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1 "Unified Parkinson’s Diseases Rating Scale"
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Original Article
N30 Somatosensory Evoked Potential Is Negatively Correlated with Motor Function in Parkinson’s Disease
Suk Yun Kang, Hyeo-Il Ma
J Mov Disord. 2016;9(1):35-39.   Published online January 25, 2016
DOI: https://doi.org/10.14802/jmd.15038
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  • 4 Web of Science
  • 2 Crossref
AbstractAbstract PDF
Objective
aaThe aim of this study was to investigate frontal N30 status in Parkinson’s disease (PD) and to examine the correlation between the amplitude of frontal N30 and the severity of motor deficits.
Methods
aaThe frontal N30 was compared between 17 PD patients and 18 healthy volunteers. Correlations between the amplitude of frontal N30 and the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score of the more severely affected side was examined.
Results
aaThe mean latency of the N30 was not significantly different between patients and healthy volunteers (p = 0.981), but the mean amplitude was lower in PD patients (p < 0.025). There was a significant negative correlation between the amplitude of N30 and the UPDRS motor score (r = -0.715, p = 0.013).
Conclusions
The frontal N30 status indicates the motor severity of PD. It can be a useful biomarker reflecting dopaminergic deficits and an objective measurement for monitoring the clinical severity of PD.

Citations

Citations to this article as recorded by  
  • Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease
    Ryoji Naganuma, Ichiro Yabe, Megumi Takeuchi, Kirari Morishita, Shingo Nakane, Ryoken Takase, Ikuko Takahashi-Iwata, Masaaki Matsushima, Mika Otsuki, Hideaki Shiraishi, Hidenao Sasaki, Wing-ho Yung
    PLOS ONE.2020; 15(9): e0232808.     CrossRef
  • Short-Term Effects of Thoracic Spine Manipulation on the Biomechanical Organisation of Gait Initiation: A Randomized Pilot Study
    Sébastien Ditcharles, Eric Yiou, Arnaud Delafontaine, Alain Hamaoui
    Frontiers in Human Neuroscience.2017;[Epub]     CrossRef

JMD : Journal of Movement Disorders