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Original Article
- Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration
- Jin Whan Cho, Jee-Young Lee, Han-Joon Kim, Joong-Seok Kim, Kun-Woo Park, Seong-Min Choi, Chul Hyoung Lyoo, Seong-Beom Koh
- J Mov Disord. 2025;18(1):35-44. Published online October 21, 2024
- DOI: https://doi.org/10.14802/jmd.24127
- 1,375 View
- 202 Download
- 1 Comments
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Abstract
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Supplementary Material - Objective
We conducted this study to assess the efficacy and safety of taltirelin hydrate (TH) in patients with ataxia due to spinocerebellar degeneration (SCD).
Methods
Patients were randomly assigned to either the taltirelin group (5 mg orally, twice daily) or the control group. The primary endpoint was the change in the Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) score at 24 weeks. The secondary endpoints included changes in the K-SARA score at 4 and 12 weeks as well as the Clinical Global Impression Scale, the five-level version of the EuroQol five-dimensional questionnaire, the Tinetti balance test, and gait analysis at 4, 12, and 24 weeks.
Results
A total of 149 patients (hereditary:nonhereditary=86:63) were enrolled. There were significant differences in the change in the K-SARA score at 24 weeks from baseline between the taltirelin group and the control group (-0.51±2.79 versus 0.36±2.62, respectively; p=0.0321). For the K-SARA items, the taltirelin group had significantly lower “Stance” and “Speech disturbance” subscores than the control group (-0.04±0.89 versus 0.23±0.79 and -0.07±0.74 versus 0.18±0.67; p=0.0270 and 0.0130, respectively). However, there were no significant differences in changes in other secondary efficacy outcome measures at 24 weeks from baseline between the two treatment arms (p>0.05).
Conclusion
Clinicians might consider the use of TH in the treatment of patients with ataxia due to SCD.
Case Report
- Jaw Dystonia Induced by Speaking
- Jong-Sam Baik, Jae-Hyeon Park, Jeong-Yeon Kim, Sang-Won Han
- J Mov Disord. 2008;1(1):55-57.
- DOI: https://doi.org/10.14802/jmd.08010
- 18,001 View
- 91 Download
- 1 Crossref
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Abstract
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We describe a 43-year-old housewife who presented with dysarthria suddenly because her masseter muscles contracted bilaterally, when she was speaking. Brain MRI showed focal signal change on midbrain. Jaw dystonia induced by speaking is very rare and we chose an anticholinergic medication, rather than botulinumtoxin injection. Her condition was markedly improved after medication. We suspected that her symptoms were related with focal lesion, so she had secondary jaw dystonia induced by speaking.
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Citations
Citations to this article as recorded by
- Non-occupational task-specific masticatory dystonia
Sang-Won Yoo, In-Seok Park, Hyung-Eun Park, Joong-Seok Kim
Neurological Sciences.2015; 36(2): 339. CrossRef
- Non-occupational task-specific masticatory dystonia
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