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- Secondary Dystonia-Clinical Clues and Syndromic Associations
- Susanne A Schneider, Kailash P Bhatia
- J Mov Disord. 2009;2(2):58-63.
- DOI: https://doi.org/10.14802/jmd.09016
- 18,268 View
- 420 Download
- 10 Crossref
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Abstract
PDF Background: Dystonia is a hyperkinetic movement disorder defined by involuntary sustained muscle spasms and unusual postures. Etiologically, dystonic syndromes can be broadly divided into primary and secondary forms, dystonia-plus syndromes and heredodegenerative forms. In particular, diagnosis of secondary dystonic syndromes can be challenging in view of the variety of causes.
Purpose: The purpose of this article is to highlight some clinical clues and syndromic associations as well as investigational findings which may be helpful in the approach to a patient with suspected secondary dystonia.
Methods: We outline characteristic clinical and neuroimaging findings which may be directive in the diagnostic process of dystonia patients and facilitate making the correct diagnosis, thus allowing initiating the best treatment.
Results: Secondary causes of dystonia include, among others, strategic brain lesions of various origins, metabolic disease, neurodegenerative conditions, and previous exposure to drugs or toxins. Presence of clinical signs including prominent oromandibular involvement, eye movement disorders, retinitis pigmentosa, deafness, peripheral neuropathy, parkinsonism or progressive dementia should alert the clinician to consider a secondary cause. Strategic lesions within the basal ganglia, but also within the brainstem, cerebellum or cortical areas may underlie dystonia and should thus be excluded.
Conclusions: When thorough clinical examination reveals features atypical of primary dystonia, syndromic associations may help the clinician to narrow down the list of differential diagnosis. Directive investigations like neuroimaging may confirm the clinical suspicion.
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Citations
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- Generalized Chorea Induced by an Unilateral Anterior Cerebral Artery Territorial Infarction
- Jae Hong Chang, Woo-Keun Seo, Moon-Ho Park, Jong-Mun Lee, Do-Young Kwon, Seong-Beom Koh
- J Mov Disord. 2009;2(1):37-39.
- DOI: https://doi.org/10.14802/jmd.09009
- 8,947 View
- 85 Download
- 3 Crossref
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Abstract
PDF
Generalized chorea caused by unilateral cerebral infarction has rarely been reported. A 58-year-old woman presented involuntary movement in her all extremities after acute cerebral infarction on her right anterior cerebral artery territory. The involuntary movements were diagnosed as generalized chorea. We didn’t find any cause of generalized chorea except the acute cerebral infarction. Here, we described the case of generalized chorea after unilateral cerebral infarction discussing the possible mechanisms.
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Citations
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Jingjing Yi, Lingru Zhang, Tao Zhang, Jianfeng Li, Yifan Zhang, Meining Zhou
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Frontiers in Neurology.2022;[Epub] CrossRef - Acute Hemichorea as an Unusual Presentation of Internal Carotid Artery Stenosis
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Journal of Movement Disorders.2013; 6(1): 17. CrossRef
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