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- Efficacy and safety of zolpidem for musician’s dystonia
- Shiro Horisawa, Kilsoo Kim, Masato Murakami, Masahiko Nishitani, Takakazu Kawamata, Takaomi Taira
- Received May 20, 2024 Accepted June 28, 2024 Published online July 1, 2024
- DOI: https://doi.org/10.14802/jmd.24121 [Accepted]
- 955 View
- 65 Download
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Abstract
PDF - Background
The efficacy and safety of zolpidem in treating musician’s dystonia are not well understood.
Objective
We aimed to retrospectively investigate the efficacy and safety of zolpidem for musician’s dystonia.
Methods
We retrospectively reviewed medical records between January 2021 and December 2023 to identify patients with musician’s dystonia who had been prescribed zolpidem. The Tubiana’s musician’s dystonia rating scale (range, 1-5; lower scores indicating greater severity) was used to evaluate musician’s dystonia.
Results
Fifteen patients were included in this study. The mean effective dose of zolpidem was 5.3±2.0 mg. The mean effective duration of zolpidem was 4.3±1.2 h. With zolpidem administration, the Tubiana’s musician’s dystonia rating scale score significantly improved from 2.2±1.0 to 4.3±0.8 (48.9% improvement, p<0.001). Two patients (13.3%) discontinued the drug owing to unsatisfactory results or sleepiness.
Conclusion
This study suggests that zolpidem may be an alternative treatment option for musician’s dystonia.
Original Articles
- Reliability and Validity of the Embouchure Dystonia Severity Rating Scale
- Tobias Mantel, André Lee, Shinichi Furuya, Masanori Morise, Eckart Altenmüller, Bernhard Haslinger
- J Mov Disord. 2023;16(2):191-195. Published online May 24, 2023
- DOI: https://doi.org/10.14802/jmd.22213
- 1,907 View
- 65 Download
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Abstract
PDF
Supplementary Material - Objective
Embouchure dystonia (ED) is a task-specific movement disorder that leads to loss of fine motor control of the embouchure and tongue muscles in wind musicians. In contrast to musicians’ hand dystonia, no validated severity rating for ED exists, posing a major obstacle for structured assessment in scientific and clinical settings. The aim of this study is to validate an ED severity rating scale (EDSRS) allowing for a standardized estimation of symptom severity in ED.
Methods
The EDSRS was set up as a composite score of six items evaluating audio-visual disease symptoms during the performance of three standardized musical tasks (sustained notes, scales, and fourths) separately for each body side. For validation, 17 musicians with ED underwent standardized audiovisual recordings during performance. Anonymized and randomized recordings were assessed by two experts in ED (raters). Statistical analysis included metrics of consistency, reliability, and construct validity with the fluctuation of the fundamental frequency of the acoustic signal (F0) (extracted in an audio analysis of the sustained notes).
Results
The EDSRS showed high internal consistency (Cronbach’s α = 0.975−0.983, corrected item-total correlations r = 0.90−0.96), interrater reliability (intraclass correlation coefficient [ICC] for agreement/consistency = 0.94/0.96), intrarater reliability over time (ICC per rater = 0.93/0.87) and good precision (standard error of measurement = 2.19/2.65), and correlated significantly with F0 variability (r = 0.55–0.60, p = 0.011–0.023).
Conclusion
The developed EDSRS is a valid and reliable tool for the assessment of ED severity in the hands of trained expert raters. Its easy applicability makes it suitable not only for routine clinical practice but also for scientific studies.
- Individual Therapeutic Singing Program for Vocal Quality and Depression in Parkinson’s Disease
- Eun Young Han, Ji Young Yun, Hyun Ju Chong, Kyoung-Gyu Choi
- J Mov Disord. 2018;11(3):121-128. Published online August 9, 2018
- DOI: https://doi.org/10.14802/jmd.17078
- 65,535 View
- 303 Download
- 14 Web of Science
- 10 Crossref
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Abstract
PDFSupplementary Material
- Objective
Patients with Parkinson’s disease (PD) frequently experience depression associated with voice problems. Singing involves the use of similar muscles and the neural networks associated with vocal function and emotional response. The purpose of this study is to enhance vocal quality and depressive symptoms of patients with PD using individual singing program.
Methods
The Individual Therapeutic Singing Program for PD (ITSP-PD) was conducted by a certified music therapist. In total, nine PD patients with a subjective voice problem or depression participated in 6 sessions over 2 weeks. We measured the Maximum Phonation Time (MPT) via the Praat test, the Voice Handicap Index (VHI), the Voice-Related Quality of Life (V-RQOL) and the Geriatric Depression Scale (GDS).
Results
In total, 8 out of 9 patients completed all the sessions; 6 out of 8 patients participated in the follow-up test after 6 months. A statistically significant change in MPT (p = 0.011) was observed between the pre- and post-tests. The VHI (p = 0.035) and the GDS (p = 0.018) were significantly lower in the post-test. In the pre-, post-, and follow-up tests, the MPT (p = 0.030), V-RQOL (p = 0.008), and GDS (p = 0.009) were significantly changed.
Conclusion
The ITSP-PD based on neurological singing therapy for PD showed therapeutic possibility for vocal function and depression in patients with PD. Our findings suggest the need for a randomized study to examine the continuing positive effects of the ITSP-PD over a longer period of time. -
Citations
Citations to this article as recorded by
- Functional data analysis of prosodic prominence in Parkinson’s disease: a pilot study
Lauri Tavi, Nelly Penttilä
Clinical Linguistics & Phonetics.2024; 38(1): 64. CrossRef - Awareness of Dysphagia-Related Complications and Risks and the Importance of Early Intervention in Patients with Parkinson’s Disease: A Qualitative Study
Kaifeng Yao, Lihua Wang, Lihua Zhang, Aderito Seixas
International Journal of Clinical Practice.2023; 2023: 1. CrossRef - Group singing improves both physical and psychological wellbeing in people with and without chronic health conditions: A narrative review
Quinn Campbell, Sally Bodkin-Allen, Nicola Swain
Journal of Health Psychology.2022; 27(8): 1897. CrossRef - Defining the Therapeutic Singing Voice: Further Examination of the Everyday Singing Practices of Music Therapists
Martina C Bingham, Elizabeth K Schwartz, Anthony Meadows
Music Therapy Perspectives.2022; 40(1): 3. CrossRef - Music affects functional brain connectivity and is effective in the treatment of neurological disorders
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Reviews in the Neurosciences.2022; 33(7): 789. CrossRef - Acute effects of singing on cardiovascular biomarkers
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Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Music Therapy and Parkinson’s Disease: A Systematic Review from 2015–2020
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International Journal of Environmental Research and Public Health.2021; 18(21): 11618. CrossRef - The use of music as an arts-based method in migrant health research: a scoping review protocol
Fran Garry, Sylvia Murphy Tighe, Anne MacFarlane, Helen Phelan
HRB Open Research.2020; 3: 75. CrossRef - Walking the thin white line – managing voice in the older adult
Jacqui Allen, Anna Miles
Speech, Language and Hearing.2019; 22(1): 25. CrossRef - Music Therapy and Music-Based Interventions for Movement Disorders
Kerry Devlin, Jumana T. Alshaikh, Alexander Pantelyat
Current Neurology and Neuroscience Reports.2019;[Epub] CrossRef
- Functional data analysis of prosodic prominence in Parkinson’s disease: a pilot study
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