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- Parkinson’s Disease and the COVID-19 Pandemic: A Review Article on the Association between SARS-CoV-2 and α-Synucleinopathy
- Smriti Sinha, Swati Mittal, Rupali Roy
- J Mov Disord. 2021;14(3):184-192. Published online July 29, 2021
- DOI: https://doi.org/10.14802/jmd.21046
- 6,588 View
- 217 Download
- 12 Web of Science
- 13 Crossref
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Abstract
PDF - There is an extensive debate on the neurological consequences of 2019 novel coronavirus disease (COVID-19) and its impact on Parkinson’s disease (PD) patients, which seems to puzzle neurologists. Links between viral infections and PD have long been suspected and studied, but the exact relationship remains elusive. Since severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) enters the brain through multiple routes and has a direct impact on the brain, cumulative damage occurs due to the activation of proinflammatory cytokines and chemokines. SARS-CoV-2 seems to aggravate PD due to its effects on α-synuclein, mitochondrial dysfunction, and dopamine depletion. A few studies have even highlighted the higher vulnerability of PD patients to COVID-19. The sudden dramatic change in lifestyle caused by the pandemic and the widespread lockdowns that were implemented have added to the hidden sorrows of PD patients, as they already have a compromised mechanism for coping with stress. This review summarizes insights from basic science and the clinical effect of SARS-CoV-2 infection on the human brain, with a specific focus on PD.
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Citations
Citations to this article as recorded by
- Assessment of the relationship between the dopaminergic pathway and severe acute respiratory syndrome coronavirus 2 infection, with related neuropathological features, and potential therapeutic approaches in COVID‐19 infection
Yousef Rasmi, Ameneh Shokati, Shima Hatamkhani, Yeganeh Farnamian, Roya Naderi, Ladan Jalali
Reviews in Medical Virology.2024;[Epub] CrossRef - SARS-CoV-2 Infection to Premature Neuronal Aging and
Neurodegenerative Diseases: Is there any Connection with Hypoxia?
Narmadhaa Sivagurunathan, Latchoumycandane Calivarathan
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Qiuhan Xu, Sisi Jiang, Ruiqing Kang, Yiling Wang, Baorong Zhang, Jun Tian
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Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2023; 50(5): 777. CrossRef - Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms
Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan, Sheng-Di Chen
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Yulia Stroylova, Anastasiia Konstantinova, Victor Stroylov, Ivan Katrukha, Fedor Rozov, Vladimir Muronetz
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Anna Vasilevskaya, Asma Mushtaque, Michelle Y. Tsang, Batoul Alwazan, Margaret Herridge, Angela M. Cheung, Maria Carmela Tartaglia
Scientific Reports.2023;[Epub] CrossRef - Vulnerability of Parkinson’s Patients to COVID-19 and Its Consequences and Effects on Them: A Systematic Review
Sorayya Rezayi, Meysam Rahmani Katigari, Leila Shahmoradi, Mehrbakhsh Nilashi, Hélio Teive
Parkinson's Disease.2023; 2023: 1. CrossRef - COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
Sebastián García Menéndez, Virna Margarita Martín Giménez, Michael F. Holick, Francisco J. Barrantes, Walter Manucha
Life Sciences.2022; 297: 120464. CrossRef - SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro
Zhengcun Wu, Xiuao Zhang, Zhangqiong Huang, Kaili Ma
International Journal of Molecular Sciences.2022; 23(6): 3394. CrossRef - COVID-19 and Parkinsonism: A Critical Appraisal
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I.M. Karaban, T.V. Hasiuk, N.V. Karasevych
INTERNATIONAL NEUROLOGICAL JOURNAL.2022; 18(3): 46. CrossRef
- Assessment of the relationship between the dopaminergic pathway and severe acute respiratory syndrome coronavirus 2 infection, with related neuropathological features, and potential therapeutic approaches in COVID‐19 infection
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