahn, Chul Hyoung Lyoo; J Mov Disord. 2022;15(2):184-186. Published online March 16, 2022; DOI: https://doi.org/10.14802/jmd.21162

3,828 View
127 Download

PDF

Case Report

A Patient with Recurrent Dyskinesia and Hyperpyrexia Syndrome: Min Seok Baek, Hyung Woo Lee, Chul Hyoung Lyoo; J Mov Disord. 2017;10(3):154-157. Published online July 14, 2017; DOI: https://doi.org/10.14802/jmd.17022

11,470 View
207 Download
8 Web of Science
8 Crossref

Abstract PDF

Dyskinesia hyperpyrexia syndrome is a rare medical emergency in Parkinson’s disease. It is characterized by continuous dyskinesia associated with hyperthermia, rhabdomyolysis, and alteration of the mental state. We present the case of a 74-year-old woman who presented with recurrent dyskinesia hyperpyrexia syndrome. Although some provocation factors and clinical manifestations seem to be shared with parkinsonism hyperpyrexia syndrome, a clear distinction in management should be considered.

Citations

Citations to this article as recorded by

Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease May Benefit from GPi Deep Brain Stimulation: A Case Report
Shi-Shi Huang, Lu-Lu Ma, Han-Song Sheng, Rong-Pei Liu, Shi-Guo Zhu, Shan-Shan Xu, Mei-Ling Sheng, Zhu-Ling Chen, Nu Zhang, Xiong Zhang, Jian-Yong Wang
Tremor and Other Hyperkinetic Movements.2025; 15: 20. CrossRef
Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa — a case report and literature review
Xiangnan Du, Xuemei Wang, Xiaokun Geng
Frontiers in Neurology.2024;[Epub] CrossRef
Case report: Reversible encephalopathy caused by dyskinesia-hyperpyrexia syndrome
Bohan Luo, Hainan Zhang, Lixia Qin
Frontiers in Neurology.2023;[Epub] CrossRef
Parkinsonism-Hyperpyrexia Syndrome and Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease: Two Cases and Literature Review
Jian-Yong Wang, Jie-Fan Huang, Shi-Guo Zhu, Shi-Shi Huang, Rong-Pei Liu, Bei-Lei Hu, Jian-Hong Zhu, Xiong Zhang
Journal of Parkinson's Disease.2022; 12(6): 1727. CrossRef
Dyskinesia-hyperpyrexia syndrome triggered by overdose of istradefylline: a case report
Shota Komori, Takashi Tsuboi, Masashi Suzuki, Tomohiko Nakamura, Masahisa Katsuno
Rinsho Shinkeigaku.2022; 62(8): 627. CrossRef
Dyskinesia-hyperpyrexia syndrome in Parkinson’s disease: a systematic review
Miao Wang, Wei Wang, Zhongbao Gao, Xi Yin, Tong Chen, Ziying Jiang, Zhenfu Wang
Clinical Autonomic Research.2021; 31(4): 529. CrossRef
Rhabdomyolysis Associated with Severe Levodopa-Induced Dyskinesia in Parkinson’s Disease: A Report of Two Cases and Literature Review
Yuvadee Pitakpatapee, Jindapa Srikajon, Tanita Sangpeamsook, Prachaya Srivanitchapoom
Tremor and Other Hyperkinetic Movements.2021;[Epub] CrossRef
Dyskinesia‐Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock–Related Emergency?
Marianna Sarchioto, Valeria Ricchi, Marta Melis, Marcello Deriu, Roberta Arca, Maurizio Melis, Francesca Morgante, Giovanni Cossu
Movement Disorders Clinical Practice.2018; 5(5): 534. CrossRef

First
Prev
Page of 1
Next
Last

Search