The hot cross bun sign is characterized by cruciform T2 signal hyperintensity in the pons and has been reported to be a specific but not pathognomic for multiple system atrophy. It reflects degeneration of pontine neurons and transverse pontocerebellar fibers, regardless of the underlying pathogenic process. Here, we report a case of hot cross bun sign following bilateral pontine infarction due to Wallerian degeneration of the pontocerebellar fibers.

Citations

Citations to this article as recorded by  

• A case of bilateral middle cerebellar peduncle infarction with hot cross bun sign
  Daisuke Kuzume, Yuko Morimoto, Satoshi Tsutsumi, Masahiro Yamasaki, Naohisa Hosomi
  Rinsho Shinkeigaku.2024; 64(3): 190.     CrossRef
• Hot Cross Bun Sign in Bilateral Middle Cerebellar Peduncle Infarction
  Katsuya Nishida, Naonobu Futamura
  Stroke.2023;[Epub]     CrossRef
• Hot Cross Bun Sign in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
  Chen Ling, Haotian Yan, Yun Yuan, Qing Peng
  Stroke.2023;[Epub]     CrossRef
• “Hot Cross Bun” Sign in a Patient with Glutamic Acid Decarboxylase 65-KDa Isoform Associated Cerebellar Ataxia: Case Report and Review of the Literature
  Ruo-Nan Duan, Jing-Zhen He, Li-Li Cao
  The Cerebellum.2023; 23(3): 1204.     CrossRef
• The “hot cross bun sign” in patients with autoimmune cerebellar ataxia: A case report and literature review
  Mange Liu, Haitao Ren, Nan Lin, Ying Tan, Siyuan Fan, Hongzhi Guan
  Frontiers in Neurology.2022;[Epub]     CrossRef
• The “Hot Cross Bun Sign” in Spinocerebellar Ataxia Types 2 and 7–Case Reports and Review of Literature
  Ansuya Kasavelu Naidoo, Cait‐Lynn Deanne Wells, Yashvir Rugbeer, Neil Naidoo
  Movement Disorders Clinical Practice.2022; 9(8): 1105.     CrossRef
• Multiple system atrophy mimicry in MRI: Watch out for paraneoplastic rhombencephalitis
  Elena Schlapakow, Vera C. Keil, Marie Paus, Cornelia Kornblum, Elke Hattingen, Thomas Klockgether
  Journal of Clinical Neuroscience.2020; 76: 238.     CrossRef
• Various Diseases and Clinical Heterogeneity Are Associated With “Hot Cross Bun”
  Shuzhen Zhu, Hualing Li, Bin Deng, Jialing Zheng, Zifeng Huang, Zihan Chang, Yanjun Huang, Zhibo Wen, Yanran Liang, Mengjue Yu, Ling-Ling Chan, Eng-King Tan, Qing Wang
  Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
• The ‘Hot Cross Bun’ Sign Is Not Always Multiple System Atrophy: Etiologies of 11 Cases
  Christopher Way, David Pettersson, Amie Hiller
  Journal of Movement Disorders.2019; 12(1): 27.     CrossRef
• Role of Magnetic Resonance Imaging in the Diagnosis of Multiple System Atrophy
  Han‐Joon Kim, Beomseok Jeon, Victor S.C. Fung
  Movement Disorders Clinical Practice.2017; 4(1): 12.     CrossRef
• Paraneoplastic neurological syndrome due to burned-out testicular tumor showing hot cross-bun sign
  H. Ishikawa, N. Kawada, A. Taniguchi, K. Odachi, A. Mizutani, M. Asahi, H. Tomimoto
  Acta Neurologica Scandinavica.2016; 133(5): 398.     CrossRef
• Diagnosis and differential diagnosis of MSA: boundary issues
  Han-Joon Kim, Beom S. Jeon, Kurt A. Jellinger
  Journal of Neurology.2015; 262(8): 1801.     CrossRef

There were few cases of thrombocytopenia associated with levodopa. Herein, we report a patient with Parkinson’s disease, who suffered thrombocytopenia related to long-term use of levodopa.

Citations

Citations to this article as recorded by  

• A 70-year-old male exhibiting parkinsonism-hyperpyrexia syndrome during levodopa carbidopa intestinal gel (LCIG) treatment and suspected carbidopa allergy due to positive drug-induced lymphocyte stimulation test (DLST)
  Aya Kawanami, Masanobu Miyashita, Yuichi Miyagi, Kazuko Hasegawa
  Rinsho Shinkeigaku.2024; 64(1): 17.     CrossRef
• Acute Thrombocytopenia Likely Induced by Apomorphine: A Case Report
  Clément Martinie De Maisonneuve, Valentin Mira, Romain Muller, Jean‐Philippe Azulay, Guillaume Hache
  Movement Disorders Clinical Practice.2024;[Epub]     CrossRef
• Dysregulated Coagulation in Parkinson’s Disease
  Xinqing Wang, Wenxin Li, Xinyue Zhao, Ning Hu, Xi Wang, Xilin Xiao, Kai Yang, Taolei Sun
  Cells.2024; 13(22): 1874.     CrossRef
• High rates of blood transfusion associated with Parkinson’s disease
  Shane Shahrestani, Julian Gendreau, Ali R. Tafreshi, Nolan J. Brown, Khashayar Dashtipour
  Neurological Sciences.2022; 43(8): 4761.     CrossRef
• Platelet abnormalities in patients with Parkinson's disease undergoing preoperative evaluation for deep brain stimulation
  Sheng-Che Chou, Chun-Hwei Tai, Sheng-Hong Tseng
  Scientific Reports.2022;[Epub]     CrossRef