KMDS
E-submission
Search
- Page Path
- HOME > Search
Original Article
- The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson’s Disease Patients
- Dong-Woo Ryu, Joong-Seok Kim, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee
- J Mov Disord. 2019;12(3):172-176. Published online August 9, 2019
- DOI: https://doi.org/10.14802/jmd.19004
- Correction in: J Mov Disord 2021;14(2):176
- 5,302 View
- 107 Download
- 7 Web of Science
- 6 Crossref
-
Abstract
PDF - Objective
Impulse control disorders (ICDs) in Parkinson’s disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
Methods
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS).
Results
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson’s Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
Conclusion
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD. -
Citations
Citations to this article as recorded by
- Frequency of Impulsive-Compulsive Behavior and Associated Psychological Factors in Parkinson’s Disease: Lack of Control or Too Much of It?
Alexandros Kapsomenakis, Dimitrios Kasselimis, Emily Vaniotis, Anastasia Bougea, Christos Koros, Athina Maria Simitsi, Leonidas Stefanis, Constantin Potagas
Medicina.2023; 59(11): 1942. CrossRef - Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy
Rong Ye, Frank H. Hezemans, Claire O'Callaghan, Kamen A. Tsvetanov, Catarina Rua, P. Simon Jones, Negin Holland, Maura Malpetti, Alexander G. Murley, Roger A. Barker, Caroline H. Williams-Gray, Trevor W. Robbins, Luca Passamonti, James B. Rowe
The Journal of Neuroscience.2023; 43(42): 7028. CrossRef - Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation
Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
Frontiers in Neurology.2021;[Epub] CrossRef - Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald
Clinical Parkinsonism & Related Disorders.2021; 5: 100113. CrossRef - A Review of the Concept of Impulsivity
Mohammed Munther Al-Hammouri, Jehad A. Rababah, Celeste Shawler
Advances in Nursing Science.2021; 44(4): 357. CrossRef - Assessment of therapeutic strategies for management of impulse control disorder in Parkinson’s disease
Mayela Rodríguez-Violante, Yazmín Ríos-Solís, Oscar Esquivel-Zapata, Fanny Herrera, Susana López-Alamillo, Cynthia Sarabia-Tapia, Amin Cervantes-Arriaga
Arquivos de Neuro-Psiquiatria.2021; 79(11): 989. CrossRef
- Frequency of Impulsive-Compulsive Behavior and Associated Psychological Factors in Parkinson’s Disease: Lack of Control or Too Much of It?
Review Article
- Maladaptive Reward-Learning and Impulse Control Disorders in Patients with Parkinson’s Disease: A Clinical Overview and Pathophysiology Update
- Jee-Young Lee, Beom Seok Jeon
- J Mov Disord. 2014;7(2):67-76. Published online October 30, 2014
- DOI: https://doi.org/10.14802/jmd.14010
- 38,069 View
- 124 Download
- 9 Web of Science
- 9 Crossref
-
Abstract
PDF
- Impulse control disorders (ICD) in Parkinson’s disease (PD) are a disabling non-motor symptom with frequencies of 13–35% among patients receiving dopamine replacement therapy. ICD in PD is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (DA). However, individual susceptibility and disease-related neural changes are also important contributors to the development of ICD. Discrepancies between nigrostriatal and mesolimbic dopaminergic degeneration and non-physiological administration of dopaminergic drugs may induce abnormal ’hyperstimulation’ of the mesolimbic system, which alters reward-learning behaviors in PD patients. In addition, DA can make patients more impulsive during decision-making and seek risk-taking behaviors. DA intake is also related to the biased representation of rewards. Ultimately, loss of negative feedback control due to dysfunctional frontostriatal connections is necessary for the establishment of ICD in PD. The subsequent behavioral and neural changes are affected by PD treatment and disease progression; thus, proper treatment guidelines for physicians are needed to prevent the development of ICD. Future studies aimed at producing novel therapeutics to control the risk factors for ICD or treat ICD behaviors in PD are warranted. This review summarizes recent advances from epidemiological and pathophysiological studies on ICD in PD. Management principles and limitations of current therapeutics are briefly discussed.
-
Citations
Citations to this article as recorded by- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
Dana Bell, Vaughn J. Waldron, P. Leon Brown
Frontiers in Behavioral Neuroscience.2023;[Epub] CrossRef - No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease
Alexandra C. Zapf, Ann-Kristin Folkerts, Larissa Kahler, Alfons Schnitzler, Paul Reker, Michael T. Barbe, Esther Florin, Elke Kalbe
Journal of Parkinson's Disease.2022; 12(3): 1045. CrossRef - Reckless Generosity, Parkinson's Disease and Dopamine: A Case Series and Literature Review
Deborah Amstutz, Joan Philipp Michelis, Ines Debove, Marie Elise Maradan‐Gachet, Martin Lenard Lachenmayer, Julia Muellner, Kyrill Schwegler, Paul Krack
Movement Disorders Clinical Practice.2021; 8(3): 469. CrossRef - Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial
Jee-Young Lee, Beomseok Jeon, Seong-Beom Koh, Won Tae Yoon, Ho-Won Lee, Oh Dae Kwon, Jae Woo Kim, Jong-Min Kim, Hyeo-Il Ma, Hee-Tae Kim, Jong Sam Baik, Jinwhan Cho
Journal of Neurology, Neurosurgery & Psychiatry.2019; 90(1): 30. CrossRef - Impulse control disorders in Parkinson disease: A cross-sectional study in Morocco
H. El Otmani, F.Z. Mouni, Z. Abdulhakeem, Z. Attar, L. Rashad, I. Saali, B. El Moutawakil, M.A. Rafai, I. Slassi, S. Nadifi
Revue Neurologique.2019; 175(4): 233. CrossRef - Dopamine Agonists and Impulse Control Disorders: A Complex Association
Marie Grall-Bronnec, Caroline Victorri-Vigneau, Yann Donnio, Juliette Leboucher, Morgane Rousselet, Elsa Thiabaud, Nicolas Zreika, Pascal Derkinderen, Gaëlle Challet-Bouju
Drug Safety.2018; 41(1): 19. CrossRef - Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors
Daniel O. Claassen, Adam J. Stark, Charis A. Spears, Kalen J. Petersen, Nelleke C. van Wouwe, Robert M. Kessler, David H. Zald, Manus J. Donahue
Movement Disorders.2017; 32(11): 1574. CrossRef - Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism
Mona Buhusi, Kaitlin Olsen, Benjamin Z. Yang, Catalin V. Buhusi
Frontiers in Behavioral Neuroscience.2016;[Epub] CrossRef - Patients’ Reluctance to undergo Deep Brain Stimulation for Parkinson’s Disease
Mi-Ryoung Kim, Ji Young Yun, Beomseok Jeon, Yong Hoon Lim, Kyung Ran Kim, Hui-Jun Yang, Sun Ha Paek
Parkinsonism & Related Disorders.2015;[Epub] CrossRef
- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat
First
Prev
