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Case Report
A Case of Abnormal Postures in the Left Extremities after Pontine Hemorrhage: Dystonia or Pseudodystonia?
Chan Wook Park, Seok Jong Chung, Young H. Sohn, Phil Hyu Lee
J Mov Disord. 2020;13(1):62-65.   Published online January 31, 2020
DOI: https://doi.org/10.14802/jmd.19074
  • 4,926 View
  • 127 Download
  • 2 Crossref
AbstractAbstract PDFSupplementary Material
It is difficult to determine the pathoanatomical correlates of dystonia because of its complex pathophysiology, and most cases with secondary dystonia are associated with basal ganglia lesions. Moreover, it is a challenging issue that patients with abnormal postures accompanied by other neurological findings in the affected body part (e.g., sensory loss) can be diagnosed with true dystonia or pseudodystonia. Here, we report a case of abnormal postures with loss of proprioception in the left extremities after right dorsal pontine hemorrhage.

Citations

Citations to this article as recorded by  
  • Rehabilitation of hemidystonia as a result of right pontine hemorrhagic stroke
    Melanie Aing, Craig DiTommaso
    The Journal of the International Society of Physical and Rehabilitation Medicine.2023; 6(4): 116.     CrossRef
  • Hemidystonia after Pontine Hemorrhage Successfully Treated with Pharmacotherapy and Intensive Rehabilitation: a Case Report
    Gyu Seong Kim, Yeon Gyu Jeong, Yoon Jeong Jeong, Seo Yeon Yoon
    Brain & Neurorehabilitation.2021;[Epub]     CrossRef
Original Articles
Automated Brainstem Segmentation Detects Differential Involvement in Atypical Parkinsonian Syndromes
Martina Bocchetta, Juan Eugenio Iglesias, Viorica Chelban, Edwin Jabbari, Ruth Lamb, Lucy L. Russell, Caroline V. Greaves, Mollie Neason, David M. Cash, David L. Thomas, Jason D. Warren, John Woodside, Henry Houlden, Huw R. Morris, Jonathan D. Rohrer
J Mov Disord. 2020;13(1):39-46.   Published online September 26, 2019
DOI: https://doi.org/10.14802/jmd.19030
  • 7,463 View
  • 241 Download
  • 15 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary Material
Objective
Brainstem segmentation has been useful in identifying potential imaging biomarkers for diagnosis and progression in atypical parkinsonian syndromes (APS). However, the majority of work has been performed using manual segmentation, which is time consuming for large cohorts.
Methods
We investigated brainstem involvement in APS using an automated method. We measured the volume of the medulla, pons, superior cerebellar peduncle (SCP) and midbrain from T1-weighted MRIs in 67 patients and 42 controls. Diagnoses were corticobasal syndrome (CBS, n = 14), multiple system atrophy (MSA, n = 16: 8 with parkinsonian syndrome, MSA-P; 8 with cerebellar syndrome, MSA-C), progressive supranuclear palsy with a Richardson’s syndrome (PSP-RS, n = 12), variant PSP (n = 18), and APS not otherwise specified (APS-NOS, n = 7).
Results
All brainstem regions were smaller in MSA-C (19–42% volume difference, p < 0.0005) and in both PSP groups (18–33%, p < 0.0005) than in controls. MSA-P showed lower volumes in all regions except the SCP (15–26%, p < 0.0005). The most affected region in MSA-C and MSA-P was the pons (42% and 26%, respectively), while the most affected regions in both the PSP-RS and variant PSP groups were the SCP (33% and 23%, respectively) and midbrain (26% and 24%, respectively). The brainstem was less affected in CBS, but nonetheless, the pons (14%, p < 0.0005), midbrain (14%, p < 0.0005) and medulla (10%, p = 0.001) were significantly smaller in CBS than in controls. The brainstem was unaffected in APS-NOS.
Conclusion
Automated methods can accurately quantify the involvement of brainstem structures in APS. This will be important in future trials with large patient numbers where manual segmentation is unfeasible.

Citations

Citations to this article as recorded by  
  • Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study
    Agnès Pérez-Millan, Sergi Borrego-Écija, John C. van Swieten, Lize Jiskoot, Fermin Moreno, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik
    Journal of Neurology.2023; 270(3): 1573.     CrossRef
  • Comparative validation of AI and non-AI methods in MRI volumetry to diagnose Parkinsonian syndromes
    Joomee Song, Juyoung Hahm, Jisoo Lee, Chae Yeon Lim, Myung Jin Chung, Jinyoung Youn, Jin Whan Cho, Jong Hyeon Ahn, Kyungsu Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Identification of the pathogenesis features of various phenotypes of multiple sclerosis based on the study of the morphological functional connectivity of subcortical gray matter structures
    A. G. Trufanov, A. Y. Polushin, E. A. Gorbunova, M. V. Lukin
    Russian Journal for Personalized Medicine.2023; 3(1): 27.     CrossRef
  • Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort
    Martina Bocchetta, Emily G Todd, Arabella Bouzigues, David M Cash, Jennifer M Nicholas, Rhian S Convery, Lucy L Russell, David L Thomas, Ian B Malone, Juan Eugenio Iglesias, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Barbara Borroni, Daniela Galim
    Brain Communications.2023;[Epub]     CrossRef
  • Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis: Study design
    Samy Abo Seada, Anke W. van der Eerden, Agnita J.W. Boon, Juan A. Hernandez-Tamames
    NeuroImage: Clinical.2023; 39: 103506.     CrossRef
  • Neuroimaging correlates of brain injury in Wilson’s disease: a multimodal, whole-brain MRI study
    Samuel Shribman, Martina Bocchetta, Carole H Sudre, Julio Acosta-Cabronero, Maggie Burrows, Paul Cook, David L Thomas, Godfrey T Gillett, Emmanuel A Tsochatzis, Oliver Bandmann, Jonathan D Rohrer, Thomas T Warner
    Brain.2022; 145(1): 263.     CrossRef
  • Nuclear imaging in Parkinson's disease: The past, the present, and the future
    Haim Golan, Olga Volkov, Eli Shalom
    Journal of the Neurological Sciences.2022; 436: 120220.     CrossRef
  • Criteria-unfulfilled multiple system atrophy at an initial stage exhibits laterality of middle cerebellar peduncles
    Minori Furuta, Masayuki Sato, Setsuki Tsukagoshi, Yoshito Tsushima, Yoshio Ikeda
    Journal of the Neurological Sciences.2022; 438: 120281.     CrossRef
  • A data-driven model of brain volume changes in progressive supranuclear palsy
    W. J. Scotton, M. Bocchetta, E. Todd, D. M. Cash, N. Oxtoby, L. VandeVrede, H. Heuer, D. C. Alexander, J. B. Rowe, H. R. Morris, A. Boxer, J. D. Rohrer, P. A. Wijeratne
    Brain Communications.2022;[Epub]     CrossRef
  • Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease
    Samuel Shribman, Maggie Burrows, Rhian Convery, Martina Bocchetta, Carole H. Sudre, Julio Acosta‐Cabronero, David L. Thomas, Godfrey T. Gillett, Emmanuel A. Tsochatzis, Oliver Bandmann, Jonathan D. Rohrer, Thomas T. Warner
    Movement Disorders.2022; 37(8): 1728.     CrossRef
  • Corticobasal syndrome and Parkinson’s disease at the beginning: asymmetrical patterns of MRI and Blink Reflex for early diagnosis
    Giulia Donzuso, Giorgia Sciacca, Antonina Luca, Calogero E. Cicero, Giovanni Mostile, Alessandra Nicoletti, Mario Zappia
    Journal of Neural Transmission.2022; 129(12): 1427.     CrossRef
  • Eye movements and association with regional brain atrophy in clinical subtypes of progressive supranuclear palsy
    Ji-Hyun Choi, Heejung Kim, Jung Hwan Shin, Jee-Young Lee, Han-Joon Kim, Jong-Min Kim, Beomseok Jeon
    Journal of Neurology.2021; 268(3): 967.     CrossRef
  • Artificial intelligence applied to neuroimaging data in Parkinsonian syndromes: Actuality and expectations
    Annalisa Vitale, Rossella Villa, Lorenzo Ugga, Valeria Romeo, Arnaldo Stanzione, Renato Cuocolo
    Mathematical Biosciences and Engineering.2021; 18(2): 1753.     CrossRef
  • Differential early subcortical involvement in genetic FTD within the GENFI cohort
    Martina Bocchetta, Emily G. Todd, Georgia Peakman, David M. Cash, Rhian S. Convery, Lucy L. Russell, David L. Thomas, Juan Eugenio Iglesias, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Ro
    NeuroImage: Clinical.2021; 30: 102646.     CrossRef
  • Quantitative MRI markers in Parkinson's disease and parkinsonian syndromes
    Germain Arribarat, Patrice Péran
    Current Opinion in Neurology.2020; 33(2): 222.     CrossRef
Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson’s Disease
Kuldeep Shetty, Syam Krishnan, Jissa Vinoda Thulaseedharan, Manju Mohan, Asha Kishore
J Mov Disord. 2019;12(2):84-90.   Published online April 5, 2019
DOI: https://doi.org/10.14802/jmd.18048
  • 13,393 View
  • 271 Download
  • 19 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Objective
Recent reports of hearing impairment in Parkinson’s disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation of PD. These reports were based on observations of elderly patients for whom presbycusis may, to some extent, have contributed to hearing dysfunction. Therefore, we aimed to explore the auditory functions in younger patients with PD. Methods We conducted a case-control study in a relatively younger (< 55 years of age at study time) population of PD patients and healthy volunteers to test whether auditory dysfunction is a significant non-motor dysfunction in PD. Pure tone audiometry (PTA) and brainstem evoked response audiometry (BERA) were performed in all participants. Results None of the patients or controls reported hearing deficits. Fifty-one patients with PD and 50 healthy volunteers who were age- and gender-matched to the patients participated. PTA-detected hearing impairment was found in 64.7% of patients and 28% of controls (p < 0.001) for both low-mid and/or high frequencies. Hearing impairment was more frequent in the younger subgroups of patients than age-matched controls, while the frequency of hearing impairment was similar in older groups of subjects. BERA was not different between patients and controls. Conclusion Asymptomatic auditory dysfunction is a common non-motor manifestation of early-onset PD and more frequent in younger patients, indicating that it may be independent of aging. The mechanism underlying this dysfunction appears to be peripheral, although a central dysfunction cannot be ruled out based on the findings of this study.

Citations

Citations to this article as recorded by  
  • Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson’s disease: new insights from non-motor spectrum
    Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Matteo Conti, Arturo Moleti, Renata Sisto, Andrea Viziano, Claudio Liguori, Tommaso Schirinzi, Nicola Biagio Mercuri, Rocco Cerroni
    Neurological Sciences.2024;[Epub]     CrossRef
  • Peripheral hearing in Parkinson’s disease: a systematic review
    Mariana S. Leme, Seisse G. G. Sanches, Renata M. M. Carvallo
    International Journal of Audiology.2023; 62(9): 805.     CrossRef
  • (Zu-)Hören mit alterndem Gehirn – eine kognitive Herausforderung
    Wilma Großmann
    Laryngo-Rhino-Otologie.2023; 102(S 01): S12.     CrossRef
  • Is Hearing Loss a Risk Factor for Idiopathic Parkinson’s Disease? An English Longitudinal Study of Ageing Analysis
    Megan Rose Readman, Fang Wan, Ian Fairman, Sally A. Linkenauger, Trevor J. Crawford, Christopher J. Plack
    Brain Sciences.2023; 13(8): 1196.     CrossRef
  • Hearing Loss and Disorders: The Repercussions of Climate Change
    Sue Sherratt
    American Journal of Audiology.2023; 32(4): 793.     CrossRef
  • Association between hearing sensitivity and dopamine transporter availability in Parkinson’s disease
    Elena Garasto, Alessandro Stefani, Mariangela Pierantozzi, Rocco Cerroni, Matteo Conti, Simone Maranesi, Nicola B Mercuri, Agostino Chiaravalloti, Orazio Schillaci, Andrea Viziano, Arturo Moleti, Renata Sisto
    Brain Communications.2023;[Epub]     CrossRef
  • Identifying Parkinson Risk Markers in Primary Care—Old Associations and New Insights
    Bhavana Patel, Shannon Chiu, Melissa J. Armstrong
    JAMA Neurology.2022; 79(4): 331.     CrossRef
  • Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
    Cristina Simonet, Jonathan Bestwick, Mark Jitlal, Sheena Waters, Aaron Ben-Joseph, Charles R. Marshall, Ruth Dobson, Soha Marrium, John Robson, Benjamin M. Jacobs, Daniel Belete, Andrew J. Lees, Gavin Giovannoni, Jack Cuzick, Anette Schrag, Alastair J. No
    JAMA Neurology.2022; 79(4): 359.     CrossRef
  • Auditory impairment in H‐ABC tubulinopathy
    Alejandra Lopez‐Juarez, Arturo Gonzalez‐Vega, Anke Kleinert‐Altamirano, Valeria Piazza, Angeles Garduno‐Robles, Milvia Alata, Carlos Villaseñor‐Mora, Jose R. Eguibar, Carmen Cortes, Luis Carlos Padierna, Victor H. Hernandez
    Journal of Comparative Neurology.2021; 529(5): 957.     CrossRef
  • The Effect of Parkinson's Disease on Otoacoustic Emissions and Efferent Suppression of Transient Evoked Otoacoustic Emissions
    Evelien De Groote, Annelies Bockstael, Dick Botteldooren, Patrick Santens, Miet De Letter
    Journal of Speech, Language, and Hearing Research.2021; 64(4): 1354.     CrossRef
  • Hearing Loss in Neurological Disorders
    Siyu Li, Cheng Cheng, Ling Lu, Xiaofeng Ma, Xiaoli Zhang, Ao Li, Jie Chen, Xiaoyun Qian, Xia Gao
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes
    Vasiliki Paplou, Nick M. A. Schubert, Sonja J. Pyott
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Auditory Dysfunction in Parkinson's Disease
    Zahra Jafari, Bryan E. Kolb, Majid H. Mohajerani
    Movement Disorders.2020; 35(4): 537.     CrossRef
  • Future Perspectives on the Relevance of Auditory Markers in Prodromal Parkinson's Disease
    Evelien De Groote, Kim De Keyser, Patrick Santens, Durk Talsma, Annelies Bockstael, Dick Botteldooren, Miet De Letter
    Frontiers in Neurology.2020;[Epub]     CrossRef

JMD : Journal of Movement Disorders