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- Brief communication COVID-19 vaccine related movement disorders: a systematic review
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Grace Elysse D. Angeles1
, Lowrence Precious C. Dichoso1
, Roland Dominic G. Jamora1,2
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DOI: https://doi.org/10.14802/jmd.24001 [Accepted]
Published online: March 19, 2024
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2Institute for Neurosciences, St. Luke’s Medical Center, Global City, Philippines
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Corresponding author:
Roland Dominic G. Jamora,
Email: rgjamora@up.edu.ph
Abstract
Objectives
Since the release of vaccines against COVID-19, there have been reports of vaccine-related neurologic complications. This study aimed to create a descriptive systematic review of movement disorders associated with COVID-19 vaccines.
Methods
We described the demographics, clinical presentation, management, outcomes, and proposed patho-mechanism. A systematic review was performed according to the PRISMA guidelines. A standardized tool was used to assess the quality of the cases.
Results
We have identified 8 articles that met our inclusion criteria consisting of 10 patients who developed movement disorders after vaccination. The majority were males (n = 8), with a median age of 64.5 years. The most common movement disorder was hemichorea. The rest presented with generalized chorea with myoclonus, cervical dystonia, and akathisia. Most cases responded with immunotherapy. The standardized tool used showed that most studies have a low risk of bias.
Conclusion
The reported incidence of vaccine-related movement disorders was low in occurrence based on available published cases that were found.
Comments on this article
hinpetch daungsupawong
March 21, 2024
Cite- Related articles
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Hinpetch Daungsupawong 1; Viroj Wiwanitkit2
1.Private Academic Consultant, Phonhong, Lao People's Democratic Republic.
2. 2.Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University India.
Dear Editor, we would like to share ideas on the publication “COVID-19 vaccine related movement disorders: a systematic review.” In essence, the purpose of this study was to look into cases of movement difficulties after vaccination. The researchers found ten patients from eight articles who had mobility abnormalities following vaccination. The majority of patients were male, with a median age of 64.5 years. The most prevalent movement problem found was hemichorea, followed by generalized chorea with myoclonus, cervical dystonia, and akathisia. Immunotherapy was proven to be an effective treatment for the majority of instances.
One potential problem in this study's approach is the small number of instances included in the analysis. With only 10 patients from 8 papers, the sample size is tiny, which may restrict the findings' generalizability. Furthermore, the use of case reports and case series for data gathering may create bias and variability in the reported results. Future research should aim for a bigger sample size and consider doing a more rigorous and systematic examination of the existing literature.
Another potential flaw in the methodology is the absence of specific information supplied on the vaccines administered to patients. distinct vaccines may have distinct modes of action and potential side effects, influencing the development of movement disorders. Incorporating information about the individual vaccine administered to each patient would enable a more detailed investigation of the potential link between vaccination and movement disorders. Future research should seek to gather and analyze this extra information.
In the future, researchers may consider undertaking a prospective cohort study to assess the occurrence of movement problems after immunization. This would enable a more thorough and controlled research into the potential link between immunization and movement disorders. Furthermore, introducing a control group of individuals who did not develop movement abnormalities following immunization could aid in the understanding of potential risk factors and mechanisms. Overall, future research in this field should aim to increase the quality and reliability of evidence on the link between immunization and movement disorders.