Journal of Movement Disorders

Original Articles

Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism: Seung Ha Lee, Han Kyeol Kim, Young Gun Lee, Chul Hyoung Lyoo, Sung Jun Ahn, Myung Sik Lee; J Mov Disord. 2017;10(1):35-39. Published online December 27, 2016; DOI: https://doi.org/10.14802/jmd.16045

9,487 View
157 Download
8 Web of Science
5 Crossref

Objective
Patients with drug-induced parkinsonism (DIP) may have nigrostriatal dopaminergic degeneration. We studied the clinical features that may indicate nigrostriatal dopaminergic degeneration in patients with DIP.
Methods
Forty-one DIP patients were classified into normal and abnormal [¹⁸F] FP-CIT scan groups. Differences in 32 clinical features and drug withdrawal effects were studied.
Results
Twenty-eight patients had normal (Group I) and 13 patients had abnormal (Group II) scans. Eight patients of Group I, but none of Group II, had taken calcium channel blockers (p = 0.040). Three patients of Group I and six of Group II had hyposmia (p = 0.018). After drug withdrawal, Group I showed greater improvement in Unified Parkinson’s Disease Rating Scale total motor scores and subscores for bradykinesia and tremors than Group II. Only hyposmia was an independent factor associated with abnormal scans, but it had suboptimal sensitivity.
Conclusion
None of the clinical features were practical indicators of nigrostriatal dopaminergic degeneration in patients with DIP.

Citations

Citations to this article as recorded by

Comparative Olfactory Profiles in Parkinson’s Disease and Drug-Induced Parkinsonism
In Hee Kwak, Young Eun Kim, Suk Yun Kang, Joong Seob Lee, Jeongjae Lee, Min Seung Kim, Dong A Yea, Hyeo-il Ma
Journal of Movement Disorders.2024; 17(1): 64. CrossRef
Retinal Thickness and Its Interocular Asymmetry Between Parkinson’s Disease and Drug-Induced Parkinsonism
Wool Suh, Sung Uk Baek, Jungsu S. Oh, Seung Yeon Seo, Jae Seung Kim, You Mie Han, Min Seung Kim, Suk Yun Kang
Journal of Korean Medical Science.2023;[Epub] CrossRef
Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced Parkinsonism
Whitley W. Aamodt, Jacob G. Dubroff, Gang Cheng, Betty Taylor, Stephanie Wood, John E. Duda, James F. Morley
npj Parkinson's Disease.2022;[Epub] CrossRef
Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism
Verónica Alejandra Cáceres-Chávez, Ricardo Hernández-Martínez, Jesús Pérez-Ortega, Marco Arieli Herrera-Valdez, Jose J. Aceves, Elvira Galarraga, José Bargas
Journal of Neurophysiology.2018; 120(6): 2922. CrossRef
Neuroimaging in Parkinson's disease: focus on substantia nigra and nigro-striatal projection
Daniela Frosini, Mirco Cosottini, Duccio Volterrani, Roberto Ceravolo
Current Opinion in Neurology.2017; 30(4): 416. CrossRef

Apathy and Olfactory Dysfunction in Early Parkinson’s Disease: Jin Yong Hong, Mun Kyung Sunwoo, Jee Hyun Ham, Jae Jung Lee, Phil Hyu Lee, Young H. Sohn; J Mov Disord. 2015;8(1):21-25. Published online January 31, 2015; DOI: https://doi.org/10.14802/jmd.14029

16,184 View
111 Download
22 Web of Science
22 Crossref

Abstract PDF

Objective Olfactory and emotional dysfunctions are very common in patients with Parkinson’s disease (PD). Olfaction and emotions share common neuroanatomical substrates. Therefore, in this study, we evaluated the association between olfactory and emotional dysfunctions in patients with PD.
Methods Parkinson’s disease patients who had been assessed for their olfactory function and neuropsychiatric symptoms including emotional dysfunction were included. A logistic regression analysis was performed to evaluate the association between low olfaction and different neuropsychiatric symptoms.
Results The patients with low olfaction (cross cultural smell identification test score ≤ 6) showed a higher prevalence of apathy when compared with those with high olfaction, whereas the frequencies of other neuropsychiatric symptoms were comparable between the two groups. A multivariate logistic regression analysis revealed that the presence of apathy/indifference [odds ratio (OR) = 2.859, p = 0.007], age 70 years or more (OR = 2.281, p = 0.009), and the male gender (OR = 1.916, p = 0.030) were significantly associated with low olfaction.
Conclusions Our results demonstrate that apathy/indifference is a unique emotional dysfunction associated with olfactory dysfunction in PD. The findings also suggest that PD patients with low olfaction have a high prevalence of apathy.

Citations

Citations to this article as recorded by

Clinical features and neurobiochemical mechanisms of olfactory dysfunction in patients with Parkinson disease
Ruidan Wang, Tenghong Lian, Mingyue He, Peng Guo, Shuyang Yu, Lijun Zuo, Yang Hu, Wei Zhang
Journal of Neurology.2024; 271(4): 1959. CrossRef
Neurons, Nose, and Neurodegenerative Diseases: Olfactory Function and Cognitive Impairment
Irene Fatuzzo, Giovanni Francesco Niccolini, Federica Zoccali, Luca Cavalcanti, Mario Giuseppe Bellizzi, Gabriele Riccardi, Marco de Vincentiis, Marco Fiore, Carla Petrella, Antonio Minni, Christian Barbato
International Journal of Molecular Sciences.2023; 24(3): 2117. CrossRef
Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson’s disease
Fardin Nabizadeh, Kasra Pirahesh, Elham Khalili
Neurological Sciences.2022; 43(7): 4193. CrossRef
The Power of Odor Persuasion: The Incorporation of Olfactory Cues in Virtual Environments for Personalized Relaxation
Silvia Francesca Maria Pizzoli, Dario Monzani, Ketti Mazzocco, Emanuela Maggioni, Gabriella Pravettoni
Perspectives on Psychological Science.2022; 17(3): 652. CrossRef
Olfaction and apathy in early idiopathic Parkinson's disease
Alfonso E. Martinez-Nunez, Kaitie Latack, Miguel Situ-Kcomt, Abhimanyu Mahajan
Journal of the Neurological Sciences.2022; 439: 120314. CrossRef
Apathy in Parkinson’s Disease: Defining the Park Apathy Subtype
Ségolène De Waele, Patrick Cras, David Crosiers
Brain Sciences.2022; 12(7): 923. CrossRef
α‐Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC‐SNCA Mice
Norihito Uemura, Jun Ueda, Toru Yoshihara, Masashi Ikuno, Maiko T. Uemura, Hodaka Yamakado, Masahide Asano, John Q. Trojanowski, Ryosuke Takahashi
Movement Disorders.2021; 36(9): 2036. CrossRef
Hyposmia may predict development of freezing of gait in Parkinson’s disease
Jae Jung Lee, Jin Yong Hong, Jong Sam Baik
Journal of Neural Transmission.2021; 128(6): 763. CrossRef
Clinical and Dopamine Depletion Patterns in Hyposmia- and Dysautonomia-Dominant Parkinson’s Disease
Han Soo Yoo, Sangwon Lee, Seong Ho Jeong, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Phil Hyu Lee
Journal of Parkinson's Disease.2021; 11(4): 1703. CrossRef
Is There a Shared Etiology of Olfactory Impairments in Normal Aging and Neurodegenerative Disease?
Mahraz Parvand, Catharine H. Rankin, Lori Beason-Held
Journal of Alzheimer's Disease.2020; 73(1): 1. CrossRef
Open questions on the nature of Parkinson’s disease: from triggers to spreading pathology
Lei Mou, Wei Ding, Pedro Fernandez-Funez
Journal of Medical Genetics.2020; 57(2): 73. CrossRef
Effect of Olfactory and Gustatory Dysfunction and Motor Symptoms on Body Weight in Patients with Parkinson’s Disease
Carla Masala, Francesco Loy, Raffaella Piras, Anna Liscia, Laura Fadda, Alan Moat, Paolo Solla, Giovanni Defazio
Brain Sciences.2020; 10(4): 218. CrossRef
Insula and Amygdala Atrophy Are Associated With Functional Impairment in Subjects With Presbycusis
Chama Belkhiria, Rodrigo C. Vergara, Simón San Martin, Alexis Leiva, Melissa Martinez, Bruno Marcenaro, Maricarmen Andrade, Paul H. Delano, Carolina Delgado
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef
Contribution of Five Functional Loci of Dopamine Metabolism-Related Genes to Parkinson’s Disease and Multiple System Atrophy in a Chinese Population
Yongping Chen, Ruwei Ou, Lingyu Zhang, Xiaojing Gu, Xiaoqin Yuan, Qian-qian Wei, Bei Cao, Bi Zhao, Ying Wu, Huifang Shang
Frontiers in Neuroscience.2020;[Epub] CrossRef
Olfactory Dysfunction Predicts Disease Progression in Parkinson’s Disease: A Longitudinal Study
Runcheng He, Yuwen Zhao, Yan He, Yangjie Zhou, Jinxia Yang, Xiaoting Zhou, Liping Zhu, Xun Zhou, Zhenhua Liu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Beisha Tang, Jifeng Guo
Frontiers in Neuroscience.2020;[Epub] CrossRef
Characteristics of apathy in treatment-naïve patients with Parkinson’s disease
Hiroo Terashi, Yuki Ueta, Haruhisa Kato, Hiroshi Mitoma, Hitoshi Aizawa
International Journal of Neuroscience.2019; 129(1): 16. CrossRef
Olfaction and taste in Parkinson’s disease: the association with mild cognitive impairment and the single cognitive domain dysfunction
Maria Paola Cecchini, Angela Federico, Alice Zanini, Elisa Mantovani, Carla Masala, Michele Tinazzi, Stefano Tamburin
Journal of Neural Transmission.2019; 126(5): 585. CrossRef
The oral microbiome of early stage Parkinson’s disease and its relationship with functional measures of motor and non-motor function
Dragos Mihaila, Jordan Donegan, Sarah Barns, Daria LaRocca, Qian Du, Danny Zheng, Michael Vidal, Christopher Neville, Richard Uhlig, Frank A. Middleton, Brenda A Wilson
PLOS ONE.2019; 14(6): e0218252. CrossRef
Hyposmia as a marker of (non-)motor disease severity in Parkinson’s disease
Dareia S. Roos, Jos W. R. Twisk, Pieter G. H. M. Raijmakers, Richard L. Doty, Henk W. Berendse
Journal of Neural Transmission.2019; 126(11): 1471. CrossRef
Correlation among olfactory function, motors’ symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson’s disease
Carla Masala, Paolo Solla, A. Liscia, G. Defazio, L. Saba, A. Cannas, A. Cavazzana, T. Hummel, A. Haehner
Journal of Neurology.2018; 265(8): 1764. CrossRef
Olfactory Dysfunction as an Early Biomarker in Parkinson’s Disease
Michelle E. Fullard, James F. Morley, John E. Duda
Neuroscience Bulletin.2017; 33(5): 515. CrossRef
Human behavioral assessments in current research of Parkinson’s disease
Tetsuya Asakawa, Huan Fang, Kenji Sugiyama, Takao Nozaki, Susumu Kobayashi, Zhen Hong, Katsuaki Suzuki, Norio Mori, Yilin Yang, Fei Hua, Guanghong Ding, Guoqiang Wen, Hiroki Namba, Ying Xia
Neuroscience & Biobehavioral Reviews.2016; 68: 741. CrossRef

First
Prev
Page of 1
Next
Last

Search