Journal of Movement Disorders

Original Article

Development of Clinical Milestones in Parkinson’s Disease After Bilateral Subthalamic Deep Brain Stimulation: Jed Noel A. Ong, Jung Hwan Shin, Seungho Jeon, Chan Young Lee, Han-Joon Kim, Sun Ha Paek, Beomseok Jeon; J Mov Disord. 2022;15(2):124-131. Published online May 26, 2022; DOI: https://doi.org/10.14802/jmd.21106

1,518 View
114 Download

Abstract PDF Supplementary Material: Objective
Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson’s disease (PD) patients does not halt disease progression, as these patients will progress and develop disabling non-levodopa responsive symptoms. These features may act as milestones that represent the overall functionality of patients after DBS. The objective of this study was to investigate the development of clinical milestones in advanced PD patients who underwent bilateral STN-DBS.
Methods
The study evaluated PD patients who underwent STN-DBS at baseline up to their last follow-up using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale. The symptoms of hallucinations, dysarthria, dysphagia, frequent falls, difficulty walking, cognitive impairment and the loss of autonomy were chosen as the clinical milestones.
Results
A total of 106 patients with a mean age of 47.21 ± 10.52 years at disease onset, a mean age of 58.72 ± 8.74 years at surgery and a mean disease duration of 11.51 ± 4.4 years before surgery were included. Initial improvement of motor symptoms was seen after the surgery with the appearance of clinical milestones over time. Using the moderately disabling criteria, 81 patients (76.41%) developed at least one clinical milestone, while 48 patients (45.28%) developed a milestone when using the severely disabling criteria.
Conclusion
STN-DBS has a limited effect on axial and nonmotor symptoms of the PD patients, in contrast to the effect on motor symptoms. These symptoms may serve as clinical milestones that can convey the status of PD patients and its impact on the patients and their caregivers. Therefore, advanced PD patients, even those treated with bilateral STN-DBS, will still require assistance and cannot live independently in the long run.

Brief communication

Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis: Vikram Venkappayya Holla, Koti Neeraja, Bharath Kumar Surisetti, Shweta Prasad, Nitish Kamble, Dwarakanath Srinivas, Ravi Yadav, Pramod Kumar Pal; J Mov Disord. 2020;13(3):218-222. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20073

7,156 View
106 Download
5 Citations

Objective
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.
Methods
Patients with DBS for movement disorders who visited the emergency room due to battery exhaustion during the nationwide lockdown from April to May 2020 were included.
Results
Two patients with subthalamic nucleus-DBS for Parkinson’s disease (PD) and one with globus pallidus interna-DBS for generalized dystonia presented with acute worsening of symptoms due to battery exhaustion. Urgent battery replacement was performed in both patients with PD. The patient with generalized dystonia was managed with medication adjustment as he chose to defer battery replacement.
Conclusion
DBS battery replacement can be an emergency. Decisions regarding DBS battery replacement should be individualized during this COVID-19 pandemic.

Citations

Citations to this article as recorded by

Effects of COVID-19 on Synaptic and Neuronal Degeneration
Mohammed S. Alqahtani, Mohamed Abbas, Mohammad Y. Alshahrani, Khulud Alabdullh, Amjad Alqarni, Fawaz F. Alqahtani, Layal K. Jambi, Adnan Alkhayat
Brain Sciences.2023; 13(1): 131. CrossRef
Needs and Perceptions of Patients With Dystonia During the COVID-19 Pandemic: A Qualitative Framework Analysis of Survey Responses From Italy
Vittorio Rispoli, Matías Eduardo Díaz Crescitelli, Francesco Cavallieri, Francesca Antonelli, Stefano Meletti, Luca Ghirotto, Franco Valzania
Frontiers in Neurology.2022;[Epub] CrossRef
Parkinsonism hyperpyraexia syndrome in Parkinson's disease patients undergoing deep brain stimulation: An indirect consequence of COVID-19 lockdowns
Onanong Phokaewvarangkul, Sasivimol Virameteekul, Roongroj Bhidayasiri
Parkinsonism & Related Disorders.2021; 87: 39. CrossRef
An Investigation Into Miniaturised Closed-Loop DBS Devices
Dean M. Corva, Scott D. Adams, Kevin E. Bennet, Parastoo Hashemi, Michael Berk, Abbas Z. Kouzani
IEEE Transactions on Medical Robotics and Bionics.2021; 3(3): 671. CrossRef
Effects of COVID-19 Lockdown on Movement Disorders Patients With Deep Brain Stimulation: A Multicenter Survey
Carla Piano, Francesco Bove, Tommaso Tufo, Isabella Imbimbo, Danilo Genovese, Alessandro Stefani, Massimo Marano, Antonella Peppe, Livia Brusa, Rocco Cerroni, Francesco Motolese, Enrico Di Stasio, Marianna Mazza, Antonio Daniele, Alessandro Olivi, Paolo C
Frontiers in Neurology.2020;[Epub] CrossRef

Review Articles

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease: Michelle Paff, Aaron Loh, Can Sarica, Andres M. Lozano, Alfonso Fasano; J Mov Disord. 2020;13(3):185-198. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20052

15,791 View
646 Download
37 Citations

Abstract PDF

Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.

Citations

Citations to this article as recorded by

Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
Journal of the Neurological Sciences.2023; 444: 120484. CrossRef
Implementing automation in deep brain stimulation: has the time come?
Marco Bonizzato, Alfonso Fasano
The Lancet Digital Health.2023; 5(2): e52. CrossRef
Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation
Joshua K. Wong, Helen S. Mayberg, Doris D. Wang, R. Mark Richardson, Casey H. Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro’ee Gilron, James F. Cavanagh, Jack W. Judy, Svjetlana Miocinovic, Annaelle D. Devergnas
Frontiers in Human Neuroscience.2023;[Epub] CrossRef
Deep brain stimulation: new programming algorithms and teleprogramming
Renato Puppi Munhoz, Ghadh Albuainain
Expert Review of Neurotherapeutics.2023; 23(5): 467. CrossRef
Brain stimulation treatments in epilepsy: Basic mechanisms and clinical advances
Thomas J. Foutz, Michael Wong
Biomedical Journal.2022; 45(1): 27. CrossRef
Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
Critical Reviews in Biotechnology.2022; 42(8): 1180. CrossRef
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Jeremy Hunt, Elizabeth J. Coulson, Rajendram Rajnarayanan, Henrik Oster, Aleksandar Videnovic, Oliver Rawashdeh
Molecular Neurodegeneration.2022;[Epub] CrossRef
Jose Delgado: A controversial trailblazer in neuromodulation
Nicholas D. Lorusso, Uma R. Mohan, Joshua Jacobs
Artificial Organs.2022; 46(4): 531. CrossRef
Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters
Angelique C. Paulk, Rina Zelmann, Britni Crocker, Alik S. Widge, Darin D. Dougherty, Emad N. Eskandar, Daniel S. Weisholtz, R. Mark Richardson, G. Rees Cosgrove, Ziv M. Williams, Sydney S. Cash
Brain Stimulation.2022;[Epub] CrossRef
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Ans
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches
Jessica Frey, Jackson Cagle, Kara A. Johnson, Joshua K. Wong, Justin D. Hilliard, Christopher R. Butson, Michael S. Okun, Coralie de Hemptinne
Frontiers in Neurology.2022;[Epub] CrossRef
Parkinson’s Disease Management via Wearable Sensors: A Systematic Review
Huma Mughal, Abdul Rehman Javed, Muhammad Rizwan, Ahmad S. Almadhor, Natalia Kryvinska
IEEE Access.2022; 10: 35219. CrossRef
Conversion to Hybrid Deep Brain Stimulation System to Enable Multi‐Contact Fractionation Can be Therapeutic
Disep I. Ojukwu, Allan R. Wang, Traci S. Hornbeck, Erika A. Lim, Jennifer Sharrard, Rohit Dhall, Vivek P. Buch, Casey H. Halpern
Movement Disorders.2022; 37(6): 1321. CrossRef
Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices—An Overview
Angelito A. Silverio, Lean Angelo A. Silverio
Frontiers in Aging.2022;[Epub] CrossRef
Single-interface bioelectronic medicines—concept, clinical applications and preclinical data
Cristian Sevcencu
Journal of Neural Engineering.2022; 19(3): 031001. CrossRef
Current Steering Using Multiple Independent Current Control Deep Brain Stimulation Technology Results in Distinct Neurophysiological Responses in Parkinson’s Disease Patients
Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Robin Gransier, Jan Wouters, Bart Nuttin, Myles Mc Laughlin
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Managing Intractable Symptoms of Parkinson's Disease: A Nonsurgical Approach Employing Infralow Frequency Neuromodulation
Stella B. Legarda, P. Andreas Michas-Martin, Dana McDermott
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Directional Deep Brain Stimulation in the Treatment of Parkinson's Disease
Akash Mishra, Ritesh A Ramdhani
Neurology.2022; 18(1): 64. CrossRef
Approach to the Treatment of Pediatric Dystonia
Carolina Gorodetsky, Alfonso Fasano
Dystonia.2022;[Epub] CrossRef
CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics
Tirthankar Sen, Rajkumar P. Thummer
Neurotoxicity Research.2022; 40(5): 1597. CrossRef
Encoding type, medication, and deep brain stimulation differentially affect memory-guided sequential reaching movements in Parkinson's disease
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Frontiers in Neurology.2022;[Epub] CrossRef
Remote programming for subthalamic deep brain stimulation in Parkinson's disease
Si Chen, Shu-jun Xu, Wei-guo Li, Teng Chen, Chao Li, Shuo Xu, Ning Yang, Yi-ming Liu
Frontiers in Neurology.2022;[Epub] CrossRef
Longevity of Deep Brain Stimulation Batteries; a Global Survey of Neurosurgeons and Neurologists
Marwan Hariz, Gun‐Marie Hariz, Patric Blomstedt
Movement Disorders.2021; 36(5): 1273. CrossRef
Basic Tips: How Do I Start Programming Deep Brain Stimulation in Parkinson Disease Patients?
Carolina Gorodetsky, Alfonso Fasano
Movement Disorders Clinical Practice.2021; 8(4): 639. CrossRef
Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions
Emily Kolaya, Bonnie L. Firestein
Biotechnology Progress.2021;[Epub] CrossRef
An Update on Medical and Surgical Treatments of Parkinson’s Disease
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar
Aging and disease.2021; 12(4): 1021. CrossRef
Experimental Characterization of Ferroelectric Capacitor Circuits for the Realization of Simply Designed Electroceuticals
Yves Olsommer, Frank R. Ihmig
Electronic Materials.2021; 2(3): 299. CrossRef
Flexible vs. standard subthalamic stimulation in Parkinson disease: A double-blind proof-of-concept cross-over trial
Derrick Soh, Ricardo Maciel, Musleh Algarni, Karlo Lizarraga, Aaron Loh, Jürgen Germann, Gavin Elias, Alexandre Boutet, Renato P. Munhoz, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 93. CrossRef
Telemedicine and Deep brain stimulation - Current practices and recommendations
Vibhash D. Sharma, Delaram Safarpour, Shyamal H. Mehta, Nora Vanegas-Arroyave, Daniel Weiss, Jeffrey W. Cooney, Zoltan Mari, Alfonso Fasano
Parkinsonism & Related Disorders.2021; 89: 199. CrossRef
Subspace-based predictive control of Parkinson’s disease: A model-based study
Mahboubeh Ahmadipour, Mojtaba Barkhordari-Yazdi, Saeid R. Seydnejad
Neural Networks.2021; 142: 680. CrossRef
Advances in Triboelectric Nanogenerators for Self‐Powered Regenerative Medicine
Samira Parandeh, Niloofar Etemadi, Mahshid Kharaziha, Guorui Chen, Ardo Nashalian, Xiao Xiao, Jun Chen
Advanced Functional Materials.2021; 31(47): 2105169. CrossRef
Implantable Pulse Generators for Deep Brain Stimulation: Challenges, Complications, and Strategies for Practicality and Longevity
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Ahmed Najjar, Michelle Paff, Anton Fomenko, Kazuaki Yamamoto, Ajmal Zemmar, Nir Lipsman, George M. Ibrahim, Clement Hamani, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano, Sun
Frontiers in Human Neuroscience.2021;[Epub] CrossRef
Microstimulation Is a Promising Approach in Achieving Better Lead Placement in Subthalamic Nucleus Deep Brain Stimulation Surgery
Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
Frontiers in Neurology.2021;[Epub] CrossRef
Revisiting brain stimulation in Parkinson’s disease
Carola A. Haas
Science.2021; 374(6564): 153. CrossRef
A New Implantable Closed-Loop Clinical Neural Interface: First Application in Parkinson’s Disease
Mattia Arlotti, Matteo Colombo, Andrea Bonfanti, Tomasz Mandat, Michele Maria Lanotte, Elena Pirola, Linda Borellini, Paolo Rampini, Roberto Eleopra, Sara Rinaldo, Luigi Romito, Marcus L. F. Janssen, Alberto Priori, Sara Marceglia
Frontiers in Neuroscience.2021;[Epub] CrossRef
Update on Parkinson's Disease Therapy
Rebecca M Gilbert
Neurology.2021; 17(2): 92. CrossRef
Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts
PareshK Doshi, Deepak Das
Neurology India.2020; 68(8): 179. CrossRef

Nutrition and Lifestyle Interventions for Managing Parkinson’s Disease: A Narrative Review: Tracy Lister; J Mov Disord. 2020;13(2):97-104. Published online May 29, 2020; DOI: https://doi.org/10.14802/jmd.20006

11,297 View
527 Download
8 Citations

Abstract PDF

The etiology of Parkinson’s disease (PD) is not fully understood, but environmental toxin overexposure, increased intestinal permeability, and dysbiosis related to nutrition and lifestyle habits are thought to be contributors. Considering these nutrition and lifestyle implications, there is a lack of practice-based programs utilizing interventions for managing symptoms or slowing the progression of the disease. The purpose of this narrative review was to identify relevant research related to nutrition and lifestyle interventions for PD, evaluate the research utilizing the evidence analysis process of the Academy of Nutrition and Dietetics to assess the quality of each research article, and group the research into categories. A grading of recommendations assessment, development and evaluation (GRADE) of either good, fair, limited, or not assignable was allocated to each category of research, including diet patterns, vitamin D, B-complex, omega-3 fatty acids, coenzyme Q10, probiotics, physical activity, stress, and sleep. An intervention based on the research presented in the review may be utilized for coaching people with PD on symptom management.

Citations

Citations to this article as recorded by

A Qualitative Analysis of Experiences With Food-Related Activities Among People Living With Parkinson Disease and Their Care-Partners
Christine C. Ferguson, Seung Eun Jung, Jeannine C. Lawrence, Joy W. Douglas, Anne Halli-Tierney, Chuong Bui, Amy C. Ellis
Journal of Applied Gerontology.2023; 42(1): 131. CrossRef
Mobile health technology, exercise adherence and optimal nutrition post rehabilitation among people with Parkinson’s Disease (mHEXANUT) – a randomized controlled trial protocol
Sigrid Ryeng Alnes, Ellisiv Lærum-Onsager, Asta Bye, Annette Vistven, Erika Franzén, Mette Holst, Therese Brovold
BMC Neurology.2023;[Epub] CrossRef
Association between smoking and all-cause mortality in Parkinson’s disease
Seo Yeon Yoon, You Hyun Park, Sang Chul Lee, Jee Hyun Suh, Seung Nam Yang, Dae Ryong Kang, Yong Wook Kim
npj Parkinson's Disease.2023;[Epub] CrossRef
Molecular insights into the pathogenic impact of vitamin D deficiency in neurological disorders
Md Jamir Anwar, Sattam Khulaif Alenezi, Ahmad Hamad Alhowail
Biomedicine & Pharmacotherapy.2023; 162: 114718. CrossRef
Effect of vitamin D and other indicators of phosphorus-calcium metabolism on cognitive functions and quality of life in patients with Parkinson's disease
D. A. Novotnyy, N. G. Zhukova, L. P. Shperling, V. A. Stolyarova, I. A. Zhukova, A. E. Agasheva, S. V. Shtaimets, O. A. Druzhinina, I. V. Shirokikh
Neurology, Neuropsychiatry, Psychosomatics.2022; 14(1): 38. CrossRef
Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease
Carmen Costas, Lilian R.F. Faro
Current Neuropharmacology.2022; 20(2): 432. CrossRef
Laboratory prognostic factors for the long-term survival of multiple system atrophy
Jung Hwan Shin, Han-Joon Kim, Chan Young Lee, Hee Jin Chang, Kyung Ah Woo, Beomseok Jeon
npj Parkinson's Disease.2022;[Epub] CrossRef
Association Between Smoking and All-Cause Mortality in Parkinson's Disease
Seo Yeon Yoon, You Hyun Park, Sang Chul Lee, Jee Hyun Suh, Seung Nam Yang, Dae Ryong Kang, Yong Wook Kim
SSRN Electronic Journal .2022;[Epub] CrossRef

Original Articles

Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson’s Disease: Hae-Won Shin, Mi Sun Kim, Sung Reul Kim, Sang Ryong Jeon, Sun Ju Chung; J Mov Disord. 2020;13(2):127-132. Published online May 29, 2020; DOI: https://doi.org/10.14802/jmd.19081

5,194 View
198 Download
4 Citations

Abstract PDF

Objective
The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson’s disease (PD) remain unclear. In this study, we aimed to evaluate the longterm effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. Methods This study included 49 consecutively included patients with PD who underwent bilateral STN-DBS. The Unified Parkinson’s Disease Rating Scale (UPDRS) scores and subscores for PIGD were assessed at baseline and at 1, 3, and 5 years postoperatively. The PIGD subscore was divided into PIGD-motor and PIGD-activities of daily living (ADL) scores according to parts III and II of the UPDRS, respectively. Results The PIGD-motor and PIGD-ADL scores at the “medication-off” state improved at 3 and 5 years, respectively. Overall, the UPDRS III and II scores at “medication-off” improved at 5 years. The UPDRS IV score also significantly improved and the levodopa equivalent daily dosage decreased at all follow-ups. Finally, the PIGD-motor score at baseline was able to predict long-term improvement in the PIGD-motor score at the 5-year follow-up. Conclusion The STN-DBS has both short- and long-term effects on PIGD, as well as overall motor function, in patients with advanced PD. The degree of PIGD at the preoperative evaluation can be used to predict long-term outcomes after STN-DBS surgery.

Citations

Citations to this article as recorded by

Long-term motor outcomes of deep brain stimulation of the globus pallidus interna in Parkinson's disease patients: Five-year follow-up
Yun Su Hwang, Sungyang Jo, Seung Hyun Lee, Nayoung Kim, Mi-Sun Kim, Sang Ryong Jeon, Sun Ju Chung
Journal of the Neurological Sciences.2023; 444: 120484. CrossRef
Smartwatch gait coordination index: New measure for human gait utilizing smartwatch sensor
Sumin Han, Rob Paul
Medicine.2023; 102(12): e33267. CrossRef
The Role of Microelectrode Recording in Deep Brain Stimulation Surgery for Parkinson’s Disease: A Systematic Review and Meta-Analysis
R. Saman Vinke, Martin Geerlings, Ashok K. Selvaraj, Dejan Georgiev, Bastiaan R. Bloem, Rianne A.J. Esselink, Ronald H.M.A. Bartels
Journal of Parkinson's Disease.2022; 12(7): 2059. CrossRef
Axial impairment and falls in Parkinson’s disease: 15 years of subthalamic deep brain stimulation
Alessandro Zampogna, Francesco Cavallieri, Francesco Bove, Antonio Suppa, Anna Castrioto, Sara Meoni, Pierre Pélissier, Emmanuelle Schmitt, Amélie Bichon, Eugénie Lhommée, Andrea Kistner, Stephan Chabardès, Eric Seigneuret, Valerie Fraix, Elena Moro
npj Parkinson's Disease.2022;[Epub] CrossRef

Association between Olfactory Deficit and Motor and Cognitive Function in Parkinson’s Disease: Han Soo Yoo, Seok Jong Chung, Yang Hyun Lee, Byoung Seok Ye, Young H. Sohn, Phil Hyu Lee; J Mov Disord. 2020;13(2):133-141. Published online April 6, 2020; DOI: https://doi.org/10.14802/jmd.19082

7,864 View
267 Download
13 Citations

Abstract PDF Supplementary Material

Objective
To investigate whether baseline olfactory dysfunction in Parkinson’s disease (PD) patients is associated with baseline and longitudinal motor and cognitive function.
Methods
We recruited 228 drug-naïve PD patients who were followed for a mean of 6 years. Patients underwent the Cross-Cultural Smell Identification Test (CCSIT), a neuropsychological test, and N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane positron emission tomography within 6 months of the baseline evaluation. Olfactory dysfunction was categorized as normosmia (CCSIT score ≥ 9), hyposmia (CCSIT score 5–8), and anosmia (CCSIT score ≤ 4). During the follow-up period, we investigated changes in the levodopa-equivalent dose (LED) and the occurrence of wearing-off, levodopa-induced dyskinesia, and dementia.
Results
Among the PD patients, 80.7% were hyposmic at the time of diagnosis, and 26.1% were anosmic. Baseline olfactory dysfunction was not associated with either initial parkinsonian motor symptoms or with the longitudinal LED increment and motor complications. Meanwhile, the anosmic group had lower baseline scores on the Korea version of the Boston Naming Test and Stroop color reading test than the normosmic and hyposmic groups. The anosmic group exhibited a higher rate of conversion to dementia than the normosmic [adjusted hazard ratio (HR) 3.99, 95% confidence interval (CI) 1.08–14.72] and hyposmic (adjusted HR 2.48, 95% CI 1.15–5.32) PD groups, regardless of baseline motor deficits and cognitive status.
Conclusion
Baseline olfactory dysfunction was not associated with motor deficits and complications, but it was associated with cognitive dysfunction and prognosis, suggesting that severe olfactory impairment may reflect early cortical involvement, probably in the frontotemporal region, and rapid spreading of Lewy body pathology.

Citations

Citations to this article as recorded by

Olfactory dysfunction is associated with motor function only in tremor-dominant Parkinson’s disease
Fardin Nabizadeh, Kasra Pirahesh, Elham Khalili
Neurological Sciences.2022; 43(7): 4193. CrossRef
Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial
Jaewon Kim, Dong Keon Yon, Kyu Yeong Choi, Jang Jae Lee, Namwoo Kim, Kun Ho Lee, Jae Gwan Kim
Alzheimer's Research & Therapy.2022;[Epub] CrossRef
The Role of Olfactory System in the Etiogenesis of Parkinson’s Diseases: An Overview
Jiju Narayanan Avanipully, Dithu Thekkekkara, Sahyadri M, Vipan K. Parihar, Santhepete Nanjundaiah Manjula
Journal of Pharmacology and Pharmacotherapeutics.2022; 13(1): 31. CrossRef
International consensus statement on allergy and rhinology: Olfaction
Zara M. Patel, Eric H. Holbrook, Justin H. Turner, Nithin D. Adappa, Mark W. Albers, Aytug Altundag, Simone Appenzeller, Richard M. Costanzo, Ilona Croy, Greg E. Davis, Puya Dehgani‐Mobaraki, Richard L. Doty, Valerie B. Duffy, Bradley J. Goldstein, David
International Forum of Allergy & Rhinology.2022; 12(4): 327. CrossRef
Does Olfactory Dysfunction Correlate with Disease Progression in Parkinson’s Disease? A Systematic Review of the Current Literature
Tommaso Ercoli, Carla Masala, Gianluca Cadeddu, Marcello Mario Mascia, Gianni Orofino, Angelo Fabio Gigante, Paolo Solla, Giovanni Defazio, Lorenzo Rocchi
Brain Sciences.2022; 12(5): 513. CrossRef
Olfactory dysfunction and striatal dopamine transporter binding in motor subtypes of Parkinson’s disease
Fardin Nabizadeh, Fatemeh Sodeifian, Kasra Pirahesh
Neurological Sciences.2022; 43(8): 4745. CrossRef
Olfaction and Executive Cognitive Performance: A Systematic Review
Vasudeva Murthy Challakere Ramaswamy, Peter William Schofield
Frontiers in Psychology.2022;[Epub] CrossRef
Nasal and Parotid Blood Pool Activity Is Significantly Correlated with Metabolic Syndrome Components and Sleep Apnea
William T. Phillips, Nasser J. Issa, Shereef B. Elhalwagi, Hilda T. Draeger, Joyce G. Schwartz, Jonathan A. Gelfond
Metabolic Syndrome and Related Disorders.2022; 20(7): 395. CrossRef
Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium
Gabriel A. de Erausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Rufus Akinyemi, Kameshwar Prasad, Giovanni D'Avossa, Gabriel
Alzheimer's & Dementia: Translational Research & Clinical Interventions.2022;[Epub] CrossRef
Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease
Joshua Harvey, Rick A. Reijnders, Rachel Cavill, Annelien Duits, Sebastian Köhler, Lars Eijssen, Bart P. F. Rutten, Gemma Shireby, Ali Torkamani, Byron Creese, Albert F. G. Leentjens, Katie Lunnon, Ehsan Pishva
npj Parkinson's Disease.2022;[Epub] CrossRef
Impact of Subthalamic Deep Brain Stimulation on Hyposmia in Patients With Parkinson's Disease Is Influenced by Constipation and Dysbiosis of Microbiota
Chao Li, Ying Hou, Xu Wang, Yue-xuan Li, Feng Li, Chao Zhang, Wei-guo Li
Frontiers in Neurology.2021;[Epub] CrossRef
Hyposmia may predict development of freezing of gait in Parkinson’s disease
Jae Jung Lee, Jin Yong Hong, Jong Sam Baik
Journal of Neural Transmission.2021; 128(6): 763. CrossRef
Clinical and Dopamine Depletion Patterns in Hyposmia- and Dysautonomia-Dominant Parkinson’s Disease
Han Soo Yoo, Sangwon Lee, Seong Ho Jeong, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Phil Hyu Lee
Journal of Parkinson's Disease.2021; 11(4): 1703. CrossRef

Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia: Mark M. Lin, Robert Laureno; J Mov Disord. 2019;12(1):37-42. Published online January 30, 2019; DOI: https://doi.org/10.14802/jmd.18046

7,820 View
259 Download
6 Citations

Abstract PDF

Objective
To evaluate whether less pulsatile levodopa therapy (LPT) can reduce the development of levodopa-induced dyskinesia (LID).
Methods
This is a retrospective cohort study of patients with Parkinson’s disease at the movement disorders clinic of Medstar Washington Hospital Center. The study was not blinded or randomized. Patients were seen between August 2002 and August 2018. During these years, we treated patients with less pulsatile (6 doses daily) levodopa treatment to reduce LID. Occurrence of LID was recorded.
Results
Ninety-five patients with Parkinson’s disease taking levodopa were divided into two groups: 1) patients who were initially managed on LPT or who switched from traditional therapy (TT) (n = 61) (mean disease duration: 7.7 ± 4.8 years, mean levodopa duration: 5.6 ± 4.5 years and mean observation time: 4.3 ± 3.4 years), and 2) patients on TT throughout the observation period or until they developed dyskinesia (n = 34) (mean disease duration: 8.3 ± 3.8 years, mean levodopa duration: 6.2 ± 4.2 years and mean observation time: 4.1 ± 3.4 years). Three of the 61 LPT patients developed dyskinesia during the observation period. One of the patients developed dyskinesia after being switched to pulsatile doses by another doctor. In the other two, dyskinesia was minimal. In contrast to this 4.9% cumulative incidence, dyskinesia occurred in 50% (17/34) of TT patients, an incidence similar to that in published data (p < 0.001).
Conclusion
Less pulsatile levodopa with 6 daily doses was associated with a low incidence of LID. Further study of this method of treatment is warranted.

Citations

Citations to this article as recorded by

Dopamine D1 Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease
Mechelle M. Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul J. Eslinger, Julio Fernandez-Mendoza, Lan Kong, Yang Yang, Bethany L. Snyder, Natalia Loktionova, Sridhar Duvvuri, David L. Gray, Xuemei Huang, Richard B. Mailman
Biomolecules.2023; 13(5): 829. CrossRef
Personalized Medicine Approach in Treating Parkinson’s Disease, Using Oral Administration of Levodopa/Carbidopa Microtablets in Clinical Practice
Helga María Grétarsdóttir, Erik Widman, Anders Johansson, Dag Nyholm
Journal of Personalized Medicine.2021; 11(8): 720. CrossRef
Current Knowledge on the Background, Pathophysiology and Treatment of Levodopa-Induced Dyskinesia—Literature Review
Michał Hutny, Jagoda Hofman, Aleksandra Klimkowicz-Mrowiec, Agnieszka Gorzkowska
Journal of Clinical Medicine.2021; 10(19): 4377. CrossRef
Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
Shi‐Ying Fan, Kai‐Liang Wang, Wei Hu, Robert S. Eisinger, Alexander Han, Chun‐Lei Han, Qiao Wang, Shimabukuro Michitomo, Jian‐Guo Zhang, Feng Wang, Adolfo Ramirez‐Zamora, Fan‐Gang Meng
Annals of Clinical and Translational Neurology.2020; 7(1): 59. CrossRef
A Stage-Based Approach to Therapy in Parkinson’s Disease
Claudia Carrarini, Mirella Russo, Fedele Dono, Martina Di Pietro, Marianna G. Rispoli, Vincenzo Di Stefano, Laura Ferri, Filomena Barbone, Michela Vitale, Astrid Thomas, Stefano Luca Sensi, Marco Onofrj, Laura Bonanni
Biomolecules.2019; 9(8): 388. CrossRef
The Gut Microbiome: A Therapeutically Targetable Site of Peripheral Levodopa Metabolism
Eoin Mulroy, Kailash P. Bhatia
Movement Disorders Clinical Practice.2019; 6(7): 547. CrossRef

Validation of the Conversion between the Mini-Mental State Examination and Montreal Cognitive assessment in Korean Patients with Parkinson’s Disease: Ryul Kim, Han-Joon Kim, Aryun Kim, Mi-Hee Jang, Hyun Jeong Kim, Beomseok Jeon; J Mov Disord. 2018;11(1):30-34. Published online January 11, 2018; DOI: https://doi.org/10.14802/jmd.17038

8,014 View
236 Download
13 Citations

Abstract PDF

Objective
Two conversion tables between the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) have recently been established for Parkinson’s disease (PD). This study aimed to validate them in Korean patients with PD and to evaluate whether they could be influenced by educational level.
Methods
A total of 391 patients with PD who undertook both the Korean MMSE and the Korean MoCA during the same session were retrospectively assessed. The mean, median, and root mean squared error (RMSE) of the difference between the true and converted MMSE scores and the intraclass correlation coefficient (ICC) were calculated according to educational level (6 or fewer years, 7–12 years, or 13 or more years).
Results
Both conversions had a median value of 0, with a small mean and RMSE of differences, and a high correlation between the true and converted MMSE scores. In the classification according to educational level, all groups had roughly similar values of the median, mean, RMSE, and ICC both within and between the conversions.
Conclusion
Our findings suggest that both MMSE-MoCA conversion tables are useful instruments for transforming MoCA scores into converted MMSE scores in Korean patients with PD, regardless of educational level. These will greatly enhance the utility of the existing cognitive data from the Korean PD population in clinical and research settings.

Citations

Citations to this article as recorded by

Comparative study of two Chinese versions of Montreal Cognitive Assessment for Screening of Mild Cognitive Impairment
Yu-Yuan Huang, Shu-Xia Qian, Qiao-Bing Guan, Ke-Liang Chen, Qian-Hua Zhao, Jia-Hong Lu, Qi-Hao Guo
Applied Neuropsychology: Adult.2021; 28(1): 88. CrossRef
Conversion between Mini‐Mental State Examination and Montreal Cognitive Assessment scores in older adults undergoing selective surgery using Rasch analysis
Xiaoying Chen, Huangliang Wen, Jinni Wang, Yayan Yi, Jialan Wu, Xiaoyan Liao
Journal of Advanced Nursing.2021; 77(2): 729. CrossRef
Converting from the Montreal Cognitive Assessment to the Mini-Mental State Examination-2
Hwabeen Yang, Daehyuk Yim, Moon Ho Park, Antony Bayer
PLOS ONE.2021; 16(7): e0254055. CrossRef
Validation of Four Methods for Converting Scores on the Montreal Cognitive Assessment to Scores on the Mini-Mental State Examination-2
Sung Hoon Kang, Moon Ho Park
Dementia and Neurocognitive Disorders.2021; 20(4): 41. CrossRef
Կոգնիտիվ վիճակի գնահատման Mini-Mental State Examination (MMSE) սանդղակի հայերեն տարբերակի ադապտացում և վալիդացում
Մ.Ա. Իսայան, Հ.Ա. Հովակիմյան, Լ.Վ. Վարդանյան, Ս.Գ. Խաչատրյան, Զ.Դ. Թավադյան
Armenian Journal of Health & Medical Sciences.2021; : 27. CrossRef
Determinant of Quality of Life in Patients with Chronic Cerebral Infarct
Yujin Lee, Joon Sung Kim, Bo Young Hong, Jung Geun Park, Jae Wan Yoo, Kyoung Bo Lee, Tae-Woo Kim, Seong Hoon Lim
Brain & Neurorehabilitation.2020;[Epub] CrossRef
Concordance of Mini-Mental State Examination, Montreal Cognitive Assessment and Parkinson Neuropsychometric Dementia Assessment in the classification of cognitive performance in Parkinson's disease
Jannik Florian Scheffels, Leon Fröhlich, Elke Kalbe, Josef Kessler
Journal of the Neurological Sciences.2020; 412: 116735. CrossRef
Hand motor functions on the presence of red fluorescent dental biofilm in older community-dwelling Koreans
Na-Ri Shin, Yeo-Jin Yi, Jun-Seon Choi
Photodiagnosis and Photodynamic Therapy.2019; 28: 120. CrossRef
Is the modified Mann Assessment of Swallowing Ability useful for assessing dysphagia in patients with mild to moderate dementia?
Eun Kyu Ji, Hae Hyun Wang, Sung June Jung, Kyoung Bo Lee, Joon Sung Kim, Bo Young Hong, Seong Hoon Lim
Journal of Clinical Neuroscience.2019; 70: 169. CrossRef
The Changes for Strength of Oropharyngeal Muscles in Patients with Dementia and Dysphagia
Eun Kyu Ji, Hae Hyun Wang, Sung June Jung, Kyoung Bo Lee, Joon Sung Kim, Bo Young Hong, Tae-Woo Kim, Seong Hoon Lim
Brain & Neurorehabilitation.2019;[Epub] CrossRef
Konversionen von kognitiven Screenings
J. F. Scheffels, H. Kräling, E. Kalbe, J. Kessler
Der Nervenarzt.2018; 89(12): 1371. CrossRef
Manual Dexterity and Aging: A Pilot Study Disentangling Sensorimotor From Cognitive Decline
Loic Carment, Abir Abdellatif, Carmelo Lafuente-Lafuente, Sylvie Pariel, Marc A. Maier, Joël Belmin, Påvel G. Lindberg
Frontiers in Neurology.2018;[Epub] CrossRef
Validation of MoCA-MMSE Conversion Scales in Korean Patients with Cognitive Impairments
Young Ik Jung, Eun Hye Jeong, Heejin Lee, Junghee Seo, Hyun-Jeong Yu, Jin Y. Hong, Mun Kyung Sunwoo
Dementia and Neurocognitive Disorders.2018; 17(4): 148. CrossRef

Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Study: Chang Soo Kim, Young Hee Sung, Min Ju Kang, Kee Hyung Park; J Mov Disord. 2016;9(2):114-119. Published online March 2, 2016; DOI: https://doi.org/10.14802/jmd.15039

15,383 View
141 Download
8 Citations

Abstract PDF

Objective
Rapid eye movement sleep behavior disorder (RBD) is associated with α-synucleinopathies, such as Parkinson’s disease (PD). We aimed to assess the differences in the clinical characteristics of PD with and without RBD.
Methods
Forty-two patients previously diagnosed with PD were evaluated for clinical history, motor and cognitive functioning using the Unified Parkinson’s Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE), autonomic symptoms, sleep characteristics using the Pittsburg Sleep Quality Index (PSQI), and the presence of RBD using the Korean version of the RBD screening questionnaire (RBDSQ). The prevalence of RBD and the patients’ demographic features were evaluated. The patients were classified into two groups, PD with RBD and PD without RBD, based on the RBDSQ scores. The motor and cognitive functions, as well as other clinical features of the two groups were compared.
Results
A total of 42 PD patients were enrolled. Eighteen patients were classified as PD with RBD. Compared to PD without RBD, PD with RBD showed higher scores of rigidity in the UPDRS subscale. Regarding sleep problems, PD with RBD revealed higher sleep disturbance, lower sleep efficiency, and lower overall sleep quality in the PSQI. There was no difference in cognitive dysfunction between the two groups according to the Korean version of the MMSE.
Conclusions
PD with RBD was associated with poorer sleep and motor symptoms. Therefore, RBD symptoms in PD are possibly poor prognostic markers.

Citations

Citations to this article as recorded by

Cerebellar Microstructural Abnormalities in Parkinson’s Disease: a Systematic Review of Diffusion Tensor Imaging Studies
Maryam Haghshomar, Parnian Shobeiri, Seyed Arsalan Seyedi, Fatemeh Abbasi-Feijani, Amirhossein Poopak, Houman Sotoudeh, Arash Kamali, Mohammad Hadi Aarabi
The Cerebellum.2022; 21(4): 545. CrossRef
A data-driven system to identify REM sleep behavior disorder and to predict its progression from the prodromal stage in Parkinson's disease
Matteo Cesari, Julie A.E. Christensen, Maria-Lucia Muntean, Brit Mollenhauer, Friederike Sixel-Döring, Helge B.D. Sorensen, Claudia Trenkwalder, Poul Jennum
Sleep Medicine.2021; 77: 238. CrossRef
Impact of Obstructive Sleep Apnea on Cognitive and Motor Functions in Parkinson's Disease
Mohamed Elfil, Eshak I. Bahbah, Mahmoud M. Attia, Mohamed Eldokmak, Brian B. Koo
Movement Disorders.2021; 36(3): 570. CrossRef
Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study
Gianpaolo Maggi, Luigi Trojano, Paolo Barone, Gabriella Santangelo
Neuropsychology Review.2021; 31(4): 643. CrossRef
Risk stratification for REM sleep behavior disorder in patients with Parkinson’s disease: A PRISMA-compliant meta-analysis and systematic review
Chengjuan Xie, Mingyu Zhu, Ying Hu
Clinical Neurology and Neurosurgery.2021; 202: 106484. CrossRef
REM sleep behavior disorder portends poor prognosis in Parkinson’s disease: A systematic review
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
Journal of Clinical Neuroscience.2018; 47: 6. CrossRef
Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang, Anmu Xie
Neurological Sciences.2017; 38(1): 163. CrossRef
Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis
Ruo-lin Zhu, Cheng-juan Xie, Pan-pan Hu, Kai Wang
Scientific Reports.2017;[Epub] CrossRef

Review Article

The Current Status of Deep Brain Stimulation for the Treatment of Parkinson Disease in the Republic of Korea: Jung-Il Lee; J Mov Disord. 2015;8(3):115-121. Published online September 10, 2015; DOI: https://doi.org/10.14802/jmd.15043

20,261 View
118 Download
6 Citations

Abstract PDF

Parkinson disease (PD) is a common neurodegenerative disease with an increasing prevalence in Korea. Deep brain stimulation (DBS) is a safe and effective surgical treatment option for this disease. The aim of this review was to provide an update regarding current DBS practices with respect to the treatment of PD in the Republic of Korea. The first DBS in Korea was performed in 2000; approximately 2,000 patients have undergone DBS for a variety of neurological disorders, the majority of whom were patients with PD. Approximately 150 new patients with PD receive DBS annually, and more than 20 centers perform DBS. However, DBS remains underutilized for many reasons, and the clinical case burden at many institutions is below the level presumed adequate for qualified practice. With a rapidly aging population and an evolving socioeconomic environment, the need for surgical intervention for PD is likely to increase significantly in the future. Many issues such as finances, education, and quality assurance must be resolved to cope with this need.

Citations

Citations to this article as recorded by

Practice Trends of Neuromodulation Therapies for Pain and Spasticity in India
Preeti P. Doshi, Marc Russo, Paresh K. Doshi
Neuromodulation: Technology at the Neural Interface.2021;[Epub] CrossRef
An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East
Chencheng Zhang, Adolfo Ramirez-Zamora, Fangang Meng, Zhengyu Lin, Yijie Lai, Dianyou Li, Jinwoo Chang, Takashi Morishita, Tooru Inoue, Shinsuke Fujioka, Genko Oyama, Terry Coyne, Valerie Voon, Paresh K. Doshi, Yiwen Wu, Jun Liu, Bhavana Patel, Leonardo A
Frontiers in Human Neuroscience.2020;[Epub] CrossRef
Canadian Assessment of Deep Brain Stimulation Access: The Canada Study
C. Michael Honey, Armaan K. Malhotra, Mandeep S. Tamber, Michel Prud’homme, Ivar Mendez, Christopher R. Honey
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2018; 45(5): 553. CrossRef
Association of Parkinsonism or Parkinson Disease with Polypharmacy in the Year Preceding Diagnosis: A Nested Case–Control Study in South Korea
Hae-Young Park, Ji-Won Park, Hyun Soon Sohn, Jin-Won Kwon
Drug Safety.2017; 40(11): 1109. CrossRef
La Enfermedad de Parkinson: Etiología, Tratamientos y Factores Preventivos
F Hurtado, Melissa Andrea N Cardenas, Fernando Cardenas, Laura Andrea León
Universitas Psychologica.2017;[Epub] CrossRef
Isolated dystypia after subthalamic nucleus deep brain stimulation in a patient with Parkinson’s disease
Si-Hoon Lee, Kipyung Jeon, Byung-chul Son, Joong-Seok Kim
Acta Neurochirurgica.2016; 158(4): 783. CrossRef

Original Article

Effect of Rivastigmine on Behavioral and Psychiatric Symptoms of Parkinson’s Disease Dementia: Yoon-Sang Oh, Joong-Seok Kim, Phil Hyu Lee; J Mov Disord. 2015;8(2):98-102. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15041

19,164 View
242 Download
27 Citations

Abstract PDF

Objective A recent study showed that rivastigmine and memantin improved behavioral and psychiatric symptoms of dementia (BPSD) in Alzheimer’s dementia. Furthermore, according to recent guidelines presented by the Movement Disorder Society, rivastigmine is efficacious for the treatment of dementia in Parkinson’s disease (PD). We investigated the efficacy of rivastigmine for BPSD in patients with Parkinson’s disease dementia (PDD).
Methods Twenty-three patients in whom cognitive impairment occurred at least one year after a diagnosis of PD participated in this open-label trial. Cognitive, psychiatric, and motor symptoms were assessed before and after 24 weeks of treatment with rivastigmine using unstructured clinical assessments and rating scales including the Unified Parkinson’s Disease Rating Scale, Mini-Mental State Examination (MMSE), and the Neuropsychiatric Inventory.
Results Age (± standard deviation) was 74.7 ± 5.9 years, average duration of PD was 3.5 ± 3.7 years, Hoehn and Yahr scores were 2.2 ± 0.8, and baseline MMSE scores were 19.1 ± 4.2. Improvements in global mental symptoms and neuropsychiatric symptoms were significant; among them, hallucination, depression and appetite changes improved. Caregiver distress significantly decreased, including distress resulting from hallucinations, depression, apathy, and appetite changes.
Conclusions Although controlled trials are required, the findings suggest that rivastigmine is useful for control of several neuropsychiatric symptoms and beneficial for caregiver distress in patients with PDD.

Citations

Citations to this article as recorded by

Parkinsonism and dementia
Christos Koros, Leonidas Stefanis, Nikolaos Scarmeas
Journal of the Neurological Sciences.2022; 433: 120015. CrossRef
Current concepts in treating mild cognitive impairment in Parkinson's disease
Jay S. Schneider, Sandhya Kortagere
Neuropharmacology.2022; 203: 108880. CrossRef
Apathy in Parkinson’s Disease: Defining the Park Apathy Subtype
Ségolène De Waele, Patrick Cras, David Crosiers
Brain Sciences.2022; 12(7): 923. CrossRef
Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis
Łucja Justyna Walczak-Nowicka, Mariola Herbet
International Journal of Molecular Sciences.2021; 22(17): 9290. CrossRef
Diagnosis and treatment of old-onset Parkinson's disease
久大立花
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2021; 58(3): 341. CrossRef
Neuropsychiatrische Störungen bei idiopathischem Parkinson-Syndrom
Mario Paulig
Nervenheilkunde.2021; 40(10): 752. CrossRef
Cannabis Dopaminergic Effects Induce Hallucinations in a Patient with Parkinson’s Disease
Katie Pizzolato, David Thacker, Nicole Del Toro-Pagán, Abeer Hanna, Jacques Turgeon, Adriana Matos, Nishita Amin, Veronique Michaud
Medicina.2021; 57(10): 1107. CrossRef
Effectiveness of clozapine, oxcarbazepine and rivastigmine combination in a bipolar disorder patient with initial cerebral atrophy
Paolo Morana, Federico Mucci, Stefano Baroni, Alessandra Della Vecchia, Armando Piccinni, Benedetto Morana, Donatella Marazziti
Clinical Case Reports.2020; 8(2): 254. CrossRef
Neuropsychiatric Disorders in Parkinson’s Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?
Kathy Dujardin, Véronique Sgambato
Frontiers in Neuroscience.2020;[Epub] CrossRef
Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson’s Disease, and Multiple Sclerosis: Diagnosis and Treatment
Susan K. Conroy, Katherine B. Brownlowe, Thomas W. McAllister
FOCUS.2020; 18(2): 150. CrossRef
Identifying and responding to fatigue and apathy in Parkinson’s disease: a review of current practice
Claudia Lazcano-Ocampo, Yi Min Wan, Daniel J van Wamelen, Lucia Batzu, Iro Boura, Nataliya Titova, Valentina Leta, Mubasher Qamar, Pablo Martinez-Martin, K Ray Chaudhuri
Expert Review of Neurotherapeutics.2020; 20(5): 477. CrossRef
Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review
Bria Mele, Shinia Van, Jayna Holroyd-Leduc, Zahinoor Ismail, Tamara Pringsheim, Zahra Goodarzi
BMJ Open.2020; 10(9): e037632. CrossRef
Pharmacological treatment of apathy in Lewy body disorders: A systematic review
Jennifer Liu, Christine A. Cooper, Daniel Weintraub, Nabila Dahodwala
Parkinsonism & Related Disorders.2019; 60: 14. CrossRef
Current treatment of behavioral and cognitive symptoms of Parkinson's disease
Irena Rektorova
Parkinsonism & Related Disorders.2019; 59: 65. CrossRef
Approach to the management of psychosis in Parkinson’s disease
Abhishek Lenka, Vasanthi Gomathinayagam, Laxman Bahroo
Annals of Movement Disorders.2019; 2(3): 83. CrossRef
Risk factors for non-motor symptoms in Parkinson's disease
Johan Marinus, Kangdi Zhu, Connie Marras, Dag Aarsland, Jacobus J van Hilten
The Lancet Neurology.2018; 17(6): 559. CrossRef
The efficacy of pharmacological approaches to therapy of the apathy syndrome in dementia disorders (the review)
A. S. Avedisova, A. B. Guekht, K. V. Zakharova, R. G. Akzhigitov
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2018; 118(4): 126. CrossRef
Rivastigmine as a Symptomatic Treatment for Apathy in Parkinson’s Dementia Complex: New Aspects for This Riddle
Rita Moretti, Paola Caruso, Matteo Dal Ben
Parkinson's Disease.2017; 2017: 1. CrossRef
Caregiver Burden in Parkinson Disease: A Critical Review of Recent Literature
Philip E. Mosley, Rebecca Moodie, Nadeeka Dissanayaka
Journal of Geriatric Psychiatry and Neurology.2017; 30(5): 235. CrossRef
Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson’s Disease: Implication for Treatment
Stephane Thobois, Stephane Prange, Véronique Sgambato-Faure, Léon Tremblay, Emmanuel Broussolle
Current Neurology and Neuroscience Reports.2017;[Epub] CrossRef
Parkinson's disease psychosis: presentation, diagnosis and management
Ruth B Schneider, Julia Iourinets, Irene H Richard
Neurodegenerative Disease Management.2017; 7(6): 365. CrossRef
Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson’s Disease
Yunlong Zhang, Feng Tan, Pingyi Xu, Shaogang Qu
Neural Plasticity.2016; 2016: 1. CrossRef
Neuropsychiatric Issues in Parkinson’s Disease
Jeffrey W. Cooney, Mark Stacy
Current Neurology and Neuroscience Reports.2016;[Epub] CrossRef
Parkinson's disease psychosis: therapy tips and the importance of communication between neurologists and psychiatrists
Daniel Martinez-Ramirez, Michael S Okun, Michael S Jaffee
Neurodegenerative Disease Management.2016; 6(4): 319. CrossRef
Pimavanserin for the treatment of Parkinson’s disease psychosis
Ines Chendo, Joaquim J Ferreira
Expert Opinion on Pharmacotherapy.2016; 17(15): 2115. CrossRef
Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments
Fleur Harrison, Liesbeth Aerts, Henry Brodaty
Current Psychiatry Reports.2016;[Epub] CrossRef
Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration
Santiago Perez-Lloret, María Cecilia Peralta, Francisco J. Barrantes
Expert Opinion on Pharmacotherapy.2016; 17(18): 2405. CrossRef

Review Article

Nonmotor Symptoms and Subthalamic Deep Brain Stimulation in Parkinson’s Disease: Han-Joon Kim, Beom S. Jeon, Sun Ha Paek; J Mov Disord. 2015;8(2):83-91. Published online May 31, 2015; DOI: https://doi.org/10.14802/jmd.15010

23,540 View
238 Download
41 Citations

Abstract PDF

Subthalamic deep brain stimulation (STN DBS) is an established treatment for the motor symptoms in patients with advanced Parkinson’s disease (PD). In addition to improvements in motor symptoms, many studies have reported changes in various nonmotor symptoms (NMSs) after STN DBS in patients with PD. Psychiatric symptoms, including depression, apathy, anxiety, and impulsivity, can worsen or improve depending on the electrical stimulation parameters, the locations of the stimulating contacts within the STN, and changes in medications after surgery. Global cognitive function is not affected by STN DBS, and there is no increase in the incidence of dementia after STN DBS compared to that after medical treatment, although clinically insignificant declines in verbal fluency have been consistently reported. Pain, especially PD-related pain, improves with STN DBS. Evidence regarding the effects of STN DBS on autonomic symptoms and sleep-related problems is limited and remains conflicting. Many symptoms of nonmotor fluctuations, which are occasionally more troublesome than motor fluctuations, improve with STN DBS. Although it is clear that NMSs are not target symptoms for STN DBS, NMSs have a strong influence on the quality of life of patients with PD, and clinicians should thus be aware of these NMSs when deciding whether to perform surgery and should pay attention to changes in these symptoms after STN DBS to ensure the optimal care for patients.

Citations

Citations to this article as recorded by

A Wellness Prescription for Parkinson's: Mid to Late-stage Disease
Gregory M Pontone, Bradley McDaniels, Adrienne M Keener, Indu Subramanian
The American Journal of Geriatric Psychiatry.2023;[Epub] CrossRef
Subthalamic Nucleus Stimulation in Parkinson's Disease: 5‐Year Extension Study of a Randomized Trial
Silje Bjerknes, Mathias Toft, Reidun Brandt, Trine Waage Rygvold, Ane Konglund, Espen Dietrichs, Stein Andersson, Inger Marie Skogseid
Movement Disorders Clinical Practice.2022; 9(1): 48. CrossRef
Effects of subthalamic deep brain stimulation on non‐motor symptoms of Parkinson's disease: A meta‐analysis
Zahra Eghlidos, Zahra Rahimian, Gholamreza Vadiee, Soodeh Jahangiri
Acta Neurologica Scandinavica.2022; 146(2): 115. CrossRef
Nomogram for Predicting Depression Improvement after Deep Brain Stimulation for Parkinson’s Disease
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Brain Sciences.2022; 12(7): 841. CrossRef
A nigra–subthalamic circuit is involved in acute and chronic pain states
Cui Yin, Tao Jia, Yiwen Luan, Xue Zhang, Cheng Xiao, Chunyi Zhou
Pain.2022; 163(10): 1952. CrossRef
A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors
Tao Jia, Ying-Di Wang, Jing Chen, Xue Zhang, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
Nature Communications.2022;[Epub] CrossRef
Basal impulses: findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation
Pavan S. UPADHYAYULA, Robert C. RENNERT, Joel R. MARTIN, John K. YUE, Jason YANG, Eva M. GILLIS-BUCK, Nikki SIDHU, Christopher K. CHEUNG, Anthony T. LEE, Reid R. HOSHIDE, Joseph D. CIACCI
Journal of Neurosurgical Sciences.2021;[Epub] CrossRef
Pallidal versus subthalamic deep-brain stimulation for meige syndrome: a retrospective study
Jiayu Liu, Hu Ding, Ke Xu, Ruen Liu, Dongliang Wang, Jia Ouyang, Zhi Liu, Zeyu Miao
Scientific Reports.2021;[Epub] CrossRef
Eight‐year follow‐up outcome of subthalamic deep brain stimulation for Parkinson’s disease: Maintenance of therapeutic efficacy with a relatively low levodopa dosage and stimulation intensity
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
CNS Neuroscience & Therapeutics.2021; 27(11): 1366. CrossRef
Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease
Gabriele Bellini, Laura A. Best, Una Brechany, Russell Mills, Nicola Pavese
Movement Disorders Clinical Practice.2020; 7(4): 373. CrossRef
Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice
Yiwen Luan, Dongliang Tang, Haichuan Wu, Weixin Gu, Yuqing Wu, Jun-Li Cao, Cheng Xiao, Chunyi Zhou
Proceedings of the National Academy of Sciences.2020; 117(18): 10045. CrossRef
Impulsivity and Compulsivity After Subthalamic Deep Brain Stimulation for Parkinson’s Disease
Sara Scherrer, Andrew H. Smith, Jaimie Gowatsky, Christina A. Palmese, Joohi Jimenez-Shahed, Brian H. Kopell, Helen S. Mayberg, Martijn Figee
Frontiers in Behavioral Neuroscience.2020;[Epub] CrossRef
Deep brain stimulation and recordings: Insights into the contributions of subthalamic nucleus in cognition
Neil M. Drummond, Robert Chen
NeuroImage.2020; 222: 117300. CrossRef
Bilateral Subthalamic Nucleus Deep Brain Stimulation under General Anesthesia: Literature Review and Single Center Experience
Hye Ran Park, Yong Hoon Lim, Eun Jin Song, Jae Meen Lee, Kawngwoo Park, Kwang Hyon Park, Woong-Woo Lee, Han-Joon Kim, Beomseok Jeon, Sun Ha Paek
Journal of Clinical Medicine.2020; 9(9): 3044. CrossRef
Subthalamic deep brain stimulation improves sleep and excessive sweating in Parkinson’s disease
Silje Bjerknes, Inger Marie Skogseid, Tuva Jin Hauge, Espen Dietrichs, Mathias Toft
npj Parkinson's Disease.2020;[Epub] CrossRef
Impacto de la estimulación subtalámica a largo plazo sobre la situación cognitiva de los pacientes con enfermedad de Parkinson avanzada
M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
Neurología.2019; 34(9): 573. CrossRef
The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action
Tora Bonnevie, Kareem A. Zaghloul
The Neuroscientist.2019; 25(1): 48. CrossRef
Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson's disease
U. Hidding, A. Gulberti, C. Pflug, C. Choe, A. Horn, L. Prilop, H. Braaß, O. Fründt, C. Buhmann, D. Weiss, M. Westphal, A.K. Engel, C. Gerloff, J.A. Köppen, W. Hamel, C.K.E. Moll, M. Pötter-Nerger
Parkinsonism & Related Disorders.2019; 62: 141. CrossRef
Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting
Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei L. Shen
Nature Neuroscience.2019; 22(6): 921. CrossRef
Long-term impact of subthalamic stimulation on cognitive function in patients with advanced Parkinson's disease
M. Acera, A. Molano, B. Tijero, G. Bilbao, I. Lambarri, R. Villoria, J. Somme, E. Ruiz de Gopegui, I. Gabilondo, J.C. Gomez-Esteban
Neurología (English Edition).2019; 34(9): 573. CrossRef
Influencia de la estimulación cerebral profunda en la carga de cuidadores de pacientes con enfermedad de Parkinson
J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
Neurología.2018; 33(3): 154. CrossRef
Alteration in the Local and Global Functional Connectivity of Resting State Networks in Parkinson’s Disease
Maryam Ghahremani, Jaejun Yoo, Sun Ju Chung, Kwangsun Yoo, Jong C. Ye, Yong Jeong
Journal of Movement Disorders.2018; 11(1): 13. CrossRef
Deep brain stimulation for patients with Parkinson's disease: Effect on caregiver burden
J.A. Crespo-Burillo, D. Rivero-Celada, A. Saenz-de Cabezón, J. Casado-Pellejero, J. Alberdi-Viñas, R. Alarcia-Alejos
Neurología (English Edition).2018; 33(3): 154. CrossRef
Clinical Markers of Anxiety Subtypes in Parkinson Disease
Martinus P. G. Broen, A. F. G. Leentjens, J. T. Hinkle, A. J. H. Moonen, M. L. Kuijf, N. M. Fischer, K. Perepezko, A. Bakker, G. M. Pontone
Journal of Geriatric Psychiatry and Neurology.2018; 31(2): 55. CrossRef
Apathy following Bilateral Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease: A Meta-Analysis
Ying Wang, Yongsheng Li, Xiaona Zhang, Anmu Xie
Parkinson's Disease.2018; 2018: 1. CrossRef
Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology
Robert S. Eisinger, Morgan E. Urdaneta, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
Frontiers in Neuroscience.2018;[Epub] CrossRef
Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Arnaud Pautrat, Marta Rolland, Margaux Barthelemy, Christelle Baunez, Valérie Sinniger, Brigitte Piallat, Marc Savasta, Paul G Overton, Olivier David, Veronique Coizet
eLife.2018;[Epub] CrossRef
Cerebrospinal fluid protein markers in PD patients after DBS-STN surgery—A retrospective analysis of patients that underwent surgery between 1993 and 2001
Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquist
Clinical Neurology and Neurosurgery.2018; 174: 174. CrossRef
Predictors to quality of life improvements after subthalamic stimulation in Parkinson’s disease
Feng‐Tao Liu, Li‐Qin Lang, Yu‐Jie Yang, Jue Zhao, Rui Feng, Jie Hu, Jian Wang, Jian‐Jun Wu
Acta Neurologica Scandinavica.2018;[Epub] CrossRef
Apathy associated with neurocognitive disorders: Recent progress and future directions
Krista L. Lanctôt, Luis Agüera‐Ortiz, Henry Brodaty, Paul T. Francis, Yonas E. Geda, Zahinoor Ismail, Gad A. Marshall, Moyra E. Mortby, Chiadi U. Onyike, Prasad R. Padala, Antonios M. Politis, Paul B. Rosenberg, Emma Siegel, David L. Sultzer, Eleenor H. A
Alzheimer's & Dementia.2017; 13(1): 84. CrossRef
Can deep brain stimulation be a therapeutic option for Parkinson's disease dementia?
Han‐Joon Kim, Beomseok Jeon, Jee‐Young Lee, Sun Ha Paek
Neurology and Clinical Neuroscience.2017; 5(1): 3. CrossRef
The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence
Mónica M Kurtis, Thadshani Rajah, Luisa F Delgado, Haidar S Dafsari
npj Parkinson's Disease.2017;[Epub] CrossRef
Delayed responses of subthalamic nucleus to deep brain stimulation in patients with Parkinson's disease
Lin Shi, Kai Zhang, Fan-Gang Meng, Guan-Yu Zhu, Ying-Chuan Chen, Jun-Jian Zhou, Zhong-Hai Zhou, Jian-Guo Zhang
Parkinsonism & Related Disorders.2017; 40: 76. CrossRef
Acute response of non-motor symptoms to subthalamic deep brain stimulation in Parkinson's disease
Margherita Fabbri, Miguel Coelho, Leonor Correia Guedes, Mario M. Rosa, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J. Ferreira
Parkinsonism & Related Disorders.2017;[Epub] CrossRef
Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals
Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa
Parkinson's Disease.2017; 2017: 1. CrossRef
Current Topics in Deep Brain Stimulation for Parkinson Disease
Atsushi UMEMURA, Genko OYAMA, Yasushi SHIMO, Madoka NAKAJIMA, Asuka NAKAJIMA, Takayuki JO, Satoko SEKIMOTO, Masanobu ITO, Takumi MITSUHASHI, Nobutaka HATTORI, Hajime ARAI
Neurologia medico-chirurgica.2016; 56(10): 613. CrossRef
In Parkinson’s disease STN stimulation enhances responsiveness of movement initiation speed to high reward value
Maja Kojovic, Andrea Higgins, Marjan Jahanshahi
Neuropsychologia.2016; 89: 273. CrossRef
Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson’s Disease
Lei-Fang Cao, Xiao-Yan Peng, Ya Huang, Bing Wang, Feng-Ming Zhou, Ruo-Xiao Cheng, Li-Hua Chen, Wei-Feng Luo, Tong Liu
Neural Plasticity.2016; 2016: 1. CrossRef
The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Do-Young Kwon, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Hae-Won Shin, Jinyoung Youn, Kun Woo Park, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Beom S. Jeon, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Jeong-Ho Park, Tae-Beom
Journal of Clinical Neurology.2016; 12(4): 393. CrossRef
Antiparkinsonian Treatment for Depression in Parkinson's Disease: Are Selective Serotonin Reuptake Inhibitors Recommended?
Philippe De Deurwaerdère, Yuqiang Ding
Translational Neuroscience and Clinics.2016; 2(2): 138. CrossRef
The Subthalamic Nucleus, Limbic Function, and Impulse Control
P. Justin Rossi, Aysegul Gunduz, Michael S. Okun
Neuropsychology Review.2015; 25(4): 398. CrossRef

Original Articles

Orthostatic and Supine Blood Pressures Are Associated with White Matter Hyperintensities in Parkinson Disease: Yoon-Sang Oh, Joong-Seok Kim, Kwang-Soo Lee; J Mov Disord. 2013;6(2):23-27. Published online October 30, 2013; DOI: https://doi.org/10.14802/jmd.13006

14,375 View
96 Download
45 Citations

Abstract PDF

Background and Purpose:

Several reports on the elderly population have suggested that orthostatic hypotension is associated with white matter hyperintensities (WMH); however, little information is available on patients with Parkinson’s disease (PD).

Methods:

We analyzed the association blood pressure profiles during tilt table testing with WMH scores in 117 patients with PD. WMH were rated using the semiquantitative visual rating system proposed by Scheltens et al.

Results:

The presence of orthostatic hypotension was associated with increasing tendency of WMH score and the blood pressure changes during tilting and supine blood pressure were positively correlated with increasing WMH score.

Conclusions:

This finding indicates that hemodynamic changes associated with orthostatic hypotension may be associated with white matter changes in patients with PD.

Citations

Citations to this article as recorded by

Association Between Gait and Dysautonomia in Patients With De Novo Parkinson’s Disease: Forward Gait Versus Backward Gait
Seon-Min Lee, Mina Lee, Eun Ji Lee, Rae On Kim, Yongduk Kim, Kyum-Yil Kwon
Journal of Movement Disorders.2023; 16(1): 59. CrossRef
Association Between Orthostatic Hypotension and Dementia in Patients With Parkinson Disease and Multiple System Atrophy
Iñigo Ruiz Barrio, Yasuo Miki, Zane T. Jaunmuktane, Thomas Warner, Eduardo De Pablo-Fernandez
Neurology.2023; 100(10): e998. CrossRef
Central retinal microvasculature damage is associated with orthostatic hypotension in Parkinson’s disease
Jong Hyeon Ahn, Min Chae Kang, Dongyoung Lee, Jin Whan Cho, Kyung-Ah Park, Jinyoung Youn
npj Parkinson's Disease.2023;[Epub] CrossRef
Interventions for orthostatic hypotension in Parkinson's disease: a systematic review and network meta-analysis
Kunshan Li, Luyi Wu, Xuejun Cui, Wei Zhang, Jun Ji, Yiwen Wu, Zhaoqin Wang, Huirong Liu, Huangan Wu, Lu Zhu
Cochrane Database of Systematic Reviews.2023;[Epub] CrossRef
Autonomic control of heart and vessels in patients with very early stage of Parkinson disease
J Oleksakova, M Javorka, B Czippelova, N Mazgutova, M Grofik, L Babalova, P Skacik, E Kurca
Physiological Measurement.2023; 44(5): 054002. CrossRef
REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson’s disease
Kangfu Yin, Chuanbin Zhou, Yongyun Zhu, Weifang Yin, Lei Yin, Bin Liu, Hui Ren, Zhong Xu, Xinglong Yang
Aging Clinical and Experimental Research.2022; 34(1): 159. CrossRef
Parkinsonism and cerebrovascular disease
Manisha Narasimhan, Raymond Schwartz, Glenda Halliday
Journal of the Neurological Sciences.2022; 433: 120011. CrossRef
Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease
Anna Pierzchlińska, Magdalena Kwaśniak-Butowska, Jarosław Sławek, Marek Droździk, Monika Białecka
Molecules.2021; 26(6): 1523. CrossRef
Adverse effects of hypertension, supine hypertension, and perivascular space on cognition and motor function in PD
Na-Young Shin, Yae Won Park, Sang-Won Yoo, Ji-Yeon Yoo, Yangsean Choi, Jinhee Jang, Kook-Jin Ahn, Bum-soo Kim, Joong-Seok Kim
npj Parkinson's Disease.2021;[Epub] CrossRef
Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders
Andrea Pilotto, Alberto Romagnolo, Andrea Scalvini, Mario Masellis, Yasushi Shimo, Laura Bonanni, Richard Camicioli, Lily L. Wang, Alok K. Dwivedi, Katherine Longardner, Federico Rodriguez-Porcel, Mark DiFrancesco, Joaquin A. Vizcarra, Elisa Montanaro, Si
Neurology.2021; 97(8): e814. CrossRef
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction
Yoshiki Hase, Tuomo M. Polvikoski, Michael J. Firbank, Lucinda J. L. Craggs, Emily Hawthorne, Charlotte Platten, William Stevenson, Vincent Deramecourt, Clive Ballard, Rose Anne Kenny, Robert H. Perry, Paul Ince, Roxana O. Carare, Louise M. Allan, Karen H
Brain Pathology.2020; 30(1): 191. CrossRef
Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease
Alexander Levit, Vladimir Hachinski, Shawn N. Whitehead
GeroScience.2020; 42(2): 445. CrossRef
The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension
Jose-Alberto Palma, Gabriel Redel-Traub, Angelo Porciuncula, Daniela Samaniego-Toro, Patricio Millar Vernetti, Yvonne W. Lui, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
Parkinsonism & Related Disorders.2020; 75: 97. CrossRef
White Matter Hyperintensities in the Synucleinopathies: Orthostatic Hypotension, Supine Hypertension, or Both?
Horacio Kaufmann, Jose‐Alberto Palma
Movement Disorders Clinical Practice.2020; 7(6): 595. CrossRef
White Matter Hyperintensities Mediate Impact of Dysautonomia on Cognition in Parkinson's Disease
Mahsa Dadar, Seyed‐Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B. Postuma, D. Louis Collins
Movement Disorders Clinical Practice.2020; 7(6): 639. CrossRef
Blood pressure lability is associated with subcortical atrophy in early Parkinson's disease
Sang-Won Yoo, Eunkyeong Yun, Mirim Bang, Uicheul Yoon, Ji-Yeon Yoo, Kwang-Soo Lee, Na-Young Shin, Joong-Seok Kim
Journal of Hypertension.2020; 38(10): 2043. CrossRef
Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults
Stephen P. Juraschek, W.T. Longstreth, Oscar L. Lopez, John S. Gottdiener, Lewis A. Lipsitz, Lewis H. Kuller, Kenneth J. Mukamal
Neurology.2020; 95(14): e1941. CrossRef
Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease
Vincent Pozorski, Jennifer M. Oh, Ozioma Okonkwo, Stephanie Krislov, Amy Barzgari, Frances Theisen, Jitka Sojkova, Barbara B. Bendlin, Sterling C. Johnson, Catherine L. Gallagher
NeuroImage: Clinical.2019; 23: 101870. CrossRef
Magnetic Resonance Imaging–Visible Perivascular Spaces in Basal Ganglia Predict Cognitive Decline in Parkinson's Disease
Yae Won Park, Na‐Young Shin, Seok Jong Chung, Jiwoong Kim, Soo Mee Lim, Phil Hyu Lee, Seung‐Koo Lee, Kook Jin Ahn
Movement Disorders.2019; 34(11): 1672. CrossRef
Orthostatic hypotension in Parkinson disease
Ylva Hivand Hiorth, Kenn Freddy Pedersen, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves
Neurology.2019; 93(16): e1526. CrossRef
Dysautonomia is associated with structural and functional alterations in Parkinson disease
Seok Jong Chung, Youn Jung Bae, Suhnyoung Jun, Han Soo Yoo, Seung Woo Kim, Yang Hyun Lee, Young H. Sohn, Seung-Koo Lee, Joon-Kyung Seong, Phil Hyu Lee
Neurology.2019; 92(13): e1456. CrossRef
Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS)
Alessandra Fanciulli, Jens Jordan, Italo Biaggioni, Giovanna Calandra–Buonaura, William P. Cheshire, Pietro Cortelli, Sabine Eschlboeck, Guido Grassi, Max J. Hilz, Horacio Kaufmann, Heinz Lahrmann, Giuseppe Mancia, Gert Mayer, Lucy Norcliffe–Kaufmann, Ann
Clinical Autonomic Research.2018; 28(4): 355. CrossRef
Reverse blood pressure dipping as marker of dysautonomia in Parkinson disease
Valeria Milazzo, Cristina Di Stefano, Fabrizio Vallelonga, Gabriele Sobrero, Maurizio Zibetti, Alberto Romagnolo, Aristide Merola, Alberto Milan, Alberto J. Espay, Leonardo Lopiano, Franco Veglio, Simona Maule
Parkinsonism & Related Disorders.2018; 56: 82. CrossRef
White matter hyperintensities are linked to future cognitive decline in de novo Parkinson's disease patients
Mahsa Dadar, Yashar Zeighami, Yvonne Yau, Seyed-Mohammad Fereshtehnejad, Josefina Maranzano, Ronald B. Postuma, Alain Dagher, D. Louis Collins
NeuroImage: Clinical.2018; 20: 892. CrossRef
Rapid Systolic Blood Pressure Changes After Standing Up Associate With Impaired Physical Performance in Geriatric Outpatients
Arjen Mol, Esmee M. Reijnierse, Marijke C. Trappenburg, Richard J. A. van Wezel, Andrea B. Maier, Carel G. M. Meskers
Journal of the American Heart Association.2018;[Epub] CrossRef
Central hemodynamics and arterial stiffness in idiopathic and multiple system atrophy
Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A. Schneider
Journal of Neurology.2017; 264(2): 327. CrossRef
Cardiovascular Autonomic Dysfunction in Patients with Drug-Induced Parkinsonism
Joong-Seok Kim, Dong-Woo Ryu, Ju-Hee Oh, Yang-Hyun Lee, Sung-Jin Park, Kipyung Jeon, Jong-Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang-Soo Lee
Journal of Clinical Neurology.2017; 13(1): 15. CrossRef
Association of arterial stiffness with cognition in patients with Lewy body disorder
Dong-Woo Ryu, Joong-Seok Kim, Jee-Eun Lee, Jeong-Wook Park, Yoon-Sang Oh, Jae-Young An, Kwang-Soo Lee
Neurological Sciences.2017; 38(7): 1307. CrossRef
Microstructural integrity of white matter tracts amongst older fallers: A DTI study
Yoke Queen Wong, Li Kuo Tan, Pohchoo Seow, Maw Pin Tan, Khairul Azmi Abd Kadir, Anushya Vijayananthan, Norlisah Ramli, Gianluigi Forloni
PLOS ONE.2017; 12(6): e0179895. CrossRef
Cerebral autoregulation is preserved in multiple sclerosis patients
Daniel Ferreira, Pedro Castro, Gonçalo Videira, João Pedro Filipe, Rosa Santos, Maria José Sá, Elsa Azevedo, Pedro Abreu
Journal of the Neurological Sciences.2017; 381: 298. CrossRef
Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease
Si-Yue Li, Ya-Li Wang, Wen-Wen Liu, Dong-Jun Lyu, Fen Wang, Cheng-Jie Mao, Ya-Ping Yang, Li-Fang Hu, Chun-Feng Liu
Chinese Medical Journal.2017; 130(9): 1085. CrossRef
Arterial Stiffness and Cardiovascular Autonomic Dysfunction in Patients with Parkinson's Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Hyun-Seok Choi, Kwang-Soo Lee
Neurodegenerative Diseases.2017; 17(2-3): 89. CrossRef
Cardiovascular autonomic dysfunctions in elderly patients with essential tremor: comparison with healthy controls
Joong-Seok Kim, Yoon-Sang Oh, Hyung-Eun Park, Si-Hoon Lee, Jeong-Wook Park, In-Uk Song, Jae-Young An, Hun-Jun Park, Byung-Chul Son, Kwang-Soo Lee
Neurological Sciences.2016; 37(5): 711. CrossRef
Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, Si-Hoon Lee, Jeong-Wook Park, Byung-chul Son, Kwang-Soo Lee
Journal of the Neurological Sciences.2016; 362: 59. CrossRef
Supine hypertension in Parkinson’s disease and multiple system atrophy
Alessandra Fanciulli, Georg Göbel, Jean Pierre Ndayisaba, Roberta Granata, Susanne Duerr, Stefano Strano, Carlo Colosimo, Werner Poewe, Francesco E. Pontieri, Gregor K. Wenning
Clinical Autonomic Research.2016; 26(2): 97. CrossRef
Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?
Claire McDonald, Julia L. Newton, David J. Burn
Movement Disorders.2016; 31(7): 937. CrossRef
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson’s Disease
Joong-Seok Kim, Si-Hoon Lee, Yoon-Sang Oh, Jeong-Wook Park, Jae-Young An, Sung-Kyung Park, Si-Ryung Han, Kwang-Soo Lee
Journal of Movement Disorders.2016; 9(2): 97. CrossRef
Autonomic Nervous System Dysfunction in Patients With Parkinson Disease Having Depression
Hyung-Eun Park, Joong-Seok Kim, Yoon-Sang Oh, In-Seok Park, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee
Journal of Geriatric Psychiatry and Neurology.2016; 29(1): 11. CrossRef
Vascular cognitive impairment, a cardiovascular complication
Adiukwu Frances, Ofori Sandra, Ugbomah Lucy
World Journal of Psychiatry.2016; 6(2): 199. CrossRef
Cardiovascular complications in patients with autonomic failure
Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
Clinical Autonomic Research.2015; 25(3): 133. CrossRef
123I-MIBG myocardial scintigraphy and neurocirculatory abnormalities in patients with dementia with Lewy bodies and Alzheimer's disease
Joong-Seok Kim, Hyung-Eun Park, Yoon-Sang Oh, In-Uk Song, Dong-Won Yang, Jeong-Wook Park, Kwang-Soo Lee
Journal of the Neurological Sciences.2015; 357(1-2): 173. CrossRef
Diagnosing and treating neurogenic orthostatic hypotension in primary care
Louis Kuritzky, Alberto J. Espay, Jeffrey Gelblum, Richard Payne, Eric Dietrich
Postgraduate Medicine.2015; 127(7): 702. CrossRef
Increased CSF biomarkers of angiogenesis in Parkinson disease
Shorena Janelidze, Daniel Lindqvist, Veronica Francardo, Sara Hall, Henrik Zetterberg, Kaj Blennow, Charles H. Adler, Thomas G. Beach, Geidy E. Serrano, Danielle van Westen, Elisabet Londos, M. Angela Cenci, Oskar Hansson
Neurology.2015; 85(21): 1834. CrossRef
Orthostatic hypotension, cerebral hypoperfusion, and visuospatial deficits in Lewy body disorders
Andrew D. Robertson, Michelle A. Messner, Zahra Shirzadi, Galit Kleiner-Fisman, Joyce Lee, Julia Hopyan, Anthony E. Lang, Sandra E. Black, Bradley J. MacIntosh, Mario Masellis
Parkinsonism & Related Disorders.2015;[Epub] CrossRef
Orthostatic Hypotension and Cognitive Impairment in <i>De Novo</i> Patients with Parkinson’s Disease
Hyo-Jin Bae, Jun-Ho Lim, Sang-Myung Cheon
Journal of Movement Disorders.2014; 7(2): 102. CrossRef

Unilateral Standing Leg Tremor as the Initial Manifestation of Parkinson Disease: Suk Yun Kang, Sook-Keun Song, Jin-Soo Kim, Young Ho Sohn; J Mov Disord. 2009;2(1):29-32.; DOI: https://doi.org/10.14802/jmd.09007

10,988 View
90 Download
2 Citations

Abstract PDF

Background:

The aim of this study was to analyze the different forms of leg tremors exhibited while standing in patients with Parkinson disease (PD), and to determine if the type of leg tremor exhibited is indicative of prognosis or treatment response in PD patients.

Methods:

We studied the clinical characteristics of five PD patients (all women; mean age, 59 years, range, 53–64 years) with unilateral standing leg tremor as the initial manifestation of PD, including their electrophysiological findings and the results of long-term follow-up.

Results:

For each patient, parkinsonism either existed at the time of onset of the initial symptoms or developed later. Patient responses to drugs were generally good, but one patient showed a poor response to drugs, even though she had only a low frequency leg tremor. For two patients whom we could observe during the 10-year follow-up period, neither the leg tremor nor parkinsonism was aggravated.

Conclusions:

There are two forms of unilateral standing leg tremor in PD. One form is high frequency, similar to the primary orthostatic tremor. The other is low frequency and similar to the parkinsonian resting tremor. Based on these observations, it appears that progression might be slow if PD patients have standing leg tremor as the initial manifestation.

Citations

Citations to this article as recorded by

Orthostatic tremor as initial presentation of Parkinson’s disease
Y R Chiew
QJM: An International Journal of Medicine.2023;[Epub] CrossRef
An unusual initial presentation of Parkinson’s disease: unilateral standing leg tremor
Jasem Yousef Al-Hashel, Walaa Ahmed Kamel, Philippe Damier, Ahmad Jasem Abdulsalam
Acta Neurologica Belgica.2020; 120(2): 415. CrossRef

First
Prev
Page of 1
Next
Last

Search