Journal of Movement Disorders

Original Articles

Association Between Statin Use and Mortality in Adults With Parkinson’s Disease: A Nationwide Cohort Study: Mincheol Park, Hokyung Lee, Yeonju Jin, Sanghee Yoo, Sung-Woo Kim, Sojeong Park, Jiwon Hong, Jin Yong Hong, Ickpyo Hong, Min Seok Baek; J Mov Disord. 2026;19(2):157-166. Published online January 20, 2026; DOI: https://doi.org/10.14802/jmd.25240

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Objective
The impact of statin use on the progression and survival of patients with Parkinson’s disease (PD) remains unclear. Moreover, evidence in Asian populations is limited. This study aimed to assess the associations between statin prescription, cumulative dosage, and all-cause mortality in PD patients.
Methods
This retrospective cohort study was conducted using sample data obtained from the Korean National Health Insurance Service (KNHIS) claims database. The study included 3,152 adults who were diagnosed with PD and whose history of statin use and cumulative dose information were obtained from claims records. Data were collected from the KNHIS database, and all eligible participants were followed longitudinally to determine all-cause mortality. The primary outcome was all-cause mortality, and the exposures were statin use (yes or no) and cumulative dose. The analysis was conducted using Cox proportional hazards regression adjusted for relevant covariates.
Results
Statin use was associated with a lower risk of all-cause mortality (hazard ratio [HR], 0.600; 95% confidence interval [CI], 0.521–0.691). Among statin users, a higher cumulative statin dose was linked to a further reduction in mortality (HR, 0.800; 95% CI, 0.761–0.842).
Conclusion
Statin use and increased cumulative exposure were associated with reduced all-cause mortality in patients with PD, and these findings suggest a potential survival benefit and warrant further investigation in diverse populations.

Citations

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Lovastatin Potentiates the Function of α7-Nicotinic Acetylcholine Receptors
Dmytro Isaev, Keun-Hang Susan Yang, Murat Oz
Pharmaceuticals.2026; 19(6): 849. CrossRef

Gait Parameters in Healthy Older Adults in Korea: Han-Kyeol Kim, Sung-Woo Kim, Jin Yong Hong, Min Seok Baek; J Mov Disord. 2025;18(1):55-64. Published online November 25, 2024; DOI: https://doi.org/10.14802/jmd.24181

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Abstract PDF Supplementary Material

Objective
Gaits constitute the most fundamental and common form of human locomotion and are essential in daily activities. We aimed to investigate gait parameters in medically and cognitively healthy older adults to determine the independent effects of age, physical attributes, and cognition on these parameters.
Methods
This retrospective study enrolled healthy older adult participants aged 50 years or older with normal cognition and no neurological symptoms or medical/surgical history that could affect gait. Quantitative gait analysis was conducted via the GAITRite Electronic Walkway, which categorizes gait parameters into spatiotemporal, spatial, temporal, phase, and variability. Gait parameters were compared between sexes across different age groups. The independent effects of age, Mini-Mental State Examination score, and physical characteristics were analyzed via a multiple regression model.
Results
This study included 184 participants with an average age of 72.2 years. After adjusting for age, height, and footwear, only the base width and its variability differed between the sexes. Gait parameters varied significantly among different age groups, revealing multiple interparameter associations. Age was independently correlated with decreased velocity, step and stride lengths, single support time percentage and increased double support time, double support time percentage, and variability parameters, excluding the coefficient of variance of base width. Height was positively correlated with velocity, step and stride lengths, and base width, whereas leg length was negatively associated with cadence and positively associated with temporal parameters of gait.
Conclusion
Gait parameters in healthy older adults were not only associated with age and physical characteristics but also had interparameter correlations.

Citations

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Relationship between joint angles and gait parameters in healthy older adults aged 60 ~ 80 years
Zhisheng Zhang, Xinyi Deng, Huihui Wu, Yue Liu, Tieyi Yang
Frontiers in Public Health.2026;[Epub] CrossRef

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