| Home | E-Submission | Sitemap | Contact Us
logo
top_img
J Mov Disord > Volume 11(2); 2018 > Article
Lee, Williams, and Anderson: Prospective Characterization of Cognitive Function in Typical and ‘Brainstem Predominant’Progressive Supranuclear Palsy Phenotypes

Abstract

Objective

Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson’s syndrome (PSP-RS) and two atypical ‘brainstem predominant’ PSP phenotypes (PSP-parkinsonism, PSP-P; and PSP-pure akinesia with gait freezing, PSP-PAGF) using a comprehensive neuropsychological battery.

Methods

Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests.

Results

The typical PSP-RS subgroup demonstrated greater impairments in processing speed [t(19) = -4.10, p = 0.001 (d =1.66)] and executive function [t(19) = -2.63, p = 0.02 (d = 1.20)] compared to the ‘brainstem predominant’ PSP phenotype.

Conclusion

This is the first prospective study to demonstrate that PSP-RS and ‘brainstem predominant’ PSP phenotypes can be differentiated on cognitive grounds. These differences correspond with variations in pathological profiles reported in the literature.

Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP). A new nosology has emerged that includes the ‘classic’ or typical PSP-Richardson’s syndrome (PSP-RS) and a variety of ‘atypical’ PSP clinical syndromes [1,2]. The atypical PSP phenotypes are differentiated from PSP-RS by distinct clinical features as well as variations in the distribution of PSP-tau pathology [2-4]. To date, the literature has largely focused on identifying pathological and neurological variations among the PSP phenotypes. The aim of this study was to determine whether the cognitive profile of typical PSP (PSP-RS) can be differentiated from the most pathologically distinct ‘brainstem predominant’ PSP phenotypes [3], namely, PSP-parkinsonism (PSP-P) and PSP-pure akinesia with gait freezing (PSP-PAGF). Despite having less severe brainstem pathology than PSP-RS, PSP-P, and PSP-PAGF are referred to as ‘brainstem predominant’ PSP phenotypes because the pathology is more concentrated in the brainstem relative to some other atypical phenotypes that have more severe cortical pathology [4-10].
Neuropsychological studies have consistently demonstrated the presence of cognitive symptoms in the majority of cases of typical PSP [11-15]. PSP-RS is associated with a specific cognitive betweenprofile, which includes cognitive slowing, deficits in attention, and early and severe frontal executive dysfunction with difficulties in allocating attentional resources, problems with planning, shifting concepts and prominent retrieval-based memory deficits [11-15]. These cognitive deficits have been linked to subcortical pathology and associated frontal deafferentation [16] as well as damage to cortical frontal regions and underlying white matter tracts [11,17].
To date, only two studies have prospectively examined the neuropsychological profiles of atypical PSP phenotypes [7,18]. Both of these studies compared PSP-P with typical PSP-RS. Although they found no significant differences between the phenotypes in general cognition or executive function, neither study comprehensively examined cognition. This has left unanswered, the question of whether clinicopathological distinctions between these PSP groups extend to differences in cognitive profiles in a prospective cohort. Clarifying this issue may aid earlier and more accurate differentiation of classic and ‘brainstem predominant’ PSP phenotypes.
To this end, this study utilized a comprehensive neuropsychological examination to prospectively investigate the severity of cognitive changes in typical PSP and the ‘brainstem predominant’ PSP phenotypes. Given the greater pathological involvement of the basal ganglia, diencephalon, brainstem, cerebellum and frontal cortical structures in PSP-RS compared to the ‘brainstem predominant’ PSP phenotypes (PSP-P, PSP-PAGF), it was predicted that the PSP-RS group would exhibit more severe deficits in processing speed, attention and executive function than the ‘brainstem predominant’ PSP phenotype group.

MATERIALS & METHODS

Participants

Fourteen patients with PSP-RS, 3 patients with PSP-P, and 4 with PSP-PAGF were recruited from a specialist movement disorder clinic at a tertiary referral hospital in Melbourne, Australia. Participants were diagnosed by an experienced movement disorder specialist (D.W.) according to the diagnostic criteria for PSP phenotypes [19]. The inclusion criteria for PSP-RS were early falls, cognitive dysfunction, eye movement abnormalities, and postural instability; PSP-P included asymmetric parkinsonian symptoms (rigidity, bradykinesia and in some cases tremor), non-axial dystonia and modest response to levodopa; and PSP-PAGF included an early history of freezing of gait or hypophonia of gradual onset without limb rigidity and tremor and no sustained response to levodopa, dementia or eye movement abnormalities. Patients with history of major focal neurological or psychiatric disorders (history of stroke, severe depression, or psychosis), major head injury, drug or alcohol abuse, and global cognitive decline (as indicated by the Mini Mental State Examination score < 24) were excluded. No participants had their diagnosis changed during the two-year follow-up period, and in all participants who have died since study commencement (n = 5), post-mortem findings have confirmed the study neurologist’s clinical diagnosis (PSP-RS).

Materials and procedures

Clinical examination

All participants underwent systematic neurological examination that included the Progressive Supranuclear Palsy Rating Scale [20] and the Hoehn and Yahr Stage of Illness Rating Scale (HYRS) [21].

Neuropsychological battery

All participants completed a comprehensive neuropsychological examination that assessed six cognitive domains: processing speed, memory, language, working memory, visuospatial function, and executive function (Table 1 for list of tests).
To minimize the influence of motor, speech and oculomotor dysfunction on test performance, baseline control comparisons, modified scoring and presentation procedures were used (Table 1).
All patients gave written informed consent to the study, which was approved by The Alfred Hospital Human Research Ethics Committee (HREC reference: 66/09).

Statistical analyses

Nonparametric Mann-Whitney tests were used to compare the clinical and demographic characteristics of the groups. Cognitive domain indices were derived by averaging the z-scores of the tests within each cognitive domain by group [22]. For 5 of the 6 indices, the aforementioned assessment modifications were incorporated into the index, allowing between-group analysis with t-tests for unpaired samples. The language index required covariation of baseline speed, so analysis of covariance was conducted for this index. Due to the limited sample size, no corrections for multiple comparisons were made.
Standardized scores were calculated for each cognitive test using published normative data. Impairment was classified relative to the normative mean as mild [≥ 1.5 standard deviations (SD)], moderate (≥ 2 SD), or severe (≥ 3 SD) [23].

RESULTS

Demographic and clinical data

As shown in Table 2, there were no significant differences between the typical and ‘brainstem predominant’ PSP phenotypes on age [mean (SD) = 69.93 (5.66) vs. 67.67 (15.63); p = 0.40], education [mean (SD) = 10.79 (2.69) vs. 13.33 (4.16); p = 0.26], levodopa medication (on levodopa = 6/14 vs. 4/7; p = 0.10; Fisher’s test) or level of clinical disability (PSPRS: p = 0.09; HYRS: p = 0.16). Thus, the groups were well matched with respect to the demographic variables and disease severity.
Not surprisingly, the PSP-RS group showed a trend towards shorter disease duration relative to the ‘brainstem predominant’ PSP phenotypes (3.7 vs. 5.8; p = 0.10).

Neuropsychological performance

As shown in Table 3, there were significant differences between the groups on processing speed, [t(19) = -4.10, p = 0.001, d = 1.66], with the PSPRS group showing significantly slower general processing speed (mean = -0.36, SD = 0.89) than the ‘brainstem predominant’ PSP group (mean = 0.76, SD = 0.35). Similarly, the PSP-RS group performed significantly worse (mean = -0.27, SD = 0.65) than those in the ‘brainstem predominant’ PSP group (mean = 0.54, SD = 0.69) on the executive function index [t(19) = -2.63, p = 0.02, d = 1.20]; the effect size of these differences was large. In contrast, no significant group differences were observed for the memory, [t(19) = -1.01, p = 0.32, d = 0.47], language [t(19) = 3.83, p = 0.42, d = 0.92], working memory [t(19) = 0.41, p = 0.19, d = 0.62], and visuospatial function indices, [t(19) = -1.13, p = 0.28, d = 0.30].
As shown in Table 4, supplementary analyses comparing PSP-P and PSP-PAGF from a clinical perspective revealed mild to moderate impairments on measures of processing speed, verbal memory and fluency for all individuals in the PSP-P group. In contrast, no individuals with PSP-PAGF demonstrated clinically significant impairment (≤ 1.5 SD) in any cognitive domains.

DISCUSSION

This study shows that typical PSP-RS has a cognitive profile that is distinct from the cognitive profile of the ‘brainstem predominant’ PSP phenotypes (PSP-P and PSP-PAGF). Specifically, we found significantly greater executive function deficits and significantly slower speed of information processing in the PSP-RS subgroup compared to the ‘brainstem predominant’ PSP phenotypes. It is unlikely that these findings were primarily due to inter-group variations in speech or motor deficits, as the groups were well matched with respect to severity, and the assessment included baseline control comparisons and measurement modifications to mitigate the influence of speech or motor deficits.
The evidence of more pronounced psychomotor slowing and executive dysfunction in the PSP-RS subgroup is largely in accordance with reported pathological differences between the typical and ‘brainstem predominant’ PSP phenotypes [3,4,8]. Specifically, the greater executive dysfunction documented in the current PSP-RS cohort corresponds well to reports of greater frontal pathology in this group [5-8]. The more pronounced psychomotor slowing also corresponds well to the more severe subcortical pathology in the PSP-RS group [4].
Clinically-driven consideration of cognition in the ‘brainstem predominant’ PSP phenotypes indicated that it may be possible to identify discrete cognitive profiles in PSP-P and PSP-PAGF. Specifically, none of the individuals in the PSP-PAGF group demonstrated clear evidence of cognitive impairment on any domain of function, whereas all of the individuals in the PSP-P group showed mild to moderate impairment in processing speed, memory and fluency.
PSP-RS has a shorter naturally occurring disease course than the ‘brainstem predominant’ PSP phenotypes, but the groups in this study were well matched in terms of disease severity. It is therefore unsurprising that the PSP-RS group trended (p = 0.10) toward having a shorter mean disease duration (3.68 years) than the ‘brainstem predominant’ PSP phenotypes (5.33; 5.50 years). This trend is unlikely to be the cause of the group differences in cognitive ability, as the PSP-RS group performed more poorly on cognitive assessment while being earlier in their disease duration than the ‘brainstem predominant’ PSP phenotypes. Given that the groups were well matched in terms of disease severity, it seems probable that the relatively greater impairment in the PSP-RS group represents a real group difference between these phenotypes.
The relatively small size of the patient sample in the current study and the fact that clinical diagnoses were made in vivo limits the interpretation of the results. However, all of the cases included in the current study have been seen at a tertiary center with a high rate of clinical diagnostic accuracy confirmed by pathological examination. Moreover, current significant findings together with the large effect sizes despite the small size of the PSP groups suggest that the reported group differences in cognition are clinically meaningful. The small sample size may, however, have resulted in insufficient statistical power to identify subtler group differences in other cognitive domains. Future work with larger cohorts would be able to address this issue.
The field of PSP research is moving away from considering PSP as a single clinical entity [1,3,6,7]. This prospective study offers the first clear evidence that typical PSP-RS can be differentiated from two ‘brainstem predominant’ PSP phenotypes (PSP-P and PSPPAGF) on the basis of cognitive ability. Specifically, individuals with PSP-RS have more impaired executive functioning and processing speed than individuals with the ‘brainstem predominant’ PSP phenotypes. The current findings provide preliminary evidence that PSP-RS and ‘brainstem predominant’ PSP phenotypes may be differentiated by the severity of cognitive deficits. Further studies, with larger sample sizes are clearly needed, but this study suggests that such work may be clinically fruitful.

Notes

Conflicts of Interest

The authors have no financial conflicts of interest.

Acknowledgments

We would like to thank Dr. Will Lee for assisting in the collection of the clinical data used in this study. We would like to thank Prof. Catrina McLean for providing the pathological diagnoses, and we are grateful for the assistance of Fairlie Hinton at the Victorian Brain Bank Network.

Table 1.
Neuropsychological tests and corresponding baseline measures
Tests Baseline (Y/N) Baseline measures/modifications
Processing speed
 TMT [24] Y Stimuli presented at eye level
 Victoria Stroop [25] Y Stimuli presented at eye level
Working memory
 Digit span [26] Y Baseline for controlling speed of speech
 Spatial span [26] N
Memory
 RAVLT [27] N
 VR [28] Y Modified scoring; motor errors performed in the copy score were not deducted from the recall score
Executive function
 WCST-6 [29] N
 COWAT [30] (Phonemic) Y Baseline for controlling speed of speech
Stimuli presented at eye level
 Victoria Stroop [25] Y Baseline for controlling speed of speech
 TOL [31] Y Removed time limit
Language
 BNT [32] Y Stimuli presented at eye level
Baseline for controlling speed of speech
 COWAT [30] (Semantic) Y Baseline for controlling speed of speech
Visuospatial function
 VOSP [33] Y Stimuli presented at eye level

BNT: Boston Naming Test, COWAT: Controlled Oral Word Association Test, RAVLT: Rey Auditory Learning Test, TMT: Trail Making Test, TOL: Tower of London test, VOSP: Visual Object and Spatial Perception Battery, VR: Visual Reproduction, WCST-64: Wisconsin Card Sorting Test-64.

Table 2.
Demographic and clinical characteristics of the PSP phenotypes
Demographical and clinical information Typical PSP (PSP-RS) ‘Brainstem predominant PSP p
M (SD) Range M (SD) Range
Age 69.93 (5.66) 67.67 (15.63) 0.40
(61-82) (51-82)
Education 10.79 p.69) 13.33 (4.16) 0.26
(8-16) (10-18)
Disease duration 3.68 (1.60) 5.83 (2.51) 0.10
(2-7) (4-9)
PSPRS 35.20 (10.40) 35.67 (14.47) 0.09
(17-50) (19-45)
HYRS 3.06 (0.63) 4.00 (1.00) 0.16
(2-4) (3-5)
On levodopa 6/14 4/7 0.10
Fisher’s test

Age, education and disease duration are in years. PSP: progressive supranuclear palsy, PSP-RS: PSP-Richardson’s syndrome, M: mean, SD: standard deviation, PSPRS: progressive supranuclear palsy rating scale, HYRS: Hoehn and Yahr Stage of Illness Rating Scale.

Table 3.
Between group comparisons [means (SD)] of the typical and ‘brainstem predominant’ PSP phenotypes on cognitive indices and the mean performance of the ‘brainstem predominant’ PSP phenotypes relative to age- and educationstratified normative data
Cognitive domains Typical PSP (n = 14) ‘Brainstem predominant PSP (n = 7) T p
Mean (SD) Mean (SD)
Executive function* -0.27 (0.65) 0.54 (0.69) -2.63 0.02¶¶
Cohen’s d = 1.20
Processing speed -0.36 (0.89) 0.76 (0.35) -4.10 0.001¶¶
Cohen’s d = 1.66
Memory -0.22 (0.83) 0.18 (0.88) -1.01 0.32
Language§ -0.24 (0.76) 0.51 (0.86) 3.83 0.42
Working memory -0.34 (0.86) 0.41 (1.14) 0.41 0.19
Visuospatial function -0.38 (4.5) 1.13 (1.0) -1.13 0.28

* Wisconsin Card Sorting Test-64; Controlled Oral Word Association Test (phonemic)††; Victoria Stroop-Color/dot ratio**; Tower of London§§;

† Trail Making Test-Part A**; Victoria Stroop-dot**,

‡ Rey Auditory Verbal Learning Test; Visual Reproduction‡‡;

§ Boston Naming Test**; Semantic Fluency††;

∥ Digit Span-forward span and backward span difference score††; Spatial span-forward span and backward span difference score;

¶ Visual Object and Space Perception Battery**; (** = presentation modification; †† = baseline comparison; ‡‡ = scoring modification; §§ = removed time limit);

¶¶ indicate statistically significant results; z-scores are relative to the means and standard deviations of the complete sample.

PSP: progressive supranuclear palsy, SD: standard deviation.

Table 4.
Mean performances of the PSP phenotypes relative to age- and education-stratified normative data
Cognitive domains Typical PSP
‘Brainstem-predominant’ PSP
PSP-RS (n = 14) PSP-P (n = 3) PSP-PAGF (n = 4)
Mean (range) Mean (range) Mean (range)
Executive function -1.8 (-2.6, 1.0)* -1.5 (-1.7, -1.2)* -0.3 (-1.8, 1.3)
Processing speed -4.9 (-10.6, -0.1)* -2.1* (-2.6, -1.0)* -0.4 (-2.2, 0.7)
Memory -1.7* (-2.3, -1.1) -1.6* (-1.7, -1.5) -1.0 (-2.5, 0.7)
Language -1.9* (-2.9, -0.6) -1.5* (-1.9, -0.8) -0.5 (-1.5, 0.6)
Working memory -0.4 (-2.2, 0.6) -0.2 (-1.7, 0.6) -1.2 (-1.4, 1.4)
Visuospatial function -1.6* (-3.3, -0.1) -1.1 (-2.1, -0.1) -0.4 (-1.3, 0.7)

* indicates impairment (≥ 1.5 SD from age- and/or education-adjusted normative mean).

Mild impairment = 1.5–2.0 SD below the normative mean; moderate impairment = 2.1–3.0 SD below the normative mean; severe impairment ≥ 3.0 SD below the normative mean. PSP: progressive supranuclear palsy, PSP-RS: PSP-Richardson’s syndrome, PSP-P: PSP-parkinsonism, PSP-PAGF: PSPpure akinesia with gait freezing, SD: standard deviation.

REFERENCES

1. Respondek G, Stamelou M, Kurz C, Ferguson LW, Rajput A, Chiu WZ, et al. The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases. Mov Disord 2014;29:1758–1766.
crossref pmid
2. Williams DR, Lee W. Clinical features and criteria for the diagnosis of progressive supranuclear palsy. Neurodegener Dis Manag 2012;2:125–133.
crossref
3. Dickson DW, Ahmed Z, Algom AA, Tsuboi Y, Josephs KA. Neuropathology of variants of progressive supranuclear palsy. Curr Opin Neurol 2010;23:394–400.
crossref pmid
4. Williams DR, de Silva R, Paviour DC, Pittman A, Watt HC, Kilford L, et al. Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson’s syndrome and PSP-parkinsonism. Brain 2005;128(Pt 6):1247–1258.
crossref pmid pdf
5. Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, et al. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson’s syndrome. Brain 2007;130(Pt 6):1566–1576.
crossref pmid pdf
6. Schofield EC, Hodges JR, Macdonald V, Cordato NJ, Kril JJ, Halliday GM. Cortical atrophy differentiates Richardson’s syndrome from the parkinsonian form of progressive supranuclear palsy. Mov Disord 2011;26:256–263.
crossref pmid
7. Agosta F, Kostić VS, Galantucci S, Mesaros S, Svetel M, Pagani E, et al. The in vivo distribution of brain tissue loss in Richardson’s syndrome and PSP-parkinsonism: a VBMDARTEL study. Eur J Neurosci 2010;32:640–647.
crossref pmid
8. Williams DR, Holton JL, Strand K, Revesz T, Lees AJ. Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsy. Mov Disord 2007;22:2235–2241.
crossref pmid
9. Ahmed Z, Josephs KA, Gonzalez J, DelleDonne A, Dickson DW. Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy. Brain 2008;131(Pt 2):460–472.
crossref pmid pdf
10. Park HK, Kim JS, Im KC, Oh SJ, Kim MJ, Lee JH, et al. Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses. Mov Disord 2009;24:237–245.
crossref pmid
11. Caso F, Agosta F, Volonté MA, Ferraro PM, Tiraboschi P, Copetti M, et al. Cognitive impairment in progressive supranuclear palsy-Richardson’s syndrome is related to white matter damage. Parkinsonism Relat Disord 2016;31:65–71.
crossref pmid
12. Bak TH, Crawford LM, Hearn VC, Mathuranath PS, Hodges JR. Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). Neurocase 2005;11:268–273.
crossref pmid
13. Gerstenecker A, Mast B, Duff K, Ferman TJ, Litvan I; ENGENE-PSP Study Group. Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy. Arch Clin Neuropsychol 2013;28:104–113.
crossref pmid pdf
14. Monza D, Soliveri P, Radice D, Fetoni V, Testa D, Caffarra P, et al. Cognitive dysfunction and impaired organization of complex motility in degenerative parkinsonian syndromes. Arch Neurol 1998;55:372–378.
crossref pmid
15. Zhang J, Rittman T, Nombela C, Fois A, Coyle-Gilchrist I, Barker RA, et al. Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson’s disease. Brain 2016;139(Pt 1):161–173.
crossref pmid pdf
16. Albert ML. Subcortical dementia: historical review and personal view. Neurocase 2005;11:243–245.
crossref pmid
17. Piattella MC, Upadhyay N, Bologna M, Sbardella E, Tona F, Formica A, et al. Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy. J Neurol 2015;262:1850–1858.
crossref pmid
18. Srulijes K, Mallien G, Bauer S, Dietzel E, Gröger A, Ebersbach G, et al. In vivo comparison of Richardson’s syndrome and progressive supranuclear palsy-parkinsonism. J Neural Transm (Vienna) 2011;118:1191–1197.
crossref pmid
19. Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges. Lancet Neurol 2009;8:270–279.
crossref pmid
20. Golbe LI, Ohman-Strickland PA. A clinical rating scale for progressive supranuclear palsy. Brain 2007;130(Pt 6):1552–1565.
crossref pmid pdf
21. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427–442.
crossref pmid
22. Arbuckle TY, Maag U, Pushkar D, Chaikelson JS. Individual differences in trajectory of intellectual development over 45 years of adulthood. Psychol Aging 1998;13:663–675.
crossref pmid pdf
23. Tuokko HA, Frerichs RJ, Kristjansson B. Cognitive impairment, no dementia: concepts and issues. Int Psychogeriatr 2001;13 Supp 1:183–202.
crossref pmid
24. Hester RL, Kinsella GJ, Ong B, McGregor J. Demographic influences on baseline and derived scores from the Trail Making Test in healthy older Australian adults. Clin Neuropsychol 2005;19:45–54.
crossref pmid
25. Troyer AK, Leach L, Strauss E. Aging and response inhibition: normative data for the Victoria Stroop. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2006;13:20–35.
crossref pmid
26. Wechsler D. Wechsler Adult Intelligence Scale - Third Edition. San Antonio: The Psychological Corporation; 1997.

27. Schmidt M. Rey Auditory Verbal Learning Test: A Handbook. Los Angeles, CA: Western Psychological Services; 1996.

28. Wechsler D. Wechsler Memory Scale - Third Edition. San Antonio: The Psychological Corporation; 1997.

29. Kongs SK, Thompson LLL, Iverson G, Heaton RK. Wisconsin Card Sorting Test - 64 Card Version. Lutz, FL: Psychological Assessment Resources; 2000.

30. Tombaugh TN, Kozak J, Rees L. Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming. Arch Clin Neuropsychol 1999;14:167–177.
pmid
31. Lee YC, Anderson JFI, Dennerstein L, Henderson VW, Szoeke C. Normative data for the Tower of London performance in Australian midlife women. Aus Psychol 2013;48:402–407.
crossref
32. Worrall LE, Yiu EM-L, Hickson LMH, Barnett HM. Normative data for the boston naming test for Australian elderly. Aphasiology 1995;9:541–551.
crossref
33. Warrington EK, James M. The Visual Object and Space Battery. Bury st Edmunds: Thames Valley Test Company; 1991.

Editorial Office
#2011 Mapo Hanwha Obelisk, 555, Dohwa-dong, Mapo-gu, Seoul, 04167, Rep. of KOREA
TEL: +82-2-6395-2876   FAX: +82-2-6395-2875   
E-mail: editor@jmdeditorial.org
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © Korean Movement Disorder Society. All rights reserved.                powerd by m2community