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JMD Scientific Statements and Guidelines in the Early View area have been typeset, copyedited, and reviewed by the writing group or author, but they have not appeared in a print or online issue of the journal. In some cases, the statement or guideline may be revised before it is eventually published in print and online.
Each manuscript published online ahead of print is citable, with the official publication date being the date of the manuscript's first online posting. JMD papers are assigned Digital Object Identifiers (DOIs), providing a persistent, permanent way to identify manuscripts published in the online environment.
Original Article
- Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration
- Jin Whan Cho, Jee-Young Lee, Han-Joon Kim, Joong-Seok Kim, Kun-Woo Park, Seong-Min Choi, Chul Hyoung Lyoo, Seong-Beom Koh
- Received May 28, 2024 Accepted October 18, 2024 Published online October 21, 2024
- DOI: https://doi.org/10.14802/jmd.24127 [Epub ahead of print]
- 624 View
- 136 Download
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Abstract
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Supplementary Material - Objective
We conducted this study to assess the efficacy and safety of taltirelin hydrate (TH) in patients with ataxia due to spinocerebellar degeneration (SCD).
Methods
Patients were randomly assigned to either the taltirelin group (5 mg orally, twice daily) or the control group. The primary endpoint was the change in the Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) score at 24 weeks. The secondary endpoints included changes in the K-SARA score at 4 and 12 weeks as well as the Clinical Global Impression Scale, the five-level version of the EuroQol five-dimensional questionnaire, the Tinetti balance test, and gait analysis at 4, 12, and 24 weeks.
Results
A total of 149 patients (hereditary:nonhereditary=86:63) were enrolled. There were significant differences in the change in the K-SARA score at 24 weeks from baseline between the taltirelin group and the control group (-0.51±2.79 versus 0.36±2.62, respectively; p=0.0321). For the K-SARA items, the taltirelin group had significantly lower “Stance” and “Speech disturbance” subscores than the control group (-0.04±0.89 versus 0.23±0.79 and -0.07±0.74 versus 0.18±0.67; p=0.0270 and 0.0130, respectively). However, there were no significant differences in changes in other secondary efficacy outcome measures at 24 weeks from baseline between the two treatment arms (p>0.05).
Conclusion
Clinicians might consider the use of TH in the treatment of patients with ataxia due to SCD.
Letters to the editor
- Muscle Dystonia Manifesting as Unilateral Rectus Abdominis Hypertrophy and Abdominal Pain in Parkinson’s Disease: A Case Report
- Chengjian Wu, Yanhui Meng, Ming Yang
- Received November 14, 2024 Accepted December 10, 2024 Published online December 10, 2024
- DOI: https://doi.org/10.14802/jmd.24230 [Epub ahead of print]
- 343 View
- 30 Download
- Complete Relief of Tardive Truncal Dystonia With a Low Dose of Levodopa/Carbidopa: A Case Report
- Shinichi Matsumoto, Satoshi Goto
- Received November 15, 2024 Accepted December 8, 2024 Published online December 9, 2024
- DOI: https://doi.org/10.14802/jmd.24231 [Epub ahead of print]
- 334 View
- 51 Download
- 1 Crossref
- The Application of Deep Brain Stimulation in the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity
- Lina Okar, Peyton Murin, Anagha Prabhune, Richard Bucholz, Pratap Chand
- Received October 10, 2024 Accepted November 30, 2024 Published online December 2, 2024
- DOI: https://doi.org/10.14802/jmd.24209 [Epub ahead of print]
- 287 View
- 46 Download
- Clozapine-Induced Negative Myoclonus Leads to Recurrent Falls: A Case Report
- Shiny Joy, Punith Saroja Bylappa, Divyani Garg, Ayush Agarwal, Achal Kumar Srivastava
- Received October 9, 2024 Accepted October 30, 2024 Published online November 11, 2024
- DOI: https://doi.org/10.14802/jmd.24207 [Epub ahead of print]
- 334 View
- 103 Download
- 1 Crossref
- Myoclonic Epilepsy of Unverricht and Lundborg in a Filipino Woman
- Kruzette Khloe L. Solijon, Sheina B. Magtuba, Noel Belonguel, Gerard Saranza
- Received August 2, 2024 Accepted October 7, 2024 Published online October 7, 2024
- DOI: https://doi.org/10.14802/jmd.24172 [Epub ahead of print]
- 435 View
- 67 Download
- Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Masquerading as Charcot-Marie-Tooth Disease: A Case Study and Literature Review of Korean Patients
- Yongmoo Kim, Seungbok Lee, Jae So Cho, Jihoon G Yoon, Sheehyun Kim, Man Jin Kim, Jong Hee Chae, Manho Kim, Jangsup Moon
- Received March 3, 2024 Accepted July 8, 2024 Published online July 9, 2024
- DOI: https://doi.org/10.14802/jmd.24054 [Epub ahead of print]
- 878 View
- 86 Download
Erratum
- Evidence-Based Review on Symptomatic Management of Huntington’s Disease
- Jung Hwan Shin, Hui-Jun Yang, Jong Hyun Ahn, Sungyang Jo, Seok Jong Chung, Jee-Young Lee, Hyun Sook Kim, Manho Kim
- Published online December 2, 2024
- DOI: https://doi.org/10.14802/jmd.24140e [Epub ahead of print]
- Corrects: J Mov Disord 2024;17(4):369
- 384 View
- 67 Download
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