Journal of Movement Disorders

Review Article

Parkinson’s Disease in Sub-Saharan Africa: A Review of Epidemiology, Genetics and Access to Care: Uduak Williams, Oliver Bandmann, Richard Walker; J Mov Disord. 2018;11(2):53-64. Published online May 30, 2018; DOI: https://doi.org/10.14802/jmd.17028

15,576 View
233 Download
36 Web of Science
39 Crossref

A low prevalence of Parkinson’s disease (PD) has been reported in the Sub-Saharan Africa (SSA) region. The genetic causes and clinical features of PD in this region have been poorly described. Very few reports have examined the availability and access to evidence-based quality care for people living with PD in this region. We reviewed all publications focusing on idiopathic PD from SSA published up to May 2016 and observed a prevalence of PD ranging from 7/100,000 in Ethiopia to 67/100,000 in Nigeria. The most recent community-based study reported a mean age at onset of 69.4 years. The infrequent occurrence of mutations in established PD genes was also observed in the region. Treatments were non-existent or at best irregular. Additionally, there is a lack of well-trained medical personnel and multidisciplinary teams in most countries in this region. Drugs for treating PD are either not available or unaffordable. Large-scale genetic and epidemiological studies are therefore needed in SSA to provide further insights into the roles of genetics and other etiological factors in the pathogenesis of PD. The quality of care also requires urgent improvement to meet the basic level of care required by PD patients.

Citations

Citations to this article as recorded by

Addressing Neurological Inequities in Developing Countries: Challenges and Strategic Solutions
Amit Kandel
Sarvodaya International Journal of Medicine.2025; 1(1): 1. CrossRef
Delivery of Allied Health Therapies to People with Parkinson’s Disease in Africa
Roberto Cilia, Marieke C.J. Dekker, Esther Cubo, Mary W. Agoriwo, Elke Kalbe, Bastiaan R. Bloem, Lorraine V. Kalia, Alice Nieuwboer
Journal of Parkinson’s Disease.2024; 14(s1): S227. CrossRef
The Role of Diet in Parkinson’s Disease
Kira N. Tosefsky, Julie Zhu, Yolanda N. Wang, Joyce S.T. Lam, Amanda Cammalleri, Silke Appel-Cresswell, Elke Kalbe, Bastiaan R. Bloem, Lorraine V. Kalia, Alice Nieuwboer
Journal of Parkinson’s Disease.2024; 14(s1): S21. CrossRef
Advancing genetic testing for neurological disorders in Tanzania: importance, challenges, and strategies for implementation
Mohamed Zahir Alimohamed, Angela Augustine Siima, Mohamed Manji
Frontiers in Neuroscience.2024;[Epub] CrossRef
Epidemiology of Parkinson’s Disease: An Update
Juan R Deliz, Caroline M. Tanner, Paulina Gonzalez-Latapi
Current Neurology and Neuroscience Reports.2024; 24(6): 163. CrossRef
Spondias mombin flavonoids showed super-binder ability with downstream molecular targets of Parkinson's disease: A structural study
John A. Olanrewaju, Leviticus O. Arietarhire, Oladimeji E. Soremekun, Ezekiel A. Olugbogi, Toluwanimi O. Afolabi, Precious O. Aribisala, Pelumi E. Alege, Abayomi O. Sodipo, Babatunji E. Oyinloye, Olaposi I. Omotuyi
Informatics in Medicine Unlocked.2024; 49: 101543. CrossRef
Breaking barriers in Parkinson’s care: the multidisciplinary team approach
Zvezdan Pirtošek
Journal of Neural Transmission.2024; 131(11): 1349. CrossRef
Structure and process of Parkinson's disease rehabilitation in the southern sector of Ghana: A cross‐sectional survey
Mary W. Agoriwo, Conran Joseph, Erika Franzén, Marianne Unger
Journal of Evaluation in Clinical Practice.2024;[Epub] CrossRef
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies
Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A. Alananzeh, Mohd Nizam Mordi
Journal of Ethnopharmacology.2023; 300: 115753. CrossRef
Particularités de la Maladie de Parkinson de la personne âgée : expérience du service de gériatrie de Fann à Dakar (Sénégal)
A. Sall, M. Ba, R. Djajheté, D. Ba, S. Zaki, M. Coumé
NPG Neurologie - Psychiatrie - Gériatrie.2023; 23(134): 85. CrossRef
The Gaps and Prospects of Movement Disorders Education and Research in Africa: A Continental Survey
Eman Hamid, Kigocha Okengo, Biniyam A. Ayele, Daniel Gams Massi, Samia Ben Sassi, Houyam Tibar, Sarah Misbah El‐Sadig, Soulaimane Mahoui, Julien Razafimahefa, Ange Eric Kouame‐Assouan, Djibrilla Ben‐Adji, Lengane Y.T. Modeste, Muhyadin Hassan Mohamed, Nes
Movement Disorders.2023; 38(2): 178. CrossRef
Transforming Parkinson's Care in Africa (TraPCAf): protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project
R. Walker, N. Fothergill-Misbah, S. Kariuki, O. Ojo, R. Cilia, M. C. J. Dekker, O. Agabi, A. Akpalu, F. Amod, M. Breckons, M. Cham, S. Del Din, C. Dotchin, S. Guggsa, J. Kwasa, D. Mushi, F. O. Nwaokorie, T. Park, L. Rochester, J. Rogathi, F. S. Sarfo, A.
BMC Neurology.2023;[Epub] CrossRef
Exploring the levodopa-paradox of freezing of gait in dopaminergic medication-naïve Parkinson’s disease populations
Jamie A. F. Jansen, Tamine T. C. Capato, Sirwan K. L. Darweesh, Egberto R. Barbosa, Rogier Donders, Bastiaan R. Bloem, Jorik Nonnekes
npj Parkinson's Disease.2023;[Epub] CrossRef
The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
Aaron Lerner
Nutrition Reviews.2022; 80(2): 282. CrossRef
Surveying Global Availability of Parkinson’s Disease Treatment
Zhao H.K. Goh, Julia L.Y. Cheong, Connie Marras, Caroline M. Tanner, Meike Kasten, Amos D. Korczyn, Lana Chahine, Raymond Lo, Alastair J. Noyce
Journal of Parkinson’s Disease.2022; 12(3): 1023. CrossRef
Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
Nikita Simone Pillay, Owen A. Ross, Alan Christoffels, Soraya Bardien
Frontiers in Genetics.2022;[Epub] CrossRef
Utility of 18F FDG-PET in Parkinsonism in an African population
Ferzana Hassan Amod, Ahmed Iqbal Bhigjee, Nozipho Nyakale
eNeurologicalSci.2022; 27: 100399. CrossRef
A Narrative Review of Specialist Parkinson’s Nurses: Evolution, Evidence and Expectation
Emma Tenison, Alice James, Louise Ebenezer, Emily J. Henderson
Geriatrics.2022; 7(2): 46. CrossRef
Treatment with bark extracts of Voacanga africana attenuates motor coordination deficit, depressive-like behavior and microglial reaction, in a mouse model of early Parkinson's disease
Salimata Diagne Houndjo, Christophe Melon, Pascal Salin, Abdoulaye Samb, Fatou Bintou Sarr, Lydia Kerkerian-Le Goff, Sylviane Lortet
Phytomedicine Plus.2022; 2(3): 100297. CrossRef
Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort
Douglas P. Loesch, Andrea R.V.R. Horimoto, Elif Irem Sarihan, Miguel Inca-Martinez, Emily Mason, Mario Cornejo-Olivas, Luis Torres, Pilar Mazzetti, Carlos Cosentino, Elison Sarapura-Castro, Andrea Rivera-Valdivia, Angel C. Medina, Elena Dieguez, Victor Ra
Parkinsonism & Related Disorders.2022; 102: 7. CrossRef
The impact of COVID‐19 on patients with neurological disorders and their access to healthcare in Africa: A review of the literature
Olivier Uwishema, Kristian Steen Frederiksen, Inês F. Silva Correia, Ashraf Mahmoud, Helen Onyeaka, Burhan Dost
Brain and Behavior.2022;[Epub] CrossRef
Perspective: Low Risk of Parkinson's Disease in Quasi-Vegan Cultures May Reflect GCN2-Mediated Upregulation of Parkin
Mark F McCarty, Aaron Lerner
Advances in Nutrition.2021; 12(2): 355. CrossRef
A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies
Wendy W. Dlamini, Searles Nielsen, Mwiza Ushe, Gill Nelson, Brad A. Racette
Frontiers in Neurology.2021;[Epub] CrossRef
Parkinson disease-associated cognitive impairment
Dag Aarsland, Lucia Batzu, Glenda M. Halliday, Gert J. Geurtsen, Clive Ballard, K. Ray Chaudhuri, Daniel Weintraub
Nature Reviews Disease Primers.2021;[Epub] CrossRef
Probing the Pre-diagnostic Phase of Parkinson's Disease in Population-Based Studies
Lisanne J. Dommershuijsen, Agnita J. W. Boon, M. Kamran Ikram
Frontiers in Neurology.2021;[Epub] CrossRef
Medicinal plants for anti-neurodegenerative diseases in West Africa
Emmanuel Ayodeji Ayeni, Yuzhou Gong, Hao Yuan, Yikao Hu, Xiaolin Bai, Xun Liao
Journal of Ethnopharmacology.2021; : 114468. CrossRef
Mapping the Diverse and Inclusive Future of Parkinson’s Disease Genetics and Its Widespread Impact
Inas Elsayed, Alejandro Martinez-Carrasco, Mario Cornejo-Olivas, Sara Bandres-Ciga
Genes.2021; 12(11): 1681. CrossRef
Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa
Akintomiwa I. Makanjuola, Funmilola T. Taiwo, Joseph O. Yaria, Rufus O. Akinyemi, Adesola Ogunniyi
Journal of Global Medicine.2021; : e35. CrossRef
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine
Sara Bandres-Ciga, Monica Diez-Fairen, Jonggeol Jeff Kim, Andrew B. Singleton
Neurobiology of Disease.2020; 137: 104782. CrossRef
Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients
Oluwafemi G. Oluwole, Helena Kuivaniemi, Shameemah Abrahams, William L. Haylett, Alvera A. Vorster, Carel J. van Heerden, Colin P. Kenyon, David L. Tabb, Michael B. Fawale, Taofiki A. Sunmonu, Abiodun Ajose, Matthew O. Olaogun, Anastasia C. Rossouw, Ludo
BMC Medical Genetics.2020;[Epub] CrossRef
Translation, Validation, Diagnostic Accuracy, and Reliability of Screening Questionnaire for Parkinsonism in Three African Countries
Ali Shalash, Njideka U. Okubadejo, Jacques Doumbe, Oluwadamilola O. Ojo, Eman Hamid, Callixte Kuate, Sara Calvo, Asmaa Helmi, Osigwe P. Agabi, Mohamed Essam, Laura Aguado, Hanan Elrassas, Tamer Roushdy, Caroline M. Tanner, Esther Cubo
Journal of Parkinson's Disease.2020; 10(3): 1113. CrossRef
Parkinson's Disease Research on the African Continent: Obstacles and Opportunities
Marieke C. J. Dekker, Toumany Coulibaly, Soraya Bardien, Owen A. Ross, Jonathan Carr, Morenikeji Komolafe
Frontiers in Neurology.2020;[Epub] CrossRef
Chitosan-Coated Hydroxypropylmethyl Cellulose Microparticles of Levodopa (and Carbidopa): In Vitro and Rat Model Kinetic Characteristics
Benedicta Obenewaa Dankyi, Seth Kwabena Amponsah, Grace Lovia Allotey-Babington, Ismaila Adams, Nana Aboadwe Goode, Henry Nettey
Current Therapeutic Research.2020; 93: 100612. CrossRef
Parkinson's disease in Nigeria: A review of published studies and recommendations for future research
Oluwafemi G. Oluwole, Helena Kuivaniemi, Jonathan A. Carr, Owen A. Ross, Matthew O.B. Olaogun, Soraya Bardien, Morenikeji A. Komolafe
Parkinsonism & Related Disorders.2019; 62: 36. CrossRef
Clinical series of Parkinson's disease in KwaZulu-Natal, South Africa: Retrospective chart review
Ferzana Hassan Amod, Ahmed Iqbal Bhigjee
Journal of the Neurological Sciences.2019; 401: 62. CrossRef
Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson’s disease
Nicola du Toit, Riaan van Coller, David G. Anderson, Jonathan Carr, Soraya Bardien
neurogenetics.2019; 20(4): 215. CrossRef
Ethnic Variation in the Manifestation of Parkinson’s Disease: A Narrative Review
Aaron Ben-Joseph, Charles R. Marshall, Andrew J. Lees, Alastair J. Noyce
Journal of Parkinson’s Disease.2019; 10(1): 31. CrossRef
Leucine rich repeat kinase 2 (LRRK2) GLY2019SER mutation is absent in a second cohort of Nigerian Africans with Parkinson disease
Njideka U. Okubadejo, Mie Rizig, Oluwadamilola O. Ojo, Hallgeir Jonvik, Olajumoke Oshinaike, Emmeline Brown, Henry Houlden, Hiroyoshi Ariga
PLOS ONE.2018; 13(12): e0207984. CrossRef
Motor Symptoms of Parkinson’s Disease – A Review Literature
Hilda Aboagyewaa Agyekum
Neurophysiology and Rehabilitation.2018; : 38. CrossRef

Original Article

Falls and Their Associated Risks in Parkinson’s Disease Patients in Nigeria: Temitope Hannah Farombi, Mayowa O Owolabi, Adesola Ogunniyi; J Mov Disord. 2016;9(3):160-165. Published online September 21, 2016; DOI: https://doi.org/10.14802/jmd.16011

19,895 View
241 Download
17 Web of Science
16 Crossref

Abstract PDF

Objective
Falls are a devastating consequence of Parkinson’s disease (PD) and are due to motor imbalance. However, the frequency of falls and their risk factors among Nigerians with PD is not known despite the significant increase in PD cases in the country. To assess fall risk factors and frequency in Nigerian PD patients.
Methods
Using an analytical design to compare falling versus non-falling patients, 81 PD patients were assessed for clinical factors, frequency of falls, and candidate risk factors for falls according to the Tinetti Balance and Gait, Unified Parkinson’s Disease Rating Scale subsection 1, and Timed Up and Go Tests. Descriptive, bivariate, and multivariate analyses were performed at the 95% confidence level.
Results
The mean age of participants was 65.6 ± 9.7 years. Falls were about three times (p < 0.001) more common in PD patients. Of the falling patients, 67.7% sustained injuries, 67.7% had recurrent falls and 44.9% admitted to having a fear of falling. The independent statistical predictors of fall were fear of falling [odds ratio (OR): 3.86], disease severity (OR: 1.09) and disease duration (OR: 1.01).
Conclusion
The frequency of falls in PD patients was significantly higher when compared with the healthy adult population, and the modifiable predictor was fear of falling with a potential to significantly reduce falls when strategically addressed.

Citations

Citations to this article as recorded by

Concept Mapping to Define Components for an Occupation-Based Intervention for Parkinson’s Disease and Anxiety
Christopher J. Lovegrove, Ingrid H.W.M. Sturkenboom, Jonathan Marsden, Katrina Bannigan
Journal of Parkinson’s Disease.2024; 14(1): 181. CrossRef
Risk factors for falls in Parkinson's disease and other parkinsonisms
Aleksandra Buczek, Michał Borończyk, Patrycja Hudzińska, Hubert Bigajski, Alicja Białas, Wiktoria Balcerzak, Klaudia Marcinkiewicz, Jakub Milczarek, Joanna Siuda
Archives of Gerontology and Geriatrics Plus.2024; 1(4): 100054. CrossRef
α‐Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration
Qiumei Yang, Yanyan Wang, Chunsong Zhao, Shimin Pang, Jing Lu, Piu Chan
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 226. CrossRef
Toxin Induced Parkinsonism and Hospitalization Related Adverse Outcome Mitigation for Parkinson’s Disease: A Comprehensive Review
Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack
Journal of Clinical Medicine.2023; 12(3): 1074. CrossRef
Smart Assistance to Reduce the Fear of Falling in Parkinson Patients Using IoT
Pratik Bhattacharjee, Suparna Biswas, Samiran Chattopadhyay, Sandip Roy, Sandip Chakraborty
Wireless Personal Communications.2023; 130(1): 281. CrossRef
PRIORITIZING FALL RISK MANAGEMENT: IRRESPECTIVE OF PARKINSON’S DISEASE PROGRESSION DURING REHABILITATION
Fakhir Ansari
Pakistan Journal of Rehabilitation.2023; 12(1): 84. CrossRef
Frequency, pattern and predictors of cognitive impairments in patients with Parkinson’s disease using the Community Screening Instrument for Dementia
Ewere Marie Ogbimi, Fatai Momodu Akemokwe, Olubunmi Ogunrin
Frontiers in Human Neuroscience.2023;[Epub] CrossRef
Cognitive status and sleep quality can explain the fear of falling and fall history in people with Parkinson’s disease
Nesreen Alissa, Reem Rehan, Alham Al-Sharman, Mariem Latrous, Ala’ S Aburub, Khalid El-Salem, Linzette Morris, Hanan Khalil
International Journal of Rehabilitation Research.2023; 46(4): 338. CrossRef
Clinical Disease Severity Mediates the Relationship between Stride Length and Speed and the Risk of Falling in Parkinson’s Disease
Yun-Ru Lai, Chia-Yi Lien, Chih-Cheng Huang, Wei-Che Lin, Yueh-Sheng Chen, Chiun-Chieh Yu, Ben-Chung Cheng, Chia-Te Kung, Chien-Feng Kung, Yi-Fang Chiang, Yun-Ting Hung, Hsueh-Wen Chang, Cheng-Hsien Lu
Journal of Personalized Medicine.2022; 12(2): 192. CrossRef
Avaliação do risco de quedas entre pessoas com doença de Parkinson
Franciny da Silva, Angela Maria Alvarez, Simony Fabíola Lopes Nunes, Maria Eduarda Massari Silva, Silvia Maria Azevedo Dos Santos
Escola Anna Nery.2022;[Epub] CrossRef
Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis
Yingying Cai, Fei Feng, Qianqian Wei, Zheng Jiang, Ruwei Ou, Huifang Shang
Frontiers in Neurology.2021;[Epub] CrossRef
Peripheral vestibular system: Age-related vestibular loss and associated deficits
Jennifer Coto, Carmen L. Alvarez, Ivette Cejas, Brett M. Colbert, Bonnie E. Levin, Joshua Huppert, Tatjana Rundek, Carey Balaban, Susan H. Blanton, David J. Lee, David Loewenstein, Michael Hoffer, Xue Zhong Liu
Journal of Otology.2021; 16(4): 258. CrossRef
Clinical correlates of sarcopenia and falls in Parkinson’s disease
Danielle Pessoa Lima, Samuel Brito de Almeida, Janine de Carvalho Bonfadini, João Rafael Gomes de Luna, Madeleine Sales de Alencar, Edilberto Barreira Pinheiro-Neto, Antonio Brazil Viana-Júnior, Samuel Ranieri Oliveira Veras, Manoel Alves Sobreira-Neto, J
PLOS ONE.2020; 15(3): e0227238. CrossRef
Parkinson's Disease Research on the African Continent: Obstacles and Opportunities
Marieke C. J. Dekker, Toumany Coulibaly, Soraya Bardien, Owen A. Ross, Jonathan Carr, Morenikeji Komolafe
Frontiers in Neurology.2020;[Epub] CrossRef
Parkinson's disease in Nigeria: A review of published studies and recommendations for future research
Oluwafemi G. Oluwole, Helena Kuivaniemi, Jonathan A. Carr, Owen A. Ross, Matthew O.B. Olaogun, Soraya Bardien, Morenikeji A. Komolafe
Parkinsonism & Related Disorders.2019; 62: 36. CrossRef
Predictive Factors of Concerns about Falling in People with Parkinson’s Disease: A 3-Year Longitudinal Study
Magnus Lindh-Rengifo, Stina B. Jonasson, Niklas Mattsson, Susann Ullén, Maria H. Nilsson
Parkinson's Disease.2019; 2019: 1. CrossRef

First
Prev
Page of 1
Next
Last

Search