Skip Navigation
Skip to contents

JMD : Journal of Movement Disorders



Page Path
HOME > Search
3 "Lewy body"
Article category
Publication year
Funded articles
Review Articles
Diagnostic Criteria for Dementia with Lewy Bodies: Updates and Future Directions
Masahito Yamada, Junji Komatsu, Keiko Nakamura, Kenji Sakai, Miharu Samuraki-Yokohama, Kenichi Nakajima, Mitsuhiro Yoshita
J Mov Disord. 2020;13(1):1-10.   Published online November 8, 2019
  • 26,687 View
  • 1,707 Download
  • 47 Web of Science
  • 52 Crossref
AbstractAbstract PDF
The aim of this article is to describe the 2017 revised consensus criteria for the clinical diagnosis of dementia with Lewy bodies (DLB) with future directions for the diagnostic criteria. The criteria for the clinical diagnosis of probable and possible DLB were first published as the first consensus report in 1996 and were revised in the third consensus report in 2005. After discussion at the International DLB Conference in Fort Lauderdale, Florida, USA, in 2015, the International DLB Consortium published the fourth consensus report including the revised consensus criteria in 2017. The 2017 revised criteria clearly distinguish between clinical features and diagnostic biomarkers. Significant new information about previously reported aspects of DLB has been incorporated, with increased diagnostic weighting given to rapid eye movement (REM) sleep behavior disorder (RBD) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. Future directions include the development of the criteria for early diagnosis (prodromal DLB) and the establishment of new biomarkers that directly indicate Lewy-related pathology, including α-synuclein imaging, biopsies of peripheral tissues (skin, etc.) for the demonstration of α-synuclein deposition, and biochemical markers (cerebrospinal fluid/blood), as well as the pathological evaluation of the sensitivity and specificity of the 2017 revised diagnostic criteria. In conclusion, the revised consensus criteria for the clinical diagnosis of DLB were reported with the incorporation of new information about DLB in 2017. Future directions include the development of the criteria for early diagnosis and the establishment of biomarkers directly indicative of Lewy-related pathology.


Citations to this article as recorded by  
  • The Role of Electroconvulsive Therapy in the Treatment of Catatonia Associated With Lewy Body Dementia: A Case Report
    Javeria Sahib Din, Thomas Boes, Ernesto Navarro Garcia, Hiba Al-Rubaye
    Cureus.2024;[Epub]     CrossRef
  • α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil
    Yunying Yang, Zhentao Zhang
    Neural Regeneration Research.2024; 19(7): 1463.     CrossRef
  • Suspecting Non-Alzheimer’s Pathologies and Mixed Pathologies: A Comparative Study Between Brain Metabolism and Tau Images
    Vincent Malotaux, Lise Colmant, Lisa Quenon, Lara Huyghe, Thomas Gérard, Laurence Dricot, Adrian Ivanoiu, Renaud Lhommel, Bernard Hanseeuw
    Journal of Alzheimer's Disease.2024; 97(1): 421.     CrossRef
  • Supercomplex formation of mitochondrial respiratory chain complexes in leukocytes from patients with neurodegenerative diseases
    Tsukasa Hara, Ryosuke Amagai, Ryuji Sakakibara, Ayako Okado-Matsumoto
    The Journal of Biochemistry.2024; 175(3): 289.     CrossRef
  • Latest advances in mechanisms of epileptic activity in Alzheimer’s disease and dementia with Lewy Bodies
    Mariane Vicente, Kwaku Addo-Osafo, Keith Vossel
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • The clinical diagnosis of Parkinson's disease
    Renato P. Munhoz, Vitor Tumas, José Luiz Pedroso, Laura Silveira-Moriyama
    Arquivos de Neuro-Psiquiatria.2024; 82(06): 001.     CrossRef
  • Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach
    Megha Manoj, Siddarth Sowmyanarayan, Arjun V. Kowshik, Jhinuk Chatterjee
    Journal of Molecular Neuroscience.2024;[Epub]     CrossRef
  • Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies
    Neha Atulkumar Singh, Austin W. Goodrich, Jonathan Graff-Radford, Mary M. Machulda, Irene Sintini, Arenn F. Carlos, Carling G. Robinson, Robert I. Reid, Val J. Lowe, Clifford R. Jack, Ronald C. Petersen, Bradley F. Boeve, Keith A. Josephs, Kejal Kantarci,
    NeuroImage.2024; 290: 120564.     CrossRef
  • Clinicopathological correlation of cerebrospinal fluid alpha‐synuclein seed amplification assay in a behavioral neurology autopsy cohort
    Niyatee Samudra, D. Luke Fischer, Steven Lenio, Argentina Lario Lago, Peter A. Ljubenkov, Julio C. Rojas, William W. Seeley, Salvatore Spina, Adam M. Staffaroni, Jonathan Tablante, Fattin Wekselman, Jennifer Lamoureux, Luis Concha‐Marambio, Lea T. Grinber
    Alzheimer's & Dementia.2024; 20(5): 3334.     CrossRef
  • New insight of exercise on dementia; combinatory effects of physical and cognitive exercise
    Hyo-Jeong Cha, Jun Hong Park, Changwan Hong
    Molecular & Cellular Toxicology.2024;[Epub]     CrossRef
  • Diagnostic Challenge of an Advanced Stage Dementia Case
    Emin Taşkıran
    European Journal of Geriatrics and Gerontology.2024; 6(1): 73.     CrossRef
  • Dementia with Lewy bodies
    Cheri M. Jrolf
    JAAPA.2024;[Epub]     CrossRef
  • Absolute quantitation of sympathetic nerve activity using [123I] metaiodobenzylguanidine SPECT-CT in neurology
    Shintaro Saito, Kenichi Nakajima, Junji Komatsu, Takayuki Shibutani, Hiroshi Wakabayashi, Hiroshi Mori, Aki Takata, Kenjiro Ono, Seigo Kinuya
    EJNMMI Reports.2024;[Epub]     CrossRef
  • Magnetic resonance imaging in the diagnosis of progressive supranuclear palsy: A case report and review of literature
    Baraka Alphonce, Francisca Komanya, Mbelwa Bitesigilwe, John R. Meda, Azan Nyundo
    Clinical Case Reports.2023;[Epub]     CrossRef
  • Parkinson's disease fluid biomarkers for differential diagnosis of atypical parkinsonian syndromes
    Jun Yang, Ayotimofe Idowu, Liana Rosenthal, Xiaobo Mao
    Clinical and Translational Discovery.2023;[Epub]     CrossRef
  • Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia
    Irene Frigerio, Max A. Laansma, Chen-Pei Lin, Emma J. M. Hermans, Maud M. A. Bouwman, John G. J. M. Bol, Yvon Galis-de Graaf, Dagmar H. Hepp, Annemieke J. M. Rozemuller, Frederik Barkhof, Wilma D. J. van de Berg, Laura E. Jonkman
    Translational Neurodegeneration.2023;[Epub]     CrossRef
  • Machine learning-based prediction of conversion coefficients for I-123 metaiodobenzylguanidine heart-to-mediastinum ratio
    Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Michael Ljungberg, Tetsuo Hosoya, Yumiko Kirihara, Mitsumasa Hashimoto
    Journal of Nuclear Cardiology.2023; 30(4): 1630.     CrossRef
  • Costs During the Last Five Years of Life for Patients with Clinical and Pathological Confirmed Diagnosis of Lewy Body Dementia and Alzheimer’s Disease
    Carolyn W. Zhu, Yian Gu, Anton J. Kociolek, Kayri K. Fernandez, Stephanie Cosentino, Yaakov Stern
    Journal of Alzheimer's Disease.2023; 92(2): 457.     CrossRef
  • Early- and late-onset of isolated rapid eye movement sleep behavior disorder: A retrospective cohort study
    Li Zhou, Bei Huang, Jing Wang, Steven WH. Chau, Joey WY. Chan, Jihui Zhang, Mandy WM. Yu, Jessie CC. Tsang, Shirley Xin Li, Vincent CT. Mok, Yun Kwok Wing, Yaping Liu
    Sleep Medicine.2023;[Epub]     CrossRef
  • Parkinson Disease Dementia Management: an Update of Current Evidence and Future Directions
    Oliver Phillips, Debolina Ghosh, Hubert H. Fernandez
    Current Treatment Options in Neurology.2023; 25(5): 93.     CrossRef
  • Rapidly progressive dementia with severe insomnia: an unusual case of progressive supranuclear palsy mimicking dementia with Lewy bodies
    Rae On Kim, Eun Ji Lee, Seong-Ik Kim, Sung-Hye Park, Kyum-Yil Kwon
    Neurological Sciences.2023; 44(8): 2953.     CrossRef
  • Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson’s disease and atypical Parkinsonian syndromes
    Nils Schröter, Thilo van Eimeren, Joseph Classen, Johannes Levin, Christoph Redecker, Martin Wolz, Lars Tönges
    Journal of Neural Transmission.2023; 130(6): 839.     CrossRef
  • Electroencephalography in young onset dementia
    Casey W Brown, Huei-Yang Chen, Peter K Panegyres
    BMC Neurology.2023;[Epub]     CrossRef
  • Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers
    Lucy L. Gibson, Carla Abdelnour, Joyce Chong, Clive Ballard, Dag Aarsland
    Current Opinion in Neurology.2023; 36(4): 264.     CrossRef
  • Coexistence of Posterior Cortical Atrophy and Parkinson’s Disease
    Eun-Byul Ko, Il-Joong Hwang, Jung-Woo Kim, Dar-Eun Jung, Ju-Suk Lee, Sang-Won Yoo, Joong-Seok Kim
    Journal of the Korean Neurological Association.2023; 41(3): 216.     CrossRef
  • Toward a new nosology of neurodegenerative diseases
    Manuel Menéndez‐González
    Alzheimer's & Dementia.2023; 19(8): 3731.     CrossRef
  • Autonomic dysfunction in dementia with Lewy bodies: Focusing on cardiovascular and respiratory dysfunction
    Katsuyoshi Mizukami
    Psychiatry and Clinical Neurosciences Reports.2023;[Epub]     CrossRef
  • Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity
    Marcelina J. Wojewska, Maria Otero-Jimenez, Jose Guijarro-Nuez, Javier Alegre-Abarrategui
    International Journal of Molecular Sciences.2023; 24(17): 13199.     CrossRef
  • Case Study 6: The Diagnostic Challenge of a 75-Year-Old Man Who Had, Then Didn’t Have, Then Did Have Alzheimer’s Disease
    Sergio A. Ramírez-Salazar, Cassie MacRae, Mel B. Feany, Michael Miller, Hyun-Sik Yang, Mary-Ellen Meadows, Scott M. McGinnis, David Silbersweig, Seth A. Gale, Kirk R. Daffner
    The Journal of Neuropsychiatry and Clinical Neurosciences.2023; 35(4): 325.     CrossRef
  • Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson’s Disease: A Comprehensive Review
    Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
    Brain Sciences.2023; 13(10): 1471.     CrossRef
  • A Unique Perspective on Lead Compounds for Dementia with the Lewy Body
    Menaka Subramani, Amuthalakshmi Sivaperuman, Ramalakshmi Natarajan, Keerthana Dhinakaran
    Medicinal Chemistry.2023; 19(10): 946.     CrossRef
  • Three-Dimensional Heart Segmentation and Absolute Quantitation of Cardiac 123I-metaiodobenzylguanidine Sympathetic Imaging Using SPECT/CT
    Shintaro Saito, Kenichi Nakajima, Takayuki Shibutani, Hiroshi Wakabayashi, Hiroto Yoneyama, Takahiro Konishi, Hiroshi Mori, Aki Takata, Seigo Kinuya
    Annals of Nuclear Cardiology.2023; 9(1): 61.     CrossRef
  • Comparison of Taiwanese and European Calibration Factors for Heart-to-Mediastinum Ratio in Multicenter 123I-mIBG Phantom Studies
    Koichi Okuda, Kenichi Nakajima, Guang-Uei Hung, Hao-Ting Wu, Derk O. Verschure, Hein J. Verberne, Chiemi Kitamura
    Annals of Nuclear Cardiology.2023; 9(1): 54.     CrossRef
  • Clinical biomarkers for Lewy body diseases
    Mai M. Abdelmoaty, Eugene Lu, Rana Kadry, Emma G. Foster, Shaurav Bhattarai, R. Lee Mosley, Howard E. Gendelman
    Cell & Bioscience.2023;[Epub]     CrossRef
  • Proteomic comparison between non‐purified cerebrospinal fluid and cerebrospinal fluid‐derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia
    Yael Hirschberg, Natalia Valle‐Tamayo, Oriol Dols‐Icardo, Sebastiaan Engelborghs, Bart Buelens, Roosmarijn E. Vandenbroucke, Yannick Vermeiren, Kurt Boonen, Inge Mertens
    Journal of Extracellular Vesicles.2023;[Epub]     CrossRef
  • The connection between cerebral amyloid angiopathy and Alzheimer’s disease
    Hans Rolf Jäger
    European Radiology.2023; 34(4): 2171.     CrossRef
  • Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia
    Stefania Kaninia, Rosaleen A. McCarthy, Zia Saad, George P Pengas
    Neurocase.2023; 29(6): 191.     CrossRef
  • Autonomic symptoms are predictive of dementia with Lewy bodies
    Wenzheng Hu, Shuai Liu, Fei Wang, Han Zhu, Xiaoshan Du, Lingyun Ma, Jinghuan Gan, Hao Wu, Xiaodan Wang, Yong Ji
    Parkinsonism & Related Disorders.2022; 95: 1.     CrossRef
  • Delusion and Delirium in Neurodegenerative Disorders: An Overlooked Relationship?
    Daniele Urso, Valentina Gnoni, Marco Filardi, Giancarlo Logroscino
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • Clinical Trajectories at the End of Life in Autopsy-Confirmed Dementia Patients With Alzheimer Disease and Lewy Bodies Pathologies
    Yian Gu, Anton Kociolek, Kayri K. Fernandez, Stephanie A. Cosentino, Carolyn Wei Zhu, Zhezhen Jin, James B. Leverenz, Yaakov B. Stern
    Neurology.2022;[Epub]     CrossRef
  • Diagnostic Performance for Differential Diagnosis of Atypical Parkinsonian Syndromes from Parkinson’s Disease Using Quantitative Indices of 18F-FP-CIT PET/CT
    Miju Cheon, Seung Min Kim, Sang-Won Ha, Min Ju Kang, Hea-Eun Yang, Jang Yoo
    Diagnostics.2022; 12(6): 1402.     CrossRef
  • The promise of amplification assays for accurate early detection of α-synucleinopathies: A review
    Regina Kurapova, Leonidas Chouliaras, John T. O'Brien
    Experimental Gerontology.2022; 165: 111842.     CrossRef
  • Progressive Olfactory Impairment and Cardiac Sympathetic Denervation in REM Sleep Behavior Disorder
    Annette Janzen, David Vadasz, Jan Booij, Markus Luster, Damiano Librizzi, Martin T. Henrich, Lars Timmermann, Mahboubeh Habibi, Elisabeth Sittig, Geert Mayer, Fanni Geibl, Wolfgang Oertel
    Journal of Parkinson's Disease.2022; 12(6): 1921.     CrossRef
  • A Systematic Review and Comparison of Neurocognitive Features of Late-Life Attention-Deficit/Hyperactivity Disorder and Dementia With Lewy Bodies
    Jennifer L. Prentice, Morgan J. Schaeffer, Alexandra K. Wall, Brandy L. Callahan
    Journal of Geriatric Psychiatry and Neurology.2021; 34(5): 466.     CrossRef
  • Dementia with Lewy bodies in first-generation immigrants in a European memory clinic
    Kurt Segers, Florence Benoit, Jean-Marie Meyts, Gérald Glibert, Sophie Levy, Murielle Surquin
    Acta Neurologica Belgica.2021; 121(1): 219.     CrossRef
  • The development of new method to differentiate between Dementia with Lewy bodies and Alzheimer’s disease by cerebral perfusion SPECT-comparison to CIScore
    Gaku Honda, Shigeki Nagamachi, Masanari Nonokuma, Koichi Takano, Yasuo Kuwabara, Kengo Yoshimitsu, Hitoshi Iida, Koji Ogomori, Hiroaki Kawasaki, Yoshio Tsuboi
    Japanese Journal of Radiology.2021; 39(2): 198.     CrossRef
  • Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease
    Xue-Bing Ding, Xin-Xin Wang, Dan-Hao Xia, Han Liu, Hai-Yan Tian, Yu Fu, Yong-Kang Chen, Chi Qin, Jiu-Qi Wang, Zhi Xiang, Zhong-Xian Zhang, Qin-Chen Cao, Wei Wang, Jia-Yi Li, Erxi Wu, Bei-Sha Tang, Ming-Ming Ma, Jun-Fang Teng, Xue-Jing Wang
    Nature Medicine.2021; 27(3): 411.     CrossRef
  • Mechanisms of Neurodegeneration in Various Forms of Parkinsonism—Similarities and Differences
    Dariusz Koziorowski, Monika Figura, Łukasz M. Milanowski, Stanisław Szlufik, Piotr Alster, Natalia Madetko, Andrzej Friedman
    Cells.2021; 10(3): 656.     CrossRef
  • Advances in computerized MRI‐based biomarkers in Alzheimer’s disease
    Raymond Wong, Yishan Luo, Vincent Chung-tong Mok, Lin Shi
    Brain Science Advances.2021; 7(1): 26.     CrossRef
  • Convolutional neural network-based automatic heart segmentation and quantitation in 123I-metaiodobenzylguanidine SPECT imaging
    Shintaro Saito, Kenichi Nakajima, Lars Edenbrandt, Olof Enqvist, Johannes Ulén, Seigo Kinuya
    EJNMMI Research.2021;[Epub]     CrossRef
  • A direct comparison of the 2005 and 2017 criteria for dementia with Lewy bodies
    Kurt Segers, Florence Benoit, Jean‐Marie Meyts, Gerald Glibert, Murielle Surquin
    Psychogeriatrics.2020; 20(5): 785.     CrossRef
  • Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity
    Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Yumiko Kirihara, Mitsumasa Hashimoto, Seigo Kinuya
    Scientific Reports.2020;[Epub]     CrossRef
123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review
Eun Joo Chung, Sang Jin Kim
J Mov Disord. 2015;8(2):55-66.   Published online May 31, 2015
  • 18,840 View
  • 198 Download
  • 45 Web of Science
  • 43 Crossref
AbstractAbstract PDF
Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.


Citations to this article as recorded by  
  • Sudden cardiac death in synucleinopathies
    Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
    Journal of Neuropathology & Experimental Neurology.2023; 82(3): 242.     CrossRef
  • Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson’s Disease and Dementia with Lewy Body from Non-Parkinson’s Diseases
    In Kook Chun
    Nuclear Medicine and Molecular Imaging.2023; 57(3): 145.     CrossRef
  • Cardiac 123I-Metaiodobenzylguanidine (MIBG) Scintigraphy in Parkinson’s Disease: A Comprehensive Review
    Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
    Brain Sciences.2023; 13(10): 1471.     CrossRef
  • Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall Risk Evaluation Questionnaire
    Masashi Tsujimoto, Keisuke Suzuki, Akinori Takeda, Naoki Saji, Takashi Sakurai, Yukihiko Washimi
    Internal Medicine.2022; 61(11): 1687.     CrossRef
  • Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson’s disease
    Don Gueu Park, Juhee Kang, Young-Sil An, Jaerak Chang, Jung Han Yoon
    Neuroscience Letters.2022; 770: 136399.     CrossRef
  • Clinical and imaging evidence of brain-first and body-first Parkinson's disease
    Jacob Horsager, Karoline Knudsen, Michael Sommerauer
    Neurobiology of Disease.2022; 164: 105626.     CrossRef
  • Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
    Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund
    Journal of Parkinson's Disease.2022; 12(4): 1125.     CrossRef
  • Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age
    G. Roberts, J.J. Lloyd, J.P.M. Kane, R. Durcan, S. Lawley, K. Howe, G.S. Petrides, J.T. O’Brien, A.J. Thomas
    Journal of Nuclear Cardiology.2021; 28(4): 1692.     CrossRef
  • Uniformity of cardiac 123I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia
    Gemma Roberts, Jim J. Lloyd, Elizabeth Jefferson, Joseph P.M. Kane, Rory Durcan, Sarah Lawley, George S. Petrides, Kim Howe, Iftikhar Haq, John T. O’Brien, Alan J. Thomas
    Journal of Nuclear Cardiology.2021; 28(5): 2151.     CrossRef
  • Myocardial Sympathetic Innervation Imaging with MIBG in Dementia with Lewy Bodies
    Gagandeep Choudhary, Pradeep Bhambhvani
    Journal of Nuclear Cardiology.2021; 28(5): 2164.     CrossRef
  • Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson’s Disease
    Juhee Kang, Jae Whan Kim, Hansol Heo, Jihyun Lee, Kwan Yong Park, Jung Han Yoon, Jaerak Chang
    Clinical and Translational Science.2021; 14(2): 606.     CrossRef
  • Gastrointestinal Dysfunction in Parkinson’s Disease
    Casper Skjærbæk, Karoline Knudsen, Jacob Horsager, Per Borghammer
    Journal of Clinical Medicine.2021; 10(3): 493.     CrossRef
  • Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson’s Disease—a Systematic Review
    Vasiliki Katsi, Ilias Papakonstantinou, Eirini Solomou, Alexios S. Antonopoulos, Charalambos Vlachopoulos, Konstantinos Tsioufis
    Current Hypertension Reports.2021;[Epub]     CrossRef
  • Lewy Body Dementias: A Coin with Two Sides?
    Ángela Milán-Tomás, Marta Fernández-Matarrubia, María Cruz Rodríguez-Oroz
    Behavioral Sciences.2021; 11(7): 94.     CrossRef
  • Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder
    Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
    Journal of Clinical Medicine.2021; 10(22): 5414.     CrossRef
  • A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index
    Fumi Sakamoto, Shinya Shiraishi, Koji Ogasawara, Noriko Tsuda, Masataka Nakagawa, Seiji Tomiguchi, Yasuyuki Yamashita
    Annals of Nuclear Medicine.2020; 34(6): 415.     CrossRef
  • Difference in cardiovascular response during orthostatic stress in Parkinson’s disease and multiple system atrophy
    Tomohiko Nakamura, Masashi Suzuki, Masamichi Ueda, Yumiko Harada, Masaaki Hirayama, Masahisa Katsuno
    Journal of Neural Transmission.2020; 127(10): 1377.     CrossRef
  • Striatal dopamine activity and myocardial 123I-metaiodobenzylguanidine uptake in early Parkinson's disease
    Yoon-Sang Oh, Joong-Seok Kim, Sang-Won Yoo, Eo-Jin Hwang, Chul Hyoung Lyoo, Kwang-Soo Lee
    Parkinsonism & Related Disorders.2019; 63: 156.     CrossRef
  • Initial Versus Follow-up Sequential Myocardial 123I-MIBG Scintigraphy to Discriminate Parkinson Disease From Atypical Parkinsonian Syndromes
    Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Yoon-Sang Oh, Sang-Won Yoo, Ie Ryung Yoo, Kwang-Soo Lee
    Clinical Nuclear Medicine.2019; 44(4): 282.     CrossRef
  • Cardiac 123I-MIBG planar heart to mediastinum ratios depend on patient size; phantom studies suggest SPECT-CT could improve quantification
    Gemma Roberts, Jim J Lloyd, George S Petrides, John T O’Brien, Alan J Thomas
    Biomedical Physics & Engineering Express.2019; 6(1): 015011.     CrossRef
  • Does sympathetic dysfunction occur before denervation in pure autonomic failure?
    Ling Guo, Murray D. Esler, Carolina Sari, Sarah Phillips, Elisabeth A. Lambert, Nora E. Straznicky, Gavin W. Lambert, Susan J. Corcoran
    Clinical Science.2018; 132(1): 1.     CrossRef
  • Validation of Iodine-131-meta-iodobenzylguanidine cardiac scintigraphy in Parkinsonism: A preliminary study
    Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
    Parkinsonism & Related Disorders.2018;[Epub]     CrossRef
  • Extensive Delayed Brain Atrophy after Resuscitation in a Patient with Multiple System Atrophy
    Sazuku Nisitani, Hirofumi Miyoshi, Yoji Katsuoka
    Frontiers in Neurology.2018;[Epub]     CrossRef
  • Optimizing Parkinson’s disease diagnosis: the role of a dual nuclear imaging algorithm
    J. William Langston, Jesse C. Wiley, Michele Tagliati
    npj Parkinson's Disease.2018;[Epub]     CrossRef
  • Diagnostic biomarkers for Parkinson’s disease at a glance: where are we?
    Ilaria Cova, Alberto Priori
    Journal of Neural Transmission.2018; 125(10): 1417.     CrossRef
  • Imaging the Autonomic Nervous System in Parkinson’s Disease
    Karoline Knudsen, Per Borghammer
    Current Neurology and Neuroscience Reports.2018;[Epub]     CrossRef
  • A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment
    Samuel D. Capouch, Martin R. Farlow, Jared R. Brosch
    Neurology and Therapy.2018; 7(2): 249.     CrossRef
  • The Utility of the Combined Use of 123I-FP-CIT and 123I-MIBG Myocardial Scintigraphy in Differentiating Parkinson’s Disease from Other Parkinsonian Syndromes
    Eiji Matsusue, Yoshio Fujihara, Kenichiro Tanaka, Yuki Aozasa, Manabu Shimoda, Hiroyuki Nakayasu, Kazuhiko Nakamura, Toshihide Ogawa
    Yonago Acta Medica.2018; 61(2): 117.     CrossRef
  • Correction of collimator-dependent differences in the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging: Determination of conversion equations using point-source imaging
    Yusuke Inoue, Yutaka Abe, Kei Kikuchi, Keiji Matsunaga, Ray Masuda, Kazutoshi Nishiyama
    Journal of Nuclear Cardiology.2017; 24(5): 1725.     CrossRef
  • Normal ‘heart’ in Parkinson's disease: is this a distinct clinical phenotype?
    J.‐S. Kim, H.‐E. Park, I.‐S. Park, Y.‐S. Oh, D.‐W. Ryu, I.‐U. Song, Y.‐A. Jung, I. R. Yoo, H.‐S. Choi, P. H. Lee, K.‐S. Lee
    European Journal of Neurology.2017; 24(2): 349.     CrossRef
  • Diagnosis of dementia with Lewy bodies: can 123I-IMP and 123I-MIBG scintigraphy yield new core features?
    Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
    The British Journal of Radiology.2017;[Epub]     CrossRef
  • Imaging Parkinson’s disease below the neck
    Per Borghammer, Karoline Knudsen, Tatyana D. Fedorova, David J. Brooks
    npj Parkinson's Disease.2017;[Epub]     CrossRef
  • The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes
    Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane
    Nuclear Medicine Communications.2017; 38(6): 487.     CrossRef
  • Cardiac sympathetic denervation and dementia in de novo Parkinson's disease: A 7-year follow-up study
    Mun Hee Choi, Jung Han Yoon, Suk Woo Yong
    Journal of the Neurological Sciences.2017; 381: 291.     CrossRef
  • Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
    Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
    Neurological Sciences.2016; 37(5): 711.     CrossRef
  • Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
    Journal of the Neurological Sciences.2016; 362: 59.     CrossRef
  • [123]FP-CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies
    J. J. van der Zande, J. Booij, P. Scheltens, P. G. H. M. Raijmakers, A. W. Lemstra
    European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1060.     CrossRef
  • Is dopamine transporter invariably impaired at the time of diagnosis in dementia with Lewy bodies?
    Flavio Nobili, Dario Arnaldi, Silvia Morbelli
    European Journal of Nuclear Medicine and Molecular Imaging.2016; 43(6): 1056.     CrossRef
  • Imaging Systemic Dysfunction in Parkinson’s Disease
    Per Borghammer, Karoline Knudsen, David J. Brooks
    Current Neurology and Neuroscience Reports.2016;[Epub]     CrossRef
  • 123I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography and 123I‐metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A comparative study
    Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco, Maria Merello, Stefano Stefanini, Anna Micheli, Pao
    Annals of Neurology.2016; 80(3): 368.     CrossRef
  • On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases
    Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori, John Duda
    PLOS ONE.2016; 11(4): e0152746.     CrossRef
  • 123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
    Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
    Journal of the Neurological Sciences.2015; 357(1-2): 173.     CrossRef
  • Orthostatic hypotension: managing a difficult problem
    Pearl K Jones, Brett H Shaw, Satish R Raj
    Expert Review of Cardiovascular Therapy.2015; 13(11): 1263.     CrossRef
Clinicopathological Correlates of Lewy Body Disease: Fundamental Issues
Tae-Beom Ahn
J Mov Disord. 2010;3(1):11-14.
  • 10,693 View
  • 62 Download
  • 3 Crossref
AbstractAbstract PDF

Lewy body pathology (LBP) is the pathological hallmark of Lewy body diseases, such as Parkinson’s disease and Lewy body dementia. Recent studies have shed new light on the role of LBP, the interactions of LBP with concomitant pathologies, and the propagation of LBP from the olfactory bulb and enteric nervous system to the central nervous system. The intrinsic difficulty with identifying clinicopathological correlates could be overcome by improving our understanding of the pathological evolution of LBP.


Citations to this article as recorded by  
  • Demencias degenerativas: ¿un dilema de síndromes o de enfermedades?
    A. Robles Bayón
    Neurología.2022; 37(6): 480.     CrossRef
  • Degenerative dementias: a question of syndrome or disease?
    A. Robles Bayón
    Neurología (English Edition).2022; 37(6): 480.     CrossRef
  • Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson’s Disease
    Murad Al-Nusaif, Yushan Lin, Tianbai Li, Cheng Cheng, Weidong Le
    International Journal of Molecular Sciences.2022; 23(24): 16184.     CrossRef

JMD : Journal of Movement Disorders Twitter