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Review Article
- Pseudobulbar Affect in Parkinsonian Disorders: A Review
- Mathew Hakimi, Carine W. Maurer
- J Mov Disord. 2019;12(1):14-21. Published online January 30, 2019
- DOI: https://doi.org/10.14802/jmd.18051
- 10,281 View
- 301 Download
- 11 Web of Science
- 11 Crossref
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Abstract
PDF - Pseudobulbar affect (PBA) is a neurological symptom of inappropriate and uncontrollable laughter or crying that occurs secondary to a variety of neurological conditions, including parkinsonian disorders. PBA is a socially and emotionally debilitating symptom that has been estimated to affect 3.6% to 42.5% of the population with Parkinson’s disease. While indexing measures and treatment options for PBA have been extensively studied in neurological conditions such as amyotrophic lateral sclerosis and multiple sclerosis, there has been considerably less attention given in the literature to PBA in parkinsonian disorders. The purpose of this review is to discuss the pathophysiology of PBA, its prevalence and impact on quality of life in parkinsonian disorders, and the treatment options currently available. Areas requiring further study, including the development of standardized, cross-culturally validated methods of symptom assessment, and evidence-based studies exploring the efficacy of current treatment options in parkinsonian disorders, are also highlighted.
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Citations
Citations to this article as recorded by
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NeuroTransmitter.2020; 31(6): 42. CrossRef - Treatment of pseudobulbar affect (PBA) in a patient with a history of traumatic brain injury, partial brain resection, and brainstem stroke: a case report
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Journal of Medical Case Reports.2020;[Epub] CrossRef
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