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Review Article
- Gastrointestinal Dysfunction in Parkinson’s Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem
- Ai Huey Tan, Kee Huat Chuah, Yuan Ye Beh, Jie Ping Schee, Sanjiv Mahadeva, Shen-Yang Lim
- J Mov Disord. 2023;16(2):138-151. Published online May 24, 2023
- DOI: https://doi.org/10.14802/jmd.22220
- 29,851 View
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- 20 Web of Science
- 24 Crossref
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Abstract
PDF - Patients with Parkinson’s disease (PD) face a multitude of gastrointestinal (GI) symptoms, including nausea, bloating, reduced bowel movements, and difficulties with defecation. These symptoms are common and may accumulate during the course of PD but are often under-recognized and challenging to manage. Objective testing can be burdensome to patients and does not correlate well with symptoms. Effective treatment options are limited. Evidence is often based on studies in the general population, and specific evidence in PD is scarce. Upper GI dysfunction may also interfere with the pharmacological treatment of PD motor symptoms, which poses significant management challenges. Several new less invasive assessment tools and novel treatment options have emerged in recent years. The current review provides an overview and a practical approach to recognizing and diagnosing common upper and lower GI problems in PD, e.g., dyspepsia, gastroparesis, small bowel dysfunction, chronic constipation, and defecatory dysfunction. Management aspects are discussed based on the latest evidence from the PD and general populations, with insights for future research pertaining to GI dysfunction in PD.
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Citations
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Journal of Neural Transmission.2025; 132(11): 1685. CrossRef - Association between cognitive and autonomic dysfunctions in patients with de novo Parkinson’s disease
Byung-Euk Joo, Jihwan You, Rae On Kim, Kyum-Yil Kwon
Scientific Reports.2025;[Epub] CrossRef - Type 2 Diabetes Mellitus and Parkinson's Disease: An Emerging Link
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Chemico-Biological Interactions.2025; 421: 111742. CrossRef - A Review of the Recent Advances in the Pharmacological Management of Parkinson’s Disease
Allan Li, Alex Cha, Maria Huang, Sanya Dhami, Sudhakar Pemminati
Cureus.2025;[Epub] CrossRef - Fecal Microbiota Transplantation for Treatment of Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Muhammad Hassan Waseem, Zain ul Abideen, Areeba Shoaib, Nohela Rehman, Muhammad Osama, Barka Sajid, Rowaid Ahmad, Zara Fahim, Muhammad Wajih Ansari, Sania Aimen, Ameer Haider Cheema, Pawan Kumar Thada
Journal of Central Nervous System Disease.2025;[Epub] CrossRef - Management of Gastrointestinal Symptoms in Patients with Movement Disorders: Focusing on Parkinson's Disease
Jungyeun Lee, Kyung Min Kim, Byung-Su Kim, Seung Woo Kim, Hee-Jin Kim, Kyoungwon Baik, Jin Myoung Seok, Jun-Sang Sunwoo, In-Uk Song, Ho Geol Woo, Eek-Sung Lee, Jin-Man Jung, Kyomin Choi, Yun Ho Choi, Seong-Beom Koh, Kwang Ik Yang
Journal of the Korean Neurological Association.2025; 43(4): 222. CrossRef - Associations between gut microbiota characteristics and non‐motor symptoms following pharmacological and surgical treatments in Parkinson's disease patients
Agnieszka Gorecka‐Mazur, Anna Krygowska‐Wajs, Agata Furgala, Jiaqi Li, Benjamin Misselwitz, Wojciech Pietraszko, Borys Kwinta, Bahtiyar Yilmaz
Neurogastroenterology & Motility.2024;[Epub] CrossRef - Clinical diagnosis, prevention, and treatment of neurodyspepsia syndrome using intelligent medicine
Jingyu Zhu, Wei Meng, Liang Liu, Peixin Hu, Yuling Liang, Wenwen Zhu, Xiaoyan Zhu
Open Life Sciences.2024;[Epub] CrossRef - Levodopa-induced dyskinesia in Parkinson's disease: Insights from cross-cohort prognostic analysis using machine learning
Rebecca Ting Jiin Loo, Olena Tsurkalenko, Jochen Klucken, Graziella Mangone, Fouad Khoury, Marie Vidailhet, Jean-Christophe Corvol, Rejko Krüger, Enrico Glaab, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Muhammad Ali, Wim Ammerlann, Giuseppe Arena, Mi
Parkinsonism & Related Disorders.2024; 126: 107054. CrossRef - Acupuncture for constipation in Parkinson’s disease: A systematic review and meta-analysis of randomized controlled trials
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Medicine.2024; 103(29): e38937. CrossRef - Alpha Synuclein Toxicity and Non-Motor Parkinson’s
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Cells.2024; 13(15): 1265. CrossRef - Novel strategies in Parkinson’s disease treatment: a review
Charles L. Mitchell, Dmitry Kurouski
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